Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Redox Report

• Publication date

  2003-08-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1179/135100003225002709PMID 14599344
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage

  2003cited by this paper
• Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms

  2003cited by this paper
• Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin.

  2002cited by this paper
• Influence of molting and starvation on the synthesis of proteolytic enzymes in the midgut gland of the white shrimp Penaeus vannamei.

  2002cited by this paper
• Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs

  2002influential reference
• Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.

  2002cited by this paper
• Formation of kynurenic and xanthurenic acids from kynurenine and 3-hydroxykynurenine in the dinoflagellate Lingulodinium polyedrum: role of a novel, oxidative pathway.

  2002cited by this paper
• N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant

  2001influential reference
• PHENOLIC AND INDOLIC RADICAL SCAVENGERS AS LUMINOPHORES

  2001cited by this paper
• DNA oxidatively damaged by chromium(III) and H(2)O(2) is protected by the antioxidants melatonin, N(1)-acetyl-N(2)-formyl-5-methoxykynuramine, resveratrol and uric acid.

  2001cited by this paper
• Significance of Melatonin in Antioxidative Defense System: Reactions and Products

  2000cited by this paper
• Chronobiology of oxidative stress and antioxidative defense mechanisms

  2000cited by this paper
• Melatonin and 5-methoxytryptamine in the bioluminescent dinoflagellate Gonyaulax polyedra. Restoration of the circadian glow peak after suppression of indoleamine biosynthesis or oxidative stress.

  1999influential reference
• Oxidative modification of glutamine synthetase by 2,2'-azobis(2- amidinopropane) dihydrochloride.

  1999cited by this paper
• Antioxidant activity applying an improved ABTS radical cation decolorization assay.

  1999cited by this paper
• Oxidative damage in the central nervous system: protection by melatonin.

  1998cited by this paper
• Antioxidative protection in a high‐melatonin organism: The dinoflagellate Gonyaulax polyedra is rescued from lethal oxidative stress by strongly elevated, but physiologically possible concentrations of melatonin

  1997cited by this paper
• Hydrogen peroxide-mediated degradation of protein: different oxidation modes of copper- and iron-dependent hydroxyl radicals on the degradation of albumin.

  1997cited by this paper
• Ubiquitous melatonin-presence and effects in unicells, plants and animals

  1996cited by this paper
• Melatonin and structurally-related, endogenous indoles act as potent electron donors and radical scavengers in vitro.

  1996cited by this paper
• On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals *

  1995cited by this paper
• The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substances.

  1993cited by this paper
• Action of kynuramine in a dinoflagellate: Stimulation of bioluminescence in Gonyaulax polyedra

  1989cited by this paper
• Structure-activity studies of melatonin analogues in prepubertal male rats.

  1988cited by this paper
• N-acetyl-5-methoxy kynurenamine, a brain metabolite of melatonin, is a potent inhibitor of prostaglandin biosynthesis.

  1984cited by this paper
• Effects of catecholamines on bioluminescence in Gonyaulax polyedra (Dinoflagellata)

  1980cited by this paper
• Properties and function of indoleamine 2,3-dioxygenase.

  1976cited by this paper
• In vitro and in vivo formation of two new metabolites of melatonin.

  1974cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Potential mechanisms for the rapid post-drought reversal of ABA-induced stomatal closure by melatonin, 5-aminolevulinic acid, and brassinosteroids

  2025cites this paper
• Melatonin hyalurosomes as a powerful antioxidant for combating skin damage induced by UV radiation

  2025cites this paper
• Effect of Melatonin Treatment on Antioxidant Metabolism and Storage Quality of “Fengtang” Plum

  2025cites this paper
• Interplay between oxidative stress, neuroinflammatory cytokines and melatonin in Alzheimer's disease: Insights from cerebrospinal fluid analysis

  2025cites this paper
• Protocol for the quantification of melatonin and AFMK in cerebrospinal fluid by LC-MS/MS

  2025cites this paper
• Melatonin—A Powerful Antioxidant in Neurodegenerative Diseases

  2025cites this paper
• Therapeutic Aspects of Melatonin-sirtuin Crosstalk: An Updated Review of Current Data Based on Cellular Mechanisms.

  2025cites this paper
• Neuro-Nutritional Approach to Neuropathic Pain Management: A Critical Review

  2025cites this paper
• Microbial synthesis of serotonin and melatonin.

  2025cites this paper
• Supplemental Use of Melatonin to Protect against Oxidative Stress Induced by Intensive Athletic Training and Competition

  2025cites this paper
• Protective Activity of Melatonin Combinations and Melatonin‐Based Hybrid Molecules in Neurodegenerative Diseases

  2024cites this paper
• Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management

  2024cites this paper
• Dysfunctional Mitochondria in Age-related Neurodegeneration: Utility of Melatonin as an Antioxidant Treatment.

  2024cites this paper
• Immunoregulatory Properties of Melatonin in the Humoral Immune System: A Narrative Review.

  2024cites this paper
• Tetrandrine Alleviates Pulmonary Fibrosis by Modulating Lung Microbiota‐Derived Metabolism and Ameliorating Alveolar Epithelial Cell Senescence

  2024cites this paper
• Non-Excitatory Amino Acids, Melatonin, and Free Radicals: Examining the Role in Stroke and Aging

  2023cites this paper
• Protective effects of exogenous melatonin therapy against oxidative stress to male reproductive tissue caused by anti-cancer chemical and radiation therapy: a systematic review and meta-analysis of animal studies

  2023cites this paper
• Melatonin improves behavioral parameters and oxidative stress in zebrafish submitted to a leucine-induced MSUD protocol

  2023cites this paper
• Melatonin facts: Lack of evidence that melatonin is a radical scavenger in living systems

  2023cites this paper
• Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in Night Shift Work

  2023cites this paper
• Metabolome subtyping reveals multi-omics characteristics and biological heterogeneity in major psychiatric disorders.

  2023cites this paper
• On the Potential Role of the Antioxidant Couple Vitamin E/Selenium Taken by the Oral Route in Skin and Hair Health

  2022cites this paper
• Melatonin induces drought tolerance by modulating lipoxygenase expression, redox homeostasis and photosynthetic efficiency in Arachis hypogaea L

  2022cites this paper
• Melatonin as the Cornerstone of Neuroimmunoendocrinology

  2022cites this paper
• Considerations on the Controlled Delivery of Bioactive Compounds through Hyaluronic Acid Membrane

  2022cites this paper
• Melatonin and the Brain–Heart Crosstalk in Neurocritically Ill Patients—From Molecular Action to Clinical Practice

  2022cites this paper
• The Crosstalk between Melatonin and Sex Steroid Hormones

  2021cites this paper
• Melatonin and Epilepsy.

  2021cites this paper
• Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

  2021cites this paper
• Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease

  2021cites this paper
• Functional interplay of melatonin in the bile duct and gastrointestinal tract to mitigate disease development: An overview

  2021cites this paper
• Potentiating the Benefits of Melatonin through Chemical Functionalization: Possible Impact on Multifactorial Neurodegenerative Disorders

  2021cites this paper
• Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities

  2021cites this paper
• Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach

  2021cites this paper
• Melatonin could Alleviate the Dysregulation of Metabolic Reprogramming in Periodontitis—Implications in Host Modulatory Therapy

  2021cites this paper
• Melatonin as a Topical/Systemic Formulation for the Management of Periodontitis: A Systematic Review

  2021cites this paper
• Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals—An Overview

  2021cites this paper
• The potential role of melatonin in retarding intervertebral disc ageing and degeneration: A systematic review.

  2021cites this paper
• Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds

  2021influential citation
• Melatonin: A Potential Agent in Delaying Leaf Senescence

  2021cites this paper
• Empowering Melatonin Therapeutics with Drosophila Models

  2021cites this paper
• A potential protection of melatonin on pathogenesis of oral sub-mucous fibrosis (OSMF) : a current update

  2021cites this paper
• EFFECT OF ADJUVANT MELATONIN WITH CLOMIPHENE CITRATE ON OVULATORY AND FERTILITY RATES IN PCOS INFERTILE PATIENTS.

  2020cites this paper
• Melatonin supplementation over different time periods until ageing modulates genotoxic parameters in mice.

  2020cites this paper
• Melatonin supplementation revives diabetic induced biochemical, histological and hematological impairments in rats

  2020cites this paper
• Serum Melatonin Levels in Patients with Sudden Sensorineural Hearing Loss

  2020cites this paper
• Melatonin in Mitochondria: Mitigating Clear and Present Dangers.

  2020cites this paper
• Melatonin levels in periodontitis versus the healthy state: A systematic review and meta-analysis.

  2020cites this paper
• Role of the Phytochemical Compounds like Modulators on Gut Microbiota and Oxidative Stress.

  2020cites this paper
• Exogenous Melatonin Ameliorates Pontine Histoarchitecture and Associated Oxidative Damage in Sodium Fluoride Induced Toxicity

  2020cites this paper
• Comparison of fertility rates of combination of enclomiphene citrate and melatonin with fertility rates of plain enclomiphene citrate in cases of dysovulatory infertility

  2020cites this paper
• Melatonin regulates the ovarian function and enhances follicle growth in aging laying hens via activating the mammalian target of rapamycin pathway

  2020cites this paper
• The Role of Sleep in Inflammatory Bowel Disease

  2020cites this paper
• Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms

  2019cites this paper
• Melatonin ameliorates the drug induced nephrotoxicity: Molecular insights.

  2019cites this paper
• Physiological and Pathological Role of Circadian Hormones in Osteoarthritis: Dose-Dependent or Time-Dependent?

  2019cites this paper
• Exogenous Melatonin Alleviates Oxidative Damages and Protects Photosystem II in Maize Seedlings Under Drought Stress

  2019cites this paper
• Inhibition of mitochondrial pyruvate dehydrogenase kinase: a proposed mechanism by which melatonin causes cancer cells to overcome cytosolic glycolysis, reduce tumor biomass and reverse insensitivity to chemotherapy

  2019cites this paper
• Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

  2018cites this paper
• Melatonin: A Versatile Protector against Oxidative DNA Damage

  2018cites this paper
• A Computer-Assisted Systematic Search for Melatonin Derivatives with High Potential as Antioxidants

  2018cites this paper
• A new free radical scavenging cascade involving melatonin and three of its metabolites (3OHM, AFMK and AMK)

  2018cites this paper
• Melatonin in Assisted Reproductive Technology: A Pilot Double-Blind Randomized Placebo-Controlled Clinical Trial

  2018cites this paper
• PR‐10 proteins as potential mediators of melatonin‐cytokinin cross‐talk in plants: crystallographic studies of LlPR‐10.2B isoform from yellow lupine

  2018cites this paper
• Efecto antioxidante de la melatonina durante la conservación de semen de cerdo

  2018cites this paper
• Metabolite Profiling of Feces and Serum in Hemodialysis Patients and the Effect of Medicinal Charcoal Tablets

  2018cites this paper
• The Potential of Melatonin for the Application in Dairy Products

  2018cites this paper
• Melatonin and the electron transport chain

  2017cites this paper
• Taxon- and Site-Specific Melatonin Catabolism

  2017cites this paper
• The Underrated Carbonate Radical (CO3•–) – Detoxification and Reduced Formation by Melatonin

  2017cites this paper
• Reversal of schizophrenia-like symptoms and immune alterations in mice by immunomodulatory drugs.

  2017cites this paper
• Radical-trapping and preventive antioxidant effects of 2-hydroxymelatonin and 4-hydroxymelatonin: Contributions to the melatonin protection against oxidative stress.

  2017cites this paper
• Melatonin reverses H‐89 induced spatial memory deficit: Involvement of oxidative stress and mitochondrial function

  2017cites this paper
• Plant mitochondria synthesize melatonin and enhance the tolerance of plants to drought stress

  2017cites this paper
• Melatonin transport into mitochondria

  2017cites this paper
• Melatonin and sirtuins: A “not‐so unexpected” relationship

  2017cites this paper
• Focus on the Melatonin Metabolite N1-Acetyl-5-methoxykynuramine (AMK)

  2017cites this paper
• Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on In Vitro Embryo Production in Mammals

  2017cites this paper
• The role and therapeutic potential of melatonin in age‐related ocular diseases

  2017cites this paper
• Enhanced production of camptothecin and biological preparation of N1-acetylkynuramine in Camptotheca acuminata cell suspension cultures

  2017cites this paper
• Dietary Sources and Bioactivities of Melatonin

  2017influential citation
• Mechanisms of Melatonin in Alleviating Alzheimer’s Disease

  2017cites this paper
• Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on Gamete Handling and In Vitro Embryo Production in Humans and Other Mammals

  2017cites this paper
• Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice

  2016cites this paper
• Novel indole-based melatonin analogues substituted with triazole, thiadiazole and carbothioamides: studies on their antioxidant, chemopreventive and cytotoxic activities

  2016cites this paper
• Effect of Transtympanic Injection of Melatonin on Cisplatin-Induced Ototoxicity.

  2016cites this paper
• Melatonin in Plants – Diversity of Levels and Multiplicity of Functions

  2016cites this paper
• Update on melatonin receptors: IUPHAR Review 20

  2016cites this paper
• Rolle einer Melatoninrezeptoraktivierung für die hepatische Mikrozirkulation nach polymikrobieller Sepsis in der Maus

  2016cites this paper
• Melatonin modulates drug-induced acute porphyria

  2016cites this paper
• Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders.

  2016cites this paper
• Melatonergic Treatment: Focus on Metabolism and Chronobiology

  2016cites this paper
• Occurrence of Serotonin, Melatonin, and Their Derivatives in Plants

  2016cites this paper
• The role of melatonin in autoimmune and atopic diseases

  2016cites this paper
• Melatonin as an antioxidant: under promises but over delivers

  2016cites this paper
• Phytomelatonin: Assisting Plants to Survive and Thrive

  2015cites this paper
• New horizons for newborn brain protection: enhancing endogenous neuroprotection

  2015cites this paper
• Melatonin: an ancient molecule that makes oxygen metabolically tolerable

  2015cites this paper
• Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

  2015cites this paper
• Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

  2015cites this paper