Retinoic acid regulatory pathways, chromosomal translocations, and acute promyelocytic leukemia

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Genes, Chromosomes and Cancer

• Publication date

  1996-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/(SICI)1098-2264(199603)15:3<147::AID-GCC1>3.0.CO;2-2PMID 8721678
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1996cited by this paper
• The PML gene encodes a phosphoprotein associated with the nuclear matrix.

  1995cited by this paper
• OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor.

  1995cited by this paper
• The PML growth-suppressor has an altered expression in human oncogenesis.

  1995cited by this paper
• A retinoic acid-triggered cascade of HOXB1 gene activation.

  1995cited by this paper
• Unique response pathways are established by allosteric interactions among nuclear hormone receptors.

  1995cited by this paper
• Acute promyelocytic leukemia: From clinic to molecular biology

  1995cited by this paper
• Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

  1995cited by this paper
• Characterization of acute promyelocytic leukemia cases with PML-RAR alpha break/fusion sites in PML exon 6: identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid.

  1995cited by this paper
• Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain.

  1995cited by this paper
• All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia. Japan Adult Leukemia Study Group.

  1995cited by this paper
• Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4.

  1995cited by this paper
• RAR‐specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage‐independent cell proliferation.

  1995cited by this paper
• 9-cis retinoic acid induces complete remission but does not reverse clinically acquired retinoid resistance in acute promyelocytic leukemia.

  1995cited by this paper
• Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia.

  1995cited by this paper
• Retinoic acid receptors and cellular retinoid binding proteins: complex interplay in retinoid signaling.

  1994cited by this paper
• The POZ domain: a conserved protein-protein interaction motif.

  1994cited by this paper
• TRANSLOCATION OF THE RARα LOCUS TO THE PML OR PLZF GENE IN ACUTE PROMYELOCYTIC LEUKAEMIA

  1994cited by this paper
• Molecular analysis of simple variant translocations in acute promyelocytic leukemia

  1994cited by this paper
• Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants.

  1994cited by this paper
• PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

  1994cited by this paper
• Acute promyelocytic leukemia: from genetics to treatment.

  1994cited by this paper
• The t(15;17) translocation alters a nuclear body in a retinoic acid‐reversible fashion.

  1994cited by this paper
• Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

  1994cited by this paper
• Identification of illegitimate recombination hot spot of the retinoic acid receptor alpha gene involved in 15;17 chromosomal translocation of acute promyelocytic leukemia.

  1994cited by this paper
• Acute promyelocytic leukemia with t(15; 17) abnormality after chemotherapy containing etoposide for langerhans' cell histiocytosis

  1994cited by this paper
• PML, a growth suppressor disrupted in acute promyelocytic leukemia

  1994cited by this paper
• Function of the retinoic acid receptors (RARs) during development (I). Craniofacial and skeletal abnormalities in RAR double mutants.

  1994cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Interstitial insertion of retinoic acid receptor-alpha gene in acute promyelocytic leukemia with normal chromosomes 15 and 17.

  1994cited by this paper
• Poor response to all-trans retinoic acid therapy in a t(11;17) PLZF/RAR alpha patient.

  1994cited by this paper
• A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein.

  1994cited by this paper
• Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines.

  1994cited by this paper
• Regulation of the expression of annexin VIII in acute promyelocytic leukemia.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
• Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.

  1994cited by this paper
• Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells.

  1994cited by this paper
• Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

  1994cited by this paper
• Early mortality and the retinoic acid syndrome in acute promyelocytic leukemia: impact of leukocytosis, low-dose chemotherapy, PMN/RAR-alpha isoform, and CD13 expression in patients treated with all-trans retinoic acid.

  1994cited by this paper
• Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

  1994cited by this paper
• Translocation of the RAR alpha locus to the PML or PLZF gene in acute promyelocytic leukaemia.

  1994cited by this paper
• The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells.

  1993cited by this paper
• Resistance to all-trans retinoic acid (ATRA) therapy in relapsing acute promyelocytic leukemia: study of in vitro ATRA sensitivity and cellular retinoic acid binding protein levels in leukemic cells.

  1993cited by this paper
• Localization of the chromosome 15 breakpoints and expression of multiple PML-RAR alpha transcripts in acute promyelocytic leukemia: a study of 28 Chinese patients.

  1993cited by this paper
• A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage.

  1993cited by this paper
• Detection of minimal residual disease in acute promyelocytic leukemia by a reverse transcription polymerase chain reaction assay for the PML/RAR-alpha fusion mRNA.

  1993cited by this paper
• Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.

  1993cited by this paper
• Molecular Heterogeneity of the PML Gene Rearrangement in Acute Promyelocytic Leukemia: Prevalence and Clinical Significance

  1993cited by this paper
• Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein.

  1993cited by this paper
• Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

  1993cited by this paper
• PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

  1993cited by this paper
• Treatment of acute promyelocytic leukemia with all-trans retinoic acid. A five-year experience.

  1993cited by this paper
• Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

  1993cited by this paper
• Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

  1993cited by this paper
• Multi-institutional study of all-trans-retinoic acid as a differentiation therapy of refractory acute promyelocytic leukemia. Leukaemia Study Group of the Ministry of Health and Welfare.

  1993cited by this paper
• Acute promyelocytic leukemia.

  1993cited by this paper
• Breakpoint clusters of the PML gene in acute promyelocytic leukemia: Primary structure of the reciprocal products of the PML‐RARA gene in a patient with t(15;17)

  1993cited by this paper
• Multi-institutional study of all-trans retinoic acid as a differentiation therapy of refractory acute promyelocytic leukemia

  1993cited by this paper
• Acute promyelocytic leukemia with t(15;17) abnormality after chemotherapy containing etoposide for langerhans cell histiocytosis

  1993cited by this paper
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  1993cited by this paper
• The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

  1993cited by this paper
• Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

  1992cited by this paper
• 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

  1992cited by this paper
• Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia

  1992cited by this paper
• Occurrence of distinct PML-RAR-alpha fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction.

  1992cited by this paper
• A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.

  1992cited by this paper
• Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia.

  1992cited by this paper
• PML/RAR‐α rearrangement in acute promyelocytic leukaemias apparently lacking the t(15;17) translocation

  1992cited by this paper
• Retinoic acid in the treatment of acute promyelocytic leukemia: Inefficacy of the 13-cis isomer and induction of complete remission by the all-trans isomer complicated by thromboembolic events

  1992cited by this paper
• Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.

  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
• Retinoic acid-resistant HL-60R cells harbor a point mutation in the retinoic acid receptor ligand-binding domain that confers dominant negative activity.

  1992cited by this paper
• Transcriptional regulation by the nuclear receptor superfamily.

  1992cited by this paper
• Retinoids in cancer therapy.

  1992cited by this paper
• Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL, M3) define a breakpoint cluster region as well as some molecular variants.

  1992cited by this paper
• Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.

  1992cited by this paper
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  1992cited by this paper
• 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

  1992cited by this paper
• Multiplicity generates diversity in the retinoic acid signalling pathways.

  1992cited by this paper
• Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.

  1992cited by this paper
• Retinoids and their receptors in differentiation, embryogenesis, and neoplasia

  1991cited by this paper
• The retinoic acid alpha receptor gene is frequently disrupted in its 5' part in Chinese patients with acute promyelocytic leukemia.

  1991cited by this paper
• Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation.

  1991cited by this paper
• Retinoids and their receptors in differentiation, embryogenesis, and neoplasia.

  1991cited by this paper
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  1991cited by this paper
• The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

  1991cited by this paper
• Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.

  1991cited by this paper
• Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).

  1991cited by this paper
• The Family of Retinoic Acid Nuclear Receptors

  1991cited by this paper
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  1991cited by this paper
• NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).

  1991cited by this paper
• Pharmacokinetics of oral all-trans retinoic acid in patients with acute promyelocytic leukemia.

  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Reading the retinoid signals

  1990cited by this paper
• All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.

  1990cited by this paper

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