The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Microbiology

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1099/mic.0.024554-0PMID 19246741
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A rat model of chronic respiratory infection with Pseudomonas aeruginosa.

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  2009cited by this paper
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• A Positive Feedback Loop Promotes Transcription Surge That Jump-Starts Salmonella Virulence Circuit

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• Pseudomonas aeruginosa in-Induced Gene Regulation 2 + Systems to Mg PmrA-PmrB Two-Component Regulatory Contribution of the PhoP-PhoQ and

  2006influential reference
• Targeting mechanisms of Pseudomonas aeruginosa pathogenesis.

  2006cited by this paper
• Recognition of antimicrobial peptides by a bacterial sensor kinase.

  2005cited by this paper
• Transcriptional Regulation of the 4-Amino-4-deoxy-L-arabinose Biosynthetic Genes in Yersinia pestis*

  2005influential reference
• Pseudomonas aeruginosa Acquires Biofilm-Like Properties within Airway Epithelial Cells

  2005cited by this paper
• Pathogen-host interactions in Pseudomonas aeruginosa pneumonia.

  2005cited by this paper
• Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.

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• PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa That Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A

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  2000influential reference
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  2000cited by this paper
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  2000cited by this paper
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  1998cited by this paper
• The type-4 pilus is the major virulence-associated adhesin of Pseudomonas aeruginosa--a review.

  1997cited by this paper
• Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors.

  1997cited by this paper
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  1996cited by this paper
• Simple screening method for lipase for transesterification in organic solvent

  1995cited by this paper
• Common virulence factors for bacterial pathogenicity in plants and animals.

  1995cited by this paper
• CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.

  1994cited by this paper
• Characterization of the ferrous iron uptake system of Escherichia coli

  1993cited by this paper
• Escherichia-Pseudomonas shuttle vectors derived from pUC18/19.

  1991cited by this paper
• A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence.

  1989cited by this paper
• Current Protocols in Molecular Biology (New York: Greene Publishing Associates and Wiley-Interscience). Host-Range Shuttle System for Gene Insertion into the Chromosomes of Gram-negative Bacteria.

  1988cited by this paper
• The regulation of pyocyanin production in Pseudomonas aeruginosa

  1982cited by this paper

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