Deletion of the Adenoviral E1b-19kD Gene Enhances Tumor Cell Killing of a Replicating Adenoviral Vector

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Human Gene Therapy

• Publication date

  2000-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/10430340050015851PMID 10697113
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The emerging fields of suicide gene therapy and virotherapy.

  2002cited by this paper
• Oncolytic viruses as therapeutic agents

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• Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

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• ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

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• cyt gene of adenoviruses 2 and 5 is an oncogene for transforming function in early region E1B and encodes the E1B 19,000-molecular-weight polypeptide

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• Adenovirus cyt+ locus, which controls cell transformation and tumorigenicity, is an allele of lp+ locus, which codes for a 19-kilodalton tumor antigen

  1984cited by this paper
• Adenovirus 2 lp+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation

  1983cited by this paper

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