Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  International Journal of Neuropsychopharmacology

• Publication date

  2006-10-01

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1017/S1461145705005900PMID 16316487
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2003influential reference
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  2003cited by this paper
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  2003influential reference
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  2003influential reference
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  2003influential reference
• Different effects of phencyclidine and methamphetamine on firing activity of medial prefrontal cortex neurons in freely moving rats.

  2003cited by this paper
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  2003influential reference
• Acute administration of phencyclidine induces tonic activation of medial prefrontal cortex neurons in freely moving rats.

  2002influential reference
• Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex.

  2001influential reference
• Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

  2001influential reference
• Control of Dorsal Raphe Serotonergic Neurons by the Medial Prefrontal Cortex: Involvement of Serotonin-1A, GABAA, and Glutamate Receptors

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  2000cited by this paper
• Serotonin model of schizophrenia: emerging role of glutamate mechanisms.

  2000cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1998influential reference
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  1998influential reference
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  1997influential reference
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  1996influential reference
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  1995cited by this paper
• Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors.

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  1993influential reference
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  1990cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists.

  1980cited by this paper
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  year unknowncited by this paper

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