Voltage‐gated sodium channel &bgr; subunits: The power outside the pore in brain development and disease

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Neuropharmacology

• Publication date

  2017-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuropharm.2017.09.018PMID 28927993PMCID PMC5856584
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Somatoform disorders in out-patient psychiatric setting: An overview

  2018cited by this paper
• Structure of the Nav1.4-β1 Complex from Electric Eel.

  2017influential reference
• Confirming the recessive inheritance of SCN1B mutations in developmental epileptic encephalopathy

  2017cited by this paper
• Association of a synonymous SCN1B variant affecting splicing efficiency with Benign Familial Infantile Epilepsy (BFIE).

  2017cited by this paper
• Upregulation of the sodium channel NaV&bgr;4 subunit and its contributions to mechanical hypersensitivity and neuronal hyperexcitability in a rat model of radicular pain induced by local dorsal root ganglion inflammation

  2016cited by this paper
• Binary architecture of the Nav1.2-β2 signaling complex

  2016cited by this paper
• β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function

  2016cited by this paper
• Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias

  2016cited by this paper
• Regulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability

  2016cited by this paper
• Structure-based site-directed photo-crosslinking analyses of multimeric cell-adhesive interactions of voltage-gated sodium channel β subunits

  2016influential reference
• Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.

  2016cited by this paper
• Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder

  2016cited by this paper
• Therapeutic Value of Voltage-Gated Sodium Channel Inhibitors in Breast, Colorectal, and Prostate Cancer: A Systematic Review

  2015cited by this paper
• Sodium channel β subunits: emerging targets in channelopathies.

  2015cited by this paper
• A new look at sodium channel β subunits

  2015cited by this paper
• Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain

  2015cited by this paper
• Α- and β-subunit composition of voltage-gated sodium channels investigated with μ-conotoxins and the recently discovered μO§-conotoxin GVIIJ.

  2015cited by this paper
• Scn1b deletion leads to increased tetrodotoxin‐sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts

  2015cited by this paper
• Crystal Structure and Molecular Imaging of the Nav Channel β3 Subunit Indicates a Trimeric Assembly*

  2014cited by this paper
• Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

  2014cited by this paper
• Review: Neuropathological features of unexplained sudden unexpected death in infancy: current evidence and controversies

  2014cited by this paper
• : A practical clinical definition of epilepsy

  2014cited by this paper
• Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum

  2014influential reference
• NaV1.5 and Regulatory β Subunits in Cardiac Sodium Channelopathies

  2014cited by this paper
• Cognitive and adaptive evaluation of 21 consecutive patients with Dravet syndrome.

  2014cited by this paper
• The role of non-pore-forming β subunits in physiology and pathophysiology of voltage-gated sodium channels.

  2014cited by this paper
• Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome.

  2014influential reference
• A disulfide tether stabilizes the block of sodium channels by the conotoxin μO§-GVIIJ

  2014cited by this paper
• Resurgent current of voltage‐gated Na+ channels

  2014influential reference
• The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding

  2013cited by this paper
• Crystallographic insights into sodium-channel modulation by the β4 subunit

  2013cited by this paper
• β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

  2013cited by this paper
• Na+ Channel-Dependent Recruitment of Navβ4 to Axon Initial Segments and Nodes of Ranvier

  2013cited by this paper
• Co‐expression of NaVβ subunits alters the kinetics of inhibition of voltage‐gated sodium channels by pore‐blocking μ‐conotoxins

  2013cited by this paper
• Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome

  2013cited by this paper
• Voltage‐gated sodium channels at 60: structure, function and pathophysiology

  2012cited by this paper
• Glycosylation of the Sodium Channel β4 Subunit is Developmentally Regulated and Involves in Neuritic Degeneration

  2012cited by this paper
• Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high‐frequency firing via differential effects on persistent Na+ currents

  2012cited by this paper
• Identification of the Cysteine Residue Responsible for Disulfide Linkage of Na+ Channel α and β2 Subunits*

  2012cited by this paper
• Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability

  2012cited by this paper
• The Sodium Channel Accessory Subunit Navβ1 Regulates Neuronal Excitability through Modulation of Repolarizing Voltage-Gated K+ Channels

  2012cited by this paper
• Autistic behavior in Scn1a+/− mice and rescue by enhanced GABAergic transmission

  2012cited by this paper
• Modulation of voltage-gated K+ channels by the sodium channel β1 subunit

  2012cited by this paper
• Unifying the definitions of sudden unexpected death in epilepsy

  2012cited by this paper
• Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

  2012cited by this paper
• Do mood instability symptoms in epilepsy represent formal bipolar disorder?

  2012cited by this paper
• Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors.

  2012cited by this paper
• A homozygous mutation of voltage‐gated sodium channel βI gene SCN1B in a patient with Dravet syndrome

  2012cited by this paper
• Sleep and Epilepsy: Strange Bedfellows No More.

  2011cited by this paper
• β-Site APP-cleaving enzyme 1 (BACE1) cleaves cerebellar Na+ channel β4-subunit and promotes Purkinje cell firing by slowing the decay of resurgent Na+ current

  2011cited by this paper
• Voltage-Gated Na+ Channel β1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy

  2011cited by this paper
• NaVβ Subunits Modulate the Inhibition of NaV1.8 by the Analgesic Gating Modifier μO-Conotoxin MrVIB

  2011cited by this paper
• Na+ Channel β Subunits: Overachievers of the Ion Channel Family

  2011cited by this paper
• Increased expression of the beta3 subunit of voltage-gated Na+ channels in the spinal cord of the SOD1G93A mouse.

  2011cited by this paper
• Na+ Channel Scn1b Gene Regulates Dorsal Root Ganglion Nociceptor Excitability in Vivo*

  2011cited by this paper
• Dravet syndrome and parent associations: The IDEA League experience with comorbid conditions, mortality, management, adaptation, and grief

  2011cited by this paper
• Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide‐mediated resurgent sodium currents

  2011cited by this paper
• Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits.

  2011cited by this paper
• Cross-Species Conservation of Open-Channel Block by Na Channel β4 Peptides Reveals Structural Features Required for Resurgent Na Current

  2011cited by this paper
• Kv1.1 Potassium Channel Deficiency Reveals Brain-Driven Cardiac Dysfunction as a Candidate Mechanism for Sudden Unexplained Death in Epilepsy

  2010cited by this paper
• Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties

  2010cited by this paper
• Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

  2010cited by this paper
• Genetics of the epilepsies: Genetic twists in the channels and other tales

  2010influential reference
• The Sodium Channel β3-Subunit Induces Multiphasic Gating in NaV1.3 and Affects Fast Inactivation via Distinct Intracellular Regions

  2010cited by this paper
• Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus.

  2010cited by this paper
• BACE: Therapeutic target and potential biomarker for Alzheimer's disease.

  2010cited by this paper
• Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit

  2010cited by this paper
• Sudden infant death syndrome-associated mutations in the sodium channel beta subunits.

  2010cited by this paper
• The importance of serine 161 in the sodium channel β3 subunit for modulation of NaV1.2 gating

  2010cited by this paper
• Functional reciprocity between Na+ channel Nav1.6 and β1 subunits in the coordinated regulation of excitability and neurite outgrowth

  2010cited by this paper
• Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel β Subunits via Paradoxical Effects on Persistent Sodium Currents

  2010cited by this paper
• Control of transient, resurgent, and persistent current by open-channel block by Na channel β4 in cultured cerebellar granule neurons

  2010cited by this paper
• Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

  2009cited by this paper
• Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis

  2009cited by this paper
• A Functional Null Mutation of SCN1B in a Patient with Dravet Syndrome

  2009cited by this paper
• Regulation of Persistent Na Current by Interactions between β Subunits of Voltage-Gated Na Channels

  2009cited by this paper
• Arrhythmia in Heart and Brain: KCNQ1 Mutations Link Epilepsy and Sudden Unexplained Death

  2009cited by this paper
• The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin.

  2009cited by this paper
• Possible role of the innate immunity in temporal lobe epilepsy

  2008cited by this paper
• Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties

  2008influential reference
• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

  2008cited by this paper
• Voltage-Gated Na+ Channel β1 Subunit-Mediated Neurite Outgrowth Requires Fyn Kinase and Contributes to Postnatal CNS Development In Vivo

  2008cited by this paper
• The voltage-gated Na+ channel Nav1.8 contains an ER-retention/retrieval signal antagonized by the β3 subunit

  2008cited by this paper
• Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans.

  2008cited by this paper
• BACE1 regulates voltage-gated sodium channels and neuronal activity

  2007cited by this paper
• The intracellular domain of the beta 2 subunit modulates the gating of cardiac Na v 1.5 channels.

  2007cited by this paper
• Genome-wide atlas of gene expression in the adult mouse brain

  2007cited by this paper
• The Intracellular Domain of the β2 Subunit Modulates the Gating of Cardiac Nav1.5 Channels

  2007cited by this paper
• The autism‐epilepsy connection

  2007cited by this paper
• Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

  2006cited by this paper
• Incidence and Predictors of Seizures in Patients with Alzheimer's Disease

  2006influential reference
• Deletion of Kv4.2 Gene Eliminates Dendritic A-Type K+ Current and Enhances Induction of Long-Term Potentiation in Hippocampal CA1 Pyramidal Neurons

  2006cited by this paper
• Isoform-specific Effects of the β2 Subunit on Voltage-gated Sodium Channel Gating*

  2006cited by this paper
• Sodium Channel β2 Subunits Regulate Tetrodotoxin-Sensitive Sodium Channels in Small Dorsal Root Ganglion Neurons and Modulate the Response to Pain

  2006cited by this paper
• Sodium channel β4 subunit: down‐regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice

  2006cited by this paper
• Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.

  2005cited by this paper
• Presenilin/γ-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel β2-Subunit Regulates Cell Adhesion and Migration*

  2005cited by this paper
• Modulation of Na(v)1.5 by beta1-- and beta3-subunit co-expression in mammalian cells.

  2005cited by this paper
• Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration.

  2005cited by this paper
• Upregulation of the Voltage-Gated Sodium Channel β2 Subunit in Neuropathic Pain Models: Characterization of Expression in Injured and Non-Injured Primary Sensory Neurons

  2005cited by this paper

• Effects of dibenzazepine compounds on Nav1.2 channels and neuronal network activity: A systematic comparison.

  2025cites this paper
• Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics

  2025cites this paper
• Saxitoxin: A Comprehensive Review of Its History, Structure, Toxicology, Biosynthesis, Detection, and Preventive Implications

  2025cites this paper
• Genetic mechanisms of dynamic functional connectivity density in diabetic retinopathy brains: a combined transcriptomic and resting-state functional magnetic resonance imaging study

  2025cites this paper
• A novel gain-of-function mutation SCN5A-N470K associated with African American familial atrial fibrillation.

  2025cites this paper
• K2P channels and ultrasound neuromodulation: A mechanosensitive memory perspective.

  2025cites this paper
• Short-term plasticity as ‘energetic memory’ of ion channel components of action potential

  2024cites this paper
• Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections

  2024cites this paper
• Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6

  2024cites this paper
• Association between human blood metabolites and cerebral cortex architecture: evidence from a Mendelian randomization study

  2024cites this paper
• Developmental exposure of zebrafish to saxitoxin causes altered expression of genes associated with axonal growth.

  2024cites this paper
• Role of protein domains in trafficking and localization of the voltage-gated sodium channel β2 subunit

  2024cites this paper
• In Silico Screening Identification of Fatty Acids and Fatty Acid Derivatives with Antiseizure Activity: In Vitro and In Vivo Validation

  2024cites this paper
• New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?

  2024cites this paper
• MicroRNA-6954-3p down-regulation contributes to orofacial neuropathic pain in mice via targeting voltage-gated sodium channel β2 subunit protein.

  2024cites this paper
• Complex synaptic and intrinsic interactions disrupt input/output functions in the hippocampus of Scn1b knockout mice

  2023influential citation
• Clinical and Genetic Features of Dravet Syndrome: A Prime Example of the Role of Precision Medicine in Genetic Epilepsy

  2023cites this paper
• Anesthetic Mechanisms: Synergistic Interactions With Lipid Rafts and Voltage-Gated Sodium Channels

  2023cites this paper
• Anti‐PD‐1 treatment protects against seizure by suppressing sodium channel function

  2023cites this paper
• Voltage-gated sodium channels in cancer and their specific inhibitors.

  2023cites this paper
• Molecular mechanisms underlying resting-state brain functional correlates of behavioral inhibition

  2023cites this paper
• Complex synaptic and intrinsic interactions disrupt input/output functions in the hippocampus of Scn1b knockout mice.

  2023cites this paper
• Defects in early synaptic formation and neuronal function in Prader-Willi syndrome

  2023cites this paper
• Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

  2023cites this paper
• Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology.

  2023cites this paper
• SCN1B Genetic Variants: A Review of the Spectrum of Clinical Phenotypes and a Report of Early Myoclonic Encephalopathy

  2022cites this paper
• Frequency-Dependent Genetic Modulation of Neuronal Oscillations: A Combined Transcriptome and Resting-State Functional MRI Study.

  2022cites this paper
• Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS

  2022cites this paper
• CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder

  2022influential citation
• Non‐canonical endogenous expression of voltage‐gated sodium channel NaV1.7 subtype by the TE671 rhabdomyosarcoma cell line

  2022cites this paper
• Closed-state inactivation of cardiac, skeletal, and neuronal sodium channels is isoform specific

  2022cites this paper
• Contribution of tetrodotoxin-resistant persistent Na+ currents to the excitability of C-type dural afferent neurons in rats

  2022cites this paper
• Genetic polymorphisms associated with the development of arrhythmic type of cardiovascular events

  2022cites this paper
• Therapeutic Potential of Targeting Regulated Intramembrane Proteolysis Mechanisms of Voltage-Gated Ion Channel Subunits and Cell Adhesion Molecules

  2022cites this paper
• The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation

  2022cites this paper
• Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect

  2021cites this paper
• Peripheral Voltage-Gated Cation Channels in Neuropathic Pain and Their Potential as Therapeutic Targets

  2021cites this paper
• Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

  2021cites this paper
• Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control

  2021cites this paper
• The Nax (SCN7A) channel: an atypical regulator of tissue homeostasis and disease

  2021cites this paper
• The physiological function of different voltage-gated sodium channels in pain

  2021cites this paper
• Brevetoxin and Conotoxin Interactions with Single-Domain Voltage-Gated Sodium Channels from a Diatom and Coccolithophore

  2021cites this paper
• The difficulty to model Huntington’s disease in vitro using striatal medium spiny neurons differentiated from human induced pluripotent stem cells

  2021cites this paper
• Mechanisms of action of currently used antiseizure drugs.

  2020cites this paper
• Excitatory and inhibitory neuron defects in a mouse model of Scn1b‐linked EIEE52

  2020cites this paper
• Neurobiological activity of conotoxins via sodium channel modulation.

  2020cites this paper
• The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer

  2020cites this paper
• Sodium channel β1 subunits are post-translationally modified by tyrosine phosphorylation, S-palmitoylation, and regulated intramembrane proteolysis

  2020cites this paper
• Individual-Level Identification of Gene Expression Associated with Volume Differences among Neocortical Areas.

  2020cites this paper
• Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics

  2020cites this paper
• Ion Channel Functions in Early Brain Development.

  2020cites this paper
• Hormones and the Regulation of Neuronal Voltage-Sensing Ion Channels

  2020cites this paper
• Nav channels in cancers: Non-classical roles

  2020cites this paper
• Predicting the impact of sodium channel mutations in human brain disease

  2019cites this paper
• Sexually Divergent Mortality and Partial Phenotypic Rescue After Gene Therapy in a Mouse Model of Dravet Syndrome

  2019cites this paper
• Role of Voltage-Gated Sodium Channels in the Mechanism of Ether-Induced Unconsciousness

  2019cites this paper
• Cognitive Functions in Epileptic Patients on Lamotrigine and Other Antiepileptic Drugs

  2019cites this paper
• Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis

  2019cites this paper
• Neuronal mechanisms of mutations in SCN8A causing epilepsy or intellectual disability

  2019cites this paper
• Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics.

  2019cites this paper
• Scn1b deletion in adult mice results in seizures and SUDEP

  2019cites this paper
• Distinct functional alterations in SCN8A epilepsy mutant channels

  2019cites this paper
• Trafficking and Function of the Voltage-Gated Sodium Channel β2 Subunit

  2019cites this paper
• N-Glycosylation of the voltage-gated sodium channel β2 subunit is required for efficient trafficking of NaV1.5/β2 to the plasma membrane

  2019cites this paper
• Voltage-Gated Sodium Channels in Drug Discovery

  2018cites this paper
• Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

  2018cites this paper
• The Axon Initial Segment: An Updated Viewpoint

  2018cites this paper
• Channelopathies go above and beyond the channels.

  2018cites this paper
• Integration of biological/pathophysiological contexts to help clarify genotype‐phenotype mismatches in monogenetic diseases. Childhood epilepsies associated with SCN2A as a case study

  2018cites this paper
• β1 subunit stabilises sodium channel Nav1.7 against mechanical stress

  2018cites this paper