Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Molecules and Cells

• Publication date

  2008-05-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2008.03.016PMID 18471974PMCID PMC2579769
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

  2007cited by this paper
• Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

  2007cited by this paper
• A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.

  2007cited by this paper
• Exploring Mechanisms of the DNA-Damage Response: p53 Pulses and their Possible Relevance to Apoptosis

  2007cited by this paper
• The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

  2007cited by this paper
• Real-time evaluation of p53 oscillatory behavior in vivo using bioluminescent imaging.

  2006cited by this paper
• Oscillations and variability in the p53 system

  2006cited by this paper
• MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.

  2006cited by this paper
• Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

  2006cited by this paper
• An excitable gene regulatory circuit induces transient cellular differentiation

  2006cited by this paper
• Wip1 phosphatase modulates ATM-dependent signaling pathways.

  2006cited by this paper
• Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

  2006influential reference
• ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

  2006cited by this paper
• Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11*

  2006cited by this paper
• PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.

  2005influential reference
• A plausible model for the digital response of p53 to DNA damage.

  2005cited by this paper
• Steady States and Oscillations in the p53/Mdm2 Network

  2005cited by this paper
• The p53 pathway: positive and negative feedback loops

  2005cited by this paper
• p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedback.

  2005cited by this paper
• The negative role of cyclin G in ATM-dependent p53 activation

  2004cited by this paper
• Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

  2004cited by this paper
• Small-Molecule Antagonists of p53-MDM2 Binding: Research Tools and Potential Therapeutics

  2004cited by this paper
• Dynamics of the p53-Mdm2 feedback loop in individual cells

  2004influential reference
• Accelerated MDM2 auto‐degradation induced by DNA‐damage kinases is required for p53 activation

  2004cited by this paper
• A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

  2004cited by this paper
• The Strength of Indecisiveness: Oscillatory Behavior for Better Cell Fate Determination

  2004cited by this paper
• Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.

  2003cited by this paper
• Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays.

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Time delay as a key to apoptosis induction in the p53 network

  2002cited by this paper
• ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

  2001cited by this paper
• Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.

  2000cited by this paper
• Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation.

  2000cited by this paper
• Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

  2000cited by this paper
• POSSIBLE OSCILLATORY BEHAVIOR IN P53–MDM2 INTERACTION COMPUTER SIMULATION

  2000cited by this paper
• Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

  1999cited by this paper
• Altered Regulation of Cyclin G in Human Breast Cancer and Its Specific Localization at Replication Foci in Response to DNA Damage in p53+/+ Cells*

  1999cited by this paper
• Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

  1999influential reference
• Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.

  1998cited by this paper
• Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

  1998cited by this paper
• Enhanced phosphorylation of p53 by ATM in response to DNA damage.

  1998cited by this paper
• Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.

  1997cited by this paper
• Mdm2 promotes the rapid degradation of p53

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

  1996cited by this paper
• The p53-mdm-2 autoregulatory feedback loop.

  1993cited by this paper
• mdm2 expression is induced by wild type p53 activity.

  1993cited by this paper
• Modeling the cell division cycle: cdc2 and cyclin interactions.

  1991cited by this paper
• Oscillatory behavior in enzymatic control processes.

  1965cited by this paper
• A quantitative description of membrane current and its application to conduction and excitation in nerve

  1952cited by this paper
• The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:

  year unknowncited by this paper

• Genetic resonance in the p53 signaling network.

  2026cites this paper
• Isolas Dynamics: A Potential Mechanism Underlying DNA Damage Repair

  2026cites this paper
• Temporal dose inversion properties of adaptive biomolecular circuits

  2025cites this paper
• Cell Confluency Affects p53 Dynamics in Response to DNA Damage.

  2025cites this paper
• Uncovering dual oscillatory regimes in p53-mdm2 dynamics: A data-driven modeling approach with implications for cancer suppression

  2025cites this paper
• JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability

  2025influential citation
• Decoding stimulus-specific regulation of promoter activity of p53 target genes

  2025cites this paper
• Pulsed stimuli enable p53 phase resetting to synchronize single cells and modulate cell fate

  2025cites this paper
• Anti-resonance in developmental signaling regulates cell fate decisions

  2025cites this paper
• Training stiff neural ordinary differential equations with explicit rational Taylor series methods.

  2025cites this paper
• Modeling heterogeneous signaling dynamics of macrophages reveals principles of information transmission in stimulus responses

  2025cites this paper
• Data-driven discovery of dynamical models in biology

  2025cites this paper
• Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage

  2025cites this paper
• Human Stress Response Specificity through Bioresonance Selectivity

  2025cites this paper
• From DNA Repair to Redox Signaling: The Multifaceted Role of APEX1 (Apurinic/Apyrimidinic Endonuclease 1) in Cardiovascular Health and Disease

  2025cites this paper
• Negative feedback and oscillations in a model for mRNA translation.

  2025cites this paper
• JNK activation dynamics drive distinct gene expression patterns over time mediated by mRNA stability

  2025cites this paper
• Amplitude and frequency encoding result in qualitatively distinct informational landscapes in cell signaling

  2025influential citation
• The Vanishing Gradient Problem for Stiff Neural Differential Equations

  2025cites this paper
• Decoding the Central Dogma: Quantitative Insights into Transcription and Translation Dynamics in the p53-Mediated DNA Damage Response.

  2025cites this paper
• Functional consequences of a p53-MDM2-p21 incoherent feedforward loop

  2024cites this paper
• Cell Death, by Any Other Name…

  2024cites this paper
• Plausible, robust biological oscillations through allelic buffering.

  2024cites this paper
• Construction of a Waddington-like landscape model that can guide clinical exploration of p53-dynamics-activating parameters in the face of divergent p53 dynamics

  2024cites this paper
• Systems Biology of the Cancer Cell.

  2024cites this paper
• Nonlinear dynamics of tumor cell cycles: From mathematical models to therapeutic insights

  2024cites this paper
• A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics

  2024cites this paper
• Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors.

  2024cites this paper
• Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model

  2024cites this paper
• Qualitatively Distinct Signaling in Cells: The Informational Landscape of Amplitude and Frequency Encoding

  2024cites this paper
• Modeling the p53-Mdm2 Dynamics Triggered by DNA Damage

  2024cites this paper
• Entrainment and multi-stability of the p53 oscillator in human cells.

  2024cites this paper
• On the Implemention of the System-Biological Approach in Modeling the Functioning of Degenerative Diseases Biomarkers

  2023cites this paper
• Dynamic behavior of P53-Mdm2-Wip1 gene regulatory network under the influence of time delay and noise.

  2023cites this paper
• A molecular mechanism for the “digital” response of p53 to stress

  2023cites this paper
• Pulsed stimuli entrain p53 to synchronize single cells and modulate cell-fate determination

  2023cites this paper
• Hopf bifurcations in an atypical p53 protein oscillator model with discrete delay or distributed delay

  2023cites this paper
• A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics

  2023cites this paper
• Cell information processing via frequency encoding and excitability

  2023cites this paper
• The mechanism accounting for DNA damage strength modulation of p53 dynamical properties

  2023cites this paper
• Cytomorphic Electrical Circuit Modeling of Tumor Suppressor p53 Protein Pathway

  2023cites this paper
• Encoding and Decoding of p53 Dynamics in Cellular Response to Stresses

  2023influential citation
• Resolving Crosstalk Between Signaling Pathways Using Mathematical Modeling and Time-Resolved Single Cell Data.

  2023cites this paper
• UBE4B Phosphorylation is Essential to Stabilize p53 in Response to DNA Damage

  2023cites this paper
• Lévy noise-induced phase transition in p53 gene regulatory network near bifurcation points

  2023cites this paper
• Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach

  2023cites this paper
• Permission to pass: on the role of p53 as a gatekeeper for aneuploidy

  2023cites this paper
• Elucidating the Implications of Diverse Dynamical Responses in p53 Protein.

  2022cites this paper
• Resembling the bottleneck effect in p53 core network including the dephosphorylation of ATM by Wip1: A computational study

  2022cites this paper
• Enhanced DNA repair through droplet formation and p53 oscillations.

  2022cites this paper
• DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities

  2022cites this paper
• Long-term p21 and p53 dynamics regulate the frequency of mitosis events and cell cycle arrest following radiation damage

  2022cites this paper
• Oscillatory dynamics of p53 pathway in etoposide sensitive and resistant cell lines

  2022cites this paper
• Dynamical analysis of a delayed p53 oscillator model with p53-Mdm2 positive feedback

  2022cites this paper
• Computational-Model-Based Biopharmaceutics for p53 Pathway Using Modern Control Techniques for Cancer Treatment

  2022cites this paper
• Dynamical behaviors of quorum sensing network mediated by combinatorial perturbation.

  2022cites this paper
• Single-cell analysis of p53 transitional dynamics unravels stimulus- and cell type-dependent signaling output motifs

  2022influential citation
• Piecewise parametric chaotic model of p53 network based on the identified unifying framework of divergent p53 dynamics

  2022cites this paper
• Stability and bifurcation analyses of p53 gene regulatory network with time delay

  2022cites this paper
• Low and high doses of ionizing radiation evoke discrete global (phospho)proteome responses.

  2022cites this paper
• Teaching computational systems biology with an eye on quantitative systems pharmacology at the undergraduate level: Why do it, who would take it, and what should we teach?

  2022cites this paper
• Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis

  2022cites this paper
• Time‐series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations

  2022cites this paper
• A common pathway to cancer: Oncogenic mutations abolish p53 oscillations.

  2022cites this paper
• microRNA-Mediated Encoding and Decoding of Time-Dependent Signals in Tumorigenesis

  2022cites this paper
• Formal verification confirms the role of p53 protein in cell fate decision mechanism

  2022cites this paper
• Cell cycle inertia underlies a bifurcation in cell fates after DNA damage

  2021cites this paper
• Robust p53 Recovery Using Chattering Free Sliding Mode Control and a Gain-Scheduled Modified Utkin Observer.

  2021cites this paper
• Long-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arrest

  2021cites this paper
• Progress and challenges in understanding the regulation and function of p53 dynamics

  2021cites this paper
• Mathematical Modelling of p53 Signalling during DNA Damage Response: A Survey

  2021cites this paper
• DNA dynamics dictates p53 functional outcome

  2021cites this paper
• Proteins from the DNA Damage Response: Regulation, Dysfunction, and Anticancer Strategies

  2021cites this paper
• ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development

  2021cites this paper
• P53-Mdm2 Loop Stability and Oscillatory Dynamics with Mdm2-Induced Delay Effect in P53

  2021cites this paper
• Spatial regulation and generation of diversity in signaling pathways

  2021cites this paper
• Regulation of cardiomyocyte DNA damage and cell death by the type 2A protein phosphatase regulatory protein alpha4

  2021cites this paper
• The p53-caspase-2 axis in the cell cycle and DNA damage response

  2021cites this paper
• Modeling the roles of 14-3-3 σ and Wip1 in p53 dynamics and programmed cell death

  2021cites this paper
• Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis

  2021influential citation
• Transition and identification of pathological states in p53 dynamics for therapeutic intervention

  2021cites this paper
• Angler Peptides: Macrocyclic Conjugates Inhibit p53:MDM2/X Interactions and Activate Apoptosis in Cancer Cells.

  2021cites this paper
• Single-cell transitional dynamics unravel stimulus- and cell type-dependent signaling outputs of distinct p53 regulatory feedback motifs

  2021influential citation
• Landscape and flux quantify the stochastic transition dynamics for p53 cell fate decision.

  2021cites this paper
• Stress induced Differential Expression of THAP9 & THAP9-AS1 in the S-phase of cell cycle

  2021cites this paper
• ATM and ATR Activation Through Crosstalk Between DNA Damage Response Pathways

  2021cites this paper
• Spatial regulation and generation of diversity in signaling pathways

  2021cites this paper
• Multiple Time Delays Induced Dynamics of p53 Gene Regulatory Network

  2021cites this paper
• Oncogenic alterations in the p53 pathway abolish oscillatory competence

  2021cites this paper
• Exploring the influence of microRNA miR-34 on p53 dynamics: a numerical study

  2021cites this paper
• A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

  2020cites this paper
• Theoretical analysis of the delay on the p53 micronetwork

  2020cites this paper
• Model-based optimization of combination protocols for irradiation-insensitive cancers

  2020cites this paper
• Multi-scale modeling identifies the role of p53-Gys2 negative feedback loop in cellular homeostasis.

  2020cites this paper
• A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest

  2020cites this paper
• Cancer Dynamics: Identification of States for Therapeutic Intervention

  2020cites this paper
• Oscillatory behavior of p53-Mdm2 system driven by transcriptional and translational time delays

  2020cites this paper
• Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback

  2020cites this paper
• Causes and Consequences of Chromosomal Instability in Fanconi Anemia. Alterations at the Cellular and Organism Level

  2020cites this paper
• Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences

  2020cites this paper