Overexpression of c‐myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway

No abstract is available for this paper.

• Publication year

  2006

• Venue

  EMBO Journal

• Publication date

  2006-08-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.emboj.7601246PMID 16874304PMCID PMC1538549
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness

  2005cited by this paper
• Transcriptional regulation and transformation by Myc proteins

  2005cited by this paper
• CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness.

  2005cited by this paper
• Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.

  2005cited by this paper
• Beta-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis.

  2005cited by this paper
• The Transcription Factor NFAT3 Mediates Neuronal Survival*

  2005cited by this paper
• NFAT transcription factors: from cell cycle to tumor development.

  2005cited by this paper
• KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells.

  2004cited by this paper
• Endothelin-1–Dependent Nuclear Factor of Activated T Lymphocyte Signaling Associates With Transcriptional Coactivator p300 in the Activation of the B Cell Leukemia-2 Promoter in Cardiac Myocytes

  2004cited by this paper
• A Novel Role for Nuclear Factor of Activated T Cells in Receptor Tyrosine Kinase and G Protein-coupled Receptor Agonist-induced Vascular Smooth Muscle Cell Motility*

  2004cited by this paper
• Genomic DNA-Chip Hybridization Reveals a Higher Incidence of Genomic Amplifications in Pancreatic Cancer than Conventional Comparative Genomic Hybridization and Leads to the Identification of Novel Candidate Genes

  2004cited by this paper
• Nuclear Factor of Activated T Cells Balances Angiogenesis Activation and Inhibition

  2004cited by this paper
• The Calcineurin/Nuclear Factor of Activated T Cells Signaling Pathway Regulates Osteoclastogenesis in RAW264.7 Cells*

  2004cited by this paper
• Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation

  2004cited by this paper
• Analysis of genomic targets reveals complex functions of MYC

  2004cited by this paper
• A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.

  2004cited by this paper
• Intracellular signaling pathways for norepinephrine- and endothelin-1-mediated regulation of myocardial cell apoptosis

  2004cited by this paper
• Cell Fusion in Skeletal Muscle: Central Role of NFATC2 in Regulating Muscle Cell Size

  2003cited by this paper
• Transcriptional regulation by calcium, calcineurin, and NFAT.

  2003cited by this paper
• SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo.

  2003cited by this paper
• Prostaglandin F2α stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway

  2003cited by this paper
• Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.

  2003cited by this paper
• A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts*

  2003influential reference
• Reconstructing MYC.

  2003cited by this paper
• Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci

  2003cited by this paper
• Transgenic overexpression of the oncofetal RNA binding protein KOC leads to remodeling of the exocrine pancreas.

  2003cited by this paper
• Ca2+/calcineurin signalling in cells of the immune system.

  2003cited by this paper
• Protein Kinase A Negatively Modulates the Nuclear Accumulation of NF-ATc1 by Priming for Subsequent Phosphorylation by Glycogen Synthase Kinase-3*

  2002cited by this paper
• c-myc Is a Downstream Target of the Smad Pathway* 210

  2002cited by this paper
• NFAT: ubiquitous regulator of cell differentiation and adaptation.

  2002cited by this paper
• A potential role for nuclear factor of activated T-cells in receptor tyrosine kinase and G-protein-coupled receptor agonist-induced cell proliferation.

  2002cited by this paper
• c-MYC Activation in Primary and Metastatic Ductal Adenocarcinoma of the Pancreas: Incidence, Mechanisms, and Clinical Significance

  2002cited by this paper
• NFAT signaling: choreographing the social lives of cells.

  2002cited by this paper
• E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.

  2002cited by this paper
• Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis.

  2002cited by this paper
• Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.

  2002cited by this paper
• Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a

  2001cited by this paper
• Signals Transduced by Ca 2 / Calcineurin and NFATc 3 / c 4 Pattern the Developing Vasculature

  2001cited by this paper
• Glycogen Synthase Kinase-3 Inhibits the DNA Binding Activity of NFATc*

  2001cited by this paper
• NFAT signaling in vertebrate development.

  2001cited by this paper
• Inaugural Article: Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

  2001cited by this paper
• Calcineurin Activity Is Required for the Initiation of Skeletal Muscle Differentiation

  2000cited by this paper
• Efficient control of tetracycline-responsive gene expression from an autoregulated bi-directional expression vector.

  1999cited by this paper
• MYC oncogenes and human neoplastic disease

  1999cited by this paper
• IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1

  1999cited by this paper
• Inhibitors of calcineurin block expression of cyclins A and E induced by fibroblast growth factor in Swiss 3T3 fibroblasts.

  1998cited by this paper
• Nuclear Factor of Activated T Cells (NFAT) as a New Component of the Signal Transduction Pathway in Glioma Cells

  1998cited by this paper
• Myc and the cell cycle.

  1998cited by this paper
• Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

  1998cited by this paper
• Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

  1998cited by this paper
• Two-site Interaction of Nuclear Factor of Activated T Cells with Activated Calcineurin*

  1998cited by this paper
• The transcription factor NF-ATc is essential for cardiac valve formation

  1998cited by this paper
• Transcription factors of the NFAT family: regulation and function.

  1997cited by this paper
• Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity (*)

  1996cited by this paper
• Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

  1996cited by this paper
• Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

  1996cited by this paper
• New pancreas cancers cell lines that represent distinct stages of ductal differentiation.

  1995influential reference
• Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells (*)

  1995cited by this paper
• Correlation between spontaneous metastatic potential and type I collagenolytic activity in a human pancreatic cancer cell line (SUIT-2) and sublines

  1992cited by this paper
• Differential regulation of the tumor suppressor molecules, retinoblastoma susceptibility gene product (Rb) and p53, during cell cycle progression of normal human T cells.

  1991cited by this paper
• Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.

  1989cited by this paper

• Calcineurin in cancer signaling networks

  2025cites this paper
• Nuclear VAV1 increases GLI1-dependent transcription in pancreatic cancer cells

  2025cites this paper
• Affinity-selected peptide ligands specifically bind i-motif DNA and modulate c-Myc gene expression

  2025cites this paper
• NFAT2 Induces Tumor Cell Proliferation and Metastasis by Acting as a Transcriptional Co-activator of the TGF-β1/SMAD Signaling Pathway and Inducing the Epithelial–Mesenchymal Transition in Liver Cancer

  2025cites this paper
• NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53

  2024cites this paper
• Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression

  2024cites this paper
• PPP3CB overexpression mediates EGFR TKI resistance in lung tumors via calcineurin/MEK/ERK signaling

  2024cites this paper
• Tanshinone IIA induces ER stress and JNK activation to inhibit tumor growth and enhance anti-PD-1 immunotherapy in non-small cell lung cancer.

  2024cites this paper
• Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

  2023cites this paper
• Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)

  2023cites this paper
• MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

  2023cites this paper
• NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells.

  2023cites this paper
• IMPA2 promotes basal-like breast cancer aggressiveness by a MYC-mediated positive feedback loop.

  2023cites this paper
• Calcium-Signalling in Human Glaucoma Lamina Cribrosa Myofibroblasts

  2023cites this paper
• The role of NFATc1 in the progression and metastasis of prostate cancer: A review on the molecular mechanisms and signaling pathways

  2023cites this paper
• WNT16b promotes the proliferation and self‐renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway

  2023cites this paper
• siRNA Mediated Gene Silencing in the Pancreatic Cancer Capan-1 Cell Line

  2022cites this paper
• Integrated genomic analysis to identify druggable targets for pancreatic cancer

  2022cites this paper
• THE EXPRESSION OF NFATC1 IS MORE PREDOMINANT IN TRIPLE NEGATIVE BREAST CARCINOMA PATIENTS

  2022cites this paper
• Precision Medicine for BRCA/PALB2-Mutated Pancreatic Cancer and Emerging Strategies to Improve Therapeutic Responses to PARP Inhibition

  2022cites this paper
• Gö-VIP-Nr: 28: Dr. Muhammad Umair Latif Klinik für Gastroenterologie, gastrointestinale Onkologie und Endokrinologie

  2022cites this paper
• Proliferation, apoptosis and invasion of human lung cancer cells are associated with NFATc1

  2022cites this paper
• Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin

  2022cites this paper
• NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression

  2022cites this paper
• Target c-Myc to treat pancreatic cancer

  2022cites this paper
• Salt-inducible kinase 3 protects tumor cells from cytotoxic T-cell attack by promoting TNF-induced NF-κB activation

  2022cites this paper
• Wnt Signaling in the Development of Bone Metastasis

  2022cites this paper
• Effects of Ketamine, S-Ketamine and MK 801 on Integrin Beta-3-mediated Cell Migration in Pancreatic Carcinoma

  2022cites this paper
• Aberrant transcription factors in the cancers of the pancreas.

  2022cites this paper
• Put in a “Ca2+ll” to Acute Myeloid Leukemia

  2022cites this paper
• NFAT1 Orchestrates Spinal Microglial Transcription and Promotes Microglial Proliferation via c‐MYC Contributing to Nerve Injury‐Induced Neuropathic Pain

  2022cites this paper
• Novel Semi-Synthetic Cu (II)–Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway

  2021cites this paper
• MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies

  2021cites this paper
• Expression, Prognosis and Gene Regulation Network of NFAT Transcription Factors in Non-Small Cell Lung Cancer

  2021cites this paper
• Promoter Hypermethylation Promotes the Binding of Transcription Factor NFATc1, Triggering Oncogenic Gene Activation in Pancreatic Cancer

  2021cites this paper
• STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer

  2021cites this paper
• Calcineurin in development and disease

  2021cites this paper
• TRPC3 promotes tumorigenesis of gastric cancer via the CNB2/GSK3β/NFATc2 signaling pathway.

  2021cites this paper
• The Effect of Cyclosporine A on Proteins Controlling Intracellular Calcium Concentration in Breast Cancer Cells

  2021cites this paper
• The potential roles of p53 signaling reactivation in pancreatic cancer therapy.

  2021cites this paper
• T-cell Immunometabolism: Therapeutic Implications in Organ Transplantation.

  2021cites this paper
• Isoform-Selective NFAT Inhibitor: Potential Usefulness and Development

  2021cites this paper
• Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer

  2021cites this paper
• Establishment and verification of a prognostic tumor microenvironment-based and immune-related gene signature in colon cancer.

  2021cites this paper
• Targeting age‐specific changes in CD4+ T cell metabolism ameliorates alloimmune responses and prolongs graft survival

  2021cites this paper
• Calcineurin Immune Signaling in Response to Zinc Challenge in the Naked Carp Gymnocypris eckloni

  2021cites this paper
• DGG-100629 inhibits lung cancer growth by suppressing the NFATc1/DDIAS/STAT3 pathway

  2021cites this paper
• Chromatin-Independent Interplay of NFATc1 and EZH2 in Pancreatic Cancer

  2021cites this paper
• Human Bone Marrow-Derived Mesenchymal Stem Cell-Secreted Exosomes Overexpressing Microrna-124-3p Inhibit DLBCL Progression By Downregulating  NFATc1

  2020cites this paper
• Promising models for cancer-induced cachexia drug discovery

  2020cites this paper
• Pharmacogenomics of Immunosuppressants

  2020cites this paper
• Bufalin inhibits human diffuse large B cell lymphoma tumorigenesis by inducing cell death through the Ca 2+/NFATC1/cMYC pathway.

  2020cites this paper
• Triptolide targets super-enhancer networks in pancreatic cancer cells and cancer-associated fibroblasts

  2020cites this paper
• Mechanisms of T-Cell Exhaustion in Pancreatic Cancer

  2020cites this paper
• Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

  2020cites this paper
• A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma

  2020cites this paper
• NFAT2 overexpression suppresses the malignancy of hepatocellular carcinoma through inducing Egr2 expression

  2020cites this paper
• Transportome Malfunctions and the Hallmarks of Pancreatic Cancer.

  2020cites this paper
• Tacrolimus and ascomycin inhibit melanoma cell growth, migration and invasion via targeting nuclear factor of activated T-cell 3

  2020cites this paper
• MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?

  2020cites this paper
• Two Birds with One Stone: NFAT1-MDM2 Dual Inhibitors for Cancer Therapy †

  2020cites this paper
• Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

  2020cites this paper
• NFAT Overexpression Correlates with CA72-4 and Poor Prognosis of Ovarian Clear-Cell Carcinoma Subtype

  2020cites this paper
• NFATC4 Promotes Quiescence and Chemotherapy Resistance in Ovarian Cancer

  2019cites this paper
• Perturbing Enhancer Activity in Cancer Therapy

  2019cites this paper
• MiR‐338 regulates NFATc1 expression and inhibits the proliferation and epithelial‐mesenchymal transition of human non‐small‐cell lung cancer cells

  2019cites this paper
• Involvement of JNK signaling pathway in lipopolysaccharide‐induced complement C3 transcriptional activation from amphioxus Branchiostoma belcheri

  2019cites this paper
• Lessons to Learn From Low-Dose Cyclosporin-A: A New Approach for Unexpected Clinical Applications

  2019cites this paper
• The critical role of calcineurin/NFAT (C/N) pathways and effective antitumor prospect for colorectal cancers

  2019cites this paper
• Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

  2019cites this paper
• SRC-3/AIB-1 Enhances Hepatic NFATC1 Transcription and Mediates Inflammation in a Tissue-Specific Manner in Morbid Obesity.

  2019cites this paper
• High expression of NFAT2 contributes to carboplatin resistance in lung cancer.

  2019cites this paper
• Higher expression of calcineurin predicts poor prognosis in unique subtype of ovarian cancer

  2019cites this paper
• Down-Regulation of Nfatc1 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Prostate Cancer Cells

  2019cites this paper
• NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4

  2019cites this paper
• WNK1 promotes renal tumor progression by activating TRPC6‐NFAT pathway

  2019cites this paper
• The active role of the transcription factor Sp1 in NFATc2-mediated gene regulation in pancreatic cancer

  2019cites this paper
• NFAT2-HDAC1 signaling contributes to the malignant phenotype of glioblastoma.

  2019cites this paper
• Palbociclib, a selective CDK4/6 inhibitor, restricts cell survival and epithelial‐mesenchymal transition in Panc‐1 and MiaPaCa‐2 pancreatic cancer cells

  2019cites this paper
• High-performance gene expression and knockout tools using sleeping beauty transposon system

  2018cites this paper
• Cyclosporine A Suppresses the Malignant Progression of Oral Squamous Cell Carcinoma in vitro.

  2018cites this paper
• Curcumin in Cancer Prevention

  2018cites this paper
• An Updated Review of Oral Cancer Stem Cells and Their Stemness Regulation.

  2018cites this paper
• PPP3CB contributes to poor prognosis through activating nuclear factor of activated T‐cells signaling in neuroblastoma

  2018cites this paper
• Ca2+/nuclear factor of activated T cells signaling is enriched in early-onset rectal tumors devoid of canonical Wnt activation

  2018cites this paper
• The Calcineurin-NFAT Pathway and Regulation of Pancreatic Function

  2018cites this paper
• B-cell receptor-mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma.

  2018cites this paper
• Arsenite increases Cyclin D1 expression through coordinated regulation of the Ca2+/NFAT2 and NF-κB pathways via ERK/MAPK in a human uroepithelial cell line.

  2018cites this paper
• CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a

  2018cites this paper
• FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients

  2018cites this paper
• NFATc1 is a tumor suppressor in hepatocellular carcinoma and induces tumor cell apoptosis by activating the FasL‐mediated extrinsic signaling pathway

  2018cites this paper
• Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism.

  2018cites this paper
• Impact of Immunosuppressive Drugs on the Metabolism of T Cells.

  2018cites this paper
• Human papillomavirus (HPV) oncoprotein E6 facilitates Calcineurin‐Nuclear factor for activated T cells 2 (NFAT2) signaling to promote cellular proliferation in cervical cell carcinoma

  2018cites this paper
• Arsenic sulfide amplifies JQ1 toxicity via mitochondrial pathway in gastric and colon cancer cells

  2018cites this paper
• Calcium signaling and cell cycle: Progression or death.

  2017cites this paper
• mRNA expression of nuclear factor of activated T-cells, cytoplasmic 2 (NFATc2) and peroxisome proliferator-activated receptor gamma (PPARG) transcription factors in colorectal carcinoma.

  2017cites this paper
• NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract

  2017cites this paper
• Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

  2017cites this paper
• Analysis of gene expression profiling variations induced by hsa-miR-145-5p-overexpression in laryngeal squamous cell carcinoma cell line Tu-177

  2017cites this paper