Effect of L-tryptophan and sodium saccharin on urinary tract carcinogenesis initiated by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Cancer Research

• Publication date

  1981-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 7248968
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of sodium saccharin and L-tryptophan on rat urine during bladder carcinogenesis.

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• Long-term toxicity of ortho-touenesulfonamide and sodium saccharin in the rat.

  1980cited by this paper
• Promoting effect of saccharin and DL-tryptophan in urinary bladder carcinogenesis.

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  1977cited by this paper
• Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats1

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• The importance of synergy between weak carcinogens in the induction of bladder cancer in experimental animals and humans.

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• A long-term study of reversible and progressive urinary bladder cancer lesions in rats fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

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• SOME BIOLOGICAL ASPECTS OF SKIN CARCINOGENISIS.

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• Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

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• For April.

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• August

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• Identification of Potential Urease Inhibitors and Antioxidants based on Saccharin Derived Analogs: Synthesis, In Vitro, and In Silico Studies

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• RECOMBINANT BCG OVEREXPRESSING C-DI-AMP DEMONSTRATES ENHANCED IMMUNOGENICITY AND ENHANCED ANTI-TUMOR CYTOTOXICITY IN MNU-INDUCED BLADDER CANCER

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• odifying Factors in urinary Bla der Carcinogenesis

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• Current animal models of bladder cancer: Awareness of translatability (Review)

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• Tumor promoters: from chemicals to inflammatory proteins

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• Pathobiology and Chemoprevention of Bladder Cancer

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• The effects of oral treatment with transfluthrin on the urothelium of rats and its metabolite, tetrafluorobenzoic acid on urothelial cells in vitro.

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• Possible roles of excess tryptophan metabolites in cancer

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• Safety of Saccharin and Its Current Status of Regulation in the World

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• Tumorigenesis and Neoplastic Progression Expression Profiling of Galectin-3-Depleted Melanoma Cells Reveals Its Major Role in Melanoma Cell Plasticity and Vasculogenic Mimicry

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• Experimental animal model and RNA interference: a promising association for bladder cancer research

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• Technique of bladder catheterization in female mice and rats for intravesical instillation in models of bladder cancer.

  2009cites this paper
• Expression profiling of Galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry.

  2008cites this paper
• Effect of Sodium Phénobarbitaland Sodium Saccharin in AIN-76A Diet on Carcinogenesis Initiated with AL[4-(5-Nitro-2-furyl)-2-thiazolyI]formamide and jY,yV-Dibutylnitrosaminein Male F344 Rats1

  2006influential citation
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• Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.

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• Chemical carcinogenesis of the urinary bladder — a status report

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• Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters

  2004cites this paper
• Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-Butyl-N-(4-hydroxybutyl)-nitrosamine

  2004cites this paper
• Promoting the effects of intravesical instillation of saline on bladder lesion development in rats pre‐treated with BBN

  2002cites this paper
• EVIDENCE ON THE CARCINOGENICITY OF SODIUM SACCHARIN

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• Tryptophan Effects or Influences on Biological Processes

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• Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats.

  2000cites this paper
• Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A.

  2000cites this paper
• Promoting effects of intravesical instillation of saline on bladder lesion development in rats pretreated with N-butyl-N-(4-hydroxybutyl) nitrosamine are inhibited by bacillus Calmette-Guerin.

  1999cites this paper
• Tumorigenicity of sodium ascorbate in male rats.

  1998cites this paper
• Quantitative Trait Loci Associated with Promoting Effects of Sodium l‐Ascorbate on Two‐stage Bladder Carcinogenesis in Rats

  1997cites this paper
• Tryptophan and carcinogenesis: review and update on how tryptophan may act.

  1997cites this paper
• Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion.

  1996cites this paper
• Subchronic toxicity study of L-isoleucine in F344 rats.

  1996cites this paper
• Study of sodium saccharin co-carcinogenicity in the rat.

  1994cites this paper
• NIEHS Awards Grants on Gene Expression

  1994cites this paper
• Change of membrane potential in rat urinary bladder epithelium treated with sodium L-ascorbate.

  1992cites this paper
• 12-O-tetradecanoylphorbol-13-acetate induces selective desquamation of superficial cells in rat urinary bladder epithelium

  1992cites this paper
• The effects of sodium saccharin with and without N-methyl-N-nitrosourea co-treatment on anchorage-independent growth of human diploid fibroblasts.

  1991cites this paper
• Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats.

  1991cites this paper
• Lack of bladder tumor promoting activity in rats fed sodium saccharin in AIN-76A diet.

  1991cites this paper
• A proposed role for silicates and protein in the proliferative effects of saccharin on the male rat urothelium.

  1991cites this paper
• The health risks of saccharin revisited.

  1990cites this paper
• EFFECTS OF MONOSODIUM SUCCINATE, DISODIUM SUCCINATE, AND SUCCINIC ACID ON URINARY BLADDER CARCINOGENESIS IN N-BUTYL-N-(4-HYDROXYBUTYL)-NITROSAMINE-INITIATED, UNILATERALLY URETER-LIGATED RATS

  1990cites this paper
• Structure‐Activity Relations in Promotion of Rat Urinary Bladder Carcinogenesis by Phenolic Antioxidants

  1990cites this paper
• Evaluation of nitrofurantoin on the two stages of urinary bladder carcinogenesis in the rat.

  1990cites this paper
• Promotion of urinary bladder carcinogenesis in experimental animals.

  1989cites this paper
• Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis.

  1989cites this paper
• Cell Growth Dynamics in Bladder Carcinogenesis: Implications for Risk Assessment

  1989cites this paper
• Various Sodium Salts, Potassium Salts, a Calcium Salt and an Ammonium Salt Induced Ornithine Decarboxylase and Stimulated DNA Synthesis in Rat Stomach Mucosa

  1989cites this paper
• Effects of trisodium nitrilotriacetate monohydrate, nitrilotriacetic acid and ammonium chloride on urinary bladder carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine.

  1988cites this paper
• The role of urinary pH and sodium ion concentration in the promotion stage of two-stage carcinogenesis of the rat urinary bladder.

  1988cites this paper
• An hypothesis of the mechanism of urinary bladder tumorigenesis in rat ingesting sodium saccharin.

  1988cites this paper
• L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3.

  1988cites this paper
• Effect of L-tryptophan excess and vitamin B6 deficiency on rat urinary bladder cancer promotion.

  1987cites this paper
• Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters.

  1987cites this paper
• Promotion by L-ascorbic acid of urinary bladder carcinogenesis in rats under conditions of increased urinary K ion concentration and pH.

  1987cites this paper
• 11 – Inhibition of Carcinogenesis by Inhibitors of Putrescine Biosynthesis

  1987cites this paper
• Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin for promotion of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats.

  1987cites this paper
• Changes in the urine and scanning electron microscopically observed appearance of the rat bladder following treatment with tumor promoters.

  1986cites this paper
• Roles of urinary sodium ion concentration and pH in promotion by ascorbic acid of urinary bladder carcinogenesis in rats.

  1986cites this paper
• Role of tryptophan in carcinogenesis.

  1986cites this paper
• Pathology of superficial bladder cancer with emphasis on carcinoma in situ.

  1986cites this paper
• Ornithine decarboxylase activity and DNA synthesis in rats after long term treatment with butylated hydroxyanisole, sodium saccharin or phenobarbital.

  1986cites this paper
• Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

  1986cites this paper
• Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.

  1986cites this paper
• Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.

  1986cites this paper
• Effect of dose on the induction of urothelial proliferation by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and its relationship to bladder carcinogenesis in the rat.

  1986cites this paper
• Sodium citrate: a promoter of bladder carcinogenesis.

  1986cites this paper
• Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats.

  1986cites this paper
• Promoting effect of nicotinamide on the development of renal tubular cell tumors in rats initiated with diethylnitrosamine.

  1985cites this paper
• Promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in rats.

  1985cites this paper
• Influence of dietary tryptophan on the induction of gamma-glutamyltranspeptidase-positive foci in the livers of rats treated with hepatocarcinogen.

  1985cites this paper
• Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol.

  1985cites this paper
• Trisodium nitriloacetate monohydrate: promoting effect in urinary bladder carcinogenesis in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

  1985cites this paper
• Dose-dependent promoting effect of trisodium nitrilotriacetate monohydrate on urinary bladder carcinogenesis in Wistar rats pretreated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

  1985cites this paper
• Multi-stage carcinogenesis in the urinary bladder.

  1985cites this paper
• Correlation of results of agglutination assays with concanavalin A and carcinogenesis experiments on promoters of bladder cancer.

  1985cites this paper
• [Prognosis of primary tumors of the bladder].

  1985cites this paper
• Immunohistochemical study of keratin in proliferative bladder epithelium induced by freezing, cyclophosphamide or N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in the rat.

  1985cites this paper
• Evaluation of the effects of cotinine and nicotine-N'-oxides on the development of tumors in rats initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide.

  1985cites this paper
• Morphologic changes in the urinary bladder and stomach after long-term administration of sodium saccharin in F344 rats.

  1985cites this paper
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  1985cites this paper
• Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards

  1984cites this paper
• Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol.

  1984cites this paper
• Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine.

  1984cites this paper
• Promotion: is saccharin a promoter in the urinary bladder?

  1984cites this paper
• A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer.

  1984cites this paper
• The mode of carcinogenic action of saccharin.

  1984cites this paper
• Role of epigenetic factors in dietary carcinogenesis.

  1984cites this paper
• Bladder freeze ulceration and sodium saccharin feeding in the rat: examination for urinary nitrosamines, mutagens and bacteria, and effects on hepatic microsomal enzymes.

  1984cites this paper
• Tryptophan-induced stimulation of hepatic ornithine decarboxylase activity in the rat.

  1983cites this paper
• Basic lead acetate: promoting effect on the development of renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine.

  1983cites this paper
• Modifying factors in urinary bladder carcinogenesis

  1983cites this paper
• The effects of saccharin on the metabolism of dietary tryptophan to indole, a known cocarcinogen for the urinary bladder of the rat.

  1983cites this paper
• Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats.

  1983cites this paper
• Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.

  1983cites this paper
• Co-carcinogenicity of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide for the urinary bladder.

  1983cites this paper
• Long term dose response study of N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide-induced urinary bladder carcinogenesis.

  1983cites this paper
• Effect of sodium saccharin on urinary bladder epithelial regenerative hyperplasia following freeze ulceration.

  1983cites this paper
• Current topics in the pathology of bladder cancer.

  1983cites this paper
• Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats.

  1983cites this paper
• Specific binding, stimulation of rodent urinary bladder epithelial ornithine decarboxylase, and induction of transitional cell hyperplasia by the skin tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

  1983influential citation
• Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroso-n-butyl-(4-hydroxybutyl)amine.

  1983cites this paper