Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Clinical Cancer Research

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-07-1041PMID 17785546
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

  2007cited by this paper
• Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers and the risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium

  2007cited by this paper
• p53 in health and disease

  2007cited by this paper
• Hypoxia-inducible factor-1α polymorphisms and TSC1/2 mutations are complementary in head and neck cancers

  2006cited by this paper
• PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

  2006cited by this paper
• Molecular determinants of Akt-induced keratinocyte transformation

  2006cited by this paper
• mTOR and cancer therapy

  2006cited by this paper
• STAT3 as a therapeutic target in head and neck cancer

  2006cited by this paper
• PIK 3 CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

  2006cited by this paper
• Fishing for prostanoids: deciphering the developmental functions of cyclooxygenase-derived prostaglandins.

  2006cited by this paper
• A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma

  2006cited by this paper
• Epidermal growth factor receptor biology in head and neck cancer.

  2006cited by this paper
• Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer.

  2006cited by this paper
• Protein kinase casein kinase 2 mediates inhibitor-kappaB kinase and aberrant nuclear factor-kappaB activation by serum factor(s) in head and neck squamous carcinoma cells.

  2006cited by this paper
• Peutz-Jeghers syndrome: clinicopathology and molecular alterations

  2006cited by this paper
• The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck.

  2006cited by this paper
• HER-2/neu in Barrett Esophagus: A Comparative Study Between Histology, Immunohistochemistry, and Fluorescence In Situ Hybridization

  2006cited by this paper
• The tuberous sclerosis complex.

  2006cited by this paper
• Cancer-specific mutations in PIK3CA are oncogenic in vivo

  2006cited by this paper
• Akt, protein kinase C, and mitogen‐activated protein kinase phosphorylation status in head and neck squamous cell carcinoma

  2005cited by this paper
• TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer.

  2005cited by this paper
• Tobacco, oral cancer, and treatment of dependence.

  2005cited by this paper
• RETRACTED: Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis

  2005cited by this paper
• Akt activation correlates with adverse outcome in tongue cancer

  2005cited by this paper
• Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer.

  2005cited by this paper
• Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck.

  2005cited by this paper
• Molecular predictors of clinical outcome in patients with head and neck squamous cell carcinoma

  2005cited by this paper
• mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes*

  2005cited by this paper
• Epidermal Growth Factor Receptor Activity Determines Response of Colorectal Cancer Cells to Gefitinib Alone and in Combination with Chemotherapy

  2005cited by this paper
• Overexpression of cyclooxygenase-2 in nasopharyngeal carcinoma and association with lymph node metastasis.

  2005cited by this paper
• Retracted: Frequent genetic and biochemical alterations of the PI 3‐K/AKT/PTEN pathway in head and neck squamous cell carcinoma

  2005cited by this paper
• The expanding TOR signaling network.

  2005cited by this paper
• Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment.

  2005cited by this paper
• Prognostic value of the epidermal growth factor receptor (EGRF) and p53 in advanced head and neck squamous cell carcinoma patients treated with induction chemotherapy.

  2005cited by this paper
• Dysregulation of the TSC-mTOR pathway in human disease

  2004cited by this paper
• Human Papillomavirus 16 E6 Oncoprotein Interferences with Insulin Signaling Pathway by Binding to Tuberin*

  2004cited by this paper
• Structure, regulation and function of PKB/AKT--a major therapeutic target.

  2004cited by this paper
• Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma

  2004cited by this paper
• Focus on head and neck cancer.

  2004cited by this paper
• Design, construction, and use of tissue microarrays.

  2004cited by this paper
• Upstream and downstream of mTOR.

  2004cited by this paper
• Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survival

  2004cited by this paper
• Metastatic squamous cell carcinoma cells that overexpress c-Met exhibit enhanced angiogenesis factor expression, scattering and metastasis in response to hepatocyte growth factor

  2004cited by this paper
• Targeting the PI3K-Akt pathway in human cancer: rationale and promise.

  2003cited by this paper
• Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.

  2003cited by this paper
• Integration of growth factor and nutrient signaling: implications for cancer biology.

  2003cited by this paper
• p53 mutations in betel-associated oral cancer from Thailand.

  2003cited by this paper
• Immunohistochemical study on overexpression of cyclooxygenase-2 in squamous cell carcinoma of the oral cavity: its importance as a prognostic predictor.

  2003cited by this paper
• Epidermal growth factor receptor as a therapeutic target in colorectal cancer.

  2003cited by this paper
• Rheb fills a GAP between TSC and TOR.

  2003cited by this paper
• Functional roles of Akt signaling in mouse skin tumorigenesis

  2002cited by this paper
• Characterization of the HER-2/neu oncogene by immunohistochemical and fluorescence in situ hybridization analysis in oral and oropharyngeal squamous cell carcinoma.

  2002cited by this paper
• Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma.

  2002cited by this paper
• BASIC SCIENCE REVIEW

  2002cited by this paper
• Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma

  2002cited by this paper
• Cyclooxygenase‐2: A novel molecular target for the prevention and treatment of head and neck cancer

  2002cited by this paper
• Amplification of the 3q26.3 locus is associated with progression to invasive cancer and is a negative prognostic factor in head and neck squamous cell carcinomas.

  2002cited by this paper
• Molecular Analysis of Surgical Margins in Head and Neck Squamous Cell Carcinoma Patients

  2002cited by this paper
• Oral cavity and pharynx cancer incidence rates in the United States, 1975-1998.

  2002cited by this paper
• Loss of PTEN expression as a prognostic marker for tongue cancer.

  2001cited by this paper
• Head and neck cancer.

  2001cited by this paper
• Annual report to the nation on the status of cancer (1973 through 1998), featuring cancers with recent increasing trends.

  2001cited by this paper
• STAT signaling in head and neck cancer

  2000cited by this paper
• Inhibition of Cyclooxygenase‐2 Expression: An Approach to Preventing Head and Neck Cancer

  1999cited by this paper
• p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India.

  1999cited by this paper
• Pattern of amplification and overexpression of the eukaryotic initiation factor 4E gene in solid tumor.

  1999cited by this paper
• Immunohistochemical detection of p53 protein accumulation in head and neck cancer: correlation with p53 gene alterations.

  1999cited by this paper
• Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

  1998cited by this paper
• Tissue microarrays for high-throughput molecular profiling of tumor specimens

  1998cited by this paper
• Sequential p53 mutation analysis of pre‐invasive and invasive head and neck squamous carcinoma

  1995cited by this paper
• Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck.

  1995cited by this paper
• The incidence of p53 mutations increases with progression of head and neck cancer.

  1993cited by this paper
• Head and neck cancer.

  1991cited by this paper
• Biological activities of EGF‐receptor mutants with individually altered autophosphorylation sites.

  1988cited by this paper
• Head and Neck

  1959cited by this paper

• Recurrent and Metastatic Head and Neck Cancer: Mechanisms of Treatment Failure, Treatment Paradigms, and New Horizons

  2025cites this paper
• Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development.

  2025cites this paper
• Genome-wide CRISPR screening reveals a PKA-driven resistance mechanism to metformin for oral cancer prevention that can be exploited by combination with NSAIDs.

  2025cites this paper
• Genome-Wide CRISPR Screening Reveals that mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer.

  2025cites this paper
• YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution

  2025cites this paper
• The Role of the PI3K/Akt/mTOR Axis in Head and Neck Squamous Cell Carcinoma

  2024cites this paper
• Oncogenic H-RAS induces metformin resistance in head and neck cancer by promoting glycolytic metabolism.

  2024cites this paper
• Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis

  2024cites this paper
• Characterising the expression of the organic cation transporter OCT3 in cutaneous papillomas of dogs.

  2024cites this paper
• NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma

  2024cites this paper
• A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC

  2024cites this paper
• Expression of PD-L1 and p-RPS6 in epithelial dysplasia and squamous cell carcinoma of the oral cavity

  2024cites this paper
• A genome-wide CRISPR screen reveals that antagonism of glutamine metabolism sensitizes head and neck squamous cell carcinoma to ferroptotic cell death.

  2024cites this paper
• Metabolic targeting of regulatory T cells in oral squamous cell carcinoma: new horizons in immunotherapy

  2024cites this paper
• A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance

  2024cites this paper
• Head and neck cancer treatment in the era of molecular medicine.

  2023cites this paper
• YAP-Driven Malignant Reprogramming of Epithelial Stem Cells at Single Cell Resolution

  2023cites this paper
• Precision Medicine in Oral Health and Diseases: A Systematic Review

  2023cites this paper
• MAMMALIAN TARGET OF RAPAMYCIN (mTOR) EXPRESSION AND LARYNGEAL SQUAMOUS CELL CARCINOMA PROGNOSIS: NOVEL PRELIMINARY EVIDENCE

  2023cites this paper
• A kinome-wide synthetic lethal CRISPR/Cas9 screen reveals that mTOR inhibition prevents adaptive resistance to CDK4/CDK6 blockade in HNSCC

  2023cites this paper
• YAP-Driven Oral Epithelial Stem Cell Malignant Reprogramming at Single Cell Resolution

  2023cites this paper
• A Comprehensive Review of Natural Products as Therapeutic or Chemopreventive Agents against Head and Neck Squamous Cell Carcinoma Cells Using Preclinical Models

  2023cites this paper
• Immunohistochemical Techniques for Phosphoproteins.

  2023cites this paper
• Altered E-cadherin/β-catenin expression in feline cutaneous squamous cell carcinomas.

  2023cites this paper
• NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma

  2023cites this paper
• A Randomized Multi-Institutional Phase II Trial of Everolimus as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck.

  2022cites this paper
• Ribosomal proteins induce stem cell-like characteristics in glioma cells as an “extra-ribosomal function”

  2022cites this paper
• Statins block mammalian target of rapamycin pathway: a possible novel therapeutic strategy for inflammatory, malignant and neurodegenerative diseases

  2022cites this paper
• Applications of single‐cell multi‐omics sequencing in deep understanding of brain diseases

  2022cites this paper
• Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling

  2021cites this paper
• Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

  2021cites this paper
• Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma

  2021influential citation
• Persistent activation of the mammalian target of rapamycin signalling pathway in cutaneous squamous cell carcinomas in cats.

  2021cites this paper
• Rapalogs induce non‐apoptotic, autophagy‐dependent cell death in HPV‐negative TP53 mutant head and neck squamous cell carcinoma

  2021cites this paper
• Inhibition of mTOR signaling and clinical activity of metformin in oral premalignant lesions

  2021cites this paper
• AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer

  2021cites this paper
• Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?

  2021influential citation
• Targeting mTOR-CCL20 Signaling May Improve Response to Docetaxel in Head and Neck Squamous Cell Carcinoma

  2021cites this paper
• FGF Expression in HPV16-positive and -negative SCC After Treatment With Small-molecule Tyrosine Kinase Inhibitors and Everolimus

  2020cites this paper
• CHARACTERIZATION OF NOTCH1 AND PI3K-PTEN-AKT/mTOR PATHWAY INTERACTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

  2020cites this paper
• Autophagy in head and neck cancer therapy

  2020cites this paper
• Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer

  2020cites this paper
• Expression of the epidermal stem cell marker p63/CK5 in cutaneous papillomas and cutaneous squamous cell carcinomas of dogs.

  2020cites this paper
• CHARACTERIZATION OF NOTCH1 AND PI3K-PTEN-AKT/mTOR PATHWAY INTERACTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

  2020cites this paper
• Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis.

  2020cites this paper
• Aberrant Expression of E-cadherin/β-catenin During Epidermal Tumourigenesis in Dogs.

  2020cites this paper
• SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

  2020cites this paper
• Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas.

  2020cites this paper
• Targeting AKT/PKB to improve treatment outcomes for solid tumors.

  2020cites this paper
• Immunohistochemical expression of selected phosphoproteins of the mTOR signalling pathway in canine cutaneous squamous cell carcinoma.

  2019cites this paper
• Targeting cellular metabolism to reduce head and neck cancer growth

  2019cites this paper
• 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer.

  2019cites this paper
• Targeting mTOR in Head and Neck Cancer—Response

  2019cites this paper
• Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma

  2019cites this paper
• The mTOR downstream regulator (p-4EBP1) is a novel independent prognostic marker in ovarian cancer

  2019cites this paper
• mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

  2019cites this paper
• Disruption of TP63-miR-27a* feedback loop by mutant TP53 in head and neck cancer.

  2019cites this paper
• Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision

  2019cites this paper
• PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer.

  2019cites this paper
• Dysregulated expression of the key effectors of the mammalian target of rapamycin signalling pathway in cutaneous papillomas of dogs.

  2019cites this paper
• HIF-1α and mTOR - Possible Novel Strategies of Targeted Therapies in p16-positive and -negative HNSCC.

  2018cites this paper
• Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7

  2018cites this paper
• Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

  2018cites this paper
• Survivin-Based Treatment Strategies for Squamous Cell Carcinoma

  2018influential citation
• PI3‐kinase pathway biomarkers in oral cancer and tumor immune cells

  2018influential citation
• CHARACTERIZATION OF NOTCH 1 AND PI 3 K-PTEN-AKT / mTOR PATHWAY INTERACTION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA

  2018cites this paper
• [Clinical importance of microtubule-associated protein 1 light chain 3 and mammalian target of rapamycin expression in oral leukoplakia and oral squamous cell carcinoma].

  2018cites this paper
• Phosphorylated ribosomal protein S6 correlation with p21 expression and inverse association with tumor size in oral squamous cell carcinoma

  2017cites this paper
• The Prognostic Role of NEDD9 and P38 Protein Expression Levels in Urinary Bladder Transitional Cell Carcinoma

  2017cites this paper
• Blockage of EGFR Pathway for Anticancer Therapy in Squamous Cell Carcinoma of the Head and Neck

  2017cites this paper
• 14 – The Molecular Biology of Head and Neck Cancer

  2017cites this paper
• Emerging Cancer Biomarkers for HNSCC Detection and Therapeutic Intervention

  2017cites this paper
• Genomics and advances towards precision medicine for head and neck squamous cell carcinoma

  2017cites this paper
• Prognostic implications of the phosphatidylinositol 3-kinase/Akt signaling pathway in oral squamous cell carcinoma: overexpression of p-mTOR indicates an adverse prognosis

  2017cites this paper
• Transformación maligna de un tumor odontogénico queratósico con gran componente inflamatorio. Presentación de un caso y revisión de la literatura

  2017cites this paper
• Understanding c-MET signalling in squamous cell carcinoma of the head & neck.

  2017cites this paper
• Targeting the mTOR Signaling Circuitry in Head and Neck Cancer

  2017cites this paper
• PI3K/AKT/mTOR pathway in pulmonary carcinoid tumours

  2017cites this paper
• mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC

  2016cites this paper
• Mastermind-like Gene Family: A New Ray of Hope in Cancer Therapeutics

  2016cites this paper
• mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer

  2016influential citation
• Combination of mTOR and EGFR targeting in an orthotopic xenograft model of head and neck cancer

  2016cites this paper
• Emerging Molecular Targets in the Treatment of Head and Neck Squamous Cell Carcinoma

  2016cites this paper
• PI3K-AKT-mTOR pathway proteins are differently expressed in oral carcinogenesis.

  2016cites this paper
• Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion

  2016cites this paper
• Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas

  2016cites this paper
• Deubiquitylating enzyme, USP9X, regulates proliferation of cells of head and neck cancer lines

  2016cites this paper
• Response-adapted volume de-escalation (RAVD) in locally advanced head and neck cancer.

  2016cites this paper
• Avaluació de factors mol·leculars associats a la resposta a anticossos monoclonals anti-EGFR: integració amb tractaments de radioteràpia en càncer de cap i coll

  2016cites this paper
• Schedule-dependent interaction between temsirolimus and cetuximab in head and neck cancer: a preclinical study

  2016cites this paper
• Significance of mammalian target of rapamycin in patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

  2016cites this paper
• The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

  2015cites this paper
• Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study

  2015cites this paper
• Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer

  2015cites this paper
• TEMHEAD: a single-arm multicentre phase II study of temsirolimus in platin- and cetuximab refractory recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) of the German SCCHN Group (AIO).

  2015cites this paper
• Baseline caspase activity predicts progression free survival of temsirolimus-treated head neck cancer patients.

  2015cites this paper
• The effect of LKB1 on the PI3K/Akt pathway activation in association with PTEN and PIK3CA in HNC

  2015cites this paper
• Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

  2015cites this paper
• Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

  2015cites this paper
• ALA- or Ce6-PDT induced phenotypic change and suppressed migration in surviving cancer cells

  2015cites this paper