HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.08-2158PMID 19098312PMCID PMC2819291
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Approaches to Prevention of Cardiovascular Complications and Events in Diabetes Mellitus

  2012cited by this paper
• STAT3: A critical transcription activator in angiogenesis

  2008cited by this paper
• Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.

  2008cited by this paper
• Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury.

  2007cited by this paper
• VEGF Signaling Through NADPH Oxidase-Derived ROS

  2007cited by this paper
• Emerging indications for statins: a pluripotent family of agents with several potential applications.

  2007cited by this paper
• Endothelial dysfunction, oxidative stress and inflammation in atherosclerosis: beneficial effects of statins.

  2007cited by this paper
• Oxygen-dependent diseases in the retina: role of hypoxia-inducible factors.

  2006cited by this paper
• Human Vascular Endothelial Growth Factor Protects Axotomized Retinal Ganglion Cells In Vivo by Activating ERK-1/2 and Akt Pathways

  2006cited by this paper
• Signal transduction of inflammatory cytokines and tumor development

  2006cited by this paper
• Role of vascular endothelial growth factor in ocular angiogenesis.

  2006cited by this paper
• Peroxynitrite increases VEGF expression in vascular endothelial cells via STAT3.

  2005cited by this paper
• HMG CoA reductase inhibitors (statins): do they have a role in age-related macular degeneration?

  2005cited by this paper
• Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress.

  2005cited by this paper
• STAT3-mediated activation of myocardial capillary growth.

  2005cited by this paper
• Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy.

  2005cited by this paper
• Contribution of vascular NAD(P)H oxidase to endothelial dysfunction in heart failure and the therapeutic effects of HMG-CoA reductase inhibitor.

  2004cited by this paper
• Modulatory effects of HMG‐CoA reductase inhibitors in diabetic microangiopathy

  2004cited by this paper
• Microtubules Regulate Angiotensin II Type 1 Receptor and Rac1 Localization in Caveolae/Lipid Rafts: Role in Redox Signaling

  2004cited by this paper
• Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes.

  2004cited by this paper
• Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema.

  2004cited by this paper
• Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives

  2003cited by this paper
• Statin effects beyond lipid lowering--are they clinically relevant?

  2003cited by this paper
• Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease

  2003cited by this paper
• Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels.

  2003cited by this paper
• Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite.

  2003cited by this paper
• Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization.

  2003cited by this paper
• Cytokine Signaling

  2002cited by this paper
• Double-Edged Role of Statins in Angiogenesis Signaling

  2002cited by this paper
• Statins Have Biphasic Effects on Angiogenesis

  2002cited by this paper
• Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis.

  2002cited by this paper
• Cerivastatin, an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase, Inhibits Endothelial Cell Proliferation Induced by Angiogenic Factors In Vitro and Angiogenesis in In Vivo Models

  2002cited by this paper
• Effects of sustained hyperoxia on revascularization in experimental retinopathy of prematurity.

  2002cited by this paper
• Vascular Endothelial Growth Factor Activates STAT Proteins in Aortic Endothelial Cells*

  2000cited by this paper
• Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

  2000cited by this paper
• Pleiotropic effects of statins in atherosclerosis and diabetes.

  2000cited by this paper
• Non-lipid-related effects of statins

  2000cited by this paper
• Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.

  1999cited by this paper
• VEGF increases retinal vascular ICAM-1 expression in vivo.

  1999cited by this paper
• Oxygen-induced retinopathy in the mouse.

  1994cited by this paper
• Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells.

  1989cited by this paper
• The FASEB Journal express article 10.1096/fj.02-1084fje. Published online June 17, 2003. VEGF differentially activates STAT3 in microvascular endothelial cells

  year unknowncited by this paper

• Protective Effects of Butyrate on Retinal Neovascularization in Preclinical Retinopathy of Prematurity Models

  2025cites this paper
• Critical roles of miR-21 in promotions angiogenesis: friend or foe?

  2025cites this paper
• Retinopathy of Prematurity—Targeting Hypoxic and Redox Signaling Pathways

  2024cites this paper
• IL1R2 promotes retinal angiogenesis to participate in retinopathy of prematurity by activating the HIF1α/PFKFB3 pathway.

  2023cites this paper
• Recent trends in drug-delivery systems for the treatment of Diabetic Retinopathy and associated Fibrosis.

  2021cites this paper
• Ursodeoxycholic Acid Halts Pathological Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy

  2020cites this paper
• Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity

  2019cites this paper
• Effect of herbal cake-partitioned moxibustion on Leptin/JAK2/STAT3 in lipid-lowering pathway of hyperlipidemia rabbits

  2019cites this paper
• Glycation and HMG-CoA Reductase Inhibitors: Implication in Diabetes and Associated Complications.

  2019cites this paper
• Statins: A Conceivable Remedial Role for the Regulation of Cancer Progression

  2019cites this paper
• Stabilization of symptomatic carotid atherosclerotic plaques by statins: a clinico-pathological analysis

  2018cites this paper
• Statins reduce testicular and ocular VEGF: A potential compromise to microcirculation.

  2018cites this paper
• Systemic use of calcium channel blockers associated with less increase in central retinal thickness after uncomplicated cataract surgery

  2018cites this paper
• STAT3-mediated activation of miR-21 is involved in down-regulation of TIMP3 and neovascularization in the ischemic retina

  2017cites this paper
• Retina Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy

  2017cites this paper
• Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy

  2017cites this paper
• Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

  2016cites this paper
• Statins in rhegmatogenous retinal detachment are associated with low intravitreal angiopoietin-2, VEGF and MMP-2 levels, and improved visual acuity gain in vitrectomized patients

  2015cites this paper
• Low intravitreal angiopoietin‐2 and VEGF levels in vitrectomized diabetic patients with simvastatin treatment

  2014cites this paper
• Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke

  2014cites this paper
• Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.

  2014cites this paper
• Anti-Angiogenic Therapy and Cardiovascular Diseases: Current Strategies and Future Perspectives

  2014cites this paper
• Protective effects of β1/2 adrenergic receptor deletion in a model of oxygen-induced retinopathy.

  2014cites this paper
• NADPH Oxidase, NOX1, Mediates Vascular Injury in Ischemic Retinopathy

  2014cites this paper
• Protective Effects of b 1 / 2 Adrenergic Receptor Deletion in a Model of Oxygen-Induced Retinopathy

  2014cites this paper
• The effect of atorvastatin on survival of rat ischemic flap

  2013cites this paper
• Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis

  2013cites this paper
• Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy.

  2013cites this paper
• Atorvastatin inhibits RhoC function and limits head and neck cancer metastasis.

  2013cites this paper
• HIF-1α siRNA reduces retinal neovascularization in a mouse model of retinopathy of prematurity.

  2013cites this paper
• Pharmacological Actions of Statins: A Critical Appraisal in the Management of Cancer

  2012cites this paper
• Retinopathy of prematurity: Where are we today?

  2012cites this paper
• Effects of Simvastatin on the Expression of VEGF in Human Retinal Pigment Epithelial Cells

  2012cites this paper
• Medical Therapies: Statins

  2012cites this paper
• Subfoveal choroidal thickness in multiple evanescent white dot syndrome

  2012cites this paper
• Caspase-14: A novel caspase in the retina with a potential role in diabetic retinopathy

  2012cites this paper
• Mechanisms underlying somatostatin receptor 2 down‐regulation of vascular endothelial growth factor expression in response to hypoxia in mouse retinal explants

  2012cites this paper
• Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity.

  2011cites this paper
• Effect of long term, non cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats.

  2011cites this paper
• Hydrogen Saline Treatment Attenuates Hyperoxia-Induced Retinopathy by Inhibition of Oxidative Stress and Reduction of VEGF Expression

  2011cites this paper
• Erythropoietin receptor antibody inhibits oxidative stress induced retinal neovascularization in mice.

  2011cites this paper
• Lipid metabolites in the pathogenesis and treatment of neovascular eye disease

  2011cites this paper
• Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade.

  2011cites this paper
• Pulmonary, Gastrointestinal and Urogenital Pharmacology Effect of long term, non cholesterol lowering dose of fluvastatin treatment on oxidative stress in brain and peripheral tissues of streptozotocin-diabetic rats

  2011cites this paper
• Simvastatin improves retinal ganglion cell survival and spatial vision after acute retinal ischemia/reperfusion in mice.

  2011cites this paper
• Arginase 2 Deletion Reduces Neuro-Glial Injury and Improves Retinal Function in a Model of Retinopathy of Prematurity

  2011cites this paper
• A Paradigm Shift in the Prevention of Retinopathy of Prematurity

  2011cites this paper
• Multi-Modal Proteomic Analysis of Retinal Protein Expression Alterations in a Rat Model of Diabetic Retinopathy

  2011cites this paper
• Statins for prevention of diabetic-related blindness: a new treatment option?

  2011cites this paper
• Diverse Effects of Statins on Angiogenesis: New Therapeutic Avenues

  2010cites this paper
• Expression, localization, and functional coupling of the somatostatin receptor subtype 2 in a mouse model of oxygen-induced retinopathy.

  2010cites this paper
• Early Intervention of Tyrosine Nitration Prevents Vaso-Obliteration and Neovascularization in Ischemic Retinopathy

  2009cites this paper
• Trans-Chalcone prevents VEGF expression and retinal neovascularization in the ischemic retina.

  2008cites this paper