Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nature Communications

• Publication date

  2013-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ncomms3712PMID 24231649
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

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• Translational aspects of sphingosine 1-phosphate biology.

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• Rab27a and Rab27b control different steps of the exosome secretion pathway

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• Membrane budding.

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• Lysosomal degradation of membrane lipids

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• Sphingosine kinase 1 regulates mucin production via ERK phosphorylation.

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• MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways

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• Sphingosine 1-phosphate receptor signaling.

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• Hybrid Structural Model of the Complete Human ESCRT‐0 Complex

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  2008cited by this paper
• Signaling by dopamine regulates D2 receptors trafficking at the membrane

  2008cited by this paper
• The emerging shape of the ESCRT machinery

  2007cited by this paper
• Involvement of Sphingosine-1-Phosphate in Glutamate Secretion in Hippocampal Neurons

  2007cited by this paper
• Biogenesis and function of multivesicular bodies.

  2007cited by this paper
• The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting.

  2007cited by this paper
• Protein Kinase D-mediated Phosphorylation and Nuclear Export of Sphingosine Kinase 2*

  2007cited by this paper
• Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer.

  2007cited by this paper
• ESCRTing proteins in the endocytic pathway.

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• Sphingosine Kinase Type 2 Activation by ERK-mediated Phosphorylation*

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  2006cited by this paper
• GIRK channel activation involves a local rearrangement of a preformed G protein channel complex.

  2006cited by this paper
• Structural and functional organization of the ESCRT-I trafficking complex.

  2006cited by this paper
• The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function Published, JLR Papers in Press, March 6, 2006.

  2006cited by this paper
• A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis.

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• Involvement of N-terminal-extended Form of Sphingosine Kinase 2 in Serum-dependent Regulation of Cell Proliferation and Apoptosis*

  2005cited by this paper
• Dynamics of receptor/G protein coupling in living cells

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• Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

  2005cited by this paper
• G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region.

  2005cited by this paper
• Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

  2005cited by this paper
• G Protein Activation without Subunit Dissociation Depends on a Gαi-specific Region*

  2005cited by this paper
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  2005cited by this paper
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• Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

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• Structure of the ESCRT-II endosomal trafficking complex

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• Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

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• The biogenesis of multivesicular endosomes

  2004cited by this paper
• Vps27 recruits ESCRT machinery to endosomes during MVB sorting

  2003cited by this paper
• The Trojan exosome hypothesis

  2003cited by this paper
• Exosomes: composition, biogenesis and function

  2002cited by this paper
• Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis

  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1.

  1999cited by this paper
• Induction of Endocytic Vesicles by Exogenous C6-ceramide*

  1999cited by this paper
• Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.

  1999cited by this paper
• The role of ceramide in cell signaling.

  1998cited by this paper
• Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.

  1998cited by this paper
• Differential regulation of CXCR4 and CCR5 endocytosis.

  1998cited by this paper
• Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.

  1998cited by this paper
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  1998cited by this paper
• Sequestration of the G protein βγ subunit complex inhibits receptor-mediated endocytosis

  1998cited by this paper
• Regulation of Golgi structure through heterotrimeric G proteins.

  1997cited by this paper
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  1991cited by this paper
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  1983cited by this paper

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