Targeted disruption of the CD18 or ICAM-1 gene inhibits choroidal neovascularization.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2003-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/IOVS.02-1246PMID 12766082
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis

  2005cited by this paper
• SENILE MACULAR DEGENERATION: A HISTOPATHOLOGIC STUDY*

  2005cited by this paper
• Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment.

  2002cited by this paper
• Vascular endothelial growth factor family and receptor expression in human choroidal neovascular membranes.

  2002cited by this paper
• Age as an independent risk factor for severity of experimental choroidal neovascularization.

  2002cited by this paper
• Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2.

  2001cited by this paper
• Choroidal neovascularization in the rat induced by adenovirus mediated expression of vascular endothelial growth factor.

  2000cited by this paper
• The Accumulation of Dendritic Cells in the Lung Is Impaired in CD18−/− But Not in ICAM-1−/− Mutant Mice1

  2000cited by this paper
• Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).

  2000cited by this paper
• Transscleral delivery of bioactive protein to the choroid and retina.

  2000cited by this paper
• Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization.

  2000cited by this paper
• CD18 and ICAM-1-dependent corneal neovascularization and inflammation after limbal injury.

  2000cited by this paper
• Vascular Endothelial Growth Factor Up-regulates ICAM-1 Expression via the Phosphatidylinositol 3 OH-kinase/AKT/Nitric Oxide Pathway and Modulates Migration of Brain Microvascular Endothelial Cells*

  2000cited by this paper
• Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1.

  2000cited by this paper
• Treatment of age-related macular degeneration.

  2000cited by this paper
• Genetic heterogeneity of angiogenesis in mice

  2000cited by this paper
• Correlation of histologic 2-dimensional reconstruction and confocal scanning laser microscopic imaging of choroidal neovascularization in eyes with age-related maculopathy.

  2000cited by this paper
• Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition

  1999cited by this paper
• Expression of vascular endothelial growth factor and its receptor (KDR/flk-1) mRNA in experimental choroidal neovascularization.

  1999cited by this paper
• Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of a single treatment in a phase 1 and 2 study.

  1999cited by this paper
• Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation.

  1999cited by this paper
• The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes.

  1999cited by this paper
• Analysis of the secretion pattern of monocyte chemotactic protein‐1 (MCP‐1) and transforming growth factor‐beta 2 (TGF‐β2) by human retinal pigment epithelial cells

  1999cited by this paper
• Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition.

  1999cited by this paper
• Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: one-year results of 2 randomized clinical trials--TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group.

  1999cited by this paper
• Fas ligand (CD95 ligand) controls angiogenesis beneath the retina

  1999cited by this paper
• Angiogenic activity of human soluble intercellular adhesion molecule-1.

  1999cited by this paper
• Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro.

  1998cited by this paper
• Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model.

  1998cited by this paper
• Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration.

  1998cited by this paper
• Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor β-1

  1998cited by this paper
• Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes.

  1998cited by this paper
• Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat

  1998cited by this paper
• Dominant-negative effect of the lymphocyte function-associated antigen-1 beta (CD18) cytoplasmic domain on leukocyte adhesion to ICAM-1 and fibronectin.

  1998cited by this paper
• PHOTOCOAGULATION OF WELL‐DEFINED CHOROIDAL NEOVASCULARIZATION IN AGE‐RELATED MACULAR DEGENERATION:Clinicopathologic Correlation

  1998cited by this paper
• Polarized secretion of IL‐6 and IL‐8 by human retinal pigment epithelial cells

  1998cited by this paper
• Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

  1997cited by this paper
• Expression of transforming growth factor-beta mRNA in experimental choroidal neovascularization.

  1997cited by this paper
• During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium.

  1996cited by this paper
• The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

  1996cited by this paper
• Expression of basic fibroblast growth factor mRNA in developing choroidal neovascularization.

  1996cited by this paper
• The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity.

  1995cited by this paper
• Expression and regulation of vascular endothelial growth factor in choroidal fibroblasts.

  1995cited by this paper
• Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing.

  1995cited by this paper
• [Surgical extraction of subretinal pseudotumors in age related macular degeneration. Clinical, morphologic and immunohistochemical results].

  1995cited by this paper
• Growth factor localization in choroidal neovascular membranes of age-related macular degeneration.

  1994cited by this paper
• Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

  1993cited by this paper
• Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study.

  1993influential reference
• Gene targeting yields a CD18-mutant mouse for study of inflammation.

  1993cited by this paper
• Modulation and function of intercellular adhesion molecule-1 (CD54) on human retinal pigment epithelial cells.

  1992influential reference
• Ulrastructural Immunocytochemistry of Subretinal Neovascular Membranes in Age-related Macular Degeneration

  1992cited by this paper
• Ultrastructural immunocytochemistry of subretinal neovascular membranes in age-related macular degeneration.

  1992influential reference
• Activated macrophages in experimental subretinal neovascularization.

  1990cited by this paper
• Pathogenesis of laser-induced choroidal subretinal neovascularization.

  1990cited by this paper
• Macrophages related to Bruch's membrane in age-related macular degeneration

  1990cited by this paper
• Ultrastructure of Bruch's membrane after krypton laser photocoagulation. II. Repair of Bruch's membrane and the role of macrophages.

  1986cited by this paper
• The role of retinal pigment epithelium in the involution of subretinal neovascularization.

  1986cited by this paper
• Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils.

  1986cited by this paper
• Correlation of choroidal subretinal neovascularization with fluorescein angiography.

  1985cited by this paper
• Oxygen tension regulates the expression of angiogenesis factor by macrophages.

  1983cited by this paper
• Subretinal neovascularization. Natural history of an experimental model.

  1982cited by this paper
• Mouse macrophage elastase. Purification and characterization as a metalloproteinase.

  1981cited by this paper
• Softening of drusen and subretinal neovascularization.

  1980cited by this paper
• Senile macular degeneration: a histopathologic study.

  1977cited by this paper
• Neovascularization after argon laser photocoagulation of macular lesions.

  1975cited by this paper
• A clinical study of the vascularity of senile disciform macular degeneration.

  1973cited by this paper
• Pathogenesis of disciform detachment of the neuroepithelium.

  1967cited by this paper

• Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration

  2024cites this paper
• Elevation of Granulocyte Colony Stimulating Factor in Human AMD Donor RPE-Choroid

  2024cites this paper
• Protective Effects of Human Pericyte-like Adipose-Derived Mesenchymal Stem Cells on Human Retinal Endothelial Cells in an In Vitro Model of Diabetic Retinopathy: Evidence for Autologous Cell Therapy

  2023cites this paper
• Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris

  2023cites this paper
• CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization

  2023cites this paper
• Two-year clinical outcomes of triple therapy with photodynamic therapy, anti-vascular endothelial growth factor agent, and triamcinolone acetonide for neovascular age-related macular degeneration

  2022influential citation
• Hypoxia Inhibits Subretinal Inflammation Resolution Thrombospondin-1 Dependently

  2022cites this paper
• Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD)

  2022cites this paper
• Choriocapillaris: Fundamentals and advancements.

  2021cites this paper
• Anti-angiogenic Properties of Bevacizumab Improve Respiratory System Inflammation in Ovalbumin-Induced Rat Model of Asthma

  2021cites this paper
• Transcription Factor NF-κβ and Molecules Derived from its Activation in Age-Related Macular Degeneration

  2021influential citation
• Downregulation of miR-146a-5p Inhibits Choroidal Neovascularization via the NF-κB Signaling Pathway by Targeting OTUD7B

  2020cites this paper
• Bruch’s membrane pathology: A mechanistic perspective

  2020cites this paper
• An overview of heat stress in tomato (Solanum lycopersicum L.)

  2020cites this paper
• Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

  2019cites this paper
• The effects of anti‐VEGF and kinin B1 receptor blockade on retinal inflammation in laser‐induced choroidal neovascularization

  2019cites this paper
• Genetic and physiological analysis of tomato (Solanum lycopersicum L.) adaption under heat and disease stress

  2019cites this paper
• Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents

  2019cites this paper
• Both Autocrine Signaling and Paracrine Signaling of HB-EGF Enhance Ocular Neovascularization

  2018cites this paper
• Role of Inflammation in Diabetic Retinopathy

  2018cites this paper
• New Therapies of Neovascular AMD—Beyond Anti-VEGFs

  2018cites this paper
• Neovascular age-related macular degeneration: intraocular inflammatory cytokines in the poor responder to ranibizumab treatment

  2018influential citation
• Galectin‐1 promotes choroidal neovascularization and subretinal fibrosis mediated via epithelialmesenchymal transition

  2018cites this paper
• The involvement of NK1 and Y2 receptor in the development of laser‐induced CNVs in C57Bl/6N mice

  2018cites this paper
• Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization

  2017cites this paper
• On phagocytes and macular degeneration

  2017cites this paper
• Mechanisms of pathophysiology and methods for regeneration of the choriocapillaris in age-related macular degeneration

  2017cites this paper
• Structural and molecular changes in the aging choroid: implications for age-related macular degeneration

  2017cites this paper
• Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets.

  2016cites this paper
• Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy

  2016cites this paper
• Selection Strategy of In Vivo Models for Ophthalmic Drug Development in Diabetic Retinopathy

  2016cites this paper
• Subretinal AAV2.COMP-Ang1 suppresses choroidal neovascularization and vascular endothelial growth factor in a murine model of age-related macular degeneration.

  2016influential citation
• Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells

  2015cites this paper
• Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells.

  2015cites this paper
• Restoring Physiologic Barriers Against Neovascular Invasion

  2015cites this paper
• Novel Pharmacological Target for the Treatment of Ocular Neovascular Diseases [an abstract of dissertation and a summary of dissertation review]

  2015cites this paper
• Choroidal neovascularization is inhibited via an intraocular decrease of inflammatory cells in mice lacking complement component C3

  2015cites this paper
• Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

  2015cites this paper
• Effect of candesartan on the expression of sclera-choroidal intercellular adhesion molecule-1 in hypercholesterolemic models

  2014cites this paper
• Genistein attenuates choroidal neovascularization.

  2014cites this paper
• Angiotensin II-related hypertension and eye diseases.

  2014cites this paper
• The ocular renin-angiotensin system: a therapeutic target for the treatment of ocular disease.

  2014cites this paper
• Increased intercellular adhesion molecule-1 immunoreactivity in the sclera-choroid complex in hypercholesterolemia experimental model

  2014cites this paper
• Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age‐related macular degeneration

  2014cites this paper
• Resveratrol prevents the development of choroidal neovascularization by modulating AMP-activated protein kinase in macrophages and other cell types.

  2014cites this paper
• Intravitreal injection of 99Tc-MDP inhibits the development of laser-induced choroidal neovascularization in rhesus monkeys

  2014cites this paper
• Effect of flaxseed on choroid-sclera complex thickness and on LDL oxidation in the sclera, choroid and retina of diet-induced hypercholesterolaemic rabbits.

  2014cites this paper
• Construction of an SSH Library of Pinellia ternata Under Heat Stress, and Expression Analysis of Four Transcripts

  2013cites this paper
• Intranasal VEGF-A and VEGF-E in a modified Levine model of stroke

  2013cites this paper
• Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor.

  2013cites this paper
• Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization.

  2013cites this paper
• Effect of Olmesartan on Leukocyte Recruitment in Choroid–Sclera Complex in Hypercholesterolemia Model

  2013cites this paper
• Suppression of Experimental Choroidal Neovascularization by Curcumin in Mice

  2012cites this paper
• The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization.

  2012cites this paper
• Recruitment of Stem Cells into the Injured Retina After Laser Injury

  2012cites this paper
• Receptor-associated prorenin system in the pathogenesis of retinal diseases.

  2012cites this paper
• [Increase of choroidal and scleral MCP-1 expression in hypercholesterolemia experimental model].

  2012cites this paper
• Photodynamic therapy combined with intravitreal bevacizumab and sub-tenon triamcinolone acetonide injections for age-related macular degeneration

  2012cites this paper
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  2012cites this paper
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• Effects of antioxidant components of AREDS vitamins and zinc ions on endothelial cell activation: implications for macular degeneration.

  2012cites this paper
• Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) inhibits experimental choroidal neovascularization in vivo and VEGF-induced cell migration and tube formation in vitro.

  2011cites this paper
• Inflammation in diabetic retinopathy.

  2011influential citation
• Evaluation of variants in the selectin genes in age-related macular degeneration

  2011cites this paper
• Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

  2011cites this paper
• Age-related macular degeneration and the other double helix. The Cogan Lecture.

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• Recruitment of blood-derived inflammatory cells mediated via tumor necrosis factor-α receptor 1b exacerbates choroidal neovascularization.

  2011influential citation
• Ocular drug delivery for bioactive proteins

  2011cites this paper
• Capítulo 25 – Tratamiento combinado farmacológico en la DMAE exudativa: Más allá de la monoterapia antiangiogénica

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• Antisense-mediated depletion of tomato endoplasmic reticulum omega-3 fatty acid desaturase enhances thermal tolerance.

  2010cites this paper
• Localization of vascular adhesion protein-1 (VAP-1) in the human eye.

  2010cites this paper
• Complement component C5a activates ICAM-1 expression on human choroidal endothelial cells.

  2010cites this paper
• Effect of sorafenib on experimental choroidal neovascularization in the rat

  2010cites this paper
• Sclerochorioretinal abnormalities in hypercholesterolemic rabbits treated with rosiglitazone.

  2010cites this paper
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  2010cites this paper
• The mouse retina as an angiogenesis model.

  2010cites this paper
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  2010cites this paper
• Retinal Vascular Permeability in Health and Disease

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2009cites this paper
• Macrophages in neovascular age-related macular degeneration: friends or foes?

  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
• Mediators of ocular angiogenesis

  2009cites this paper
• Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization.

  2009cites this paper
• Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells.

  2008cites this paper
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  2008cites this paper
• (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.

  2008cites this paper
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  2008cites this paper
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  2008cites this paper
• Effect of bevacizumab on inflammation and proliferation in human choroidal neovascularization.

  2008cites this paper
• Vascular adhesion protein‐1 blockade suppresses choroidal neovascularization

  2008cites this paper
• Animal Models of Choroidal Neovascularization

  2008cites this paper
• Angiogenic Factors and Inhibitors

  2008cites this paper
• Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin.

  2008cites this paper