Drosophila Rheb GTPase is required for cell cycle progression and cell growth

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Cell Science

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.00661PMID 12893813
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling.

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  2002influential reference
• Control of growth and organ size in Drosophila

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• The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

  2001cited by this paper
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• Characterization of Rheb functions using yeast and mammalian systems.

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• Fission yeast Tor1 functions in response to various stresses including nitrogen starvation, high osmolarity, and high temperature

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  2001cited by this paper
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  2001cited by this paper
• The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

  2000cited by this paper
• Do growth and cell division rates determine cell size in multicellular organisms?

  2000influential reference
• Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

  2000cited by this paper
• The Ras branch of small GTPases: Ras family members don't fall far from the tree.

  2000cited by this paper
• Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.

  2000cited by this paper
• Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

  2000cited by this paper
• Regulation of cellular growth by the Drosophila target of rapamycin dTOR.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Drosophila myc regulates cellular growth during development.

  1999cited by this paper
• Drosophila S6 kinase: a regulator of cell size.

  1999cited by this paper
• From small flies come big discoveries about size control

  1999cited by this paper
• The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster.

  1999cited by this paper
• Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms.

  1998cited by this paper
• Systematic gain-of-function genetics in Drosophila.

  1998cited by this paper
• Coordination of growth and cell division in the Drosophila wing.

  1998cited by this paper
• Induction of Drosophila eye development by decapentaplegic.

  1997cited by this paper
• The Tuberous Sclerosis 2 Gene Product, Tuberin, Functions as a Rab5 GTPase Activating Protein (GAP) in Modulating Endocytosis*

  1997cited by this paper
• The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation*

  1997cited by this paper
• Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36.

  1996cited by this paper
• A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

  1995cited by this paper
• Identification of Tuberin, the Tuberous Sclerosis-2 Product. TUBERIN POSSESSES SPECIFIC Rap1GAP ACTIVITY (*)

  1995cited by this paper
• rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

  1994cited by this paper
• A Drosophila third chromosome Minute locus encodes a ribosomal protein.

  1994cited by this paper
• Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein.

  1993cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993cited by this paper
• Analysis of genetic mosaics in developing and adult Drosophila tissues.

  1993cited by this paper
• The regulation of the cell cycle during Drosophila embryogenesis: the transition to polyteny.

  1991cited by this paper
• IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase protein

  1991cited by this paper
• IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein.

  1991influential reference
• The GTPase superfamily: conserved structure and molecular mechanism

  1991cited by this paper
• The beginning of pattern formation in the Drosophila compound eye: the morphogenetic furrow and the second mitotic wave.

  1991cited by this paper
• Drosophila: A laboratory manual

  1990cited by this paper
• A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

  1989cited by this paper
• Coordination of growth with cell division in the yeast Saccharomyces cerevisiae.

  1977cited by this paper
• Minutes: mutants of drosophila autonomously affecting cell division rate.

  1975cited by this paper

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• Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth

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• Sex-biased regulation of body size by nutrient-responsive signaling pathways in Drosophila

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• Opposing Action of Hedgehog and Insulin Signaling Balances Proliferation and Autophagy to Determine Follicle Stem Cell Lifespan.

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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
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  2011cites this paper
• An emerging role for TOR signaling in mammalian tissue and stem cell physiology

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  2010cites this paper
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