Cardiovascular Disease (CVD) is the most common cause of death in industrialized countries, and myocardial infarction (MI) is a major CVD with significant morbidity and mortality. Following MI, the left ventricle (LV) undergoes a wound healing response to ischemia that results in extracellular matrix (ECM) scar formation to replace necrotic myocytes. While ECM accumulation following MI is termed cardiac fibrosis, this is a generic term that does not differentiate between ECM accumulation that occurs in the infarct region to form a scar that is structurally necessary to preserve left ventricle (LV) wall integrity and ECM accumulation that increases LV wall stiffness to exacerbate dilation and stimulate the progression to heart failure. This review focuses on post-MI LV ECM remodeling, targeting the discussion on ECM biomarkers that could be useful for predicting MI outcomes.
Understanding cardiac extracellular matrix remodeling to develop biomarkers of myocardial infarction outcomes.
S. Nielsen,A. Mouton,K. DeLeon-Pennell,F. Genovese,M. Karsdal,M. Lindsey
Published 2017 in Matrix Biology
ABSTRACT
PUBLICATION RECORD
- Publication year
2017
- Venue
Matrix Biology
- Publication date
2017-12-14
- Fields of study
Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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