The therapeutic potential of cell identity reprogramming for the treatment of aging‐related neurodegenerative disorders

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Progress in neurobiology

• Publication date

  2017-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.pneurobio.2016.01.006PMID 26844759PMCID PMC5848468
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Parkinson's disease].

  2022influential reference
• Huntington's disease: an update of therapeutic strategies.

  2015cited by this paper
• Direct Reprogramming of RESTing Astrocytes.

  2015cited by this paper
• Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

  2015influential reference
• Can insulin signaling pathways be targeted to transport Aβ out of the brain?

  2015cited by this paper
• Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion

  2015cited by this paper
• Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules.

  2015cited by this paper
• SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

  2015influential reference
• eview xploring the Alzheimer amyloid-peptide conformational nsemble : A review of molecular dynamics approaches

  2015cited by this paper
• Single-cell transcriptome analysis reveals dynamic changes in lncRNA expression during reprogramming.

  2015cited by this paper
• Riluzole as a Neuroprotective Drug for Spinal Cord Injury: From Bench to Bedside

  2015cited by this paper
• Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons.

  2015cited by this paper
• Neuron NeuroResource Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

  2014influential reference
• 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.

  2014cited by this paper
• Development and applications of CRISPR-Cas9 for genome engineering.

  2014cited by this paper
• In vivo conversion of astrocytes to neurons in the injured adult spinal cord

  2014influential reference
• Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

  2014cited by this paper
• Direct lineage reprogramming of mouse fibroblasts to functional midbrain dopaminergic neuronal progenitors.

  2014influential reference
• Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

  2014cited by this paper
• Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

  2014cited by this paper
• CellNet: network biology applied to stem cell engineering.

  2014cited by this paper
• Enhancing the efficiency of direct reprogramming of human primary fibroblasts into dopaminergic neuron-like cells through p53 suppression

  2014cited by this paper
• Sequential histone-modifying activities determine the robustness of transdifferentiation

  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
• Induced pluripotent stem cell-derived neural cells survive and mature in the nonhuman primate brain.

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• Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons

  2013influential reference
• Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

  2013cited by this paper
• Generation of induced neurons via direct conversion in vivo

  2013influential reference
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  2013cited by this paper
• Generation of oligodendroglial cells by direct lineage conversion

  2013cited by this paper
• In Vivo Cell Reprogramming towards Pluripotency by Virus-Free Overexpression of Defined Factors

  2013cited by this paper
• Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

  2013influential reference
• Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.

  2013cited by this paper
• Environmental Impact on Direct Neuronal Reprogramming In Vivo in the Adult Brain

  2013cited by this paper
• In vivo reprogramming of astrocytes to neuroblasts in the adult brain

  2013influential reference
• The changing scene of amyotrophic lateral sclerosis

  2013influential reference
• Characterization of Induced Neural Progenitors from Skin Fibroblasts by a Novel Combination of Defined Factors

  2013cited by this paper
• Chromatin dynamics during cellular reprogramming

  2013cited by this paper
• Molecular roadblocks for cellular reprogramming.

  2012cited by this paper
• Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2

  2012cited by this paper
• Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors.

  2012cited by this paper
• Direct reprogramming of fibroblasts into neural stem cells by defined factors.

  2012cited by this paper
• Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

  2012cited by this paper
• Nonviral Direct Conversion of Primary Mouse Embryonic Fibroblasts to Neuronal Cells

  2012cited by this paper
• Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

  2012influential reference
• Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

  2012cited by this paper
• Direct conversion of fibroblasts into stably expandable neural stem cells.

  2012influential reference
• Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

  2012cited by this paper
• Chromatin modifying enzymes as modulators of reprogramming

  2012cited by this paper
• Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.

  2012influential reference
• Alzheimer mechanisms and therapeutic strategies.

  2012influential reference
• Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

  2012cited by this paper
• A molecular roadmap of reprogramming somatic cells into iPS cells.

  2012cited by this paper
• Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

  2012cited by this paper
• Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes.

  2012cited by this paper
• Direct conversion of human fibroblasts to dopaminergic neurons

  2011influential reference
• LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.

  2011influential reference
• MicroRNA-mediated conversion of human fibroblasts to neurons

  2011cited by this paper
• Induction of human neuronal cells by defined transcription factors

  2011cited by this paper
• Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

  2011cited by this paper
• Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.

  2011cited by this paper
• Human oocytes reprogram somatic cells to a pluripotent state

  2011influential reference
• A functionally characterized test set of human induced pluripotent stem cells

  2011cited by this paper
• The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

  2011cited by this paper
• Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

  2011cited by this paper
• Conversion of mouse and human fibroblasts into functional spinal motor neurons.

  2011influential reference
• Clinical diagnosis and management of amyotrophic lateral sclerosis

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• Reprogrammed mouse astrocytes retain a “memory” of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts

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• Specification of transplantable astroglial subtypes from human pluripotent stem cells

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• Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines.

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• Etiology and pathogenesis of Parkinson's disease

  2011cited by this paper
• Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors

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• The many faces of tau.

  2011cited by this paper
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  2011cited by this paper
• In brief

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• A Pericyte Origin of Spinal Cord Scar Tissue

  2011cited by this paper
• The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

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• Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

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• Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

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  2011cited by this paper
• Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.

  2011influential reference
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  2011influential reference
• Reprogramming factor expression initiates widespread targeted chromatin remodeling.

  2011cited by this paper
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  2010cited by this paper
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  2010cited by this paper
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  2010influential reference
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  2010cited by this paper
• Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

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• Aβ Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

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• Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

  2010cited by this paper
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