A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Carcinogenesis

• Publication date

  1984-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/CARCIN/5.4.437PMID 6705147
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1981cited by this paper
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  1981cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1980cited by this paper
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  1979cited by this paper
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  1979cited by this paper
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  1978cited by this paper
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  1977cited by this paper
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  1977cited by this paper
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  1976cited by this paper
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  1976cited by this paper
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  1973cited by this paper
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  1972cited by this paper
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  1971cited by this paper
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  1969cited by this paper
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  1964cited by this paper
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  1957cited by this paper

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  2023cites this paper
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  2018cites this paper
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  2018cites this paper
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  2016cites this paper
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  1998cites this paper
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  1998cites this paper
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