Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex.

No abstract is available for this paper.

• Publication year

  1984

• Venue

  Science

• Publication date

  1984-08-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.6206567PMID 6206567
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Alterations in protein synthetic capability of nerve cells in Alzheimer's disease.

  1981cited by this paper
• RIBONUCLEASE ACTIVITIES IN VARIOUS CLASSES OF NUCLEI FROM BOVINE CEREBRUM

  1979cited by this paper
• Role of mammalian RNase inhibitor in cell-free protein synthesis.

  1979cited by this paper
• Rat brain ribonucleases.

  1978cited by this paper
• Ribonuclease inhibitor from human placenta. Purification and properties.

  1977cited by this paper
• Purification of an akaline ribonuclease from soluble fraction of beef brian

  1975cited by this paper
• Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver.

  1975cited by this paper
• Alkaline ribonuclease and ribonuclease inhibitor in mammary gland during the lactation cycle and in the R3230AC mammary tumour.

  1975cited by this paper
• Purification of an alkaline ribonuclease from soluble fraction of beef brain.

  1975cited by this paper
• Ribonucleases of beef brain nuclei. Purification and characterization of an alkaline RNAase.

  1974cited by this paper
• Specificity of the natural rat liver ribonuclease inhibitor towards nuclease activities of subcellular fractions.

  1974cited by this paper
• Alkaline ribonuclease inhibitor in rat thyroid.

  1972cited by this paper
• A suggested control function for the animal tissue ribonuclease-ribonuclease inhibitor system, based on studies of isolated cells and phytohaemagglutinin-transformed lymphocytes.

  1970cited by this paper
• PURIFICATION AND CHARACTERISTICS OF RNase INHIBITOR FROM PIG CEREBRAL CORTEX

  1970cited by this paper
• Preparation of polysomes from rat brain tissue.

  1966cited by this paper
• The inhibition of rat liver polyribosome breakdown in the presence of liver supernatant.

  1966cited by this paper
• Changes in the activity of rat adrenal ribonuclease and ribonuclease inhibitor after administration of corticotrophin.

  1965cited by this paper
• STUDIES OF BRAIN LYSOSOMES—I SUBCELLULAR DISTRIBUTION OF FIVE ACID HYDROLASES, SUCCINATE DEHYDROGENASE AND GANGLIOSIDES IN RAT BRAIN *

  1964cited by this paper
• Ribonuclease. IX. Further studies on ribonuclease inhibitor.

  1962cited by this paper
• Ribonuclease. VIII. Studies on the inactive ribonuclease in the supernatant fraction of rat liver.

  1958cited by this paper
• Ribonuclease. V. Studies on the properties and distribution of ribonuclease inhibitor in the rat.

  1956cited by this paper

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  2024cites this paper
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  2023cites this paper
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• References

  2021cites this paper
• References

  2021cites this paper
• Susceptibility to gingipains and transcriptomic response to P. gingivalis highlights the ribosome, hypothalamus, and cholinergic neurons

  2020cites this paper
• Dysregulation of the de novo proteome accompanies pathology progression in the APP/PS1 mouse model of Alzheimer’s disease

  2020cites this paper
• Characterization of Cerebellum-Specific Ribosomal DNA Epigenetic Modifications in Alzheimer’s Disease: Should the Cerebellum Serve as a Control Tissue After All?

  2020cites this paper
• Alzheimer's disease.

  2020cites this paper
• Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia

  2020cites this paper
• Age-dependent shift in the de novo proteome accompanies pathogenesis in an Alzheimer’s disease mouse model

  2020cites this paper
• Tau-mediated dysregulation of RNA: Evidence for a common molecular mechanism of toxicity in frontotemporal dementia and other tauopathies.

  2020cites this paper
• Evidence for nucleolar dysfunction in Alzheimer’s disease

  2019cites this paper
• Donor specific transcriptomic analysis of Alzheimer’s disease associated hypometabolism highlights a unique donor, microglia, and ribosomal proteins

  2019cites this paper
• Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model

  2019cites this paper
• Tau drives translational selectivity by interacting with ribosomal proteins

  2019cites this paper
• Neuroprotective effects of a novel carnosine-hydrazide derivative on hippocampal CA1 damage after transient cerebral ischemia.

  2019cites this paper
• Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer’s disease mouse model

  2019cites this paper
• Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimerâ€TMs disease mouse model

  2018cites this paper
• Molecular properties underlying regional vulnerability to Alzheimer’s disease pathology

  2018cites this paper
• Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress

  2018cites this paper
• A Selection of Important Genes and Their Correlated Behavior in Alzheimer’s Disease

  2018cites this paper
• Biological Functions of ribonuclease 1 and angiogenin

  2018cites this paper
• Sequestration of Ribosome during Protein Aggregate Formation: Contribution of ribosomal RNA

  2017cites this paper
• Altered mechanisms of protein synthesis in frontal cortex in Alzheimer disease and a mouse model.

  2017cites this paper
• Identification of learning-induced changes in protein networks in the hippocampi of a mouse model of Alzheimer's disease

  2016cites this paper
• Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome

  2016cites this paper
• Nuclear Tau and Its Potential Role in Alzheimer’s Disease

  2016cites this paper
• Oxidative stress and lipid peroxidation are upstream of amyloid pathology.

  2015cites this paper
• Energy metabolism and Protein synthesis in Parkinson's disease and Dementia with Lewy Bodies

  2015cites this paper
• Role of 4-Hydroxynonenal-Protein Adducts in Human Diseases

  2015cites this paper
• Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

  2015cites this paper
• Oxidative Stress and Proteostasis Network: Culprit and Casualty of Alzheimer’s-Like Neurodegeneration

  2014influential citation
• Effects of Oxidative Stress on the Solubility of HRD1, a Ubiquitin Ligase Implicated in Alzheimer’s Disease

  2014cites this paper
• Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain.

  2013cites this paper
• Interaction of aldehydes derived from lipid peroxidation and membrane proteins

  2013cites this paper
• Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

  2012cites this paper
• 4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

  2012cites this paper
• Impairment of protein synthesis is an early effect of amyloid-β in neurons

  2012cites this paper
• Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease

  2011cites this paper
• A Novel Origin for Granulovacuolar Degeneration in Aging and Alzheimer’s Disease: Parallels to Stress Granules

  2011cites this paper
• Lipid peroxidation and neurodegenerative disease.

  2011cites this paper
• Redox Proteomics of Oxidatively Modified Brain Proteins in Mild Cognitive Impairment

  2010cites this paper
• Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E.

  2009cites this paper
• mTOR-dependent signalling in Alzheimer's disease

  2008cites this paper
• Nuclear bodies in neurodegenerative disease.

  2008cites this paper
• Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease.

  2008cites this paper
• Abnormalities of the nucleus and nuclear inclusions in neurodegenerative disease: a work in progress

  2007cites this paper
• On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease

  2006cites this paper
• Ribosome Dysfunction Is an Early Event in Alzheimer's Disease

  2005cites this paper
• Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron*

  2005cites this paper
• Influence of vitamin B12 on brain methionine adenosyltransferase activity in senile dementia of the Alzheimer's type

  2005cites this paper
• Immunohistochemical study of the hnRNP A2 and B1 in the hippocampal formations of brains with Alzheimer's disease.

  2005cites this paper
• Biochemical and molecular studies using human autopsy brain tissue

  2003cites this paper
• How important are brain banks for alcohol research?

  2003cites this paper
• Effect of Chromium on Certain Aspects of Metabolic Toxicities

  2003cites this paper
• Brain aging and Alzheimer's disease; use it or lose it.

  2002cites this paper
• Human Brain Nascent Polypeptide-associated Complex α Subunit Is Decreased in Patients with Alzheimer's Disease and Down Syndrome

  2002cites this paper
• Alterations in the interaction between iron regulatory proteins and their iron responsive element in normal and Alzheimer's diseased brains.

  2000cites this paper
• Diminished neuronal metabolic activity in Alzheimer's disease

  1999cites this paper
• Decrease in Peptide Methionine Sulfoxide Reductase in Alzheimer's Disease Brain

  1999cites this paper
• The Expression of Several Mitochondrial and Nuclear Genes Encoding the Subunits of Electron Transport Chain Enzyme Complexes, Cytochrome c Oxidase, and NADH Dehydrogenase, in Different Brain Regions in Alzheimer's Disease

  1999cites this paper
• Skeletal muscle ribonuclease activities in chronically ethanol-treated rats.

  1998cites this paper
• Impact of protein malnutrition on subcellular nucleic acid and protein status of brain of aluminum-exposed rats.

  1998cites this paper
• The expression of key oxidative stress-handling genes in different brain regions in alzheimer’s disease

  1998cites this paper
• Expression of GABA(A) receptor isoform genes in the cerebral cortex of cirrhotic and alcoholic cases assessed by S1 nuclease protection assays.

  1998cites this paper
• Reduced neuronal activity and reactivation in Alzheimer's disease.

  1998cites this paper
• Reduced Neuronal Activity is One of the Major Hallmarks of Alzheimer’s Disease

  1997cites this paper
• 19 – Ribonuclease Inhibitor

  1997cites this paper
• Secretion of ribonucleases by normal and immortalized cells grown in serum-free culture conditions

  1997cites this paper
• Microdensitometric measures of cytoplasmic RNA and total protein in pyramidal neurons of the insular cortex and midfrontal gyrus in patients with Alzheimer's disease

  1995cites this paper
• Thiol-Disulfide Exchange of Ribonuclease Inhibitor Bound to Ribonuclease A EVIDENCE OF ACTIVE INHIBITOR-BOUND RIBONUCLEASE (*)

  1995cites this paper
• Distribution and expression of the alpha-tubulin mRNA in the hippocampus and the temporal cortex in Alzheimer's disease.

  1995cites this paper
• Purification and characterization of human brain ribonuclease inhibitor.

  1994cites this paper
• NGF mRNA is not decreased in frontal cortex from Alzheimer's disease patients.

  1994cites this paper
• Preliminary evidence: decreased GAP-43 message in tangle-bearing neurons relative to adjacent tangle-free neurons in Alzheimer's disease parahippocampal gyrus.

  1994cites this paper
• Expression of the β-Amyloid Precursor Protein Gene and the Pathogenesis of Alzheimer’s Disease

  1994cites this paper
• Modulation of cytosolic RNase activity by endogenous RNase inhibitor in rat vaginal epithelial cells on estradiol administration

  1994cites this paper
• Pre‐and Postmortem Influences on Brain RNA

  1993cites this paper
• The brain-to-liver mercury ratio increases with aging in mice.

  1993cites this paper
• Structure and action of mammalian ribonuclease (angiogenin) inhibitor.

  1993cites this paper
• Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases.

  1993cites this paper
• Characterisation of a tryptic peptide from human placental ribonuclease inhibitor which inhibits ribonuclease activity.

  1992cites this paper
• DNA repair mechanisms in neurological diseases: facts and hypotheses.

  1992cites this paper
• RNA Metabolism in Human Brain During Aging and in Alzheimer’s Disease: Rna Synthesis in the Nuclei Isolated from Postmortem Brain Tissue

  1992cites this paper
• Increased phosphorylation of elongation factor 2 in Alzheimer's disease.

  1992cites this paper
• Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease.

  1992cites this paper
• Spectrophotometric ribonuclease assays using dinucleoside monophosphate substrates.

  1992cites this paper
• Aluminum interrupts the formation of alkaline-ribonuclease-inhibitor complex from bovine brain.

  1991cites this paper
• Differential expression of beta amyloid protein precursor (APP) and tau mRNA in the aged human brain: individual variability and correlation between APP-751 and four-repeat tau.

  1991cites this paper
• Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

  1991cites this paper