Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  1999-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/ajpendo.1999.277.6.E1070PMID 29597538
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Glucose toxicity.

  2001cited by this paper
• Malonyl-CoA, fuel sensing, and insulin resistance.

  1999cited by this paper
• Toxicity of hyperglycaemia in type 2 diabetes.

  1998cited by this paper
• Increased flux through the hexosamine biosynthesis pathway inhibits glucose transport acutely by activation of protein kinase C.

  1997cited by this paper
• Reversal of chronic alterations of skeletal muscle protein kinase C from fat-fed rats by BRL-49653.

  1997influential reference
• Diet-Induced Muscle Insulin Resistance in Rats Is Ameliorated by Acute Dietary Lipid Withdrawal or a Single Bout of Exercise: Parallel Relationship Between Insulin Stimulation of Glucose Uptake and Suppression of Long-Chain Fatty Acyl-CoA

  1997cited by this paper
• Role of the glucosamine pathway in fat-induced insulin resistance.

  1997cited by this paper
• Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action

  1997cited by this paper
• Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats.

  1997influential reference
• Alterations in the Expression and Cellular Localization of Protein Kinase C Isozymes ε and θ Are Associated With Insulin Resistance in Skeletal Muscle of the High-Fat–Fed Rat

  1997cited by this paper
• Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

  1996cited by this paper
• Effects of prolonged glucose infusion on insulin secretion, clearance, and action in normal subjects.

  1996cited by this paper
• Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites.

  1996cited by this paper
• Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle.

  1996cited by this paper
• Growth Hormone–Induced Insulin Resistance and Its Relationship to Lipid Availability in the Rat

  1996cited by this paper
• A malonyl-CoA fuel sensing mechanism in muscle: effects of insulin, glucose and denervation.

  1996cited by this paper
• Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects.

  1996cited by this paper
• Chronic Activation of Protein Kinase C in Soleus Muscles and Other Tissues of Insulin-Resistant Type II diabetic Goto-Kakizaki (GK), Obese/Aged, and Obese/Zucker Rats: A Mechanism For Inhibiting Glycogen Synthesis

  1996cited by this paper
• Effects of insulin on the translocation of protein kinase C-theta and other protein kinase C isoforms in rat skeletal muscles.

  1995cited by this paper
• Insulin increases mRNA levels of protein kinase C-alpha and -beta in rat adipocytes and protein kinase C-alpha, -beta and -theta in rat skeletal muscle.

  1995cited by this paper
• Disordered metabolism in diabetes: Have we underemphasized the fat component?

  1994cited by this paper
• Impaired glucose transport in skeletal muscle but normal GLUT-4 tissue distribution in glucose-infused rats.

  1994cited by this paper
• Effects of insulin on protein kinase-C (PKC) in HIRC-B cells: specific activation of PKC epsilon and its resistance to phorbol ester-induced down-regulation.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol.

  1994cited by this paper
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  1992cited by this paper
• Enhanced Stimulation of Diacylglycerol and Lipid Synthesis by Insulin in Denervated Muscle: Altered Protein Kinase C Activity and Possible Link to Insulin Resistance

  1991cited by this paper
• Insulin resistance in normal rats infused with glucose for 72 h.

  1991cited by this paper
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  1991cited by this paper
• Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.

  1991cited by this paper
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  1991cited by this paper
• Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance.

  1991cited by this paper
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  1987cited by this paper
• Dose-response curves for in vivo insulin sensitivity in individual tissues in rats.

  1985cited by this paper
• Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

  1984cited by this paper

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