Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Progress in Molecular Biology and Translational Science

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/bs.pmbts.2017.02.003PMID 28413031PMCID PMC5411014
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• From varices to venous ulceration: the story of chronic venous disease described by metalloproteinases

  2017cited by this paper
• Pharmacologic treatment to improve venous leg ulcer healing.

  2016cited by this paper
• Nonthermal, Nontumescent Endovenous Treatment of Varicose Veins.

  2016cited by this paper
• The advent of non-thermal, non-tumescent techniques for treatment of varicose veins

  2016cited by this paper
• Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines

  2016cited by this paper
• Clinico-histopathological study of varicose vein and role of matrix metalloproteinases-1, matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinase-1 in varicose vein formation

  2016cited by this paper
• Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers

  2015cited by this paper
• Treatment of Truncal Incompetence and Varicose Veins with a Single Administration of a New Polidocanol Endovenous Microfoam Preparation Improves Symptoms and Appearance.

  2015cited by this paper
• Role of matrix metalloproteinases in non‐healing venous ulcers

  2015cited by this paper
• Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease

  2015cited by this paper
• Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins

  2015cited by this paper
• Doxycycline speeds up healing of chronic venous ulcers

  2015cited by this paper
• Decreased PGE2 Content Reduces MMP-1 Activity and Consequently Increases Collagen Density in Human Varicose Vein

  2014cited by this paper
• Quantifying the degree graduated elastic compression stockings enhance venous emptying.

  2014cited by this paper
• The influence of elastin degradation products, glucose and atorvastatin on metalloproteinase-1, -2, -9 and tissue inhibitor of metalloproteinases-1, -2, -3 expression in human retinal pigment epithelial cells.

  2014cited by this paper
• Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways

  2014cited by this paper
• RETRACTED ARTICLE: Molecular basis underlying inhibition of metastasis of gastric cancer by anti-VEGFa treatment

  2014cited by this paper
• Deep Sea Water Prevents Balloon Angioplasty-Induced Hyperplasia through MMP-2: An In Vitro and In Vivo Study

  2014cited by this paper
• Chymase inhibition improves vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

  2014cited by this paper
• The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs

  2014cited by this paper
• Urokinase Stimulates Production of Matrix Metalloproteinase-9 in Fibroblasts with Involvement of Reactive Oxygen Species

  2014cited by this paper
• MMP‐1 and MMP‐9 regulate epidermal growth factor‐dependent collagen loss in human carotid plaque smooth muscle cells

  2014cited by this paper
• Glycosaminoglycan sulodexide inhibition of MMP-9 gelatinase secretion and activity: possible pharmacological role against collagen degradation in vascular chronic diseases.

  2013cited by this paper
• Compression stockings significantly improve hemodynamic performance in post-thrombotic syndrome irrespective of class or length.

  2013cited by this paper
• Matrix Metalloproteinases: Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling

  2013cited by this paper
• Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins.

  2013cited by this paper
• EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone.

  2013cited by this paper
• Increased activation of the hypoxia-inducible factor pathway in varicose veins.

  2012cited by this paper
• Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease.

  2012cited by this paper
• Molecular Mechanisms Regulating the Vascular Prostacyclin Pathways and Their Adaptation during Pregnancy and in the Newborn

  2012cited by this paper
• Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones.

  2012cited by this paper
• A review of familial, genetic, and congenital aspects of primary varicose vein disease.

  2012cited by this paper
• Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2

  2012cited by this paper
• A genetic study of chronic venous insufficiency.

  2012cited by this paper
• Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases.

  2011cited by this paper
• Sclerotherapy: it is back and better.

  2011cited by this paper
• Polymorphisms in MMP-9 and TIMP-2 in Chinese patients with varicose veins.

  2011cited by this paper
• Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins.

  2011cited by this paper
• Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins.

  2010cited by this paper
• Interstitial flow induces MMP-1 expression and vascular SMC migration in collagen I gels via an ERK1/2-dependent and c-Jun-mediated mechanism.

  2010cited by this paper
• Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava.

  2010cited by this paper
• Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.

  2010cited by this paper
• MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides.

  2010cited by this paper
• To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition.

  2010cited by this paper
• Inhibitory effect of TIMP influences the morphology of varicose veins.

  2010cited by this paper
• Pathogenesis of primary varicose veins

  2009cited by this paper
• TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

  2009cited by this paper
• In vitro differences between smooth muscle cells derived from varicose veins and normal veins.

  2009cited by this paper
• Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins.

  2008cited by this paper
• Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.

  2008cited by this paper
• Forkhead Factor, FOXO3a, Induces Apoptosis of Endothelial Cells Through Activation of Matrix Metalloproteinases

  2008cited by this paper
• Mechanisms of varicose vein formation: valve dysfunction and wall dilation

  2008cited by this paper
• Tanshinone IIA from Salvia miltiorrhiza BUNGE inhibits human aortic smooth muscle cell migration and MMP‐9 activity through AKT signaling pathway

  2008cited by this paper
• Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas.

  2008cited by this paper
• Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation.

  2007cited by this paper
• Positive feedback regulation between MMP-9 and VEGF in human RPE cells.

  2007cited by this paper
• Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases

  2007cited by this paper
• Ehlers-Danlos Syndrome (EDS) type IV. Review of the literature

  2007cited by this paper
• Hemodynamic impairment, venous segmental disease, and clinical severity scoring in limbs with Klippel-Trenaunay syndrome.

  2007cited by this paper
• HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.

  2007cited by this paper
• Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects*

  2007cited by this paper
• Comparison of extracellular matrix in skin and saphenous veins from patients with varicose veins: does the skin reflect venous matrix changes?

  2007cited by this paper
• Current advances in the pathogenesis of varicose veins.

  2007cited by this paper
• HIF‐1α and HIF‐2α play a central role in stretch‐induced but not shear‐stress‐induced angiogenesis in rat skeletal muscle

  2007cited by this paper
• Conception of the Venous Hemodynamics in the Lower Extremity

  2006cited by this paper
• Varicose veins associated with CADASIL result from a novel mutation in the Notch3 gene

  2006cited by this paper
• Venoruton® vs Daflon®: Evaluation of Effects on Quality of Life in Chronic Venous Insufficiency

  2006cited by this paper
• Adenovirus-mediated small interfering RNA against matrix metalloproteinase-2 suppresses tumor growth and lung metastasis in mice

  2006cited by this paper
• Endothelium : Signaling , Oxidative Stress , and Gene Expression Series

  2006cited by this paper
• Structure and function of matrix metalloproteinases and TIMPs.

  2006cited by this paper
• Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure.

  2006cited by this paper
• Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.

  2006cited by this paper
• The epidemiology of chronic venous insufficiency and varicose veins.

  2005cited by this paper
• Gene Expression Profiles in Varicose Veins Using Complementary DNA Microarray

  2005cited by this paper
• Four‐Year Follow‐up on Endovascular Radiofrequency Obliteration of Great Saphenous Reflux

  2005cited by this paper
• Synthesis and SAR of highly selective MMP-13 inhibitors.

  2005cited by this paper
• PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

  2005cited by this paper
• Decreased Production of Collagen Type III in Cultured Smooth Muscle Cells from Varicose Vein Patients Is due to a Degradation by MMPs: Possible Implication of MMP-3

  2005cited by this paper
• Linkage to the FOXC2 region of chromosome 16 for varicose veins in otherwise healthy, unselected sibling pairs

  2005cited by this paper
• Histopathological changes and expression of adhesion molecules and laminin in varicose veins.

  2005cited by this paper
• Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction.

  2004cited by this paper
• Revision of the CEAP classification for chronic venous disorders: consensus statement.

  2004cited by this paper
• Transactivation of Epidermal Growth Factor Receptor Mediates Catecholamine-Induced Growth of Vascular Smooth Muscle

  2004cited by this paper
• Oxidative Cross-linking of Tryptophan to Glycine Restrains Matrix Metalloproteinase Activity

  2004cited by this paper
• Prospective randomized controlled trial: conventional versus powered phlebectomy.

  2004cited by this paper
• Immunocytochemical characterisation of the inflammatory cell infiltrate of varicose veins.

  2004cited by this paper
• New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups.

  2004cited by this paper
• Hypertension-induced venous valve remodeling.

  2004cited by this paper
• Morphologic characteristics of varicose veins: possible role of metalloproteinases.

  2003cited by this paper
• Endovenous laser treatment of saphenous vein reflux: long-term results.

  2003cited by this paper
• The Influence of Environmental Factors in Chronic Venous Insufficiency

  2003cited by this paper
• Epidemiology of venous insufficiency in an occupational population.

  2003cited by this paper
• Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats.

  2003cited by this paper
• Uniaxial strain upregulates matrix-degrading enzymes produced by human vascular smooth muscle cells.

  2003cited by this paper
• Statins Inhibit Secretion of Metalloproteinases-1, -2, -3, and -9 From Vascular Smooth Muscle Cells and Macrophages

  2003cited by this paper
• Metalloproteinase inhibitors: biological actions and therapeutic opportunities

  2002cited by this paper
• Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane‐type matrix metalloproteinases in venous leg ulcers

  2002cited by this paper
• α4β1 Integrin Activation of L-Type Calcium Channels in Vascular Smooth Muscle Causes Arteriole Vasoconstriction

  2002cited by this paper
• Design, Synthesis, and Characterization of Potent, Slow-binding Inhibitors That Are Selective for Gelatinases*

  2002cited by this paper
• Varicose veins possess greater quantities of MMP-1 than normal veins and demonstrate regional variation in MMP-1 and MMP-13.

  2002cited by this paper

• Matrix Metalloproteinase 14 in Corneal Neovascularization.

  2026cites this paper
• Nursing Care Strategies for Varicose Veins: A Narrative Review

  2025cites this paper
• Pathophysiological Bases and Clinical Uses of Metalloproteases in Cardiovascular Disease: A Scoping Review

  2025cites this paper
• Analysis of the Combined Effects of a Novel Combination of Hypersmin, Pumpkin Seed and Amaranthus Extracts in an In Vitro Model of Chronic Venous Insufficiency

  2025cites this paper
• Innovative Approaches and Future Directions in the Management and Understanding of Varicose Veins: A Systematic Review.

  2024cites this paper
• ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila.

  2024cites this paper
• Changes of the serum properties and its effect on the endothelial cells restoration in patients with chronic venous disease treated with sulodexide

  2024cites this paper
• Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs

  2024cites this paper
• An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies.

  2024cites this paper
• Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast

  2024cites this paper
• Molecular Determinants of Chronic Venous Disease: A Comprehensive Review

  2023cites this paper
• Ulcères de jambe d’origine veineuse ou mixtes à prédominance veineuse

  2023cites this paper
• The effect of the A82G mutation in the MMP-12 gene and C634G mutation in the VEGF-A gene on the course of lower limb varicose veins and the risk of disease recurrence

  2023cites this paper
• Úlceras de la pierna de origen venoso o mixto de predominio venoso

  2023cites this paper
• Phenotype and function of smooth muscle cells derived from the human normal great saphenous vein in response to hypoxia

  2023influential citation
• Chronic venous insufficiency and venous leg ulcers: Aetiology, on the pathophysiology‐based treatment

  2023cites this paper
• Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health

  2023cites this paper
• Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets, Mechanisms, and Insights for Therapeutic Interventions

  2023cites this paper
• Outlook on Chronic Venous Disease Treatment: Phytochemical Screening, In Vitro Antioxidant Activity and In Silico Studies for Three Vegetal Extracts

  2023cites this paper
• The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities

  2022cites this paper
• The expression of matrix metalloproteinases and their tissue inhibitors in the vein wall following superficial venous thrombosis

  2021cites this paper
• The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

  2021cites this paper
• Investigation of association between genetic polymorphisms of MMP2, MMP8, MMP9 and TIMP2 and development of varicose veins in the Slovak Population - pilot study.

  2021cites this paper
• Efficacy and safety of Buyang Huanwu decoction in the treatment of varicose veins of the lower extremities

  2021cites this paper
• The Biomechanics of Venous Remodeling

  2021cites this paper
• Downregulation of miR-29b-3p promotes α-tubulin deacetylation by targeting the interaction of matrix metalloproteinase-9 with integrin β1 in nasal polyps

  2021cites this paper
• The principles of directed cell migration

  2021cites this paper
• An increase in elastogenic components in the placental villi of women with chronic venous disease during pregnancy is associated with decreased EGFL7 expression level

  2021cites this paper
• Mechanisms of Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins.

  2021cites this paper
• Signaling pathways associated with structural changes in varicose veins: a case–control study

  2021cites this paper
• The influence of compression therapy on the level of inflammatory biomarkers in patients with chronic venous disease.

  2021cites this paper
• Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management

  2021cites this paper
• Heparanase as active player in endothelial glycocalyx remodeling

  2021cites this paper
• Imbalance in matrix metalloproteinases and tissue inhibitor of metalloproteinases from splenic veins and great saphenous veins under high hemodynamics

  2020cites this paper
• Histological, Immunohistochemical, Morphometric and Molecular Changes in the Wall of Human Varicose Veins

  2020cites this paper
• Roles of Endovascular Calyx Related Enzymes in Endothelial Dysfunction and Diabetic Vascular Complications

  2020cites this paper
• Zinc salicylate reduces airway smooth muscle cells remodelling by blocking mTOR and activating p21(Waf1/Cip1).

  2020cites this paper
• Chronic Venous Disease Patients Showed Altered Expression of IGF-1/PAPP-A/STC-2 Axis in the Vein Wall

  2020cites this paper
• Matrix Metalloproteinases in Obesity After Gastric Bypass Surgery—an Experimental Study

  2020cites this paper
• Disequilibrium in MMPs and the tissue inhibitor of metalloproteinases in different segments of the varicose great saphenous vein wall.

  2019cites this paper
• Effect of a peptide construct on differentiated macrophage MMP-2 and MMP-9 levels of varicose patients.

  2019cites this paper
• [Venous wall weackness pathogenesis in varicose vein disease].

  2019cites this paper
• Anterior dislocation of the hip sustained for 32 years and a venous reflux disorder treated with a total hip arthroplasty : a case report

  2019cites this paper
• Chronic venous disease: from symptoms to microcirculation.

  2019cites this paper
• Mechanisms of physiological tissue remodeling in animals: Manipulating tissue, organ, and organism morphology.

  2019cites this paper
• Genetic Factors of Comorbidity of Pelvic Organ Prolapse, Stress Urinary Incontinence, and Chronic Venous Insufficiency of the Lower Limbs in Women

  2018cites this paper
• Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency.

  2018cites this paper
• Extracellular Matrix Macromolecules as Potential Targets of Cardiovascular Pharmacotherapy.

  2018cites this paper
• Pathophysiology of Chronic Venous Disease and Venous Ulcers.

  2018cites this paper
• Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK‐1 channel

  2018cites this paper
• Regulation and function of endothelial glycocalyx layer in vascular diseases.

  2018cites this paper
• Varicose veins and the chronicity of venous pathology

  2018cites this paper
• Chronic venous disorders: from macrocirculation to microcirculation

  2018cites this paper
• Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins

  2018cites this paper
• Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus

  2017cites this paper
• Variability of MMP/TIMP and TGF-β1 Receptors throughout the Clinical Progression of Chronic Venous Disease

  2017cites this paper
• Remodelat vascular a les malalties pulmonars: perfil d'expressió gènica i biomarcadors

  2017cites this paper
• TGF-β1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology

  2017influential citation