Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC theta, varies with muscle type and in response to fructose-induced insulin resistance.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Endocrinology

• Publication date

  1994-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ENDO.135.6.7988419PMID 7988419
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

  1993cited by this paper
• Protein kinase C: Mediator or inhibitor of insulin action?

  1993cited by this paper
• Differential effect of aging on protein kinase C activity in rat adipocytes and soleus muscle.

  1993cited by this paper
• A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF.

  1993cited by this paper
• Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?

  1993cited by this paper
• Syndromes of Insulin Resistance in the Rat: Inducement by Diet and Amelioration with Benfluorex

  1993cited by this paper
• Protein kinase C isoenzymes: divergence in signal transduction?

  1993cited by this paper
• A New Protein Kinase C, nPKCη′, and nPCKθ Are Expressed in Human Platelets: Involvement of nPKCη′ and nPKCθ in Signal Transduction Stimulated by PAF

  1993cited by this paper
• Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

  1993cited by this paper
• Unique expression pattern of protein kinase C‐θ: high mRNA levels in normal mouse testes and in T‐lymphocytic cells and neoplasms

  1993cited by this paper
• Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets.

  1993cited by this paper
• Effects of insulin on diacylglycerol/protein kinase-C signalling and glucose transport in rat skeletal muscles in vivo and in vitro.

  1992cited by this paper
• Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.

  1992cited by this paper
• A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle

  1992cited by this paper
• Characterization of insulin receptor kinase activity and autophosphorylation in different skeletal muscle types.

  1991cited by this paper
• Interrelated effects of insulin and glucose on diacylglycerol-protein kinase-C signalling in rat adipocytes and solei muscle in vitro and in vivo in diabetic rats.

  1991cited by this paper
• Role of phospholipases in generating lipid second messengers in signal transduction 1

  1991cited by this paper
• Effects of insulin and phospholipase C in control and denervated rat skeletal muscle.

  1991cited by this paper
• Insulin activation of protein kinase C: a reassessment.

  1991cited by this paper
• Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

  1991cited by this paper
• Insulin administration in vivo increases 1,2-diacylglycerol in rat skeletal muscle.

  1991cited by this paper
• 'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways.

  1991cited by this paper
• 1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo. Studies with insulin, exercise, muscle denervation, and vasopressin.

  1990cited by this paper
• Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.

  1990cited by this paper
• Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.

  1990cited by this paper
• The molecular heterogeneity of protein kinase C and its implications for cellular regulation

  1988cited by this paper
• Quantitative measurement of sn-1,2-diacylglycerols.

  1987cited by this paper
• Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

  1986cited by this paper
• Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate.

  1986cited by this paper
• Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats.

  1985cited by this paper
• The role of protein kinase C in cell surface signal transduction and tumour promotion

  1984cited by this paper
• Muscle fiber type composition of the rat hindlimb.

  1984cited by this paper
• Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

  1984cited by this paper
• Mechanism of insulin resistance in fructose-fed rats.

  1982cited by this paper
• Insulin Binding and Glucose Uptake Differences in Rodent Skeletal Muscles

  1981cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• A rapid method of total lipid extraction and purification.

  1959cited by this paper

• Myofiber-specific lipidomics unveil differential contributions to insulin sensitivity in individuals of African and European ancestry

  2024cites this paper
• Skeletal Muscle Consequences of Phosphatidylethanolamine Synthesis Deficiency

  2023cites this paper
• Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats

  2021cites this paper
• Effects of Rosemary Extract and Rosemary Extract Polyphenols on Skeletal Muscle Insulin Resistance

  2018cites this paper
• Dietary Fructose Enhances the Ability of Low Concentrations of Angiotensin II to Stimulate Proximal Tubule Na+ Reabsorption

  2017cites this paper
• The role of pyruvate dehydrogenase kinase in glucose and ketone body metabolism

  2014cites this paper
• Fatty Acid Induced Insulin Resistance in the Brain

  2013cites this paper
• Enhanced prereceptor glucocorticoid metabolism and lipogenesis impair insulin signaling in the liver of fructose-fed rats.

  2013cites this paper
• Role of heme arginate in modulation of inflammation and type 2 diabetes

  2012influential citation
• GPCRs in rat primary skeletal muscle cells

  2012cites this paper
• Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise

  2011influential citation
• Regulation of renal brush-border glucose transport in response to metabolic dysregulation

  2011cites this paper
• Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

  2010cites this paper
• The role of protein kinase C in the pathogenesis of insulin resistance and its complications

  2010cites this paper
• Effects of high-fat feeding on skeletal muscle insulin signalling in sarcolipin knockout mice

  2010cites this paper
• Vascular insulin resistance through fat.

  2010cites this paper
• Insulin potentiates FcepsilonRI-mediated signaling in mouse bone marrow-derived mast cells.

  2010cites this paper
• Cell and Molecular Biology

  2009cites this paper
• Chapter 2. Calcineurin signaling and the slow oxidative skeletal muscle fiber type.

  2009cites this paper
• Protein Kinase C θ Activation Induces Insulin-Mediated Constriction of Muscle Resistance Arteries

  2008cites this paper
• Muscular diacylglycerol metabolism and insulin resistance.

  2008cites this paper
• Beneficial impact of L-carnitine in liver: a study in a rat model of syndrome X

  2008influential citation
• Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance*

  2007cites this paper
• Increase in Nitric Oxide and Reductions in Blood Pressure, Protein Kinase C β II and Oxidative Stress by L-Carnitine: A Study in the Fructose-Fed Hypertensive Rat

  2007cites this paper
• Differential expression of PKC isoforms in developing zebrafish

  2007cites this paper
• Measuring insulin sensitivity and the effect of alternative dietary interventions and exercise on metabolic control

  2007cites this paper
• Kinase-dependent pathways and the development of insulin resistance in hepatocytes

  2007cites this paper
• Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

  2007cites this paper
• Specific protein kinase C isoforms as transducers and modulators of insulin signaling.

  2006cites this paper
• PKCθ is a key player in the development of insulin resistance

  2006cites this paper
• PKCtheta is a key player in the development of insulin resistance.

  2006cites this paper
• Irbesartan restores the in-vivo insulin signaling pathway leading to Akt activation in obese Zucker rats

  2006cites this paper
• Effects of the Resistance and Chinese Medicine TSJN on Insulin Hypertension in Fructose-Fed Rats

  2006cites this paper
• The Vicious Circle of Leptin and Obesity

  2006cites this paper
• Signaling Pathways Controlling Muscle Fiber Size and Type In Response To Nerve Activity

  2006cites this paper
• Signaling pathways in skeletal muscle remodeling.

  2006cites this paper
• A long-term sucrose-rich diet increases diacylglycerol content and membrane nPKCθ expression and alters glucose metabolism in skeletal muscle of rats

  2006cites this paper
• Metabolic effects of fructose

  2006cites this paper
• LE STRESS OXYDANT INDUIT PAR VOIE METABOLIQUE (REGIMES ALIMENTAIRES) OU PAR VOIE GAZEUSE (HYPEROXIE) ET EFFET DE LA GLISODIN

  2006influential citation
• Fructose, insulin resistance, and metabolic dyslipidemia

  2005cites this paper
• Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

  2005cites this paper
• Regulation of skeletal muscle fiber type and slow myosin heavy chain 2 gene expression by inositol trisphosphate receptor 1

  2005cites this paper
• Hepatic adaptations to sucrose and fructose.

  2005cites this paper
• Inhibition of ryanodine receptor 1 in fast skeletal muscle fibers induces a fast-to-slow muscle fiber type transition

  2004cites this paper
• Repression of slow myosin heavy chain 2 gene expression in fast skeletal muscle fibers by muscarinic acetylcholine receptor and Gαq signaling

  2003cites this paper
• Transgenic mice with dominant negative PKC‐theta in skeletal muscle: A new model of insulin resistance and obesity

  2003cites this paper
• Glucose-induced TGF-beta1 and TGF-beta receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-alpha.

  2003cites this paper
• Glucose-Induced TGF-&bgr;1 and TGF-&bgr; Receptor-1 Expression in Vascular Smooth Muscle Cells Is Mediated by Protein Kinase C-&agr;

  2003cites this paper
• Increased skeletal muscle expression of PKC‐θ but not PKC‐α mRNA in type 2 diabetes: inverse relationship with in‐vivo insulin sensitivity

  2003cites this paper
• Inhibitory effect of hypocrellin A on protein kinase C in liver and skeletal muscle of obese Zucker rats.

  2003cites this paper
• Insulin action in skeletal muscle: isozyme-specific effects of protein kinase C.

  2002cites this paper
• Protein kinase C(theta) in T cell activation.

  2002cites this paper
• Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.

  2002cites this paper
• PROTEIN KINASE Cµ IN TC ELL ACTIVATION

  2002cites this paper
• Exercise-induced signal transduction and gene regulation in skeletal muscle.

  2002cites this paper
• Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle.

  2002cites this paper
• [The role of protein kinase C in the pathophysiology of diabetic retinopathy].

  2002cites this paper
• Differential changes in protein kinase C associated with regeneration of rat extensor digitorum longus and soleus muscles.

  2002cites this paper
• Protein Kinase C and Lipid‐Induced Insulin Resistance in Skeletal Muscle

  2002cites this paper
• Insulin Action in Skeletal Muscle

  2002cites this paper
• Protein kinase C signaling controls skeletal muscle fiber types.

  2001cites this paper
• Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle.

  2001cites this paper
• The role of protein kinase C isoforms in insulin action

  2001cites this paper
• Increased protein kinase C theta in skeletal muscle of diabetic patients.

  2001cites this paper
• Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes

  2001cites this paper
• A high-fructose diet induces changes in pp185 phosphorylation in muscle and liver of rats.

  2000cites this paper
• The adaptive response of transforming growth factor-beta 2 and -beta RII in the overloaded, regenerating and denervated muscles of rats.

  2000cites this paper
• Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply.

  2000cites this paper
• The effects of an angiotensin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats.

  2000cites this paper
• Protein kinase C modulates insulin action in human skeletal muscle.

  2000cites this paper
• Effects of the Chinese medicine, TSJN on insulin resistance and hypertension in fructose-fed rats.

  2000cites this paper
• A high fructose diet affects the early steps of insulin action in muscle and liver of rats.

  2000cites this paper
• Protein kinase Ctheta expression is increased upon differentiation of human skeletal muscle cells: dysregulation in type 2 diabetic patients and a possible role for protein kinase Ctheta in insulin-stimulated glycogen synthase activity.

  2000cites this paper
• Protein Kinase Cθ Expression Is Increased upon Differentiation of Human Skeletal Muscle Cells: Dysregulation in Type 2 Diabetic Patients and a Possible Role for Protein Kinase Cθ in Insulin-Stimulated Glycogen Synthase Activity.

  2000cites this paper
• The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats

  2000influential citation
• Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

  2000cites this paper
• Amelioration of denervation-induced atrophy by clenbuterol is associated with increased PKC-alpha activity.

  2000cites this paper
• Alterations in protein kinase A and protein kinase C levels in heart failure due to genetic cardiomyopathy.

  1999cites this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cites this paper
• Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

  1999cites this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cites this paper
• Differential expression of protein kinase C isoforms in streptozotocin-induced diabetic rats.

  1999cites this paper
• Effect of chronic electrostimulation of rabbit skeletal muscle on calmodulin level and protein kinase activity.

  1999cites this paper
• Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats.

  1999cites this paper
• Tissue- and isoform-specific effects of aging in rats on protein kinase C in insulin-sensitive tissues.

  1999cites this paper
• Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats - effects of feeding.

  1999cites this paper
• Dephosphorylation increases insulin-stimulated receptor kinase activity in skeletal muscle of obese Zucker rats

  1999cites this paper
• Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

  1999cites this paper
• Protein kinase C activity regulates slow myosin heavy chain 2 gene expression in slow lineage skeletal muscle fibers

  1999cites this paper
• Protein Kinase C Isozymes in Skeletal Muscles During the Early Stage of Genetic and Streptozocin Diabetes

  1998cites this paper
• Complementary measures for promoting insulin sensitivity in skeletal muscle.

  1998cites this paper
• New perspectives on PKCtheta, a member of the novel subfamily of protein kinase C.

  1998cites this paper
• Utility of metformin as an adjunct to hydroxycitrate/carnitine for reducing body fat in diabetics.

  1998cites this paper
• New Perspectives on PKCθ, a Member of the Novel Subfamily of Protein Kinase C

  1998cites this paper
• MECHANISMS OF INSULIN RESISTANCE AND NEW PHARMACOLOGICAL APPROACHES TO METABOLISM AND DIABETIC COMPLICATIONS

  1998cites this paper
• Qualitative immunoblot analysis of PKC isoforms expressed in airway smooth muscle.

  1997cites this paper
• Lipid Abnormalities in Muscle of Insulin‐resistant Rodents The Malonyl CoA Hypothesis a

  1997cites this paper
• Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat.

  1997cites this paper
• The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance.

  1997cites this paper
• Is insulin resistance in the spontaneously hypertensive rat related to changes in protein kinase C in skeletal muscle?

  1997cites this paper