mTOR-dependent signalling in Alzheimer's disease

J. Pei,J. Hugon

Published 2008 in Journal of Cellular and Molecular Medicine

ABSTRACT

•  Introduction •  Neurodegeneration and neurofibrillary degeneration in Alzheimer's disease brains •  Dysfunction of protein synthesis mediated by mTOR‐dependent signalling in Alzheimer's disease brains •  Neurodegeneration mediated by mTOR‐dependent signalling •  Tau phosphorylation mediated by mTOR‐dependent signalling •  mTOR‐dependent signalling in lymphocytes of AD: potential biomarkers for AD diagnosis •  mTOR‐dependent signalling and other neurodegenerative diseases •  Perspectives •  Conclusions

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