Runx2 (Cbfa1, AML-3) Interacts with Histone Deacetylase 6 and Represses the p21CIP1/WAF1 Promoter

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Molecular and Cellular Biology

• Publication date

  2002-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.22.22.7982-7992.2002PMID 12391164PMCID PMC134736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Isolation and Characterization of a Novel Class II Histone Deacetylase, HDAC10*

  2002influential reference
• Molecular Cloning and Characterization of a Novel Histone Deacetylase HDAC10*

  2002influential reference
• RUNX: a trilogy of cancer genes.

  2002influential reference
• Isolation and Characterization of Mammalian HDAC10, a Novel Histone Deacetylase*

  2002influential reference
• Cloning and Functional Characterization of HDAC11, a Novel Member of the Human Histone Deacetylase Family*

  2002influential reference
• Mutations in the RUNX2 gene in patients with cleidocranial dysplasia

  2002influential reference
• ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain

  2001cited by this paper
• The human histone deacetylase family.

  2001influential reference
• Mechanism for Nucleocytoplasmic Shuttling of Histone Deacetylase 7*

  2001cited by this paper
• Runx2: A novel oncogenic effector revealed by in vivo complementation and retroviral tagging

  2001influential reference
• Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin–proteasome‐mediated degradation

  2001cited by this paper
• A specific targeting signal directs Runx2/Cbfa1 to subnuclear domains and contributes to transactivation of the osteocalcin gene.

  2001cited by this paper
• runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins

  2001cited by this paper
• Class II histone deacetylases: structure, function, and regulation.

  2001influential reference
• Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1

  2001influential reference
• Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin.

  2001influential reference
• Identification of Components of the Murine Histone Deacetylase 6 Complex: Link between Acetylation and Ubiquitination Signaling Pathways

  2001influential reference
• Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

  2001cited by this paper
• The emerging role of class II histone deacetylases.

  2001influential reference
• Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

  2000cited by this paper
• Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5.

  2000influential reference
• A Mechanism of Repression by Acute Myeloid Leukemia-1, the Target of Multiple Chromosomal Translocations in Acute Leukemia*

  2000cited by this paper
• Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation.

  2000cited by this paper
• Cbfa1 Is a Positive Regulatory Factor in Chondrocyte Maturation*

  2000influential reference
• Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm.

  2000cited by this paper
• A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia.

  2000cited by this paper
• Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription.

  2000cited by this paper
• Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.

  2000influential reference
• Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

  2000influential reference
• Glucocorticoids Inhibit Developmental Stage-specific Osteoblast Cell Cycle

  2000influential reference
• Crystal structure of the nuclear matrix targeting signal of the transcription factor acute myelogenous leukemia-1/polyoma enhancer-binding protein 2alphaB/core binding factor alpha2.

  1999cited by this paper
• Three proteins define a class of human histone deacetylases related to yeast Hda1p.

  1999influential reference
• Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

  1999influential reference
• The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts.

  1999cited by this paper
• Identification of a New Family of Higher Eukaryotic Histone Deacetylases

  1999cited by this paper
• A New Family of Human Histone Deacetylases Related toSaccharomyces cerevisiae HDA1p*

  1999influential reference
• Crystal Structure of the Nuclear Matrix Targeting Signal of the Transcription Factor Acute Myelogenous Leukemia-1/Polyoma Enhancer-binding Protein 2αB/Core Binding Factor α2*

  1999cited by this paper
• Histone Deacetylase Inhibitor Activates the p21/WAF1/Cip1 Gene Promoter through the Sp1 Sites

  1999influential reference
• HDAC4 deacetylase associates with and represses the MEF2 transcription factor

  1999influential reference
• The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation

  1998cited by this paper
• Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ

  1998cited by this paper
• Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

  1998influential reference
• Intranuclear targeting of AML/CBFalpha regulatory factors to nuclear matrix-associated transcriptional domains.

  1998cited by this paper
• TLE, the human homolog of groucho, interacts with AML1 and acts as a repressor of AML1-induced transactivation.

  1998influential reference
• The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.

  1998cited by this paper
• Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene.

  1997cited by this paper
• Developmental regulation of osteocalcin expression in MC3T3‐E1 osteoblasts: Minimal role of the proximal E‐box cis‐acting promoter elements

  1997influential reference
• Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts.

  1997cited by this paper
• Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation.

  1997influential reference
• Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.

  1997influential reference
• Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development.

  1997influential reference
• Groucho-dependent and -independent repression activities of Runt domain proteins

  1997influential reference
• Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia.

  1997cited by this paper
• Expression patterns of bone‐related proteins during osteoblastic differentiation in MC3T3‐E1 cells

  1996influential reference
• AML-2 is a potential target for transcriptional regulation by the t(8;21) and t(12;21) fusion proteins in acute leukemia.

  1996influential reference
• Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

  1996influential reference
• PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene.

  1993influential reference
• WAF1, a potential mediator of p53 tumor suppression.

  1993influential reference
• Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

  1993influential reference
• Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells.

  1988influential reference
• In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria

  1983influential reference
• Groucho / TLE / Resp proteins associate with the nuclear matrix and repress RUNX ( CBF α / AML / PEBP 2 α ) dependent activation of tissue-specific gene transcription

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