Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cell and Tissue Research

• Publication date

  2017-11-23

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1007/s00441-017-2729-2PMID 29170823PMCID PMC5750094
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules

  2017cited by this paper
• NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes

  2017cited by this paper
• The therapeutic potential of cell identity reprogramming for the treatment of aging‐related neurodegenerative disorders

  2017cited by this paper
• Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

  2017cited by this paper
• Stimulation of functional neuronal regeneration from Müller glia in adult mice

  2017cited by this paper
• Brain repair from intrinsic cell sources: Turning reactive glia into neurons.

  2017cited by this paper
• Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients.

  2016cited by this paper
• Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.

  2016cited by this paper
• Viral vectors for gene therapy: Current state and clinical perspectives

  2016cited by this paper
• In vivo reprogramming reactive glia into iPSCs to produce new neurons in the cortex following traumatic brain injury

  2016cited by this paper
• The p53 Pathway Controls SOX2-Mediated Reprogramming in the Adult Mouse Spinal Cord.

  2016cited by this paper
• Understanding the NG2 Glial Scar after Spinal Cord Injury

  2016cited by this paper
• Lineage, fate, and fate potential of NG2-glia.

  2016cited by this paper
• Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

  2016cited by this paper
• Physiological, pathological, and engineered cell identity reprogramming in the central nervous system

  2016cited by this paper
• In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells.

  2016cited by this paper
• Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming

  2015cited by this paper
• Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons.

  2015cited by this paper
• Small Molecules Efficiently Reprogram Human Astroglial Cells into Functional Neurons.

  2015cited by this paper
• In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry

  2015cited by this paper
• Regeneration through reprogramming adult cell identity in vivo.

  2015cited by this paper
• In Vivo Reprogramming for Brain and Spinal Cord Repair

  2015cited by this paper
• NG2-proteoglycan-dependent contributions of oligodendrocyte progenitors and myeloid cells to myelin damage and repair

  2015cited by this paper
• Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later.

  2015cited by this paper
• Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis.

  2015cited by this paper
• SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain

  2015cited by this paper
• Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome‐wide expression analysis

  2015cited by this paper
• In vivo reprogramming for tissue repair

  2015cited by this paper
• Cell-based therapies for Parkinson disease—past insights and future potential

  2015cited by this paper
• Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

  2015cited by this paper
• Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke.

  2015cited by this paper
• Reawakening the sleeping beauty in the adult brain: neurogenesis from parenchymal glia.

  2015cited by this paper
• Brains in metamorphosis: reprogramming cell identity within the central nervous system.

  2014cited by this paper
• In vivo conversion of astrocytes to neurons in the injured adult spinal cord

  2014cited by this paper
• Proneural bHLH genes in development and disease.

  2014cited by this paper
• Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

  2014cited by this paper
• iPS cell technologies: significance and applications to CNS regeneration and disease

  2014cited by this paper
• Regeneration of the damaged central nervous system through reprogramming technology: basic concepts and potential application for cell replacement therapy.

  2014cited by this paper
• Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

  2014cited by this paper
• Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

  2014cited by this paper
• In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model.

  2014cited by this paper
• Reprogramming the fate of human glioma cells to impede brain tumor development

  2014cited by this paper
• Environmental Impact on Direct Neuronal Reprogramming In Vivo in the Adult Brain

  2013cited by this paper
• Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons

  2013cited by this paper
• Cell Therapy for Parkinson's Disease: What Next?

  2013cited by this paper
• Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

  2013cited by this paper
• Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

  2013cited by this paper
• Generation of induced neurons via direct conversion in vivo

  2013cited by this paper
• In vivo reprogramming of astrocytes to neuroblasts in the adult brain

  2013cited by this paper
• In vivo reprogramming of circuit connectivity in postmitotic neocortical neurons

  2013cited by this paper
• Post-injury protective astrogenesis from SVZ niche is controlled by Notch modulator Thbs4

  2013cited by this paper
• Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury

  2013cited by this paper
• Direct lineage reprogramming of post-mitotic callosal neurons into corticofugal neurons in vivo

  2013cited by this paper
• Sox10‐iCreERT2: A mouse line to inducibly trace the neural crest and oligodendrocyte lineage

  2012cited by this paper
• Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

  2012cited by this paper
• Local generation of glia is a major astrocyte source in postnatal cortex

  2012cited by this paper
• Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

  2012cited by this paper
• Age-dependent fate and lineage restriction of single NG2 cells

  2011cited by this paper
• The stem cell potential of glia: lessons from reactive gliosis

  2011cited by this paper
• Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

  2011cited by this paper
• Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex

  2011cited by this paper
• Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

  2010cited by this paper
• Direct conversion of fibroblasts to functional neurons by defined factors

  2010cited by this paper
• NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

  2010cited by this paper
• Modulation of Fate Determinants Olig2 and Pax6 in Resident Glia Evokes Spiking Neuroblasts in a Model of Mild Brain Ischemia

  2010cited by this paper
• Astrocytes: biology and pathology

  2009cited by this paper
• Molecular dissection of reactive astrogliosis and glial scar formation.

  2009cited by this paper
• Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

  2009cited by this paper
• The glial nature of embryonic and adult neural stem cells.

  2009cited by this paper
• A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

  2009cited by this paper
• Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis

  2009cited by this paper
• Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

  2009cited by this paper
• Postinjury Niches Induce Temporal Shifts in Progenitor Fates to Direct Lesion Repair after Spinal Cord Injury

  2009cited by this paper
• Neurod1 is essential for the survival and maturation of adult-born neurons

  2009cited by this paper
• GFAP promoter elements required for region‐specific and astrocyte‐specific expression

  2008cited by this paper
• Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

  2008cited by this paper
• Directed differentiation of hippocampal stem/progenitor cells in the adult brain

  2008cited by this paper
• PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice

  2008cited by this paper
• Consequence of the loss of Sox2 in the developing brain of the mouse

  2008cited by this paper
• Glial cell loss, proliferation and replacement in the contused murine spinal cord

  2007cited by this paper
• Prominent oligodendrocyte genesis along the border of spinal contusion lesions

  2007cited by this paper
• Functional Properties of Neurons Derived from In Vitro Reprogrammed Postnatal Astroglia

  2007cited by this paper
• NG2 cells generate both oligodendrocytes and gray matter astrocytes

  2007cited by this paper
• In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus.

  2007cited by this paper
• Molecular development of corticospinal motor neuron circuitry.

  2007cited by this paper
• Fusion of Microglia with Pyramidal Neurons after Retroviral Infection

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche.

  2006cited by this paper
• Early Postnatal Astroglial Cells Produce Multilineage Precursors and Neural Stem Cells In Vivo

  2006cited by this paper
• Growth Factor Treatment and Genetic Manipulation Stimulate Neurogenesis and Oligodendrogenesis by Endogenous Neural Progenitors in the Injured Adult Spinal Cord

  2006cited by this paper
• Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair.

  2005cited by this paper
• Cell proliferation and replacement following contusive spinal cord injury

  2005cited by this paper
• Neuronal fate determinants of adult olfactory bulb neurogenesis

  2005cited by this paper
• Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

  2004cited by this paper
• Molecular diversity of astrocytes with implications for neurological disorders.

  2004cited by this paper
• Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6.

  2004cited by this paper
• Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis

  2004cited by this paper
• Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells.

  2004cited by this paper
• SOX2 functions to maintain neural progenitor identity.

  2003cited by this paper
• The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.

  2002cited by this paper

• Adult hippocampal neurogenesis: New avenues for treatment of brain disorders

  2025cites this paper
• Metabolic Reprogramming in Spinal Cord Injury and Analysis of Potential Therapeutic Targets

  2025cites this paper
• Navigating the Lipid Landscape: The Role of Fatty Acid Synthase in Neural Stem Cell Fate and Central Nervous System Function

  2025cites this paper
• Effects of crocin on the enhancement of in vitro neurogenesis: Involvement of Notch and CREB/BDNF signaling pathways

  2024cites this paper
• Advances in neuronal reprogramming for neurodegenerative diseases: Strategies, controversies, and opportunities.

  2024cites this paper
• NG2 glia reprogramming induces robust axonal regeneration after spinal cord injury

  2024cites this paper
• Micro- and Nanostructured Fibrous Composites via Electro-Fluid Dynamics: Design and Applications for Brain

  2024cites this paper
• Introduction to stem cell biology and its role in treating neurologic disorders.

  2024cites this paper
• Shining the Light on Astrocytic Ensembles

  2023cites this paper
• Neuronal regeneration after injury: a new perspective on gene therapy

  2023cites this paper
• Neuronal conversion from glia to replenish the lost neurons

  2023cites this paper
• In vivo cell fate reprogramming for spinal cord repair.

  2023cites this paper
• NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury

  2023cites this paper
• Strategies and mechanisms of neuronal reprogramming.

  2023cites this paper
• A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

  2022cites this paper
• Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury Regenerative Rehabilitation in TBI

  2022cites this paper
• In vivo glia‐to‐neuron conversion: pitfalls and solutions

  2022cites this paper
• Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion.

  2022cites this paper
• Application and prospects of somatic cell reprogramming technology for spinal cord injury treatment

  2022influential citation
• The bHLH Transcription Factors in Neural Development and Therapeutic Applications for Neurodegenerative Diseases

  2022cites this paper
• Stem cell-derived neuronal relay strategies and functional electrical stimulation for treatment of spinal cord injury.

  2021cites this paper
• Utilising Induced Pluripotent Stem Cells in Neurodegenerative Disease Research: Focus on Glia

  2021cites this paper
• Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise

  2021cites this paper
• Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of Lithium carbonate and Crocin on BDNF and GDNF Expression as Neurotrophic Factors

  2021cites this paper
• Revisiting astrocyte to neuron conversion with lineage tracing in vivo.

  2021cites this paper
• Single-Cell Genomics: Catalyst for Cell Fate Engineering

  2021cites this paper
• Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury

  2021cites this paper
• Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review

  2021cites this paper
• Regeneration Through in vivo Cell Fate Reprogramming for Neural Repair

  2020cites this paper
• Unraveling the adult cell progeny of early postnatal progenitor cells

  2020cites this paper
• How to reprogram human fibroblasts to neurons

  2020cites this paper
• Rapid and efficient in vivo astrocyte-to-neuron conversion with regional identity and connectivity?

  2020cites this paper
• Valproic acid-induced changes of 4D nuclear morphology in astrocyte cells

  2020cites this paper
• Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain

  2020cites this paper
• bHLH transcription factors in neural development, disease, and reprogramming.

  2019cites this paper
• Unraveling and overcoming hurdles in direct neuronal reprogramming

  2019cites this paper
• Inducing Different Neuronal Subtypes from Astrocytes in the Injured Mouse Cerebral Cortex

  2019influential citation
• Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain

  2019cites this paper
• Direct Lineage Reprogramming in the CNS.

  2019cites this paper
• In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation.

  2018cites this paper
• A partition-type tubular scaffold loaded with PDGF-releasing microspheres for spinal cord repair facilitates the directional migration and growth of cells

  2018cites this paper
• New approaches for brain repair—from rescue to reprogramming

  2018cites this paper
• Delivery of Brain-Derived Neurotrophic Factor by 3D Biocompatible Polymeric Scaffolds for Neural Tissue Engineering and Neuronal Regeneration

  2018cites this paper
• Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

  2018cites this paper
• Autotherapies: Enhancing Endogenous Healing and Regeneration.

  2018cites this paper
• Neural stem cells: developmental mechanisms and disease modeling

  2017cites this paper
• bHLH factors in neurogenesis and neuronal subtype specification

  2013cites this paper
• Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain

  year unknowncites this paper