Leptin enhances insulin sensitivity by direct and sympathetic nervous system regulation of muscle IGFBP-2 expression: evidence from nonrodent models.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Endocrinology

• Publication date

  2014-03-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/en.2013-2099PMID 24654786
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IGFBP2 is neither sufficient nor necessary for the physiological actions of leptin on glucose homeostasis in male ob/ob mice.

  2014cited by this paper
• Differential effects of acute and chronic estrogen treatment on thermogenic and metabolic pathways in ovariectomized sheep.

  2013cited by this paper
• Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin

  2013cited by this paper
• Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

  2013cited by this paper
• Sex differences in the metabolic effects of testosterone in sheep.

  2012cited by this paper
• Hepatic leptin signalling and subdiaphragmatic vagal efferents are not required for leptin-induced increases of plasma IGF binding protein-2 (IGFBP-2) in ob/ob mice

  2012cited by this paper
• Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice.

  2012cited by this paper
• Selective insulin and leptin resistance in metabolic disorders.

  2012cited by this paper
• Dietary Monounsaturated Fat in Early Life Regulates IGFBP2: Implications for Fat Mass Accretion and Insulin Sensitivity

  2011cited by this paper
• Central leptin activates mitochondrial function and increases heat production in skeletal muscle.

  2011cited by this paper
• Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia.

  2011cited by this paper
• Central infusion of leptin does not increase AMPK signaling in skeletal muscle of sheep.

  2011cited by this paper
• Leptin in human physiology and pathophysiology.

  2011cited by this paper
• IGFBP-2 at the interface of growth and metabolism--implications for childhood obesity.

  2011cited by this paper
• The action of leptin on appetite-regulating cells in the ovine hypothalamus: demonstration of direct action in the absence of the arcuate nucleus.

  2010cited by this paper
• Adipocytes IGFBP‐2 Expression in Prepubertal Obese Children

  2010cited by this paper
• Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism.

  2010cited by this paper
• Innervation of skeletal muscle by leptin receptor-containing neurons.

  2010cited by this paper
• Antidiabetic effects of IGFBP2, a leptin-regulated gene.

  2010cited by this paper
• IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis.

  2009cited by this paper
• Profiling postprandial thermogenesis in muscle and fat of sheep and the central effect of leptin administration.

  2008cited by this paper
• IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells

  2007cited by this paper
• IGF-Binding Protein-2 Protects Against the Development of Obesity and Insulin Resistance

  2007cited by this paper
• Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.

  2006cited by this paper
• Insulin-like growth factor binding protein-2 (IGFBP-2) is a marker for the metabolic syndrome.

  2006cited by this paper
• Intracellular signal transduction pathways induced by leptin in C2C12 cells

  2005cited by this paper
• Differential Impact of Simple Childhood Obesity on the Components of the Growth Hormone-Insulin-like Growth Factor (IGF)-IGF Binding Proteins Axis

  2004cited by this paper
• Leptin signaling in the central nervous system and the periphery.

  2004cited by this paper
• Cellular actions of the insulin-like growth factor binding proteins.

  2002cited by this paper
• Acute stimulation of glucose uptake by leptin in l6 muscle cells.

  2002cited by this paper
• Intracellular signalling: Key enzyme in leptin-induced anorexia

  2001cited by this paper
• Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep.

  2001cited by this paper
• Characterisation of the IGF system in a primary adult human skeletal muscle cell model, and comparison of the effects of insulin and IGF-I on protein metabolism.

  2000cited by this paper
• Development of leptin resistance in rat soleus muscle in response to high-fat diets.

  2000cited by this paper
• Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/obmice.

  1999cited by this paper
• Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation

  1999cited by this paper
• Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats.

  1999cited by this paper
• Circulating levels of free insulin‐like growth factors in obese subjects: the impact of Type 2 diabetes

  1999cited by this paper
• Leptin stimulates glucose uptake in C2C12 muscle cells by activation of ERK2.

  1999cited by this paper
• Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: evidence for a dissociation of effects on appetite and neuroendocrine function.

  1999cited by this paper
• Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats.

  1999cited by this paper
• Leptin and the regulation of body weight in mammals

  1998cited by this paper
• Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone

  1997cited by this paper
• Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

  1997cited by this paper
• Acute stimulation of glucose metabolism in mice by leptin treatment

  1997cited by this paper
• The Leptin Receptor*

  1997cited by this paper
• Receptor-mediated regional sympathetic nerve activation by leptin.

  1997cited by this paper
• Intracerebroventricular Leptin Increases Lumbar and Renal Sympathetic Nerve Activity and Blood Pressure in Normal Rats

  1997cited by this paper
• Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

  1996cited by this paper
• Effects of the obese gene product on body weight regulation in ob/ob mice.

  1995cited by this paper
• Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family.

  1995cited by this paper
• Weight-reducing effects of the plasma protein encoded by the obese gene.

  1995cited by this paper
• Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis.

  1994cited by this paper
• Somatotropin in lactating cows: effect on response to epinephrine and insulin.

  1990cited by this paper
• Role of set‐point theory in regulation of body weight

  1990cited by this paper
• The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

  1981cited by this paper
• Printed in U.S.A. Copyright © 2001 by The Endocrine Society High Leptin Levels Acutely Inhibit Insulin-Stimulated Glucose Uptake without Affecting Glucose Transporter 4 Translocation in L6 Rat Skeletal Muscle Cells

  year unknowncited by this paper

• IGFBP-2 in Critical Illness: A Prognostic Marker in the Growth Hormone/Insulin-like Growth Factor Axis

  2024cites this paper
• Endogenous Opioids in the Homeostatic Regulation of Hunger, Satiety, and Hedonic Eating: Neurobiological Foundations.

  2024cites this paper
• Cross-species transcriptomics identifies obesity associated genes between human and mouse studies

  2024cites this paper
• High tissue-sodium associates with systemic inflammation and insulin resistance in obese individuals.

  2023cites this paper
• Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass

  2023cites this paper
• Adipokines in glucose and lipid metabolism

  2023cites this paper
• Maternal Nutrition During Gestation Alters Histochemical Properties, and mRNA and microRNA Expression in Adipose Tissue of Wagyu Fetuses

  2022cites this paper
• Research progress of intramuscular fat formation based on co-culture

  2022cites this paper
• Potential Role of Insulin Growth-Factor-Binding Protein 2 as Therapeutic Target for Obesity-Related Insulin Resistance

  2021cites this paper
• RabGAPs TBC1D1 and TBC1D4 in skeletal muscle function and exercise.

  2020cites this paper
• Maternal circulating leptin profile during pregnancy and gestational diabetes mellitus.

  2020cites this paper
• Risk of hypertension following perinatal adversity: IUGR and prematurity.

  2019cites this paper
• Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects

  2019cites this paper
• Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin

  2019cites this paper
• Obesity and Immunity

  2019cites this paper
• IGFBP-2 and aging: a 20-year longitudinal study on IGFBP-2, IGF-I, BMI, insulin sensitivity and mortality in an aging population.

  2019cites this paper
• Leptin, An Adipokine With Central Importance in the Global Obesity Problem.

  2018cites this paper
• Serum IGFBP‐2 levels are associated with reduced insulin sensitivity in obese children

  2018cites this paper
• The role of adipokines in skeletal muscle inflammation and insulin sensitivity

  2018cites this paper
• Leptin is a physiological regulator of skeletal muscle angiogenesis and is locally produced by PDGFRα and PDGFRβ expressing perivascular cells

  2018cites this paper
• The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes

  2018cites this paper
• Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes

  2017cites this paper
• The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling.

  2017cites this paper
• The metabolic effects of leptin therapy and glucagon suppression therapy in mouse models of diabetes

  2017cites this paper
• Role of IGF Binding Proteins in Regulating Metabolism.

  2016cites this paper
• Adipose tissue: an endocrine organ playing a role in metabolic regulation

  2016cites this paper
• Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species.

  2016cites this paper
• симптомы, митохондриальная дисфункция, терапия менопаузальных симптомов, сукцинат аммония Effectiveness and safety of using a succinate-based dietary supplement for women in menopause

  2016cites this paper
• Leptin and Hormones: Energy Homeostasis.

  2016cites this paper
• Leptin and Intermediary Metabolism: Focus on Glucoregulation and Lipids

  2015cites this paper
• Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - consensus and dissent on metabolic control and malignant potential.

  2015cites this paper
• The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice.

  2015cites this paper
• IGFBP-2 - taking the lead in growth, metabolism and cancer

  2015influential citation
• IGFBP-2: a critical player in cancer and metabolism

  2015cites this paper
• Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif

  2015cites this paper
• Mechanisms Linking Inflammation to Insulin Resistance

  2015cites this paper
• IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?

  2015cites this paper
• The role of leptin in regulating bone metabolism.

  2015cites this paper
• Childhood obesity: Current and novel approaches.

  2015cites this paper
• IGFBP-2: The dark horse in metabolism and cancer.

  2015cites this paper
• Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism.

  2015cites this paper
• The RGD-sequence present in IGFBP-2 is required for reduced glucose clearance after oral

  2015cites this paper
• IGFBP-2 inhibits adipogenesis and lipogenesis in human visceral, but not subcutaneous, adipocytes

  2014cites this paper
• MICROVASCULAR COMPLICATIONS — NEPHROPATHY ( B ROSHAN

  2014cites this paper
• Diminished mTOR signaling: a common mode of action for endocrine longevity factors

  2014cites this paper
• Effect of Black Soybean Koji Extract on Glucose Utilization and Adipocyte Differentiation in 3T3-L1 Cells

  2014cites this paper
• Effect of periodontal treatment on adipokines in type 2 diabetes.

  2014cites this paper
• Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesitya

  2014cites this paper
• Best Practice & Research Clinical Endocrinology & Metabolism

  2013cites this paper