Formation of human myocardium in the rat heart from human embryonic stem cells.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  American Journal of Pathology

• Publication date

  2005-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0002-9440(10)62041-XPMID 16127147PMCID PMC1698736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes: Insights Into the Development of Cell-Based Pacemakers

  2005cited by this paper
• Distribution pattern of α and β myosin in normal and diseased human ventricular myocardium

  2005cited by this paper
• Electromechanical integration of cardiomyocytes derived from human embryonic stem cells

  2004cited by this paper
• Evidence for Fusion Between Cardiac and Skeletal Muscle Cells

  2004cited by this paper
• Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

  2004cited by this paper
• Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

  2004cited by this paper
• Adult cardiac stem cells are multipotent and support myocardial regeneration.

  2003cited by this paper
• Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture With Visceral Endoderm-Like Cells

  2003cited by this paper
• Scalable Production of Embryonic Stem Cell-Derived Cardiomyocytes

  2003cited by this paper
• Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts

  2003cited by this paper
• Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes

  2003cited by this paper
• Human Embryonic Stem Cells Develop Into Multiple Types of Cardiac Myocytes: Action Potential Characterization

  2003cited by this paper
• Stem cell therapy for ischemic heart disease.

  2003cited by this paper
• Transplantation of cells for cardiac repair.

  2003cited by this paper
• Myocyte and myogenic stem cell transplantation in the heart.

  2003cited by this paper
• Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host

  2003cited by this paper
• Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

  2003cited by this paper
• Characterization and Enrichment of Cardiomyocytes Derived From Human Embryonic Stem Cells

  2002influential reference
• Cardiomyocyte differentiation of mouse and human embryonic stem cells *

  2002cited by this paper
• Cellular therapies for myocardial infarct repair.

  2002cited by this paper
• Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

  2002cited by this paper
• Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

  2002cited by this paper
• Stem cell differentiation requires a paracrine pathway in the heart

  2002cited by this paper
• Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.

  2002cited by this paper
• Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart

  2002cited by this paper
• Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs.

  2002cited by this paper
• Autologous cell transplantation for the treatment of damaged myocardium.

  2002cited by this paper
• Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects.

  2002cited by this paper
• Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting.

  2002influential reference
• Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes.

  2001cited by this paper
• Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies.

  2001influential reference
• Heat Shock Protein 70 Gene Transfection Protects Mitochondrial and Ventricular Function Against Ischemia-Reperfusion Injury

  2001cited by this paper
• Cell Therapy Attenuates Deleterious Ventricular Remodeling and Improves Cardiac Performance After Myocardial Infarction

  2001cited by this paper
• Bone marrow cells regenerate infarcted myocardium

  2001cited by this paper
• Feeder-free growth of undifferentiated human embryonic stem cells

  2001cited by this paper
• Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in a rat model of extensive myocardial infarction.

  2001cited by this paper
• Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

  2000cited by this paper
• The Ki‐67 protein: From the known and the unknown

  2000influential reference
• Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair.

  2000cited by this paper
• Transmural replacement of myocardium after skeletal myoblast grafting into the heart. Too much of a good thing?

  2000cited by this paper
• Electromechanical Coupling between Skeletal and Cardiac Muscle

  2000cited by this paper
• Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts.

  1999cited by this paper
• Embryonic stem cell lines derived from human blastocysts.

  1998cited by this paper
• Constitutive and inducible hsp70s are involved in oxidative resistance evoked by heat shock or ethanol.

  1998cited by this paper
• Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease.

  1998cited by this paper
• Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis

  1997cited by this paper
• Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium.

  1997cited by this paper
• Skeletal myoblast transplantation for repair of myocardial necrosis.

  1996influential reference
• Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.

  1996cited by this paper
• Cardioprotective effects of 70-kDa heat shock protein in transgenic mice.

  1996cited by this paper
• DNA synthesis and multinucleation in embryonic stem cell-derived cardiomyocytes.

  1995cited by this paper
• Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

  1995cited by this paper
• Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium.

  1994cited by this paper
• Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress.

  1993cited by this paper
• Antibodies defining rat endothelial cells: RECA-1, a pan-endothelial cell-specific monoclonal antibody.

  1992cited by this paper
• Distribution pattern of alpha and beta myosin in normal and diseased human ventricular myocardium.

  1989cited by this paper
• Development changes in the human cardiac isomyosin distribution: an immunohistochemical study using monoclonal antibodies.

  1987cited by this paper
• Distribution of α- and β-myosin heavy chains in the ventricular fibers of the postnatal developing rat

  1987cited by this paper
• Distribution of alpha- and beta-myosin heavy chains in the ventricular fibers of the postnatal developing rat.

  1987cited by this paper
• Glycogen content in human embryonic heart.

  1975cited by this paper

• Population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection.

  2025cites this paper
• Cardiomyocytes in Hypoxia: Cellular Responses and Implications for Cell-Based Cardiac Regenerative Therapies

  2025cites this paper
• Localized ultrasonic stimulation using a piezoelectric micromachined ultrasound transducer array for selective neural differentiation of magnetic cell-based robots

  2025cites this paper
• Pluripotent stem cell-based approaches for heart repair and the potential of genetic modifications

  2025cites this paper
• Computational modeling of gelation of hydrogel for myocardial infarction therapy in rat myocardium: Capturing non-linear losses using time-dependent viscosity

  2025cites this paper
• Human pluripotent stem cell-based cardiac repair: Lessons learned and challenges Ahead.

  2025cites this paper
• Refining the Guinea Pig (Cavia porcellus) Cryo-Injury Model for Cardiac Regeneration and Functional Characterization.

  2025cites this paper
• Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin

  2025cites this paper
• Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes

  2024cites this paper
• Challenges and perspectives of heart repair with pluripotent stem cell-derived cardiomyocytes

  2024cites this paper
• Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

  2024cites this paper
• Interplay of piezoelectricity and electrical stimulation in tissue engineering and regenerative medicine

  2024cites this paper
• Improving iPSC Differentiation Using a Nanodot Platform

  2024cites this paper
• Advanced cell and gene therapies in cardiology

  2024cites this paper
• Graft–host coupling changes can lead to engraftment arrhythmia: a computational study

  2023cites this paper
• Impulse initiation in engrafted pluripotent stem cell-derived cardiomyocytes can stimulate the recipient heart

  2023cites this paper
• miR-182/183-Rasa1 axis induced macrophage polarization and redox regulation promotes repair after ischemic cardiac injury

  2023cites this paper
• Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts

  2023cites this paper
• Cellular reprogramming of fibroblasts in heart regeneration.

  2023cites this paper
• HLA‐Ehigh/HLA‐Ghigh/HLA‐IIlow Human iPSC‐Derived Cardiomyocytes Exhibit Low Immunogenicity for Heart Regeneration

  2023cites this paper
• Human PSC-derived cardiac cells and their products: therapies for cardiac repair.

  2023cites this paper
• Charting the Path: Navigating Embryonic Development to Potentially Safeguard against Congenital Heart Defects

  2023cites this paper
• Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury

  2022cites this paper
• State of the Field: Cellular Therapy Approaches in Microvascular Regeneration.

  2022cites this paper
• Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

  2022cites this paper
• Compatibility and function of human induced pluripotent stem cell derived cardiomyocytes on an electrospun nanofibrous scaffold, generated from an ionomeric polyurethane composite.

  2022cites this paper
• Cardiac Cell Therapy with Pluripotent Stem Cell-Derived Cardiomyocytes: What Has Been Done and What Remains to Do?

  2022cites this paper
• Maturation of human pluripotent stem cell derived cardiomyocytes in vitro and in vivo.

  2021cites this paper
• Transplantation of Human Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Regenerative Therapy

  2021cites this paper
• Understanding stem cells and its pivotal role in regenerative medicine.

  2021cites this paper
• How to repair a broken heart with pluripotent stem cell-derived cardiomyocytes.

  2021cites this paper
• Perspective on Stem Cell Therapy in Organ Fibrosis: Animal Models and Human Studies

  2021cites this paper
• Function Follows Form

  2021cites this paper
• In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

  2021influential citation
• Contractile force of transplanted cardiomyocytes contributes to heart function after injury

  2021cites this paper
• In situ maturated early-stage human induced pluripotent stem cell-derived cardiomyocytes improve cardiac function by enhancing segmentary contraction in infarcted rats

  2021influential citation
• Development and characterization of a high fat diet-streptozotocin induced type 2 diabetes model in nude athymic rats

  2021cites this paper
• Cardiac Regeneration: New Hope for an Old Dream.

  2020cites this paper
• Cardiomyocyte Induction and Regeneration for Myocardial Infarction Treatment: Cell Sources and Administration Strategies

  2020cites this paper
• Pluripotent Stem Cells for Cardiac Regeneration　- Current Status, Challenges, and Future Perspectives.

  2020cites this paper
• Perspective on human pluripotent stem cell‐derived cardiomyocytes in heart disease modeling and repair

  2020cites this paper
• Genome-wide transcriptome analysis reveals equine embryonic stem cell-derived tenocytes resemble fetal, not adult tenocytes

  2020cites this paper
• Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury

  2020cites this paper
• Illuminating the Regenerative Properties of Stem Cells In Vivo with Bioluminescence Imaging

  2020cites this paper
• Stem Cells and the Future of Heart Transplantation

  2020cites this paper
• Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

  2020cites this paper
• Optical mapping of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts

  2020cites this paper
• Biotechnology: Discoveries and Their Applications in Societal Welfare

  2020cites this paper
• Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo

  2020cites this paper
• Robust Cardiac Regeneration: Fulfilling the Promise of Cardiac Cell Therapy.

  2020cites this paper
• Stem Cell-Based and Gene Therapies in Heart Failure

  2020cites this paper
• Cardiac tissue engineering

  2020cites this paper
• Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

  2020cites this paper
• Cellular Basis for Myocardial Regeneration and Repair

  2020cites this paper
• Sonic Hedgehog upregulation does not enhance the survival and engraftment of stem cell-derived cardiomyocytes in infarcted hearts

  2020cites this paper
• The role of regenerative therapy in the treatment of right ventricular failure: a literature review

  2020cites this paper
• Human Pluripotent Stem Cell-Derived Cardiomyocytes with Ischemia Resistant Gap Junctions

  2020cites this paper
• Mending a broken heart: current strategies and limitations of cell-based therapy

  2020cites this paper
• Human Embryonic Stem Cell-Derived Cardiomyocytes Regenerate the Infarcted Pig Heart but Induce Ventricular Tachyarrhythmias

  2019cites this paper
• Human embryonic stem cells: Distinct molecular personalities and applications in regenerative medicine

  2019cites this paper
• Scaffolds for bladder tissue engineering

  2019cites this paper
• Apela Promotes Cardiomyocyte Differentiation from Transgenic Human Embryonic Stem Cell Lines

  2019cites this paper
• Multicellularity in the Cardiovascular System

  2019cites this paper
• Noninvasive application of mesenchymal stem cell spheres derived from hESC accelerates wound healing in a CXCL12-CXCR4 axis-dependent manner

  2019cites this paper
• Cardiac Tissue Engineering

  2019cites this paper
• Function Follows Form - A Review of Cardiac Cell Therapy.

  2019cites this paper
• A genome-wide screen for essential genes that controls the formation of human heart progenitors

  2018cites this paper
• 26 Differentiation , Characterization and Applications of Human Embryonic Stem Cell – Derived Cardiomyocytes

  2018cites this paper
• OBSOLETE: Myocardial Repair

  2018cites this paper
• Changing Metabolism in Differentiating Cardiac Progenitor Cells—Can Stem Cells Become Metabolically Flexible Cardiomyocytes?

  2018influential citation
• Cell-Based Therapies for Cardiac Regeneration: A Comprehensive Review of Past and Ongoing Strategies

  2018cites this paper
• Concise Review: Optimized Strategies for Stem Cell‐Based Therapy in Myocardial Repair: Clinical Translatability and Potential Limitation

  2018cites this paper
• Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

  2018cites this paper
• The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction

  2018cites this paper
• Emerging Therapies for Congestive Heart Failure

  2018influential citation
• Development of Biomimetic Models of Human Cardiac Tissue

  2018cites this paper
• [Stem cells: searching predisposition to cardiac commitment by surface markers expression].

  2018cites this paper
• Current Progress in the Rejuvenation of Aging Stem/Progenitor Cells for Improving the Therapeutic Effectiveness of Myocardial Repair

  2018cites this paper
• Células madre: buscando marcadores de superficie celular que predispongan compromiso de diferenciación cardiaca

  2018cites this paper
• Development, Proliferation, and Growth of the Mammalian Heart.

  2018cites this paper
• Biological therapies targeting arrhythmias: are cells and genes the answer?

  2018cites this paper
• Embryonic Stem Cells in Development and Regenerative Medicine.

  2018cites this paper
• Role of Caveolin-1 in Hypoxia and Proneural to Mesenchymal Transition of Glioblastoma

  2018cites this paper
• Pluripotent and Mesenchymal Stem Cells—Challenging Sources for Derivation of Myoblast

  2018cites this paper
• Optimizing Blended Collagen-Fibrin Hydrogels for Cardiac Tissue Engineering with Human iPSC-derived Cardiomyocytes

  2018cites this paper
• Ethical and Safety Issues of Stem Cell-Based Therapy

  2018cites this paper
• Stem Cell for Aesthetic and Antiaging

  2017cites this paper
• Stem Cell Engineering and Differentiation for Disease Modeling and Cell-based Therapies

  2017cites this paper
• 5 Cytoprotection and Preconditioning for Stem Cell Therapy

  2017cites this paper
• Engineered microvessels for improved integration with host coronary circulation and for the generation of pre-vascularized cardiac constructs

  2017cites this paper
• State of the Art in Cardiomyocyte Transplantation

  2017cites this paper
• Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology

  2017cites this paper
• Serum-Free Xenogen-Free Culture Conditions Support Human Explant-Derived Cardiac Stem Cell Growth

  2017cites this paper
• Tissue Engineering Strategies to Improve Post-MI Engraftment of hESC-Derived Cardiomyocytes

  2017influential citation
• Programming cells for cardiac repair.

  2017cites this paper
• Recent Progress Using Pluripotent Stem Cells for Cardiac Regenerative Therapy.

  2017cites this paper
• Stem cells and heart disease - Brake or accelerator?

  2017cites this paper
• Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids.

  2017cites this paper
• Regenerating Heart Using a Novel Compound and Human Wharton Jelly Mesenchymal Stem Cells.

  2017cites this paper
• In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts

  2017influential citation