Research review: the neurobiology and genetics of maltreatment and adversity.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Child Psychology and Psychiatry and Allied Disciplines

• Publication date

  2010-10-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1111/j.1469-7610.2010.02271.xPMID 20546078
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Genetic Basis of Complex Human Disease: Extending the Utility of Twin Studies (P05.123)

  2012cited by this paper
• Converging evidence for abnormalities of the prefrontal cortex and evaluation of midsagittal structures in pediatric posttraumatic stress disorder: an MRI study.

  2009cited by this paper
• Long-term effects of cognitive behavior therapy on brain activation in spider phobia.

  2009cited by this paper
• Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment.

  2009cited by this paper
• Effects of stress throughout the lifespan on the brain, behaviour and cognition

  2009cited by this paper
• Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

  2009cited by this paper
• Effects of stress throughout the lifespan on the brain, behaviour and cognition

  2009influential reference
• Early Adverse Events, HPA Activity and Rostral Anterior Cingulate Volume in MDD

  2009cited by this paper
• MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma.

  2009cited by this paper
• Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood.

  2009cited by this paper
• Amygdala, hippocampal and corpus callosum size following severe early institutional deprivation: the English and Romanian Adoptees study pilot.

  2009cited by this paper
• Childhood sexual abuse is associated with reduced gray matter volume in visual cortex of young women.

  2009cited by this paper
• ENDURANCE: getting the timing right

  2009cited by this paper
• Voxel-Based Morphometry: An Automated Technique for Assessing Structural Changes in the Brain

  2009cited by this paper
• Assessing a Child’s Experience of Multiple Maltreatment Types: Some Unfinished Business

  2009cited by this paper
• Effect of childhood emotional abuse and age on cortisol responsivity in adulthood.

  2009cited by this paper
• The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women.

  2009cited by this paper
• Lower CSF oxytocin concentrations in women with a history of childhood abuse

  2009cited by this paper
• Preliminary evidence for white matter tract abnormalities in young adults exposed to parental verbal abuse.

  2009cited by this paper
• Cortisol, callous-unemotional traits, and pathways to antisocial behavior

  2009cited by this paper
• Psychobiology and molecular genetics of resilience

  2009cited by this paper
• Neurostructural imaging findings in children with post‐traumatic stress disorder: Brief review

  2009cited by this paper
• Suicide attempts, gender, and sexual abuse: data from the 2000 British Psychiatric Morbidity Survey.

  2009cited by this paper
• Cerebellar volume and cognitive functioning in children who experienced early deprivation.

  2009cited by this paper
• Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology.

  2009cited by this paper
• Lasting epigenetic influence of early-life adversity on the BDNF gene.

  2009cited by this paper
• The neuropsychiatry of the cerebellum — insights from the clinic

  2008cited by this paper
• Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study.

  2008cited by this paper
• Maternal behavior predicts infant cortisol recovery from a mild everyday stressor.

  2008cited by this paper
• Childhood parental loss and adult hypothalamic-pituitary-adrenal function.

  2008cited by this paper
• Effects of an attachment-based intervention on the cortisol production of infants and toddlers in foster care

  2008cited by this paper
• Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects.

  2008cited by this paper
• Hippocampal and amygdala volumes in children and adults with childhood maltreatment‐related posttraumatic stress disorder: A meta‐analysis

  2008cited by this paper
• Gene-environment interaction in posttraumatic stress disorder

  2008cited by this paper
• Intervention effects on foster parent stress: Associations with child cortisol levels

  2008cited by this paper
• Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.

  2008cited by this paper
• The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma.

  2008cited by this paper
• Posttraumatic stress symptoms and brain function during a response‐inhibition task: an fMRI study in youth

  2008cited by this paper
• Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development.

  2008influential reference
• Effects of an attachment-based intervention on daily cortisol moderated by dopamine receptor D4: A randomized control trial on 1- to 3-year-olds screened for externalizing behavior

  2008cited by this paper
• The cerebellum on the rise in human emotion

  2008cited by this paper
• How can the study of biological processes help design new interventions for children with severe antisocial behavior?

  2008influential reference
• Integrating biological measures into the design and evaluation of preventive interventions

  2008cited by this paper
• The link between childhood trauma and depression: insights from HPA axis studies in humans.

  2008cited by this paper
• Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

  2008influential reference
• Brain-Derived Neurotrophic Factor-5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children

  2007cited by this paper
• Effects of a therapeutic intervention for foster preschoolers on diurnal cortisol activity.

  2007cited by this paper
• Personality, adrenal steroid hormones, and resilience in maltreated children: A multilevel perspective

  2007cited by this paper
• Morphologic Alterations in the Corpus Callosum in Abuse-Related Posttraumatic Stress Disorder: A Preliminary Study

  2007cited by this paper
• Understanding genetic risk for aggression: clues from the brain's response to social exclusion.

  2007cited by this paper
• Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA

  2007cited by this paper
• Mnemonic contributions of hippocampal place cells

  2007cited by this paper
• Cortisol and post-traumatic stress disorder in adults

  2007cited by this paper
• The importance of stress and genetic variation in human aggression

  2007cited by this paper
• Meta-analysis of gene–environment interactions in developmental psychopathology

  2007cited by this paper
• Epigenetic regulation in psychiatric disorders

  2007cited by this paper
• Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds

  2007cited by this paper
• Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment.

  2007cited by this paper
• Stress Predicts Brain Changes in Children: A Pilot Longitudinal Study on Youth Stress, Posttraumatic Stress Disorder, and the Hippocampus

  2007cited by this paper
• If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans.

  2007cited by this paper
• Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children.

  2006cited by this paper
• Hippocampal and amygdalar volumes in dissociative identity disorder.

  2006cited by this paper
• Meeting of minds: the medial frontal cortex and social cognition

  2006cited by this paper
• Genes for susceptibility to violence lurk in the brain.

  2006cited by this paper
• Foster Children’s Diurnal Production of Cortisol: An Exploratory Study

  2006cited by this paper
• Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder.

  2006cited by this paper
• Abnormal Brain Connectivity in Children After Early Severe Socioemotional Deprivation: A Diffusion Tensor Imaging Study

  2006cited by this paper
• Neuroendocrine and neurotransmitter correlates in children with antisocial behavior.

  2006cited by this paper
• Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects.

  2006cited by this paper
• Regional differences of the prefrontal cortex in pediatric PTSD: an MRI study

  2006cited by this paper
• Bringing basic research on early experience and stress neurobiology to bear on preventive interventions for neglected and maltreated children

  2006cited by this paper
• Developmental imaging genetics: Challenges and promises for translational research

  2006cited by this paper
• Gene–environment interactions in psychiatry: joining forces with neuroscience

  2006cited by this paper
• Neural mechanisms of genetic risk for impulsivity and violence in humans.

  2006cited by this paper
• Child maltreatment and the developing HPA axis.

  2006cited by this paper
• Developing Evidence‐Based Interventions for Foster Children: An Example of a Randomized Clinical Trial with Infants and Toddlers

  2006cited by this paper
• The impact of early institutional rearing on the ability to discriminate facial expressions of emotion: an event-related potential study.

  2005cited by this paper
• Measuring the severity of child maltreatment.

  2005cited by this paper
• Strategy for investigating interactions between measured genes and measured environments.

  2005cited by this paper
• Contributions of the amygdala to emotion processing: from animal models to human behavior.

  2005cited by this paper
• Physically abused children's regulation of attention in response to hostility.

  2005cited by this paper
• An event-related potential study of the processing of affective facial expressions in young children who experienced maltreatment during the first year of life

  2005cited by this paper
• Circadian rhythm of salivary cortisol in Holocaust survivors with and without PTSD.

  2005cited by this paper
• The cognitive control of emotion.

  2005cited by this paper
• Maternal care as a model for experience-dependent chromatin plasticity?

  2005cited by this paper
• An event-related potential study of the impact of institutional rearing on face recognition

  2005cited by this paper
• Minireview: glucocorticoids--food intake, abdominal obesity, and wealthy nations in 2004.

  2004cited by this paper
• Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress.

  2004cited by this paper
• Epigenetic programming by maternal behavior

  2004influential reference
• Exposure to postnatal depression predicts elevated cortisol in adolescent offspring.

  2004cited by this paper
• Associations in the course of personality disorders and Axis I disorders over time.

  2004cited by this paper
• Childhood neglect is associated with reduced corpus callosum area.

  2004cited by this paper
• Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression.

  2004cited by this paper
• Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task--reversal of effects with maternal-like licking stimulation.

  2004cited by this paper
• Pituitary volumes in pediatric maltreatment-related posttraumatic stress disorder.

  2004cited by this paper
• Child maltreatment.

  2004cited by this paper
• Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse.

  2004cited by this paper
• Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder.

  2004cited by this paper
• Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions.

  2004cited by this paper
• Hippocampal Volume and Memory Performance in a Community-Based Sample of Women with Posttraumatic Stress Disorder Secondary to Child Abuse

  2004cited by this paper

• Epilogue: Forum on Addressing Childhood Trauma and Maltreatment Through the Lens of the ICF.

  2026cites this paper
• Forum: Addressing Childhood Trauma and Maltreatment Through the Lens of the ICF.

  2026cites this paper
• Dyadic developmental psychotherapy for children with developmental trauma histories: An exploration of children’s therapeutic experiences

  2025cites this paper
• Childhood Maltreatment Impacts Cognitive Function in Emerging Adulthood: A Systematic Review and Meta-Analysis.

  2025cites this paper
• Autonomic Dysregulation Mediates the Association Between Childhood Trauma and Pain Severity: Evidence from a Mediation Model

  2025cites this paper
• Instability in the environment and children’s in-school self-regulatory behaviors

  2025cites this paper
• Childhood Maltreatment and Cognitive Performance in Bipolar Disorder: The Potential Role of Inflammation.

  2025cites this paper
• Deciphering the mediating role of childhood maltreatment in the association between genetic risk and developmental trajectories of school-age reactive and proactive aggression.

  2025cites this paper
• Emotional cognition in patients with borderline personality disorder and patients with bipolar disorder type II: Evidence for transdiagnostic and differential diagnostic differences?

  2025cites this paper
• Social Pediatrics Unit: Interdisciplinary and intersectoral care model for patients who are victims of child abuse

  2025cites this paper
• Testing the ecophenotype hypothesis: Differences in white matter microstructure in youth with conduct disorder with versus without a history of childhood abuse.

  2025cites this paper
• Childhood Maltreatment and Somatic Symptoms in Adulthood: Establishing a New Research Pathway

  2025cites this paper
• Longitudinal associations between adolescent adversity, brain development and behavioural and emotional problems

  2025cites this paper
• The Relationship Between Insufficient Sleep and Depressive Symptoms in Chinese Adolescents: A National Survey of Contributing Factors

  2025cites this paper
• Longitudinal impact of different categories of adverse childhood experiences on social participation and informal social support among middle-aged and older adults in China

  2025cites this paper
• Enhanced trauma‐informed policing (E‐TIP): A neurocognitive, organizational, and leadership framework for advancing officer well‐being and public safety

  2025cites this paper
• Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder

  2025cites this paper
• A novel multidimensional, perinatal social and material deprivation paradigm induces aggressive behavior and cortical gene expression reprogramming in young adult mice.

  2025cites this paper
• Psychological Resilience Buffers Depression and Post-Traumatic Stress Disorder Due to Childhood Trauma in Thai Seniors

  2025cites this paper
• Violence Exposure and Cognitive Outcomes Among Children in Low- and Middle-Income Countries (LMICs): A Systematic Review

  2025cites this paper
• Adoption and development from infancy to adulthood: A systematic review of longitudinal studies and future directions.

  2025cites this paper
• Exploring attachment representations and traumatic reenactment in foster children

  2025cites this paper
• Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.

  2024cites this paper
• Child Maltreatment and Psychopathology: A Brief Review on the Potential Role of the Hypothalamic-pituitary-adrenal Axis.

  2024cites this paper
• Exploring the Impact of Challenging Childhood Experiences on the Personality Development of Emerging Adults

  2024cites this paper
• Identifying the Mechanisms Linking Child Abuse Victimization and Substance Use and Misuse Among an Adult Population in China

  2024cites this paper
• Adult Mental Health Associated with Adverse and Positive Childhood Experiences Among 1st and 2nd Generation Asian Americans

  2024cites this paper
• Developing an Understanding of Complex Trauma Among Child Sexual Assault Survivors in South Africa: Implications for Practice

  2024cites this paper
• No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults

  2024cites this paper
• The neurobiological effects of childhood maltreatment on brain structure, function, and attachment

  2024cites this paper
• The Role of Alpha-Linolenic Acid and Other Polyunsaturated Fatty Acids in Mental Health: A Narrative Review

  2024cites this paper
• Acute social defeat during adolescence promotes long-lasting aggression through activation of the medial amygdala

  2024cites this paper
• The mediator role of identity salience and defeat and entrapment in the relationship between centrality of events and existential annihilation anxiety

  2024cites this paper
• Revisiting the use of adverse childhood experience screening in healthcare settings

  2024cites this paper
• Childhood Maltreatment and Early Maladaptive Schemas: the Role of Self-Forgiveness

  2024cites this paper
• Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.

  2024cites this paper
• Einfluss früher Gewalterfahrungen von Frauen auf die Mutter-Kind-Beziehung

  2023cites this paper
• [The impact of adverse childhood experiences on mental and somatic health in childhood and adolescence].

  2023cites this paper
• Attachment Security and Cortical Activity Measured by Functional Near-Infrared Spectroscopy During a Working Memory Task in Healthy Young Adults.

  2023cites this paper
• The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.

  2023cites this paper
• The effectiveness of Sandplay Therapy versus Cognitive Behavioral Therapy: a comparative study

  2023cites this paper
• Salivary secretory immunoglobulin A as a potential biomarker of psychosocial stress response during the first stages of life: A systematic review.

  2023cites this paper
• Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys

  2023cites this paper
• Association between childhood trauma, cognition, and psychosocial function in a large sample of partially or fully remitted patients with bipolar disorder and healthy participants

  2023cites this paper
• Traumatic Sequelae of Exposure to Street Gangs in Young Women Placed in Residential Care During Adolescence: Examining the Dose-Response Relationship

  2023cites this paper
• Impact of Family Violence on Antisocial Behaviors in Two Developmental Periods: the Investigation of the Moderating Role of a Haplotypic Serotonergic Polygenic Score

  2023cites this paper
• Altered Topological Structure of the Brain White Matter in Maltreated Children through Topological Data Analysis

  2023cites this paper
• Impact of violence against women on quality of life and menopause-related disorders.

  2023cites this paper
• The relationship between childhood trauma and insomnia among college students with major depressive disorder: Mediation by the role of negative life events and dysfunctional attitudes.

  2023cites this paper
• SARS-CoV-2 pandemic as a catalyst? Development of emotional problems of preschool children of mothers with childhood maltreatment experiences in the course of the pandemic–a longitudinal analysis

  2023cites this paper
• Resistance exercise was safe for the pregnancy and offspring's development and partially protected rats against early life stress-induced effects.

  2023cites this paper
• A Cross-Sectional Study: Structural and Related Functional Connectivity Changes in the Brain: Stigmata of Adverse Parenting in Patients with Major Depressive Disorder?

  2023cites this paper
• Correlations between childhood maltreatment, anxiety and depressive symptoms, and risk behaviors in adolescent schoolchildren

  2023cites this paper
• The relationship between diurnal cortisol slope and cognitive development among children maltreated as infants.

  2023cites this paper
• Positive coping supports children’s emotional wellness: Behavioral evidence and neuroendocrine mechanisms

  2023cites this paper
• Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery

  2023cites this paper
• Altered topological structure of the brain white matter in maltreated children through topological data analysis

  2023cites this paper
• Childhood adversity and approach/avoidance-related behaviour in boys

  2022cites this paper
• Relationship Between Childhood Abuse and Body Mass Index in Young Adulthood: Mediated by Depression and Anxiety?

  2022cites this paper
• Parents’ Experiences of Change in Developmental and Transactional Processes After Time-Limited Intersubjective Child Psychotherapy – A Qualitative Study

  2022cites this paper
• Longitudinal Associations Between Parenting and Child Behaviour Problems and the Moderating Effect of Child Callous Unemotional Traits in Foster and Biological Families

  2022cites this paper
• Does Seclusion Alter Amygdala Activity and Amygdala-Medial Prefrontal Cortex Connectivity Leading to Emotional Dysregulation in Children? A Case for Ending Seclusion and Restraint In Public Schools

  2022cites this paper
• Maternal History of Child Maltreatment and Household Chaos: Examining the Mediating Role of Maternal and Child Psychopathology

  2022cites this paper
• Sleep quality, caregiver burden, and individual resilience among parents of children with epilepsy.

  2022cites this paper
• Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis.

  2022cites this paper
• Longterm Consequences of Childhood Maltreatment

  2022cites this paper
• Going beyond risk factor: Childhood maltreatment and associated modifiable targets to improve life-long outcomes in mood disorders.

  2022cites this paper
• Early life adversity has long-term effects on sociality and interaction style in female baboons

  2022cites this paper
• Childhood adversity and cognitive impairment in later life

  2022cites this paper
• Depressive disorders in childhood

  2022cites this paper
• Neutrophil-to-lymphocyte ratio (NLR) variations in relationship with childhood maltreatment in patients with anorexia nervosa: a retrospective cohort study

  2022cites this paper
• Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder

  2022cites this paper
• Examining the effectiveness of trauma-focused cognitive behavioral therapy on children and adolescents' executive function.

  2022cites this paper
• Chapter 23: Maltreated and traumatized children and young people

  2022cites this paper
• Child Maltreatment and Global Health: Biocultural Perspectives

  2022cites this paper
• Opportunities to Discuss Diversity-Related Topics in Neuroscience Courses.

  2022cites this paper
• Adverse Childhood Experiences: Piloting a Group Therapy Program Using Psychoeducation, Music Therapy, and the Creative Arts for Adults with Complex Concurrent Disorders in an Inpatient Setting

  2022cites this paper
• Mediators of the Relationship Between Adverse Childhood Experiences (ACEs) and Symptoms of Anxiety, Depression, and Suicidality among Adults

  2022cites this paper
• Neurodevelopmental mechanisms linking early experiences and mental health: Translating science to promote well-being among youth.

  2022cites this paper
• City, University of London Institutional Repository

  2022cites this paper
• Childhood adversity and vagal regulation: A systematic review and meta-analysis.

  2022cites this paper
• A Prospective Study of the Impact of Severe Childhood Deprivation on Brain White Matter in Adult Adoptees: Widespread Localized Reductions in Volume But Unaffected Microstructural Organization

  2022cites this paper
• Adverse childhood experiences and fronto-subcortical structures in the developing brain

  2022cites this paper
• Validation and standardization of the Childhood Trauma Screener (CTS) in the general population

  2022cites this paper
• Cortical thickness and curvature abnormalities in patients with major depressive disorder with childhood maltreatment: Neural markers of vulnerability?

  2022cites this paper
• Longstanding health risk across the life course: The influence of early-life experience on health status throughout the life span.

  2022cites this paper
• The relational genomics of cognitive function: A longitudinal study.

  2021cites this paper
• How childhood trauma and recent adverse events are related to hair cortisol levels in a large adult cohort.

  2021cites this paper
• Daily Reports of Aggressive Behaviors in Interpersonal Conflicts

  2021cites this paper
• Early Childhood Adversity, Stress, and Developmental Pathways of Suicide Risk

  2021cites this paper
• Transforming the paradigm of child welfare

  2021cites this paper
• When it’s OK not to think: using the music of silence, sound and language to recover a live object for a child frozen into a ‘robot’ state of mind by trauma

  2021cites this paper
• An E�cient SMOTE Based Machine Learning classi�cation for Prediction & Detection of PCOS

  2021cites this paper
• Longitudinal examination of resilience among child welfare-involved adolescents: The roles of caregiver-child relationships and deviant peer affiliation.

  2021cites this paper
• Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience.

  2021cites this paper
• Risk of Suicidal Behavior in Children and Adolescents Exposed to Maltreatment: The Mediating Role of Borderline Personality Traits and Recent Stressful Life Events

  2021cites this paper
• Parental incarceration and child physical health outcomes from infancy to adulthood: A critical review and multilevel model of potential pathways

  2021cites this paper
• Lifetime adversity interacts with peritraumatic data-driven processing to predict intrusive memories.

  2021cites this paper
• Mentoring Children in Foster Care: Examining Relationship Histories as Moderators of Intervention Impact on Children's Mental Health and Trauma Symptoms.

  2021cites this paper
• Australian Maltreated Infants and Young Children Can Achieve Positive Relational Health With Neurodevelopmentally- and Trauma-Informed Interventions Provided Within Relationally-Positive and Stable Environments

  2021cites this paper