T cell activation requires force generation

The T cell receptor requires force for triggering. Here, Hu and Butte show that T cells generate pushing and pulling forces against an antigen-coated AFM cantilever in an actin-dependent fashion. Exogenous, oscillating forces delivered by the cantilever rescued T cell receptor signaling in the absence of an intact F-actin cytoskeleton. These findings highlight the importance of mechanical forces in T cell activation.

• Publication year

  2016

• Venue

  Journal of Cell Biology

• Publication date

  2016-06-06

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1083/jcb.201511053PMID 27241914PMCID 4896056
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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