Mechanisms of bacterial persistence during stress and antibiotic exposure

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Science

• Publication date

  2016-12-16

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1126/science.aaf4268PMID 27980159
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Linking bacterial type I toxins with their actions.

  2016influential reference
• Combatting bacterial persister cells

  2016cited by this paper
• Rapid Curtailing of the Stringent Response by Toxin-Antitoxin Module-Encoded mRNases

  2016cited by this paper
• In Vitro Emergence of High Persistence upon Periodic Aminoglycoside Challenge in the ESKAPE Pathogens

  2016cited by this paper
• High Persister Mutants in Mycobacterium tuberculosis

  2016cited by this paper
• Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

  2016cited by this paper
• Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

  2016cited by this paper
• Persistence and resistance as complementary bacterial adaptations to antibiotics

  2016cited by this paper
• A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA

  2016cited by this paper
• Fumarate-Mediated Persistence of Escherichia coli against Antibiotics

  2016cited by this paper
• Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence

  2016cited by this paper
• ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

  2016cited by this paper
• Toxin-antitoxin systems in bacterial growth arrest and persistence.

  2016influential reference
• Persister formation in Staphylococcus aureus is associated with ATP depletion

  2016influential reference
• VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

  2016cited by this paper
• Ranking of persister genes in the same Escherichia coli genetic background demonstrates varying importance of individual persister genes in tolerance to different antibiotics

  2015influential reference
• Distinct type I and type II toxin-antitoxin modules control Salmonella lifestyle inside eukaryotic cells

  2015cited by this paper
• Persister Heterogeneity Arising from a Single Metabolic Stress.

  2015influential reference
• The MqsR/MqsA toxin/antitoxin system protects Escherichia coli during bile acid stress.

  2015cited by this paper
• Transcriptional Adaptation of Drug-tolerant Mycobacterium tuberculosis During Treatment of Human Tuberculosis.

  2015cited by this paper
• Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration?

  2015cited by this paper
• HipBA–promoter structures reveal the basis of heritable multidrug tolerance

  2015cited by this paper
• Fitness trade‐offs explain low levels of persister cells in the opportunistic pathogen Pseudomonas aeruginosa

  2015cited by this paper
• Many Means to a Common End: the Intricacies of (p)ppGpp Metabolism and Its Control of Bacterial Homeostasis

  2015cited by this paper
• Transposon Mutagenesis Identifies Novel Genes Associated with Staphylococcus aureus Persister Formation

  2015cited by this paper
• Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases

  2015influential reference
• Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli

  2015cited by this paper
• Stationary-Phase Persisters to Ofloxacin Sustain DNA Damage and Require Repair Systems Only during Recovery

  2015cited by this paper
• Recent functional insights into the role of (p)ppGpp in bacterial physiology

  2015cited by this paper
• Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms.

  2015cited by this paper
• Contribution of Stress Responses to Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms

  2015cited by this paper
• MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

  2015cited by this paper
• Inhibition of stationary phase respiration impairs persister formation in E. coli

  2015cited by this paper
• Persisters unmasked

  2015cited by this paper
• Ribosome Hibernation Facilitates Tolerance of Stationary-Phase Bacteria to Aminoglycosides

  2015cited by this paper
• Antimicrobial Tolerance in Biofilms

  2015cited by this paper
• Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance.

  2015influential reference
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

  2014cited by this paper
• Cecum Lymph Node Dendritic Cells Harbor Slow-Growing Bacteria Phenotypically Tolerant to Antibiotic Treatment

  2014cited by this paper
• Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

  2014cited by this paper
• Phenotypic variation of Salmonella in host tissues delays eradication by antimicrobial chemotherapy.

  2014cited by this paper
• Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

  2014cited by this paper
• Molecular mechanisms underlying bacterial persisters.

  2014cited by this paper
• SOS, the formidable strategy of bacteria against aggressions.

  2014influential reference
• The Role of Bacterial Biofilms in Chronic Infections

  2014cited by this paper
• Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

  2014cited by this paper
• Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics.

  2014cited by this paper
• Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery.

  2014cited by this paper
• Selective Target Inactivation Rather than Global Metabolic Dormancy Causes Antibiotic Tolerance in Uropathogens

  2014cited by this paper
• Phenotypic bistability in Escherichia coli's central carbon metabolism

  2014cited by this paper
• The Stringent Response Controls Catalases in Pseudomonas aeruginosa and Is Required for Hydrogen Peroxide and Antibiotic Tolerance

  2013cited by this paper
• Metabolic control of persister formation in Escherichia coli.

  2013cited by this paper
• Microbial persistence and the road to drug resistance.

  2013cited by this paper
• (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity.

  2013cited by this paper
• Activated ClpP kills persisters and eradicates a chronic biofilm infection

  2013cited by this paper
• The role of bacterial biofilms in chronic infections

  2013cited by this paper
• Molecular mechanism of bacterial persistence by HipA.

  2013cited by this paper
• A problem of persistence: still more questions than answers?

  2013cited by this paper
• Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

  2013cited by this paper
• Quantitative analysis of persister fractions suggests different mechanisms of formation among environmental isolates of E. coli

  2013cited by this paper
• Differential regulation by ppGpp versus pppGpp in Escherichia coli

  2013cited by this paper
• Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

  2013cited by this paper
• A Moderate Toxin, GraT, Modulates Growth Rate and Stress Tolerance of Pseudomonas putida

  2013cited by this paper
• Dynamic Persistence of Antibiotic-Stressed Mycobacteria

  2013cited by this paper
• Dormancy Is Not Necessary or Sufficient for Bacterial Persistence

  2013cited by this paper
• Regulation of toxin-antitoxin systems by proteolysis.

  2013cited by this paper
• Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

  2013cited by this paper
• Dose‐dependent reduction of replication elongation rate by (p)ppGpp in Escherichia coli and Bacillus subtilis

  2013cited by this paper
• Tolerance of Escherichia coli to Fluoroquinolone Antibiotics Depends on Specific Components of the SOS Response Pathway

  2013cited by this paper
• Arrested Protein Synthesis Increases Persister-Like Cell Formation

  2013cited by this paper
• GENETIC VARIATION FOR ANTIBIOTIC PERSISTENCE IN ESCHERICHIA COLI

  2012cited by this paper
• Regulation of the Escherichia coli HipBA Toxin-Antitoxin System by Proteolysis

  2012cited by this paper
• Conditional cooperativity in toxin–antitoxin regulation prevents random toxin activation and promotes fast translational recovery

  2012cited by this paper
• A Stress-Inducible Quorum-Sensing Peptide Mediates the Formation of Persister Cells with Noninherited Multidrug Tolerance

  2012cited by this paper
• Bacterial persistence increases as environmental fitness decreases

  2012cited by this paper
• Isolation of Highly Persistent Mutants of Salmonella enterica Serovar Typhimurium Reveals a New Toxin-Antitoxin Module

  2012cited by this paper
• Evolution of Stress Response in the Face of Unreliable Environmental Signals

  2012cited by this paper
• Relacin, a Novel Antibacterial Agent Targeting the Stringent Response

  2012cited by this paper
• Direct binding targets of the stringent response alarmone (p)ppGpp

  2012cited by this paper
• Bacterial persistence and toxin-antitoxin loci.

  2012influential reference
• Role of Oxidative Stress in Persister Tolerance

  2012cited by this paper
• Large mutational target size for rapid emergence of bacterial persistence

  2012cited by this paper
• Identity and Function of a Large Gene Network Underlying Mutagenic Repair of DNA Breaks

  2012cited by this paper
• Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance.

  2012cited by this paper
• Microbial seed banks: the ecological and evolutionary implications of dormancy

  2011cited by this paper
• Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

  2011influential reference
• Bacterial persistence by RNA endonucleases

  2011cited by this paper
• Stationary-Phase Gene Regulation in Escherichia coli §

  2011cited by this paper
• Toxin-Antitoxin Systems Influence Biofilm and Persister Cell Formation and the General Stress Response

  2011cited by this paper
• The RpoS-mediated general stress response in Escherichia coli.

  2011influential reference
• Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies.

  2011cited by this paper
• Age of Inoculum Strongly Influences Persister Frequency and Can Mask Effects of Mutations Implicated in Altered Persistence

  2011cited by this paper
• Bet hedging or not? A guide to proper classification of microbial survival strategies

  2011cited by this paper
• Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism.

  2011cited by this paper
• Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters

  2011cited by this paper
• TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

  2010cited by this paper
• The Three RelE Homologs of Mycobacterium tuberculosis Have Individual, Drug-Specific Effects on Bacterial Antibiotic Tolerance

  2010cited by this paper
• Delineation of a Bacterial Starvation Stress Response Network Which Can Mediate Antibiotic Tolerance Development

  2010influential reference
• How antibiotics kill bacteria: from targets to networks

  2010cited by this paper
• Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

  2010influential reference

• Bacterial biofilm conundrum: insight into the frontiers of antibiotic resistance and state-of-the-art anti-biofilm interventions.

  2026cites this paper
• Characterization of streptomycin-induced persister cells in Erwinia pyrifoliae

  2026cites this paper
• Utilizing Lactic Acid Bacteria Dormancy: Enhancing Physiological Control of Food Processing, Preservation, and Probiotic Delivery

  2026cites this paper
• Parameter sensitivity and critical transition anticipation in bistable toxin-antitoxin dynamics.

  2026cites this paper
• Molecular Basis of Persister Awakening and Lag-Phase Recovery in Escherichia coli After Antibiotic Exposure

  2026cites this paper
• Mechanisms and clinical implications of bacterial persistence in recurrent urinary tract infections.

  2026cites this paper
• From Host-Derived Pressures to the Environmental Anti-Antimicrobial Peptides Resistome: Mechanisms, Reservoirs and Implications for Therapeutic Peptide Design.

  2026cites this paper
• Antimicrobial Armageddon: The Professional Guide to Conquering Antibiotic Resistance.

  2026cites this paper
• DEAD-box ATPase–marked condensates coordinate compartmentalized translation and antibiotic persistence

  2026cites this paper
• Antibiotic exposure dynamically generates a substantial number of heterogeneous persisters along a spectrum of tolerance

  2026cites this paper
• A nutrient bottleneck controls antibiotic efficacy in structured bacterial populations.

  2026cites this paper
• A Clinically Silent Resistance Phenotype That Promotes Acinetobacter baumannii Survival During Colistin Therapy

  2026cites this paper
• Gentamicin fails to eradicate Staphylococcus aureus biofilm in vitro, even in combination with rifampin

  2026cites this paper
• Beyond Resistance: Phenotypic Plasticity in Bacterial Responses to Antibiotics, Oxidative Stress and Antimicrobial Photodynamic Inactivation

  2026cites this paper
• Innate immune priming by n-dodecyl-β-D-maltoside in murine models of bacterial and viral infection

  2026cites this paper
• Chemical Evolution of Natural Product for Discovery and Mechanistic Exploration of Antibiotic against MRSA.

  2026cites this paper
• Insightful approach for screening triclocarban-degrading microbes via enzyme-guided strategy: Detoxification regulation and energy metabolism by Diaphorobacter polyhydroxybutyrativorans.

  2026cites this paper
• Comparative transcriptomics reveals genes commonly induced by distinct stressors in Chlamydia

  2026cites this paper
• Survival of ampicillin-treated uropathogenic Escherichia coli is independent of single-cell growth rates

  2026cites this paper
• Single-cell analysis reveals critical toxin/antitoxin ratio triggering persister resuscitation

  2026cites this paper
• Characterizing ceftriaxone tolerance in Neisseria gonorrhoeae across in vitro and in vivo models

  2026cites this paper
• Induced tolerance to UV stress drives survival heterogeneity in isogenic E. coli cell populations

  2026cites this paper
• Motility Functions as an Essential Defense in the Bacterial Persister Lifecycle

  2025cites this paper
• TrackRefiner a tool for refinement of bacillus cell tracking data

  2025cites this paper
• Bistability in type I toxin-antitoxin systems may lead to stress-induced persister formation

  2025cites this paper
• Mechanisms shaping the transcriptome of E. coli to non-lethal rifampicin stress

  2025cites this paper
• Targeting Drug-Tolerant Persister Cancer Cells: Can Nanomaterial-Based Strategies Be Helpful for Anti-DTP Therapies?

  2025cites this paper
• Exploring the concept of bacterial memory

  2025cites this paper
• Reassessing the tmRNA-SmpB complex as a virulence determinant.

  2025cites this paper
• Rapid and efficient labeling by a selective organic fluorophore probe highlights heterogeneity of mycobacterial populations and persister resuscitation

  2025cites this paper
• EPIGENETIC AND GENETIC RESPONSES OF ESCHERICHIA COLI PERSISTER CELLS TO CIPROFLOXACIN STRESS: INSIGHTS INTO THE ROLE OF NUCLEOID-ASSOCIATED PROTEINS

  2025cites this paper
• Prolonged Starvation Drives Epigenetic Remodeling: Insights from DNA Methylation Profiling in the Aquatic Pathogen Flavobacterium columnare

  2025cites this paper
• Deciphering meropenem persistence in Acinetobacter baumannii facilitates discovery of anti-persister activity of thymol

  2025cites this paper
• Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR

  2025cites this paper
• A novel plasmid-encoded transposon-derived small RNA reveals the mechanism of sRNA-regulated bacterial persistence

  2025cites this paper
• An uncharacterized small protein MicN mediates the transcriptional reprogramming of Salmonella through regulating the RpoS-RNA polymerase interaction

  2025cites this paper
• Comparative Transcriptomics Reveals Genes Commonly Induced by Distinct Stressors in Chlamydia

  2025cites this paper
• The pH gradient contributes to persistence in Mycobacterium tuberculosis

  2025cites this paper
• Deploying Soft Drugs in the Fight against MRSA with Detailed Biological Evaluation of 4-(n-Alkoxy)-phenoxy Betaine Amphiphiles Active against MDR Staphylococcus aureus and Enterococcus sp.

  2025cites this paper
• Tolerance evolution in cyanobacteria under chronic copper and moxifloxacin stress: Phenotypic plasticity and genomic fixation

  2025cites this paper
• Antitoxin control of optimal transcriptional repression in the atypical HigB–HigA toxin–antitoxin system from Proteus vulgaris

  2025cites this paper
• Sonoporation-enhanced the antibacterial efficacy of aminoglycosides against Gram-negative persisters

  2025cites this paper
• The impact of bacterial purine metabolism on antibiotic efficacy

  2025cites this paper
• Uropathogenic Escherichia coli in a Diabetic Dog with Recurrent UTIs: Genomic Insights and the Impact of Glucose and Antibiotics on Biofilm Formation

  2025cites this paper
• Inhibition of Mycobacterium tuberculosis UvrB by small molecules: Potent NER disruption and structural insights into dimer conformation.

  2025cites this paper
• Population-Level Dynamics and Community-Mediated Resistance to Antimicrobial Peptides

  2025cites this paper
• The role of bacterial metabolism in antimicrobial resistance

  2025cites this paper
• Priestia megaterium cells are primed for surviving lethal doses of antibiotics and chemical stress

  2025cites this paper
• Synthetic Cation Transporters Eradicate Drug-Resistant Staphylococcus aureus, Persisters, and Biofilms

  2025cites this paper
• Structural insights into the Shigella flexneri GmvAT toxin‐antitoxin system

  2025cites this paper
• Beyond Genes: Non-Canonical Mechanisms Driving Antimicrobial Resistance in Bacteria

  2025cites this paper
• The small bacterial membrane protein YohP induces nucleoid condensation in E. coli and inhibits oligomerization of antimicrobial peptides

  2025cites this paper
• A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics

  2025cites this paper
• Response and Formation Mechanism of Highly Antibiotic-Resistant Dormant Subpopulations in Bioaerosol during Aerosolizing from Aquatic Environments.

  2025cites this paper
• Benzodioxane-benzamides targeting bacterial cell division protein FtsZ potentially disrupt SlmA-mediated nucleoid occlusion and reversible biomolecular condensation

  2025cites this paper
• Two‐Layer Droplet Arrays Enable Dynamic Manipulation of Cell Microenvironment During High‐Throughput Bacterial Cultivation

  2025cites this paper
• Metabolite-driven reprogramming of bacterial persisters: Mechanisms and therapeutic opportunities for overcoming antibiotic tolerance.

  2025cites this paper
• Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp

  2025cites this paper
• Metabolic silencing induced by the small bacterial membrane protein YohP

  2025cites this paper
• Modulation of Backbone Charge in Polyfluorene Polyelectrolytes for Potent Antibacterial Application

  2025cites this paper
• Toxin–Antitoxin Modules: Genetic Elements with Many Faces and Functions

  2025cites this paper
• Delayed delivery of antibiotics by ultrasound-mediated rupture of polylactic acid pockets: In vitro and in vivo studies

  2025cites this paper
• Bacterial programmed cell death and toxin-antitoxin system in bacteria

  2025cites this paper
• Protein Kinases in Mediating Phage-Bacteria Interactions

  2025cites this paper
• Metabolic Rewiring of Bacterial Pathogens in Response to Antibiotic Pressure—A Molecular Perspective

  2025cites this paper
• Microbe-plant interactions of Escherichia coli and Salmonella

  2025cites this paper
• Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing

  2025cites this paper
• Autolysin N617 Deamidation as a Molecular Target of Chelerythrine in Methicillin-Resistant Staphylococcus aureus

  2025cites this paper
• Oleanolic acid derivative bardoxolone combats multidrug-resistant Staphylococcus aureus by destroying cell membrane and pyruvate metabolism pathway.

  2025cites this paper
• A general mechanism for initiating the bacterial general stress response

  2025cites this paper
• Bioenergetic stress potentiates antimicrobial resistance and persistence

  2025influential citation
• Disruption of sulfur transferase complex increases bacterial intramacrophage persistence

  2025cites this paper
• Using random perturbations to infer the structure of feedback control in gene expression.

  2025cites this paper
• Induced tolerance to UV stress drives survival heterogeneity in isogenic E. coli cell populations

  2025cites this paper
• The Three-Pronged Strategy: A Bilayer Hydrogel Treats Diabetic Chronic Wound through Microalgae Oxygen Therapy, Ag─FA NP Antibacterial, and Synergistic Scavenging of ROS.

  2025cites this paper
• A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections.

  2025cites this paper
• Differentially culturable Mycobacterium tuberculosis in cough-generated aerosols of patients with pulmonary tuberculosis DCTB in cough-generated aerosols

  2025cites this paper
• Macrophage‐derived reactive oxygen species promote Salmonella aggresome formation contributing to bacterial antibiotic persistence

  2025cites this paper
• An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

  2025cites this paper
• Fast evolution of SOS-independent multi-drug resistance in bacteria

  2025cites this paper
• No two are alike: on the role of Klebsiella pneumoniae permeability barriers in antibiotic susceptibility and persistence

  2025cites this paper
• Experimental assessment of antibiotic resistance in a Biofilm - Grazer system.

  2025cites this paper
• The identification Mycobacterium tuberculosis genes that modulate long term survival in the presence of rifampicin and streptomycin

  2025cites this paper
• Abundance and transmission of antibiotic resistance and virulence genes through mobile genetic elements in integrated chicken and fish farming system

  2025cites this paper
• Keratin degradation reflects a starvation survival strategy in Fervidobacterium islandicum AW-1

  2025cites this paper
• Antibiotic-recalcitrant Salmonella exploits post-antibiotic microbiota disruption to achieve virulence-dependent transmission.

  2025cites this paper
• Targeting bacterial persistence with bacteriophages: a next-generation antimicrobial strategy.

  2025cites this paper
• Furan derivatives and antibacterial anthraquinone- isochroman hybrid identified from the marine- derived fungus Penicillium citrirum 8413.

  2025cites this paper
• A bacterial toxin-antitoxin system involved in an unusual response to genotoxic stress

  2025cites this paper
• Prenylated flavonoids combat metabolically dormant methicillin-resistant Staphylococcus aureus by targeting FarR

  2025cites this paper
• Integrating a cationic backbone with a hydrophobic core: A structure-function strategy for designing self-assembling antimicrobial peptides with enhanced activity

  2025cites this paper
• AI-Driven Modelling, Antimicrobial Discovery, and Precision Therapeutics for Targeting Bacterial Persisters

  2025cites this paper
• Injectable and tissue adhesive chrysomycin A-laden chitosan hydrogel depot for MRSA-infected wound healing and tumor recurrence prevention.

  2025cites this paper
• Mitigating ROS signalling pathway-mediated defence mechanism: a novel approach to counteract bacterial resistance using natural antioxidant-based antibiotics

  2025cites this paper
• Nanobiotechnology approaches for the remediation of persistent and emerging organic pollutants: strategies, interactions, and effectiveness

  2025cites this paper
• Enhancing Antibiotic-Resistant Bacterial Infection Therapy: Self-Assembling Gemini Quaternary Ammonium-Functionalized Peptide Nanoassemblies with Multiple Antibacterial Mechanisms.

  2025cites this paper
• Intracellular MRSA-targeted lipid-polymer hybrid nanoparticles for macrophage reprogramming and intracellular MRSA eradication

  2025cites this paper
• Designing Effective Antimicrobial Agents: Structural Insights into the Antibiofilm Activity of Ionic Liquids.

  2025cites this paper
• Metabolic byproduct utilization and the evolution of mutually beneficial cooperation in Escherichia coli.

  2025cites this paper
• Pt-Induced Sublattice Distortion Facilitates Enzyme Cascade Reactions for Eradicating Intracellularly Methicillin-Resistant Staphylococcus aureus and Enhancing Diabetic Wound Healing.

  2025cites this paper