The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Angewandte Chemie

• Publication date

  2018-04-09

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1002/anie.201710482PMID 29513400PMCID PMC5912692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals

  2018cited by this paper
• Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material

  2017cited by this paper
• An automated synthesizer for electrochemical 18F-fluorination of organic compounds.

  2017cited by this paper
• Use machine learning to find energy materials 

  2017cited by this paper
• Illuminating developmental biology through photochemistry.

  2017cited by this paper
• The natural productome

  2017cited by this paper
• Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

  2017cited by this paper
• A fully automated flow-based approach for accelerated peptide synthesis.

  2017cited by this paper
• The chemical evolution of oligonucleotide therapies of clinical utility

  2017cited by this paper
• Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.

  2017cited by this paper
• A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow.

  2017cited by this paper
• Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

  2017cited by this paper
• Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

  2017cited by this paper
• On the synthesis of machine learning and automated reasoning for an artificial synthetic organic chemist

  2017cited by this paper
• Engineering chemistry for the future of chemical synthesis

  2017cited by this paper
• The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds.

  2017cited by this paper
• Continuous Preparation and Use of Dibromoformaldoxime as a Reactive Intermediate for the Synthesis of 3-Bromoisoxazolines

  2017cited by this paper
• Computer-Assisted Retrosynthesis Based on Molecular Similarity

  2017cited by this paper
• Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate

  2017cited by this paper
• Neural-Symbolic Machine Learning for Retrosynthesis and Reaction Prediction.

  2017cited by this paper
• Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals

  2017cited by this paper
• The Hitchhiker's Guide to Flow Chemistry ∥.

  2017cited by this paper
• Automated glycan assembly using the Glyconeer 2.1 synthesizer

  2017cited by this paper
• Automation of route identification and optimisation based on data-mining and chemical intuition.

  2017cited by this paper
• Synergy of synthesis, computation and NMR reveals correct baulamycin structures

  2017cited by this paper
• Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

  2017cited by this paper
• Development and Scale-up of an Efficient Miyaura Borylation Process Using Tetrahydroxydiboron

  2017cited by this paper
• Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models

  2017cited by this paper
• 3D printed fluidics with embedded analytic functionality for automated reaction optimisation

  2017cited by this paper
• Self-Aware Smart Products: Systematic Literature Review, Conceptual Design and Prototype Implementation

  2017cited by this paper
• A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

  2017cited by this paper
• A Unified Continuous Flow Assembly Line Synthesis of Highly Substituted Pyrazoles and Pyrazolines

  2017cited by this paper
• Concise, diastereoconvergent synthesis of endiandric-type tetracycles by iterative cross coupling

  2016cited by this paper
• Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

  2016cited by this paper
• A redox-flow battery with an alloxazine-based organic electrolyte

  2016cited by this paper
• Design of efficient molecular organic light-emitting diodes by a high-throughput virtual screening and experimental approach.

  2016cited by this paper
• Contrast agents for molecular photoacoustic imaging

  2016cited by this paper
• On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

  2016cited by this paper
• Computer-Assisted Synthetic Planning: The End of the Beginning.

  2016cited by this paper
• Mastering the game of Go with deep neural networks and tree search

  2016cited by this paper
• Organic Photoredox Catalysis.

  2016cited by this paper
• Construction of Iterative Tetrahydrofuran Ring Units and Total Synthesis of (+)-Goniocin.

  2016cited by this paper
• Continuous Consecutive Reactions with Inter‐Reaction Solvent Exchange by Membrane Separation

  2016cited by this paper
• Suzuki–Miyaura cross-coupling optimization enabled by automated feedback

  2016cited by this paper
• 3D printing of versatile reactionware for chemical synthesis

  2016cited by this paper
• Applications of 3D printing in healthcare

  2016cited by this paper
• The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot

  2016cited by this paper
• Stereocontrolled Synthesis of Paracentrone

  2016cited by this paper
• Rapid multistep kinetic model generation from transient flow data† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6re00109b Click here for additional data file.

  2016cited by this paper
• Iterative protecting group-free cross-coupling leading to chiral multiply arylated structures

  2016cited by this paper
• Self-optimisation of the final stage in the synthesis of EGFR kinase inhibitor AZD9291 using an automated flow reactor

  2016cited by this paper
• Synthesis of 2-BMIDA 6,5-bicyclic heterocycles by Cu(i)/Pd(0)/Cu(ii) cascade catalysis of 2-iodoaniline/phenols.

  2016cited by this paper
• TTF[Ni(dmit)2]2: From single-crystals to thin layers, nanowires, and nanoparticles

  2016cited by this paper
• MIDA boronates are hydrolysed fast and slow by two different mechanisms

  2016cited by this paper
• Enabling Technologies for the Future of Chemical Synthesis

  2016cited by this paper
• Customisable 3D printed microfluidics for integrated analysis and optimisation.

  2016cited by this paper
• Engineering chemistry: integrating batch and flow reactions on a single, automated reactor platform

  2016cited by this paper
• Feedback in Flow for Accelerated Reaction Development.

  2016cited by this paper
• Computergestützte Syntheseplanung: Das Ende vom Anfang

  2016cited by this paper
• Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

  2016cited by this paper
• Synthesis of the Acyclic Carbon Skeleton of Filipin III.

  2016cited by this paper
• Oxidative Difunctionalization of Alkenyl MIDA Boronates: A Versatile Platform for Halogenated and Trifluoromethylated α-Boryl Ketones.

  2016cited by this paper
• On-chip integration of organic synthesis and HPLC/MS analysis for monitoring stereoselective transformations at the micro-scale.

  2016cited by this paper
• Azobenzene photocontrol of peptides and proteins.

  2016cited by this paper
• Short Enantioselective Total Synthesis of Tatanan A and 3‐epi‐Tatanan A Using Assembly‐Line Synthesis

  2016cited by this paper
• Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation.

  2016cited by this paper
• Regioselective routes to orthogonally-substituted aromatic MIDA boronates.

  2016cited by this paper
• Online monitoring and analysis for autonomous continuous flow self-optimizing reactor systems

  2016cited by this paper
• Iterative Synthesis of Oligo[n]rotaxanes in Excellent Yield.

  2016cited by this paper
• Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.

  2016cited by this paper
• Automation of the Radiosynthesis of Six Different 18F-labeled radiotracers on the AllinOne

  2016cited by this paper
• Progress and prospects for small-molecule probes of bacterial imaging.

  2016cited by this paper
• Peptide therapeutics: current status and future directions.

  2015cited by this paper
• Iterative Syntheses—The Gateway to New Automation Protocols.

  2015cited by this paper
• Automating organic synthesis

  2015cited by this paper
• 3.3-million-year-old stone tools from Lomekwi 3, West Turkana, Kenya

  2015cited by this paper
• Chemistry Central Journal themed issue: Dial-a-Molecule

  2015cited by this paper
• One-Pot Homologation of Boronic Acids: A Platform for Diversity-Oriented Synthesis.

  2015cited by this paper
• Synthesis of many different types of organic small molecules using one automated process

  2015cited by this paper
• From synthesis to function via iterative assembly of N-methyliminodiacetic acid boronate building blocks.

  2015cited by this paper
• Synthesis of Previously Inaccessible Borylated Heterocycle Motifs Using Novel Boron-Containing Amphoteric Molecules.

  2015cited by this paper
• Maschinengestützte organische Synthese

  2015cited by this paper
• Process Intensified Flow Synthesis of 1H-4-Substituted Imidazoles: Toward the Continuous Production of Daclatasvir

  2015cited by this paper
• Organische Synthese: Vormarsch der Maschinen

  2015cited by this paper
• Machine‐Assisted Organic Synthesis

  2015cited by this paper
• Iterative Synthesen: das Tor zu neuen Automationsprotokollen

  2015cited by this paper
• A three-minute synthesis and purification of ibuprofen: pushing the limits of continuous-flow processing.

  2015cited by this paper
• Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

  2015cited by this paper
• Photoacoustic Probes for Ratiometric Imaging of Copper(II).

  2015cited by this paper
• Glycine receptor mechanism elucidated by electron cryo-microscopy

  2015cited by this paper
• Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients.

  2015cited by this paper
• Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.

  2015cited by this paper
• Dial-a-molecule workshop: computational prediction of reaction outcomes and optimum synthetic routes

  2015cited by this paper
• The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

  2015cited by this paper
• The synthesis machine.

  2015cited by this paper
• Initial Work on the Characterization of Additive Manufacturing (3D Printing) Using Software Image Analysis

  2015cited by this paper
• Organic synthesis: march of the machines.

  2015cited by this paper
• Heck coupling using a vinyliodo-MIDA boronate: an efficient and modular access to polyene frameworks.

  2015cited by this paper
• Cheaper faster drug development validated by the repositioning of drugs against neglected tropical diseases

  2015cited by this paper
• Kontinuierliche Durchflussverfahren: ein Werkzeug für die sichere Synthese von pharmazeutischen Wirkstoffen

  2015cited by this paper

• An Overview of Ultrasound Irradiation as A Greener Approach in Chemistry for Rapid and Efficient Synthesis

  2026cites this paper
• Fe3O4-based magnetic nanoparticles for the removal of water contaminants.

  2026cites this paper
• Universal peptide synthesis via solid-phase methods fused with chemputation

  2025cites this paper
• Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology

  2025cites this paper
• Automated Iterative N─C and C─C Bond Formation

  2025cites this paper
• A Cobotic, Digitally Controlled Schlenk‐line Unlocks Access to Elusive Lewis‐Base Stabilised Copper Bis(Disilylamides)

  2025cites this paper
• Atom-by-Atom Iterative Synthetic Logic: Laying the Foundation for Programmable Automated Construction of Small Organic Molecules

  2025cites this paper
• mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules

  2025cites this paper
• Defying the oxidative-addition prerequisite in cross-coupling through artful single-atom catalysts

  2025cites this paper
• Five-membered heterocycles as promising platforms for molecular logic gate construction

  2025cites this paper
• Biological AIE Molecules: Innovations in Synthetic Design and AI‐Driven Discovery

  2025cites this paper
• Environmentally friendly PAEs alternatives with desired synthesizability by machine learning methods

  2025cites this paper
• Accelerated small angle neutron scattering algorithms for polymeric materials.

  2025cites this paper
• NMR-Solver: Automated Structure Elucidation via Large-Scale Spectral Matching and Physics-Guided Fragment Optimization

  2025cites this paper
• Generalization of High-Throughput Experimentation in Organic Chemistry: Case Study on the Flortaucipir Synthesis

  2025cites this paper
• Programmable Microwaveable Chemistry in the Chemputer

  2025cites this paper
• Roboticized AI-assisted microfluidic photocatalytic synthesis and screening up to 10,000 reactions per day

  2024cites this paper
• An integrated self-optimizing programmable chemical synthesis and reaction engine

  2024cites this paper
• Alcohols as Alkyl Synthons Enabled by Photoredox-Catalyzed Deoxygenative Activation

  2024cites this paper
• Parametric effect of continuous synthesis of metal nanoparticles within microchannels and application: A review study

  2024cites this paper
• Small Data Machine Learning Approaches in Molecular and Materials Science.

  2024cites this paper
• Alkoxide-Assisted Stereoselective Functionalization of 1,2-Bis-boronic Esters Under Photoredox Catalysis.

  2024cites this paper
• Chemoselective Deprotection of Symmetrically Diprotected Resorcinol N-Methyliminodiacetate (MIDA) Boronates Using the MIDA Boronate Moiety as a Blocking Group: Synthesis of Monoprotected Resorcinol MIDA Boronates.

  2024cites this paper
• Rapid automated iterative small-molecule synthesis

  2024cites this paper
• Iterative SuFEx approach for sequence-regulated oligosulfates and its extension to periodic copolymers

  2024cites this paper
• The Lab of the Future: Self-Driving Labs for Molecule Discovery

  2024cites this paper
• Harnessing alcohols as sustainable reagents for late-stage functionalisation: synthesis of drugs and bio-inspired compounds.

  2024cites this paper
• Computer-aided automated flow chemical synthesis of polymers

  2024cites this paper
• High-Speed Circulation Flow Platform Facilitating Practical Large-Scale Heterogeneous Photocatalysis

  2024cites this paper
• Augmenting DMTA using predictive AI modelling at AstraZeneca.

  2024cites this paper
• Button-Push On-Demand Synthesis for Rapid Optimization of Antiviral Peptidomimetics.

  2024cites this paper
• CrystalX: Ultra-Precision Crystal Structure Resolution and Error Correction Using Deep Learning

  2024cites this paper
• A Versatile Route to Acyl (MIDA)Boronates.

  2023cites this paper
• Oxazaborolidinones: Steric Coverage Effect of Lewis Acidic Boron Center in Suzuki-Miyaura Coupling Reactions.

  2023cites this paper
• İLAÇ TASARIMINDA YAPAY ZEKÂ UYGULAMALARI

  2023cites this paper
• Transforming organic chemistry research paradigms: moving from manual efforts to the intersection of automation and artificial intelligence

  2023cites this paper
• Automation to Enable High-Throughput Chemical Proteomics.

  2023cites this paper
• Sequential One-Pot (Het)arene Thioetherification and Amination with Nickel and Visible Light

  2023cites this paper
• Impact of Alkyl-Based Side Chains in Conjugated Materials for Bulk Heterojunction Organic Photovoltaic Cells—A Review

  2023cites this paper
• MIDA and TIDA Boronates Stabilize α-Radicals Through B-N Hyperconjugation.

  2023cites this paper
• Computational approaches streamlining drug discovery

  2023cites this paper
• Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis

  2023cites this paper
• Open-Source Chromatographic Data Analysis for Reaction Optimization and Screening

  2023cites this paper
• Modern machine learning for tackling inverse problems in chemistry: molecular design to realization.

  2022cites this paper
• In Silico and In Vitro Analysis of Acetylcholinesteraseand Glutathione S-Transferase Enzymes of Substituted Pyrazoles

  2022cites this paper
• A catalyst acceleration platform toward realizing the energy transition

  2022cites this paper
• Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling

  2022cites this paper
• Recent advances in the synthesis and reactivity of MIDA boronates.

  2022cites this paper
• Photo‐Induced Homologation of Carbonyl Compounds for Iterative Syntheses

  2022cites this paper
• The way to AI-controlled synthesis: how far do we need to go?

  2022cites this paper
• Copper-Catalyzed Protoboration of 1,3-Diynes as a Platform for Iterative Functionalization

  2022cites this paper
• In silico active learning for small molecule properties

  2022cites this paper
• Stereospecific Csp3 Suzuki–Miyaura Cross-Coupling That Evades β-Oxygen Elimination

  2022cites this paper
• Synthesis of 3-Borylated Pyrrolidines by 1,3-Dipolar Cycloaddition of Alkenyl Boronates and Azomethine Ylide.

  2022cites this paper
• Digitization and validation of a chemical synthesis literature database in the ChemPU

  2022cites this paper
• Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.

  2022cites this paper
• HPLC-Based Automated Synthesis of Glycans in Solution.

  2022cites this paper
• Ketones as strategic building blocks for the synthesis of natural product-inspired compounds.

  2022cites this paper
• Getting Chemical and Biochemical Engineers Excited about Additive Manufacturing

  2022cites this paper
• A computer algorithm to discover iterative sequences of organic reactions

  2022influential citation
• Automated iterative Csp3–C bond formation

  2022cites this paper
• Toward autonomous materials research: Recent progress and future challenges

  2022cites this paper
• An Adaptive Auto‐Synthesizer using Online PAT Feedback to Flexibly Perform a Multistep Reaction

  2022cites this paper
• Digitizing Chemical Synthesis in 3D Printed Reactionware

  2022cites this paper
• Standardisierung und Kontrolle von Grignard‐Reaktionen mittels Online‐NMR in einer universellen chemischen Syntheseplattform

  2021cites this paper
• Automated Experimentation Powers Data Science in Chemistry.

  2021cites this paper
• Direct and Divergent Solid-Phase Synthesis of Azobenzene and Spiropyran Derivatives.

  2021cites this paper
• C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative

  2021cites this paper
• Automated synthesis of prexasertib and derivatives enabled by continuous-flow solid-phase synthesis

  2021cites this paper
• Automation and computer-assisted planning for chemical synthesis

  2021cites this paper
• Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses

  2021cites this paper
• Ready, Set, Flow! Automated Continuous Synthesis and Optimization

  2021cites this paper
• Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

  2021cites this paper
• Green Aspects of Flow Chemistry for Drug Discovery

  2021cites this paper
• Novel schiff base synthesis of E-N-(1-(1H-phenothiazin-2yl)-ethylidene)-3-((E)-(2-phenylhydrazono) methyl) aniline “Turn-on” fluorescent chemosensor for sensitivity and selectivity of detection of Cr3+ and Pb2+ ions

  2021cites this paper
• Opportunities and challenges in translational science

  2021cites this paper
• Insight into the recent advances of microwave pretreatment technologies for the conversion of lignocellulosic biomass into sustainable biofuel.

  2021cites this paper
• Determining usefulness of machine learning in materials discovery using simulated research landscapes.

  2021cites this paper
• An integrated console for capsule-based, automated organic synthesis†

  2021cites this paper
• Toward Better and Smarter Batteries by Combining AI with Multisensory and Self‐Healing Approaches

  2021cites this paper
• Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity

  2021cites this paper
• Standardization and Control of Grignard Reactions in a Universal Chemical Synthesis Machine using online NMR

  2021cites this paper
• Machine-Learning-Guided Discovery of 19F MRI Agents Enabled by Automated Copolymer Synthesis.

  2021cites this paper
• Energy-, time-, and labor-saving synthesis of α-ketiminophosphonates: machine-learning-assisted simultaneous multiparameter screening for electrochemical oxidation

  2021cites this paper
• Fidelity of Robotic Chemical Operations of Homogenous and Heterogeneous Reactions

  2021cites this paper
• Progress, challenges and future directions of heterocycles as building blocks in iterative methodologies towards sequence-defined oligomers and polymers

  2021cites this paper
• Recent Advances in Autonomous Synthesis of Materials

  2021cites this paper
• Chemputation and the Standardization of Chemical Informatics

  2021cites this paper
• Materials design for resilience in the biointegration of electronics

  2021cites this paper
• Using automated synthesis to understand the role of side chains on molecular charge transport

  2021cites this paper
• Application of Improved Yolov3 for Pill Manufacturing System

  2021cites this paper
• Current Topics in Ionic Liquid Crystals.

  2021cites this paper
• Is Aromaticity a Driving Force in Catalytic Cycles? A Case from the Cycloisomerization of Enynes Catalyzed by All-Metal Aromatic Pd3+ Clusters and Carboxylic Acids.

  2021cites this paper
• In-flow enantioselective homogeneous organic synthesis

  2021cites this paper
• Transition to sustainable chemistry through digitalization

  2021cites this paper
• Remote Synthesis of Layered Double Hydroxide Nanosheets Through the Automatic Chemical Robot

  2021cites this paper
• The roles of computer-aided drug synthesis in drug development

  2021cites this paper
• Part Marking Detection Using Machine Learning

  2020cites this paper
• Digitizing Chemistry Using the Chemical Processing Unit: From Synthesis to Discovery.

  2020cites this paper
• Toward “On‐Demand” Materials Synthesis and Scientific Discovery through Intelligent Robots

  2020cites this paper