The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Molecular and Cellular Biology

• Publication date

  1991-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.11.10.5364-5371.1991PMID 1656230PMCID PMC361610
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31.

  1991cited by this paper
• Developmental regulation of gap junction gene expression during mouse embryonic development.

  1991cited by this paper
• Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts

  1990cited by this paper
• Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication.

  1990cited by this paper
• The v‐ras oncogene inhibits the expression of differentiation markers and facilitates expression of cytokeratins 8 and 18 in mouse keratinocytes

  1990cited by this paper
• Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II.

  1990cited by this paper
• Expression of the gap junction protein connexin43 in embryonic chick lens: Molecular cloning, ultrastructural localization, and post-translational phosphorylation

  1990cited by this paper
• Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

  1990cited by this paper
• Retinoid‐enhanced gap junctional communication is achieved by increased levels of connexin 43 mRNA and protein

  1990cited by this paper
• Tyrosine phosphorylation is an early and specific event involved in primary keratinocyte differentiation

  1990cited by this paper
• Modulation of gap junction transcript and protein expression during pregnancy in the rat

  1990cited by this paper
• Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines

  1990cited by this paper
• Molecular characterization and functional expression of the human cardiac gap junction channel

  1990cited by this paper
• Inhibition of electrical coupling in pairs of murine pancreatic acinar cells by OAG and isolated protein kinase C

  1989cited by this paper
• Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA

  1989cited by this paper
• Similar and synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment of mouse primary keratinocytes.

  1989influential reference
• Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes

  1989cited by this paper
• p21H‐ras‐induced morphological transformation and increases in c‐myc expression are independent of functional protein kinase C.

  1989cited by this paper
• Identification of a phorbol ester-repressible v-src-inducible gene.

  1989cited by this paper
• Acid and base hydrolysis of phosphoproteins bound to immobilon facilitates analysis of phosphoamino acids in gel-fractionated proteins.

  1989cited by this paper
• Potential role of the human Ha‐ras oncogene in the inhibition of gap junctional intercellular communication

  1989cited by this paper
• The protein kinase C family: heterogeneity and its implications.

  1989cited by this paper
• Specific viral oncogenes cause differential effects on cell‐to‐cell communication, relevant to the suppression of the transformed phenotype by normal cells

  1988cited by this paper
• Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells.

  1988cited by this paper
• Topology of the 32‐kd liver gap junction protein determined by site‐directed antibody localizations.

  1988cited by this paper
• The cellular src gene product regulates junctional cell-to-cell communication.

  1988cited by this paper
• Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

  1988cited by this paper
• Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts

  1987cited by this paper
• Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of BALB/c 3T3 cells.

  1987cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication.

  1987cited by this paper
• Connexin43: a protein from rat heart homologous to a gap junction protein from liver

  1987cited by this paper
• Reduced number of gap junctions in rat hepatocarcinomas detected by monoclonal antibody.

  1986cited by this paper
• An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

  1986cited by this paper
• c‐myc and c‐fos expression in differentiating mouse primary keratinocytes.

  1986cited by this paper
• Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein

  1986cited by this paper
• v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis.

  1986cited by this paper
• Molecular cloning of cDNA for rat liver gap junction protein

  1986cited by this paper
• Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

  1985cited by this paper
• Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells.

  1985cited by this paper
• Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses

  1985cited by this paper
• Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters.

  1984cited by this paper
• Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells

  1984cited by this paper
• Antibodies to gap-junctional protein selectively disrupt junctional communication in the early amphibian embryo

  1984cited by this paper
• The relevance of gap junctions to stage I tumor promotion in mouse epidermis.

  1984cited by this paper
• Transformation of epidermal cells in culture.

  1983cited by this paper
• Role of differentiation in determining responses of epidermal cells to phorbol esters.

  1982cited by this paper
• Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

  1982cited by this paper
• Junctional intercellular communication: the cell-to-cell membrane channel.

  1981cited by this paper
• Calcium regulation of growth and differentiation of mouse epidermal cells in culture.

  1980cited by this paper
• Tumor promoters inhibit metabolic cooperation in cocultures of epidermal and 3T3 cells.

  1979cited by this paper
• Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

  1979cited by this paper
• Junctional intercellular communication and the control of growth.

  1979cited by this paper
• Gap junctions, electrotonic coupling, and intercellular communication.

  1978cited by this paper
• Metabolic Coupling, Ionic Coupling and Cell Contacts

  1972cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Metabolic Adaptation of Regenerative Hematopoiesis Depends on Docking-Independent Mitochondrial Connexin-43.

  2025cites this paper
• Inhibitory Effects of Alpha-Connexin Carboxyl-Terminal Peptide on Canine Mammary Epithelial Cells: A Study on Benign and Malignant Phenotypes

  2024cites this paper
• Design of A3B-Porphyrin Conjugates with Terpyridine as Potential Theranostic Agents: Synthesis, Complexation with Fe(III), Gd(III), and Photodynamic Activity

  2023cites this paper
• Implication of Connexin 43 as a Tumor Suppressor in Pathogenesis of Breast Cancer

  2021cites this paper
• Cx43 phosphorylation–mediated effects on ERK and Akt protect against ischemia reperfusion injury and alter the stability of the stress-inducible protein NDRG1

  2019cites this paper
• Gambogic Acid and Its Analogs Inhibit Gap Junctional Intercellular Communication

  2018cites this paper
• Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease

  2018cites this paper
• The role of connexin 43 gap junction formation in monocytes trans-endothelial migration

  2017cites this paper
• Genetics: Transcribing for the enemy

  2016cites this paper
• Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer

  2016cites this paper
• Terbinafine inhibits gap junctional intercellular communication.

  2016cites this paper
• Gap junctions and cancer: communicating for 50 years

  2016cites this paper
• Development and Validation of a Novel In Vitro Model for the Assessment of Heterocellular Interactions Mediated by Connexin43

  2015cites this paper
• S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function

  2014cites this paper
• MicroRNAs in Stem Cells and Cancer Stem Cells

  2014cites this paper
• Role of group I metabotropic glutamate receptors, mGluR1/mGluR5, in connexin43 phosphorylation and inhibition of gap junctional intercellular communication in H9c2 cardiomyoblast cells

  2014cites this paper
• dominant phasic inhibition to dominant phasic excitation Transition to seizures in the isolated immature mouse hippocampus: a switch from

  2013cites this paper
• Post-Transcriptional Regulation of Connexin43 in H-Ras-Transformed Cells

  2013cites this paper
• Investigation on the effects of experimental STZ-induced diabetic rat model on basal membrane structures and gap junctions of skin

  2012cites this paper
• Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.

  2012cites this paper
• Functions of connexin 46 in lens and solid tumors during hypoxia

  2012cites this paper
• Investigation of the Reciprocal Relationship between the Expression of Two Gap Junction Connexin Proteins, Connexin46 and Connexin43*

  2011cites this paper
• Reduced gap junctional communication among astrocytes in experimental diabetes: Contributions of altered connexin protein levels and oxidative–nitrosative modifications

  2011cites this paper
• Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells.

  2011cites this paper
• Reopening of ATP‐sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord

  2011cites this paper
• Gap junctions and connexins as therapeutic targets in cancer

  2010cites this paper
• DISTINCT ROLES FOR Cx37 AND Cx40 IN REGULATING VASCULAR RESPONSES FOLLOWING ISCHEMIA

  2010cites this paper
• Connexin43 phosphorylation: structural changes and biological effects.

  2009influential citation
• Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication.

  2009cites this paper
• Cancer Modeling: How Far Can We Go?

  2009cites this paper
• EXPRESSION OF GAP JUNCTION PROTEIN CX43 IN DEVELOPING MICE EPIDERMIS

  2009cites this paper
• Biochemistry of Connexins

  2009cites this paper
• Regulation of gap junctional intercellular communication by TCDD in HMEC and MCF-7 breast cancer cells.

  2009cites this paper
• Signaling pathways involved in connexin43 expression and cellular sub-localization in human astrocytoma

  2009cites this paper
• Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation

  2008cites this paper
• Connexin 37 profoundly slows cell cycle progression in rat insulinoma cells.

  2008cites this paper
• Impaired Gap Junction Formation and Intercellular Calcium Signaling in Urinary Bladder Cancer Cells can be Improved by Gö6976

  2007cites this paper
• Connexin43 behaviour in cardiac myocytes exposed to ischaemia and hypoxia

  2007cites this paper
• Regulation of Gap Junction Intercellular Communication in Primary Canine Lens Epithelial Cells: Role of Protein Kinase C

  2007cites this paper
• Influence of environmental and chemical factors on cellular signaling in lens epithelial cells

  2007influential citation
• Herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication.

  2007cites this paper
• Connexins as precocious markers and molecular targets for chemical and pharmacological agents in carcinogenesis.

  2007cites this paper
• The role of phosphoinositide 3-kinase/akt signaling pathway in tumor-associated angiogenesis, wound healing, and carcinogenesis.

  2006cites this paper
• Developmental regulation and expression of the zebrafish connexin43 gene

  2005cites this paper
• Temporal regulation of connexin phosphorylation in embryonic and adult tissues.

  2005cites this paper
• Nerve growth factor increases connexin43 phosphorylation and gap junctional intercellular communication

  2005cites this paper
• The Mitogenic Effects of Transforming Growth Factors 1 and 2 in C 3 H / 1 OT 1 h Cells Occur in the Presence of Enhanced Gap Junctional Communication ’

  2005cites this paper
• Nonylphenol Alters Connexin 43 Levels and Connexin 43 Phosphorylation Via an Inhibition of the p38-Mitogen-Activated Protein Kinase Pathway1

  2005cites this paper
• Connexin phosphorylation as a regulatory event linked to gap junction channel assembly.

  2005cites this paper
• Up-regulation of gap junctional intercellular communication and connexin43 expression by retinoic acid in human endometrial stromal cells.

  2005cites this paper
• Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia

  2005cites this paper
• Expression of connexins 26, 32 and 43 in the human colon--an immunohistochemical study.

  2004cites this paper
• Gap junction communication between cells aggregated on a cellulose-coated polystyrene: influence of connexin 43 phosphorylation.

  2004cites this paper
• Gap junction diseases of the skin.

  2004cites this paper
• The effects of connexin phosphorylation on gap junctional communication.

  2004cites this paper
• Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368

  2004influential citation
• Ubiquitination and Down-regulation of Gap Junction Protein Connexin-43 in Response to 12-O-Tetradecanoylphorbol 13-Acetate Treatment*

  2004cites this paper
• Gap junction diseases of the skin

  2004cites this paper
• Recovery of gap junctional intercellular communication after phorbol ester treatment requires proteasomal degradation of protein kinase C.

  2003cites this paper
• The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression

  2003cites this paper
• Altered connexin expression and wound healing in the epidermis of connexin-deficient mice

  2003cites this paper
• Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence.

  2003influential citation
• Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation

  2003influential citation
• Connexin43 and Connexin45 Form Heteromeric Gap Junction Channels in Which Individual Components Determine Permeability and Regulation

  2002cites this paper
• Antiviral agents alter ability of HSV-2 to disrupt gap junctional intercellular communication between mammalian cells in vitro.

  2002cites this paper
• Phosphorylation of Connexin43 and Regulation of Cardiac Gap Junction

  2002cites this paper
• The Molecular Basis of Skin Carcinogenesis

  2002cites this paper
• Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.

  2002cites this paper
• Gap junction assembly: PTX-sensitive G proteins regulate the distribution of connexin43 within cells.

  2001cites this paper
• Cadmium-induced alterations of connexin expression in the promotion stage of in vitro two-stage transformation.

  2001cites this paper
• Polyamines regulate gap junction communication in connexin 43-expressing cells.

  2001cites this paper
• c-Src Regulates the Interaction between Connexin-43 and ZO-1 in Cardiac Myocytes*

  2001cites this paper
• A Self-restricted CD38-connexin 43 Cross-talk Affects NAD+ and Cyclic ADP-ribose Metabolism and Regulates Intracellular Calcium in 3T3 Fibroblasts*

  2001cites this paper
• HSV-2 disrupts gap junctional intercellular communication between mammalian cells in vitro.

  2001cites this paper
• Phosphorylation of Connexin43 on Serine368 by Protein Kinase C Regulates Gap Junctional Communication

  2000influential citation
• Gap junction genes and their regulation

  2000cites this paper
• Analysis of connexin phosphorylation sites.

  2000cites this paper
• Regulation of gap junctions by phosphorylation of connexins.

  2000cites this paper
• GAP junctions during neoplastic transformation

  2000cites this paper
• Relationship of gap junction formation to phosphorylation of connexin43 in mouse preimplantation embryos

  2000cites this paper
• Post-transcri ptional events in the expression of gap junctions

  2000cites this paper
• PDGF regulates gap junction communication and connexin43 phosphorylation by PI 3-kinase in mesangial cells.

  2000cites this paper
• Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis.

  2000cites this paper
• Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells

  2000cites this paper
• A useful marker for evaluating tissue-engineered products: Gap-junctional communication for assessment of the tumor-promoting action and disruption of cell differentiation in tissue-engineered products

  2000cites this paper
• Deficiency of Connexin 43 Gap Junctions Is an Independent Marker for Breast Tumors 1

  1999cites this paper
• Carcinogenesis and the plasma membrane.

  1999cites this paper
• PKC role in mechanically induced Ca2+ waves and ATP-induced Ca2+ oscillations in airway epithelial cells.

  1999cites this paper
• PKC role in mechanically induced Ca 2 1 waves and ATP-induced Ca 2 1 oscillations in airway epithelial cells

  1999cites this paper
• In vivo association of pp60v‐src and the gap‐junction protein connexin 43 in v‐src–transformed fibroblasts

  1999cites this paper
• Benzo[A]Pyrene and Dibenzo[A, L]Pyrene do not Alter gap Junction Communication in Rat Liver Epithelial Cells

  1999cites this paper
• Quiescent mammary epithelial cells have reduced connexin43 but maintain a high level of gap junction intercellular communication.

  1999cites this paper
• Deficiency of connexin43 gap junctions is an independent marker for breast tumors.

  1999cites this paper
• Chapter 15: Regulation of Connexin43 by Tyrosine Protein Kinases

  1999cites this paper
• Effects of TPA on dye transfer and dye leakage in fibroblasts transfected with a connexin 43 mutation at ser368.

  1999cites this paper
• Gap junctions in the limb regeneration blastema of the axolotl, Ambystoma mexicanum, are not distributed uniformly and are regulated by retinoic acid

  1999cites this paper
• Regulation of cell‐cell communication in rat bone cells: The effect of phorbol esters

  1999cites this paper
• Chapter 24: Role of Gap Junctions in Cellular Growth Control and Neoplasia: Evidence and Mechanisms

  1999cites this paper
• Formation of a distinct connexin 43 phosphoisoform in mitotic cells is dependent upon p 34 cdc 2 kinase

  1998cites this paper
• Phosphorylation of lens-fiber connexins in lens organ cultures.

  1998cites this paper