Dual Roles of Oct4 in the Maintenance of Mouse P19 Embryonal Carcinoma Cells: As Negative Regulator of Wnt/β-Catenin Signaling and Competence Provider for Brachyury Induction

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Stem Cells and Development

• Publication date

  2011-01-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/scd.2010.0209PMID 21083502PMCID PMC3112048
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TOWARDS AN INTEGRATED VIEW OF Wnt SIGNALING IN MOUSE ADRENOCORTICAL FUNCTIONAL ZONATION

  2012cited by this paper
• GSK3: a multifaceted kinase in Wnt signaling.

  2010cited by this paper
• Towards an integrated view of Wnt signaling in development

  2009cited by this paper
• Aggregated P19 mouse embryonal carcinoma cells as a simple in vitro model to study the molecular regulations of mesoderm formation and axial elongation morphogenesis

  2009cited by this paper
• Expression of Scl in mesoderm rescues hematopoiesis in the absence of Oct-4.

  2009cited by this paper
• Ectopic expression of mouse Sry interferes with Wnt/beta-catenin signaling in mouse embryonal carcinoma cell lines.

  2008cited by this paper
• Requirement of Oct3/4 function for germ cell specification.

  2008influential reference
• The Groucho/TLE/Grg family of transcriptional co-repressors

  2008cited by this paper
• Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data

  2008cited by this paper
• Identification of an OCT4 and SRY regulatory module using integrated computational and experimental genomics approaches.

  2007cited by this paper
• Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene

  2007cited by this paper
• How is pluripotency determined and maintained?

  2007cited by this paper
• Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells.

  2007cited by this paper
• Derivation of pluripotent epiblast stem cells from mammalian embryos

  2007cited by this paper
• New cell lines from mouse epiblast share defining features with human embryonic stem cells

  2007cited by this paper
• β-Catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells

  2007cited by this paper
• POU‐V factors antagonize maternal VegT activity and β‐Catenin signaling in Xenopus embryos

  2007cited by this paper
• Conserved roles for Oct4 homologues in maintaining multipotency during early vertebrate development

  2006cited by this paper
• The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

  2006cited by this paper
• The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.

  2006influential reference
• Wnt/β-catenin signaling and body plan formation in mouse embryos

  2006cited by this paper
• WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells

  2006cited by this paper
• WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells.

  2006cited by this paper
• Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells.

  2006cited by this paper
• wnt3a but not wnt11 supports self-renewal of embryonic stem cells.

  2006cited by this paper
• Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

  2006cited by this paper
• Wnt/beta-catenin signaling and body plan formation in mouse embryos.

  2006cited by this paper
• Core transcriptional regulatory circuitry in human embryonic stem cells.

  2005cited by this paper
• Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst

  2005cited by this paper
• Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.

  2005cited by this paper
• Transcriptional Regulation of Nanog by OCT4 and SOX2*

  2005influential reference
• Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation.

  2005cited by this paper
• Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis

  2005cited by this paper
• Hedgehog Signaling Induces Cardiomyogenesis in P19 Cells*

  2005cited by this paper
• Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

  2004cited by this paper
• Oct4 is required for primordial germ cell survival

  2004cited by this paper
• Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway.

  2003cited by this paper
• BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.

  2003cited by this paper
• Secreted antagonists of the Wnt signalling pathway

  2003cited by this paper
• Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway

  2003cited by this paper
• The PDZ Protein Tax-interacting Protein-1 Inhibits β-Catenin Transcriptional Activity and Growth of Colorectal Cancer Cells*

  2003cited by this paper
• Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells

  2002cited by this paper
• Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.

  2002influential reference
• Differentiating Embryonic Stem Cells: GAPDH, But Neither HPRT Nor β-Tubulin Is Suitable as an Internal Standard for Measuring RNA Levels

  2002cited by this paper
• Nodal signalling in the epiblast patterns the early mouse embryo

  2001cited by this paper
• Oct‐4: Gatekeeper in the Beginnings of Mammalian Development

  2001cited by this paper
• Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

  2000cited by this paper
• Wnt Signaling Regulates the Function of MyoD and Myogenin*

  2000cited by this paper
• Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury.

  2000influential reference
• Brachyury is a target gene of the Wnt/beta-catenin signaling pathway.

  2000influential reference
• Requirement for β-Catenin in Anterior-Posterior Axis Formation in Mice

  2000cited by this paper
• Oct‐4: Control of totipotency and germline determination

  2000cited by this paper
• Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein

  2000cited by this paper
• LDL-receptor-related proteins in Wnt signal transduction

  2000cited by this paper
• Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein.

  2000cited by this paper
• A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless, and Hedgehog signaling pathways.

  1999cited by this paper
• Roles of Axin in the Wnt signalling pathway.

  1999cited by this paper
• Expression of the T-box gene Eomesodermin during early mouse development.

  1999cited by this paper
• Requirement for Wnt3 in vertebrate axis formation

  1999cited by this paper
• Brachyury (T) expression in embryonal carcinoma P19 cells resembles its expression in primitive streak and tail‐bud but not that in notochord

  1999cited by this paper
• T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.

  1999cited by this paper
• Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo

  1998cited by this paper
• Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.

  1998cited by this paper
• A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor.

  1998cited by this paper
• Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon Carcinoma

  1997cited by this paper
• Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.

  1996influential reference
• The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.

  1996cited by this paper
• Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.

  1995cited by this paper
• The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo.

  1995cited by this paper
• Efficient hormone-inducible protein function in Xenopus laevis.

  1995cited by this paper
• Expression of Cdx‐2 in the mouse embryo and placenta: Possible role in patterning of the extra‐embryonic membranes

  1995influential reference
• Dominant interfering alleles define a role for c-Myb in T-cell development.

  1994cited by this paper
• Functional domains of the Drosophila Engrailed protein.

  1993cited by this paper
• Use of a conditional MyoD transcription factor in studies of MyoD trans-activation and muscle determination.

  1993cited by this paper
• Active repression of transcription by the engrailed homeodomain protein.

  1991cited by this paper
• A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells.

  1990cited by this paper
• A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

  1990cited by this paper
• New type of POU domain in germ line-specific protein Oct-4

  1990cited by this paper
• Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

  1988influential reference
• GAL4-VP16 is an unusually potent transcriptional activator

  1988influential reference
• Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells

  1982cited by this paper

• Establishment of sheep induced pluripotent stem cells using sheep-derived reprogramming factors and exploration of pluripotency maintenance mechanisms via RNA-seq analysis

  2025cites this paper
• Pcgf5: An important regulatory factor in early embryonic neural induction

  2024cites this paper
• BPA Exposure Affects Mouse Gastruloids Axial Elongation by Perturbing the Wnt/β-Catenin Pathway

  2024cites this paper
• Valproic acid promotes SOD2 acetylation: a potential mechanism of valproic acid-induced oxidative stress in developing systems

  2021cites this paper
• Oct4-mediated inhibition of Lsd1 activity promotes the active and primed state of pluripotency enhancers

  2019cites this paper
• DMRTC2, PAX7, BRACHYURY/T and TERT Are Implicated in Male Germ Cell Development Following Curative Hormone Treatment for Cryptorchidism-Induced Infertility

  2017influential citation
• Mechanisms Regulating Stemness and Differentiation in Embryonal Carcinoma Cells

  2017cites this paper
• The role of Oct4 in murine endoderm development

  2016cites this paper
• Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and embryonic stem (ES) cells.

  2015cites this paper
• Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal

  2015cites this paper
• Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and Embryonic Stem (ES) cells.

  2015cites this paper
• Attenuation of Wnt/β-catenin activity reverses enhanced generation of cardiomyocytes and cardiac defects caused by the loss of emerin.

  2015cites this paper
• Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and Embryonic Stem (ES) cells.

  2015cites this paper
• Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and Embryonic Stem (ES) cells.

  2015cites this paper
• Wnt/ß-catenin signalling and the dynamics of fate decisions in early mouse embryos and Embryonic Stem (ES) cells.

  2015cites this paper
• Melatonin promotes the acquisition of neural identity through extracellular‐signal‐regulated kinases 1/2 activation

  2014cites this paper
• A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells

  2013cites this paper
• Biological and Quantitative Models for Stem Cell Self-Renewal and Differentiation

  2013cites this paper
• Regulation of developmental competence and commitment towards the definitive endoderm lineage in human embryonic stem cells.

  2013cites this paper
• Quantitative Approaches to Model Pluripotency and Differentiation in Stem Cells

  2013cites this paper
• Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.

  2012cites this paper
• Hyperosmotic stress enzyme signaling modulates OCT4, NANOG, and REX1 expression and induces prioritized differentiation of murine embryonic stem cells

  2012cites this paper
• Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell.

  2012cites this paper
• Wnt pathway regulation of embryonic stem cell self-renewal.

  2012cites this paper
• RNA-Seq of Human Neurons Derived from iPS Cells Reveals Candidate Long Non-Coding RNAs Involved in Neurogenesis and Neuropsychiatric Disorders

  2011cites this paper