Regulation of cancer metabolism by oncogenes and tumor suppressors.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Methods in Enzymology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-416618-9.00003-0PMID 24862260
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.

  2013cited by this paper
• The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans.

  2013cited by this paper
• MYC, metabolism, cell growth, and tumorigenesis.

  2013cited by this paper
• Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

  2013cited by this paper
• Metabolic Regulation by p53 Family Members

  2013cited by this paper
• Loss of RBF1 changes glutamine catabolism.

  2013cited by this paper
• Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

  2013cited by this paper
• AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.

  2013cited by this paper
• TAp73 enhances the pentose phosphate pathway and supports cell proliferation

  2013cited by this paper
• The multiple connections between pRB and cell metabolism.

  2013cited by this paper
• Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

  2013cited by this paper
• Control of Glutamine Metabolism By the Tumor Suppressor Rb

  2013cited by this paper
• Exploiting the bad eating habits of Ras-driven cancers

  2013cited by this paper
• Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors.

  2013cited by this paper
• Molecular Pathways Molecular Pathways : Targeting MYC-induced Metabolic Reprogramming and Oncogenic Stress in Cancer

  2013cited by this paper
• EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.

  2012cited by this paper
• Systemic elevation of PTEN induces a tumor-suppressive metabolic state.

  2012cited by this paper
• A metabolic prosurvival role for PML in breast cancer.

  2012cited by this paper
• Revisiting global gene expression analysis.

  2012cited by this paper
• p63/p73 in the control of cell cycle and cell death.

  2012cited by this paper
• Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

  2012cited by this paper
• Cancer metabolism: current perspectives and future directions

  2012cited by this paper
• Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

  2012cited by this paper
• Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice

  2012cited by this paper
• Serine starvation induces stress and p53 dependent metabolic remodeling in cancer cells

  2012cited by this paper
• Faculty Opinions recommendation of Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

  2012cited by this paper
• TAp73 depletion accelerates aging through metabolic dysregulation.

  2012cited by this paper
• AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

  2012cited by this paper
• Transcriptional amplification in tumor cells with elevated c-Myc.

  2012cited by this paper
• The LKB1 complex-AMPK pathway: the tree that hides the forest

  2011cited by this paper
• Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

  2011cited by this paper
• Adenosine monophosphate-activated protein kinase: a central regulator of metabolism with roles in diabetes, cancer, and viral infection.

  2011cited by this paper
• Structure of Mammalian AMPK and its regulation by ADP

  2011cited by this paper
• Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency

  2011cited by this paper
• NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

  2011cited by this paper
• E2F transcription factor-1 regulates oxidative metabolism

  2011cited by this paper
• Regulation of metabolism by hypoxia-inducible factor 1.

  2011cited by this paper
• 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.

  2011cited by this paper
• Activation of a metabolic gene regulatory network downstream of mTOR complex 1.

  2010cited by this paper
• Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

  2010cited by this paper
• MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells.

  2010cited by this paper
• Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

  2010cited by this paper
• Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

  2010cited by this paper
• Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

  2010cited by this paper
• MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU

  2010cited by this paper
• Targeting mitochondrial glutaminase activity inhibits oncogenic transformation.

  2010cited by this paper
• Subtle variations in Pten dose determine cancer susceptibility

  2010cited by this paper
• Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.

  2010cited by this paper
• Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

  2010cited by this paper
• MYC as a regulator of ribosome biogenesis and protein synthesis

  2010cited by this paper
• Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.

  2010cited by this paper
• Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation.

  2009cited by this paper
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

  2009cited by this paper
• Abstract #LB-186: c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

  2009cited by this paper
• p53 and metabolism

  2009cited by this paper
• The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

  2009cited by this paper
• c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism

  2009cited by this paper
• Kinase activity-independent suppression of p73α by AMP-activated kinase α (AMPKα)

  2009cited by this paper
• Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.

  2009cited by this paper
• Prolyl hydroxylases as regulators of cell metabolism.

  2009cited by this paper
• AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.

  2009cited by this paper
• Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

  2009cited by this paper
• Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells*

  2008cited by this paper
• Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

  2008cited by this paper
• Regulation of TORC1 by Rag GTPases in nutrient response

  2008cited by this paper
• Track 1 – Track 5

  2008cited by this paper
• The PTEN–PI3K pathway: of feedbacks and cross-talks

  2008cited by this paper
• p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

  2008cited by this paper
• Common corruption of the mTOR signaling network in human tumors

  2008cited by this paper
• Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia*

  2008cited by this paper
• Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

  2008cited by this paper
• Defining the role of mTOR in cancer.

  2007cited by this paper
• Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1

  2007cited by this paper
• Hypoxia signalling controls metabolic demand.

  2007cited by this paper
• AKT/PKB signaling: navigating downstream.

  2007cited by this paper
• HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.

  2007cited by this paper
• Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis.

  2007cited by this paper
• DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.

  2006cited by this paper
• HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia.

  2006cited by this paper
• HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.

  2006cited by this paper
• TIGAR, a p53-inducible regulator of glycolysis and apoptosis.

  2006cited by this paper
• p53 Regulates Mitochondrial Respiration

  2006cited by this paper
• Nuclear factor-κB and inhibitor of κB kinase pathways in oncogenic initiation and progression

  2006cited by this paper
• The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

  2006cited by this paper
• Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.

  2006cited by this paper
• TOR signaling in growth and metabolism.

  2006cited by this paper
• K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts.

  2005cited by this paper
• AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

  2005cited by this paper
• c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

  2005cited by this paper
• Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis

  2005cited by this paper
• K-ras Codon-Specific Mutations Produce Distinctive Metabolic Phenotypes in Human Fibroblasts

  2005cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• The LKB1 tumor suppressor negatively regulates mTOR signaling.

  2004cited by this paper
• Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

  2004cited by this paper
• Akt Stimulates Aerobic Glycolysis in Cancer Cells

  2004cited by this paper
• Signaling to NF-kappaB.

  2004cited by this paper
• The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression

  2004cited by this paper
• TSC2 mediates cellular energy response to control cell growth and survival.

  2003cited by this paper

• The Multi-Target lncRNA–miRNA–mRNA TRIAD in Pancreatic Cancer Diagnosis and Therapy

  2026cites this paper
• Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

  2025cites this paper
• Poor diagnostic value of isocitrate dehydrogenase 1 R132H immunohistochemistry for determination of isocitrate dehydrogenase 1 status in patients with glioblastoma

  2025cites this paper
• Recent advances in mitochondria‐targeting theranostic agents

  2024cites this paper
• Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment

  2024cites this paper
• Molecular skin fluorescence imaging: A tool for evaluating early melanoma development

  2024cites this paper
• LPCAT2-mediated lipid droplet production supports pancreatic cancer chemoresistance and cell motility.

  2024cites this paper
• Targeting Cancer Metabolism to Improve Outcomes with Immune Checkpoint Inhibitors

  2023influential citation
• Transcriptome analysis identifies oncogenic tissue remodeling during progression from common nevi to early melanoma.

  2023cites this paper
• Hypoxic Preconditional Engineering Small Extracellular Vesicles Promoted Intervertebral Disc Regeneration by Activating Mir‐7‐5p/NF‐Κb/Cxcl2 Axis

  2023cites this paper
• Design and Characterization of pMyc/pMax Peptide-Coupled Gold Nanosystems for Targeting Myc in Prostate Cancer Cell Lines

  2023cites this paper
• The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways

  2023cites this paper
• How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy

  2023cites this paper
• Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications

  2023cites this paper
• Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives

  2023cites this paper
• Targeting lactate metabolism for cancer immunotherapy - a matter of precision.

  2022cites this paper
• FLI1 accelerates leukemogenesis through transcriptional regulation of pyruvate kinase-L/R and other glycolytic genes

  2022cites this paper
• Screening and diagnosis of triple negative breast cancer based on rapid metabolic fingerprinting by conductive polymer spray ionization mass spectrometry and machine learning

  2022cites this paper
• An Update on the Metabolic Landscape of Oncogenic Viruses

  2022cites this paper
• Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy

  2022cites this paper
• Metabolite-derived protein modifications modulating oncogenic signaling

  2022cites this paper
• Mechanical and metabolic interplay in the brain metastatic microenvironment

  2022cites this paper
• Enzyme Trafficking and Co-Clustering Precede and Accurately Predict Human Breast Cancer Recurrences: An Interdisciplinary Review.

  2022cites this paper
• The absence of cellular glucose triggers oncogene AEG-1 that instigates VEGFC in HCC: A possible genetic root cause of angiogenesis.

  2022cites this paper
• Targeting metabolism to overcome cancer drug resistance: A promising therapeutic strategy for diffuse large B cell lymphoma.

  2022cites this paper
• Pathogenesis and Current Treatment of Osteosarcoma: Perspectives for Future Therapies

  2021cites this paper
• Cutting edge: Metabolic immune reprogramming, reactive oxygen species, and cancer

  2021cites this paper
• Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis

  2021cites this paper
• The prognostication potential of BRCA genes expression in gliomas: a genetic survival analysis study.

  2021cites this paper
• Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing

  2021cites this paper
• Dissecting the Molecular Response of Human Escs to Iron-Mediated Oxidative Stress by Genetic Silencing of FTH1 Gene

  2021cites this paper
• Glucose deprivation enhances resistance to paclitaxel via ELAVL2/4-mediated modification of glycolysis in ovarian cancer cells

  2021cites this paper
• Metabolic control of cancer progression as novel targets for therapy.

  2021cites this paper
• Генетические предикторы развития злокачественных новообразований (обзор литературы)

  2021cites this paper
• Genetic Predictors of Malignancy: a Literature Review

  2021cites this paper
• Multi-generational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p.

  2020cites this paper
• Clinicopathological Analysis and Prognostic Assessment of Transcobalamin I (TCN1) in Patients with Colorectal Tumors

  2020cites this paper
• TFB1M Promotes Hepatocellular Carcinoma Growth and Metastasis by Increasing Aerobic Glycolysis

  2020cites this paper
• Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer.

  2020cites this paper
• Cancer cell metabolism: rewiring the mitochondrial hub.

  2020cites this paper
• mTOR Regulation of Metabolism in Hematologic Malignancies

  2020cites this paper
• Metabolic Plasticity in Chemotherapy Resistance

  2020cites this paper
• mTOR complex 2 is an integrator of cancer metabolism and epigenetics.

  2020cites this paper
• Metabolic Escape Routes of Cancer Stem Cells and Therapeutic Opportunities

  2020cites this paper
• Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

  2020cites this paper
• Epigenetic mechanisms and the hallmarks of cancer: an intimate affair.

  2020cites this paper
• Warburg and Krebs and related effects in cancer

  2019cites this paper
• Targeting strategies for glucose metabolic pathways and T cells in colorectal cancer.

  2019cites this paper
• How Viral and Intracellular Bacterial Pathogens Reprogram the Metabolism of Host Cells to Allow Their Intracellular Replication

  2019cites this paper
• Assessment of Metabolic Signature for Cancer Diagnosis Using Desorption Electrospray Ionization Mass Spectrometric Imaging.

  2019cites this paper
• Heart myxoma develops oncogenic and metastatic phenotype

  2019cites this paper
• The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways

  2019cites this paper
• Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells

  2019cites this paper
• Metabolomics for Investigating Physiological and Pathophysiological Processes.

  2019cites this paper
• Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

  2019cites this paper
• Mitochondrial Pathways in Cancer

  2019cites this paper
• The Role of RB in Prostate Cancer Progression.

  2019cites this paper
• Maspin and GLUT-1 expression in endometrial carcinomas and prognostic relevance

  2019cites this paper
• Synthèse sur support solide de dérivés aminostéroïdiens pour le développement d'agents anticancéreux et synthèse d'inhibiteurs stéroïdiens de la CYP1B1, une enzyme présentant un potentiel comme cible thérapeutique

  2018cites this paper
• mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression

  2018cites this paper
• SPARC Inhibits Metabolic Plasticity in Ovarian Cancer

  2018cites this paper
• Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells.

  2018cites this paper
• Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

  2018cites this paper
• Impact of Immunosuppressive Drugs on the Metabolism of T Cells.

  2018cites this paper
• Bioinformatics analysis of gene expression profiles to diagnose crucial and novel genes in glioblastoma multiform.

  2018cites this paper
• The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?

  2018cites this paper
• Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

  2018cites this paper
• PET Imaging on Dynamic Metabolic Changes after Combination Therapy of Paclitaxel and the Traditional Chinese Medicine in Breast Cancer-Bearing Mice

  2018cites this paper
• Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities.

  2018cites this paper
• Integrative omics analysis of p53‐dependent regulation of metabolism

  2018cites this paper
• Suppression of p16 increases nucleotide synthesis via mTORC1

  2018cites this paper
• Regulation of cellular gene expression by nanomaterials

  2018cites this paper
• Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma

  2018cites this paper
• LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response.

  2018cites this paper
• Oncogenic Phenotypes Induced by Overexpression of the DEK Proto-oncogene

  2017cites this paper
• Molecular Mechanisms Underlying the Inhibitory Effects of Qingzaojiufei Decoction on Tumor Growth in Lewis Lung Carcinoma

  2017cites this paper
• Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment

  2017influential citation
• Overexpression of the human DEK oncogene reprograms cellular metabolism and promotes glycolysis

  2017cites this paper
• Is There a Therapeutic Window for Metabolism-Based Cancer Therapies?

  2017cites this paper
• The “ins and outs” of prostate metabolism towards carcinogenesis: the case of methoxychlor

  2017cites this paper
• Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors

  2017cites this paper
• Oncogene-Driven Metabolic Alterations in Cancer

  2017influential citation
• Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids

  2017cites this paper
• Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells

  2017cites this paper
• A Transcriptional Regulatory Role for the Membrane Type-1 Matrix Metalloproteinase in Carcinogen-Induced Inflammasome Gene Expression

  2017cites this paper
• To Eat and to Be Eaten: Mutual Metabolic Adaptations of Immune Cells and Intracellular Bacterial Pathogens upon Infection

  2017cites this paper
• Interplay between Oncogenes and Tumor Suppressor Genes in Human Disease

  2016cites this paper
• Drugging the addict: non‐oncogene addiction as a target for cancer therapy

  2016cites this paper
• Role of Oncogenes and Tumor Suppressors in Metabolic Reprogramming and Cancer Therapeutics: A Review

  2016cites this paper
• Detection of Lung Cancer through Metabolic Changes Measured in Blood Plasma

  2016cites this paper
• MULTIPLE MYELOMA ( P KAPOOR , SECTION EDITOR ) Signaling Pathways and Emerging Therapies in Multiple Myeloma

  2016cites this paper
• Tumor Metabolism, the Ketogenic Diet and β-Hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy

  2016influential citation
• Metabolic phenotyping of human blood plasma: a powerful tool to discriminate between cancer types?

  2016cites this paper
• The effect of immunosuppressive molecules on T-cell metabolic reprogramming.

  2016cites this paper
• The c.*229C > T gene polymorphism in 3′UTR region of the topoisomerase IIβ binding protein 1 gene and LOH in BRCA1/2 regions and their effect on the risk and progression of human laryngeal carcinoma

  2016cites this paper
• G4 DNA in ras genes and its potential in cancer therapy.

  2016cites this paper
• Restoration of Brain Acid Soluble Protein 1 Inhibits Proliferation and Migration of Thyroid Cancer Cells

  2016cites this paper
• Emerging roles of p53 and other tumour-suppressor genes in immune regulation

  2016cites this paper
• Pleiotropic Functions of RB Protein in Tumor Suppression

  2015cites this paper
• ATF4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2‐deoxyglucose in the same cells

  2015cites this paper