Sonic hedgehog signalling in T-cell development and activation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Nature reviews. Immunology

• Publication date

  2007-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nri2151PMID 17690714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Zoned out: functional mapping of stromal signaling microenvironments in the thymus.

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• Bone morphogenetic protein‐2/4 signalling pathway components are expressed in the human thymus and inhibit early T‐cell development

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• The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development.

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• Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling.

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• β-Selection: Abundance of TCRβ–/γδ– CD44–CD25– (DN4) cells in the foetal thymus

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• Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation

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  2006cited by this paper
• Trafficking on serpentines: molecular insight on how maturating T cells find their winding paths in the thymus

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• The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes.

  2005cited by this paper
• Sonic Hedgehog Is Produced by Follicular Dendritic Cells and Protects Germinal Center B Cells from Apoptosis1

  2005cited by this paper
• Communicating with Hedgehogs

  2005cited by this paper
• Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms.

  2005cited by this paper
• Shaping the T Cell Repertoire1

  2005cited by this paper
• Immunohistochemical staining of hedgehog pathway-related proteins in human thymomas.

  2005cited by this paper
• Regulation of lymphoid development, differentiation, and function by the Notch pathway.

  2005cited by this paper
• CD4-CD8 lineage commitment: an inside view

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• A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube.

  2005cited by this paper
• Thymic T Cell Development and Progenitor Localization Depend on CCR7

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• Notch regulation of lymphocyte development and function

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• An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis

  2004cited by this paper
• Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development

  2004cited by this paper
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• The role of morphogens in T-cell development.

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• BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis.

  2003cited by this paper
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  2003cited by this paper
• Expression of Hedgehog Proteins in the Human Thymus

  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Embryonic origins of mammalian hematopoiesis.

  2003cited by this paper
• A positive look at double-negative thymocytes

  2002cited by this paper
• Regulation of thymocyte differentiation: pre-TCR signals and beta-selection.

  2002cited by this paper
• The Developmentally Regulated Expression of Twisted Gastrulation Reveals a Role for Bone Morphogenetic Proteins in the Control of T Cell Development

  2002cited by this paper
• Sonic Hedgehog Promotes Cell Cycle Progression in Activated Peripheral CD4+ T Lymphocytes1

  2002cited by this paper
• Bone Morphogenetic Protein 2/4 Signaling Regulates Early Thymocyte Differentiation1

  2002cited by this paper
• Wnt‐1 and Wnt‐4 regulate thymic cellularity

  2002cited by this paper
• Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development.

  2002cited by this paper
• Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3.

  2002cited by this paper
• Role of thymic organ structure and stromal composition in steady‐state postnatal T‐cell production

  2002cited by this paper
• On the brink of becoming a T cell.

  2002cited by this paper
• Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells1

  2002cited by this paper
• Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.

  2002cited by this paper
• Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

  2002cited by this paper
• T-cell development and the CD4–CD8 lineage decision

  2002cited by this paper
• Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling.

  2002cited by this paper
• Gli and hedgehog in cancer: tumours, embryos and stem cells

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• Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling.

  2002cited by this paper
• Eyes Absent, a key repressor of polar cell fate during Drosophila oogenesis

  2002cited by this paper
• Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset.

  2001cited by this paper
• Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

  2001cited by this paper
• Immature thymocytes that fail to express TCRβ and/or TCRγ δ proteins die by apoptotic cell death in the CD44‐CD25‐ (DN4) subset

  2001cited by this paper
• The Hedgehog and Wnt signalling pathways in cancer

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• The Fetal Liver Counterpart of Adult Common Lymphoid Progenitors Gives Rise to All Lymphoid Lineages, CD45+CD4+CD3− Cells, As Well As Macrophages1

  2001cited by this paper
• Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

  2001cited by this paper
• Hedgehog signaling in animal development: paradigms and principles.

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• T cell progenitors emerge earlier than B cell progenitors in the murine fetal liver.

  2000cited by this paper
• Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities.

  2000cited by this paper
• Mouse Gli 1 mutants are viable but have defects in SHH signaling in combination with a Gli 2 mutation

  2000cited by this paper
• Thymus organogenesis and molecular mechanisms of thymic epithelial cell differentiation.

  2000cited by this paper
• Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte.

  2000cited by this paper
• Precursor Thymocyte Proliferation and Differentiation Are Controlled by Signals Unrelated to the Pre-TCR1

  2000cited by this paper
• Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.

  2000cited by this paper
• Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.

  2000cited by this paper
• The specification of neuronal identity by graded Sonic Hedgehog signalling.

  1999cited by this paper
• Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.

  1999cited by this paper
• Gli genes in development and cancer

  1999cited by this paper
• Sonic Hedgehog-induced Activation of the Gli1Promoter Is Mediated by GLI3*

  1999cited by this paper
• Studies on the phenotype of migrant thymic stem cells

  1999cited by this paper
• Deficient T cell fate specification in mice with an induced inactivation of Notch1.

  1999cited by this paper
• Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.

  1999cited by this paper
• Critical involvement of Tcf-1 in expansion of thymocytes.

  1998cited by this paper
• The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice.

  1998cited by this paper
• Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.

  1997cited by this paper
• Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

  1996cited by this paper
• Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

  1996cited by this paper
• Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity.

  1996cited by this paper
• An HMG-box-containing T-cell factor required for thymocyte differentiation

  1995cited by this paper
• Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

  1993cited by this paper
• Control points in early T-cell development.

  1993cited by this paper
• RAG-1-deficient mice have no mature B and T lymphocytes.

  1992cited by this paper

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