The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripheral lymphocytes.

The effects of Salmonella endotoxin and staphylococcal enterotoxin B (SEB) were examined in vitro on mouse and human lymphocyte populations from unsensitized subjects. These substances were found to be extremely stimulatory to mouse spleen cells as measured by 3H-thymidine incorporation. In regards to size, general morphologic features, and staining properties, the cell cultures appear identical to cultures stimulated by phytohemagglutinin (PHA). However, endotoxin failed to stimulate human peripheral lymphocytes while PHA and SEB produced a response over a wide dosage range. Attempts to detect stimulation of human lymphoid cells by endotoxin using various mammalian sera as augmentors were unsuccessful.

• Publication year

  1970

• Venue

  Journal of Immunology

• Publication date

  1970-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.105.6.1453PMID 4921787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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