The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Chemico-Biological Interactions

• Publication date

  1998-11-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0009-2797(98)00092-1PMID 9920463
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Quercetin inhibits the growth of a multidrug-resistant estrogen-receptor-negative MCF-7 human breast-cancer cell line expressing type II estrogen-binding sites

  2004cited by this paper
• Effects of quercetin on drug metabolizing enzymes and oxidation of 2', 7-dichlorofluorescin in HepG2 cells

  1997cited by this paper
• Glutathione conjugation of chlorambucil: measurement and modulation by plant polyphenols.

  1997cited by this paper
• The response of primary rat and human osteoblasts and an immortalized rat osteoblast cell line to orthopaedic materials: comparative sensitivity of several toxicity indices

  1997cited by this paper
• Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells.

  1996cited by this paper
• Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.

  1996cited by this paper
• Heterogenous effects of natural flavonoids on monooxygenase activities in human and rat liver microsomes.

  1995cited by this paper
• Quercetin, a potent and specific inhibitor of the human P-form phenosulfotransferase.

  1995cited by this paper
• Effects of bioflavonoids on hepatic P450 activities.

  1995cited by this paper
• The activity of xenobiotic enzymes and the cytotoxicity of mitoxantrone in MCF 7 human breast cancer cells treated with inducing agents.

  1995cited by this paper
• Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468.

  1994cited by this paper
• Culture of a differentiated liver cell line, Hep G2, in serum with application to a bioartificial liver: effect of supplementation of serum with amino acids.

  1994cited by this paper
• Induction of apoptosis by quercetin: involvement of heat shock protein.

  1994cited by this paper
• Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes.

  1994cited by this paper
• Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice.

  1993cited by this paper
• Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands.

  1993cited by this paper
• Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis.

  1993cited by this paper
• Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man.

  1993cited by this paper
• Grapefruit juice–felodipine interaction: Mechanism, predictability, and effect of naringin

  1993cited by this paper
• Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract.

  1993cited by this paper
• The combination of quercetin and cytosine arabinoside synergistically inhibits leukemic cell growth.

  1992cited by this paper
• The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs.

  1992cited by this paper
• Enhancement of the antiproliferative activity of cis‐diamminedichloroplatinum(II) by quercetin

  1990cited by this paper
• Inhibition of ethoxy- and pentoxy-resorufin dealkylases of rat liver by flavones and flavonols: structure-activity relationship

  1989cited by this paper
• Induction of monooxygenase and transferase activities in rat by dietary administration of flavonoids.

  1989cited by this paper
• Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

  1988cited by this paper
• Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line.

  1988cited by this paper
• Inhibition of phosphorylase kinase, and tyrosine protein kinase activities by quercetin.

  1985cited by this paper
• [59] Glutathione reductase

  1985cited by this paper
• Glutathione reductase.

  1985cited by this paper
• In vitro and in vivo activation of oxidative drug metabolism by flavonoids.

  1984cited by this paper
• Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.

  1981cited by this paper
• Biospecific adsorption of hepatic DT-diaphorase on immobilized dicoumarol. II. Purification of mitochondrial and microsomal DT-diaphorase from 3-methylcholanthrene-treated rats.

  1981cited by this paper
• Hepatotoxicity studies with primary cultures of rat liver cells

  1978cited by this paper
• A fluorometric method for determination of oxidized and reduced glutathione in tissues.

  1976cited by this paper
• Hepatic triphosphopyridine nucleotide-cytochrome c reductase: isolation, characterization, and kinetic studies.

  1962cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Anticancer Drug Discovery from Natural Compounds Targeting PI3K/AKT/mTOR Signaling Pathway.

  2024cites this paper
• Using Flavonoid Substitution Status to Predict Anticancer Effects in Human Melanoma Cancers: An In Vitro Study

  2024cites this paper
• The Role of P-Glycoprotein (P-gp) in Cancer Multidrug Resistance (MDR): Challenges for Inhibiting P-gp in the Context of Overcoming MDR

  2023cites this paper
• Exploring the Remarkable Chemotherapeutic Potential of Polyphenolic Antioxidants in Battling Various Forms of Cancer

  2023cites this paper
• Effect of Purple Sweet Potato Using Different Cooking Methods on Cytoprotection against Ethanol-Induced Oxidative Damage through Nrf2 Activation in HepG2 Cells

  2023cites this paper
• Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa

  2022cites this paper
• Intelligent poly(l-histidine)-based nanovehicles for controlled drug delivery.

  2022cites this paper
• LC–MS/MS Phytochemical Profiling, Antioxidant Activity, and Cytotoxicity of the Ethanolic Extract of Atriplex halimus L. against Breast Cancer Cell Lines: Computational Studies and Experimental Validation

  2022cites this paper
• Kaempferol Regresses Carcinogenesis through a Molecular Cross Talk Involved in Proliferation, Apoptosis and Inflammation on Human Cervical Cancer Cells, HeLa

  2022cites this paper
• Effects of propolis and its bioactive components on breast cancer cell pathways and the molecular mechanisms involved

  2021cites this paper
• Chemopreventive and Therapeutic Potential of Natural Agents and Their Combinations for Breast Cancer

  2021cites this paper
• Molecular docking , Synthesis and ADME Studies of New Pyrazoline Derivatives as Potential Anticancer Agents.

  2021cites this paper
• Molecular Docking, synthesis, anticancer assessment and ADME study of naproxen containing imidazole ring derivatives

  2021cites this paper
• Various mechanisms of quercetin on inhibiting breast cancer growth: A review.

  2021cites this paper
• The Effects of Quercetin on the Apoptosis of Human Breast Cancer Cell Lines MCF-7 and MDA-MB-231: A Systematic Review

  2021cites this paper
• Antioxidant Activity and Mechanism of Resveratrol and Polydatin Isolated from Mulberry (Morus alba L.)

  2021cites this paper
• Medicinal Plants Used by the Indigenous People of the Philippines: A Systematic Review of Ethnobotanical Surveys and Bioactive compounds

  2021cites this paper
• A Review of Quercetin: Anticancer Activity

  2020cites this paper
• Innovations in Food Technology: Current Perspectives and Future Goals

  2020cites this paper
• Dietary Factors Associated with Cancer

  2020cites this paper
• Myricetin induces apoptosis and autophagy by inhibiting PI3K/Akt/mTOR signalling in human colon cancer cells

  2020cites this paper
• Study of Anticancer Activity of Pratensein and Pratensein Glycoside Isolated from Cuscuta kotchiana

  2020cites this paper
• Different propolis samples, phenolic content, and breast cancer cell lines: Variable cytotoxicity ranging from ineffective to potent

  2019cites this paper
• Changes of the stability and bioactivity of quercetin and myricetin in BGC-823 cells in response to heat treatment and Fe2+/Cu2+ addition

  2019cites this paper
• Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide.

  2018cites this paper
• Molecular docking and ADME properties of bioactive molecules against human acid-beta-glucosidase enzyme, cause of Gaucher’s disease

  2018cites this paper
• Effect of dietary flavonoids on hepatic CYP 2 E 1 and 3 A 4 activity – Implication for food-drug interactions

  2017cites this paper
• Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

  2017cites this paper
• Natural Products as Alternative Choices for P-Glycoprotein (P-gp) Inhibition

  2017cites this paper
• Breast Cancer and Flavonoids as Treatment Strategy

  2017cites this paper
• Еvaluation of biocompatibility and antioxidant efficiency of chitosan-alginate nanoparticles loaded with quercetin.

  2017cites this paper
• Status and trends of nutraceuticals from onion and onion by-products: A critical review

  2017cites this paper
• United States Patent ( 10 ) Patent No . : US 7 , 763 , 292 B 2

  2017cites this paper
• Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors.

  2017cites this paper
• Myricetin Inhibits Angiogenesis by Inducing Apoptosis and Suppressing PI3K/Akt/mTOR Signaling in Endothelial Cells

  2017cites this paper
• Theobroma cacao: Review of the Extraction, Isolation, and Bioassay of Its Potential Anti-cancer Compounds.

  2016cites this paper
• Myricetin: A Dietary Molecule with Diverse Biological Activities

  2016cites this paper
• Structural characterization and comparative biomedical properties of phloroglucinol from Indian brown seaweeds

  2016cites this paper
• Ajwa Date (Phoenix dactylifera L.) Extract Inhibits Human Breast Adenocarcinoma (MCF7) Cells In Vitro by Inducing Apoptosis and Cell Cycle Arrest

  2016cites this paper
• Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm. ex Decne. leaves from Algeria

  2016cites this paper
• The dietary phytochemical myricetin induces ROS-dependent breast cancer cell death

  2016cites this paper
• Phytochemical characterization and bioactive properties of Osyris quadripartita Salzm . ex Decne . from Algeria

  2016cites this paper
• Cocoa polyphenols in oxidative stress: Potential health implications

  2016cites this paper
• Myricetin inhibits proliferation and induces apoptosis and cell cycle arrest in gastric cancer cells

  2015cites this paper
• Antiproliferative effect of Phytosome complex of Methanolic extact ofTerminalia Arjuna bark on Human Breast Cancer Cell Lines (MCF-7)

  2015cites this paper
• Involvement of the modulation of cancer cell redox status in the anti-tumoral effect of phenolic compounds

  2015cites this paper
• HOW DOES QUERCETIN AND TAMOXIFEN AFFECT THE APOPTOSIS OF COLON CANCER CELLS

  2015cites this paper
• Quercetin Inhibits Vascular Endothelial Growth Factor-Induced Choroidal and Retinal Angiogenesis in vitro

  2015cites this paper
• A flavonoid isolated from Streptomyces sp. (ERINLG-4) induces apoptosis in human lung cancer A549 cells through p53 and cytochrome c release caspase dependant pathway.

  2014cites this paper
• Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2

  2014cites this paper
• Inhibitory effects of quercetin on angiogenesis in larval zebrafish and human umbilical vein endothelial cells.

  2014cites this paper
• Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin

  2014cites this paper
• Cytotoxicity of dietary flavonoids on different human cancer types

  2014cites this paper
• Direct and indirect antimicrobial effects of α -mangostin on pathogenic microorganisms

  2014cites this paper
• Antiproliferative effect of Portlandia extracts and their fractions on breast cancer cells.

  2014cites this paper
• Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells.

  2013cites this paper
• Winter wheat hull (husk) is a valuable source for tricin, a potential selective cytotoxic agent.

  2013cites this paper
• Protective effects of oligomeric and polymeric procyanidin fractions from defatted grape seeds on tert-butyl hydroperoxide-induced oxidative damage in HepG2 cells.

  2013cites this paper
• Potential for preventive effects of cocoa and cocoa polyphenols in cancer.

  2013cites this paper
• Effects of flavonoids on CYP1 expression in RL95-2 endometrial carcinoma cells

  2012cites this paper
• Natural compounds as inducers of cell death

  2012cites this paper
• Profiling Flavonoid Cytotoxicity in Human Breast Cancer Cell Lines: Determination of Structure-Function Relationships

  2012cites this paper
• In vitro antiproliferative and anti-oxidant activities of methanol extracts of Urena lobata and Viscum album against breast cancer cell lines

  2012cites this paper
• Hydroxytyrosyl acetate contributes to the protective effects against oxidative stress of virgin olive oil

  2012cites this paper
• (Iso)flav(an)ones, chalcones, catechins, and theaflavins as anticarcinogens: mechanisms, anti-multidrug resistance and QSAR studies.

  2012cites this paper
• In vivo antioxidant activity of total flavonoids from indocalamus leaves in aging mice caused by D-galactose.

  2012cites this paper
• Factors Affecting Phytochemical Composition and Antioxidant Activity of Ontario Vegetable Crops

  2012influential citation
• Role of propolis in improving the histological and ultrastructural changes of liver after treatment with tamoxifen

  2012cites this paper
• Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

  2012cites this paper
• Induction of Apoptosis by Polyphenolic Compounds in Cancer Cells

  2012cites this paper
• Profiling flavonoid cytotoxicity in human breast cancer cell lines

  2012cites this paper
• Anticancer, chemopreventive and radioprotective potential of black plum (Eugenia jambolana lam.).

  2011cites this paper
• Alkyl hydroxytyrosyl ethers show protective effects against oxidative stress in HepG2 cells.

  2011cites this paper
• The aroma, taste, color and bioactive constituents of tea

  2011cites this paper
• NPC Natural Product Communications

  2011cites this paper
• EvaluationofEffectsofQuercetin(3,3',4',5,7-pentohidroxyflavon) onApoptosisandTelomeraseEnzymeActivityinMCF-7and NIH-3T3CellLinesComparedwithTamoxifen

  2011cites this paper
• Phytochemicals in Cereals, Pseudocereals and Pulses

  2011cites this paper
• Flavonoids and sesquiterpenes from Tecurium ramosissimum promote antiproliferation of human cancer cells and enhance antioxidant activity: a structure-activity relationship study.

  2011cites this paper
• Effect of flavonone hesperidin on the apoptosis of human mammary carcinoma cell line MCF-7

  2011cites this paper
• Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells

  2011cites this paper
• Protective Effect of Quercetin on Oxidative Stress in Glucose-6-Phosphate Dehydrogenase-Deficient Erythrocytes in Vitro

  2010cites this paper
• Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats.

  2010cites this paper
• Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

  2010influential citation
• After cellular internalization, quercetin causes Nrf2 nuclear translocation, increases glutathione levels, and prevents neuronal death against an oxidative insult.

  2010cites this paper
• In vitro cytotoxicity and antioxidant activities of five medicinal plants of Malvaceae family from Cameroon.

  2010cites this paper
• Evaluation of Effects of Quercetin (3, 3', 4', 5, 7-pentohidroxyflavon) on Apoptosis and Telomerase Enzyme Activity in MCF-7 and NIH-3T3 Cell Lines Compared with Tamoxifen

  2010cites this paper
• Uptake, Metabolism and Biological Effect of the Olive Oil Phenol Hydroxytyrosol in Human HepG2 Cells

  2010cites this paper
• Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit

  2009cites this paper
• Immunomodulatory and anticancer activities of phenolics from Garcinia mangostana fruit pericarp.

  2009cites this paper
• Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells.

  2009cites this paper
• A Cell Culture Model for the Assessment of the Chemopreventive Potential of Dietary Compounds

  2009cites this paper
• Interactions of Flavones and Related Compounds with Nucleic Acids

  2009cites this paper
• Inhibitory effects of gallic acid and quercetin on UDP‐glucose dehydrogenase activity

  2008cites this paper
• Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract.

  2008cites this paper
• Quercetin inhibits choroidal and retinal angiogenesis in vitro

  2008cites this paper
• Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide

  2007cites this paper
• Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells

  2007cites this paper
• Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.

  2007cites this paper
• Effect of coffee melanoidin on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide.

  2007cites this paper
• The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation.

  2007cites this paper