Glutathione S-transferases: reaction mechanism, structure, and function.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Chemical Research in Toxicology

• Publication date

  1991-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/TX00020A001PMID 1782341
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of action of glutathione-dependent enzymes.

  2006cited by this paper
• The glutathione-binding site in glutathione S-transferases. Investigation of the cysteinyl, glycyl and gamma-glutamyl domains.

  1990cited by this paper
• Construction, expression, and preliminary characterization of chimeric class μ glutathione S‐transferases with altered catalytic properties

  1990cited by this paper
• Crystallization of glutathione S-transferase from human placenta.

  1990cited by this paper
• Expression in Escherichia coli of rat liver cytosolic glutathione S-transferase Yc cDNA.

  1990cited by this paper
• Crystallization of GST2, a human class alpha glutathione transferase.

  1989cited by this paper
• Expression of a cDNA encoding a rat liver glutathione S-transferase Ya subunit in Escherichia coli.

  1989cited by this paper
• Observation of a substituent effect on the stereoselectivity of glutathione S-transferase toward para-substituted 4-phenyl-3-buten-2-ones.

  1989cited by this paper
• Formation of the 1-(S-glutathionyl)-2,4,6-trinitrocyclohexadienate anion at the active site of glutathione S-transferase: evidence for enzymic stabilization of sigma-complex intermediates in nucleophilic aromatic substitution reactions.

  1989cited by this paper
• Glutathione S-transferases: gene structure, regulation, and biological function.

  1989cited by this paper
• Studies on the active site of rat glutathione S-transferase isoenzyme 4-4. Chemical modification by tetrachloro-1,4-benzoquinone and its glutathione conjugate.

  1989cited by this paper
• Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase.

  1989cited by this paper
• Interaction of rat glutathione S-transferases 7-7 and 8-8 with gamma-glutamyl- or glycyl-modified glutathione analogues.

  1989cited by this paper
• Localization of a portion of the active site of two rat liver glutathione S-transferases using a photoaffinity label.

  1989cited by this paper
• Expression of an enzymatically active Yb3 glutathione S-transferase in Escherichia coli and identification of its natural form in rat brain.

  1988cited by this paper
• Substrate specificity of rat liver glutathione S-transferase isoenzymes for a series of glutathione analogues, modified at the gamma-glutamyl moiety.

  1988cited by this paper
• Synthesis and nucleophilic reactivity of a series of glutathione analogues, modified at the gamma-glutamyl moiety.

  1988cited by this paper
• Active site-directed irreversible inhibition of glutathione S-transferases by the glutathione conjugate of tetrachloro-1,4-benzoquinone.

  1988cited by this paper
• Glutathione transferase from bovine placenta. Preparation, biochemical characterization, crystallization, and preliminary crystallographic analysis of a neutral class PI enzyme.

  1988cited by this paper
• Glutathione transferases--structure and catalytic activity.

  1988cited by this paper
• Dissection of the catalytic mechanism of isozyme 4-4 of glutathione S-transferase with alternative substrates.

  1988cited by this paper
• Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family.

  1988cited by this paper
• The Meisenheimer complex of glutathione and trinitrobenzene. A potent inhibitor of the glutathione S-transferase from Galleria mellonella.

  1988cited by this paper
• Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain.

  1987cited by this paper
• Expression of human glutathione S-transferase 2 in Escherichia coli. Immunological comparison with the basic glutathione S-transferases isoenzymes from human liver.

  1987cited by this paper
• Evidence for the involvement of histidine at the active site of glutathione S-transferase psi from human liver.

  1987cited by this paper
• Crystallization and a preliminary X-ray diffraction study of isozyme 3-3 of glutathione S-transferase from rat liver.

  1987cited by this paper
• Enzyme-catalyzed detoxication reactions: mechanisms and stereochemistry.

  1987cited by this paper
• Rat liver glutathione S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital.

  1986cited by this paper
• Cloning and sequence analysis of a cDNA for a rat liver glutathione S-transferase Yb subunit.

  1986cited by this paper
• Reactivity of small thiolate anions and cysteine-25 in papain toward methyl methanethiosulfonate.

  1986cited by this paper
• Rat glutathione S-transferases supergene family. Characterization of an anionic Yb subunit cDNA clone.

  1986cited by this paper
• Microsomal glutathione transferase. Primary structure.

  1985cited by this paper
• Investigation of the kinetic and stereochemical recognition of arene and azaarene oxides by isozymes A2 and C2 of glutathione S-transferase.

  1984cited by this paper
• Glutathione transferases: nomenclature.

  1984cited by this paper
• Stereoselectivity of isozyme C of glutathione S-transferase toward arene and azaarene oxides.

  1983cited by this paper
• Microsomal glutathione transferase. Purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition.

  1983cited by this paper

• Design, synthesis, and antifungal evaluation of Prp8 Intein-targeting small molecule inhibitors against Cryptococcus neoformans.

  2026cites this paper
• Differential proteomic analysis reveals key players in rice resistance to Rhizoctonia solani pathogenesis.

  2025cites this paper
• Tetrahymena thermophila glutathione-S-transferase superfamily: an eco-paralogs gene network differentially responding to various environmental abiotic stressors and an update on this gene family in ciliates

  2025cites this paper
• Artificial Intelligence-Driven de Novo Design of Robust Enzymes to Enhance Their Performance.

  2025cites this paper
• Role of Aralkylamine N-Acetyltransferase in the Response to Antioxidative Stress in the Fruit Fly Drosophila Melanogaster Adults.

  2024cites this paper
• Low-molecular-weight thiol transferases in redox regulation and antioxidant defence

  2024influential citation
• Differential interactions of ethacrynic acid and diethyl maleate with glutathione S-transferases and their glutathione co-factor in the house fly.

  2024cites this paper
• Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer

  2024cites this paper
• Research advances in molecular mechanisms regulating heat tolerance in cool‐season turfgrasses

  2024cites this paper
• Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis

  2024cites this paper
• Effects of Hydrolysed Poultry Byproduct Meal on Metabolic, Inflammatory and Oxidative Parameters in Cats.

  2024cites this paper
• In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme

  2023influential citation
• Gcm counteracts Toll-induced inflammation and impacts hemocyte number through cholinergic signaling

  2023cites this paper
• (E)-2-Benzylidenecyclanones: Part XVIII Study the Possible Link between Glutathione Reactivity and Cancer Cell Cytotoxic Effects of Some Cyclic Chalcone Analogs A Comparison of the Reactivity of the Open-Chain and the Seven-Membered Homologs

  2023cites this paper
• Elucidating structure and dynamics of glutathione S-transferase from Rhipicephalus (Boophilus) microplus

  2022cites this paper
• Observing How Glutathione and S-Hexyl Glutathione Bind to Glutathione S-Transferase from Rhipicephalus (Boophilus) microplus

  2022influential citation
• Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress

  2022cites this paper
• Biophysical description of Bromosulfophthalein interaction with the 28-kDa glutathione transferase from Schistosoma japonicum.

  2022cites this paper
• iTRAQ-based quantitative proteomics analysis of defense responses triggered by the pathogen Rhizoctonia solani infection in rice

  2022cites this paper
• Structural and Functional Characterization of One Unclassified Glutathione S-Transferase in Xenobiotic Adaptation of Leptinotarsa decemlineata

  2021cites this paper
• Non-synonymous substitution of evolutionarily conserved residue in Tau class glutathione transferases alters structural and catalytic features.

  2021cites this paper
• Black mulberry (Morus nigra L.) polysaccharide ameliorates palmitate-induced lipotoxicity in hepatocytes by activating Nrf2 signaling pathway.

  2021cites this paper
• Structure and function of one unclassified-class glutathione S-transferase in Leptinotarsa decemlineata

  2021cites this paper
• Michael addition reaction of symmetrically halogenated bischalcones with reduced glutathione assessed by RP-HPLC and RP-HPLC-ESI-MS

  2021cites this paper
• Identification of glutathione-S-transferase m19 and m34 among responsive GST genes against 1-chloro-2,4-dinitrobenzene treatment of Tetrahymena thermophila.

  2021cites this paper
• Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

  2021cites this paper
• Enzymatic suppression activity of Alpinia galanga extract against polyphagous lepidopteran pest Spodoptera litura (Fabricius)

  2021cites this paper
• Potentiation Effects of Ficus sycomorus Active Fraction Against Permethrin-Resistant Field-Population of Anopheles coluzzii (Diptera: Culicidae)

  2021cites this paper
• Association Analysis of rs1695 and rs1138272 Variations in GSTP1 Gene and Breast Cancer Susceptibility

  2020cites this paper
• Detoxification Enzyme-Catalyzed Conjugation Reactions

  2020cites this paper
• Structural and biochemical characterization of a glutathione transferase from the citrus canker pathogen Xanthomonas.

  2020cites this paper
• Preformulation studies of l-glutathione: physicochemical properties, degradation kinetics, and in vitro cytotoxicity investigations

  2020cites this paper
• Comparative transcriptome analysis uncovers roles of hydrogen sulfide for alleviating cadmium toxicity in Tetrahymena thermophila

  2020cites this paper
• GLORYx: Prediction of the Metabolites Resulting from Phase 1 and Phase 2 Biotransformations of Xenobiotics

  2020cites this paper
• Nrf2 Activation and Its Coordination with the Protective Defense Systems in Response to Electrophilic Stress

  2020cites this paper
• A genetically encoded biosensor roKate for monitoring the redox state of the glutathione pool

  2019cites this paper
• Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both

  2019cites this paper
• Animal and plant factors which affect larkspur toxicosis in cattle: Sex, age, breed, and plant chemotype.

  2019cites this paper
• Integrated application of multi-omics provides insights into cold stress responses in pufferfish Takifugu fasciatus

  2019cites this paper
• Metabolism of Strained Rings: Glutathione S-transferase–Catalyzed Formation of a Glutathione-Conjugated Spiro-azetidine without Prior Bioactivation

  2019cites this paper
• Adaptive Responses to Electrophilic Stress and Reactive Sulfur Species as their Regulator Molecules

  2019influential citation
• Bio-inspired ultrasensitive colorimetric detection of methyl isothiocyanate on nylon-6 nanofibrous membrane: A comparison of biological thiol reactivities.

  2019cites this paper
• Genome-wide analysis of the Tetrahymena thermophila glutathione S-transferase gene superfamily.

  2019cites this paper
• Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

  2018cites this paper
• Monomeric Camelus dromedarius GSTM1 at low pH is structurally more thermostable than its native dimeric form

  2018cites this paper
• Glutathione transferase modulates acute ethanol‐induced sedation in Drosophila neurones

  2018influential citation
• Reagent‐induced asymmetric induction in addition reaction of reduced glutathione onto bis‐Mannich chalcones

  2018cites this paper
• Chapter 11 Substrate Specificities and Kinetic Parameters of Recombinant Drosophila melanogaster Glutathione S-Transferases E 6 and E 7

  2018cites this paper
• A comparative study on oxidative stress response in the hepatopancreas and midgut of the white shrimp Litopenaeus vannamei under gradual changes to low or high pH environment

  2018cites this paper
• Cometabolic degradation of thiophene with benzene as primary substrate

  2018cites this paper
• Simple, selective and fast detection of acrylamide based on glutathione S-transferase

  2018cites this paper
• Comparative sensitivity of the hepatopancreas and midgut in the white shrimp Litopenaeus vannamei to oxidative stress under cyclic serious/medium hypoxia

  2018cites this paper
• Substrate Specificities and Kinetic Parameters of Recombinant Drosophila melanogaster Glutathione S-Transferases E6 and E7

  2018cites this paper
• In silico Study of Iron, Zinc and Copper Binding Proteins of Pseudomonas syringae pv. lapsa: Emphasis on Secreted Metalloproteins

  2018cites this paper
• Highly sensitive colorimetric paper sensor for methyl isothiocyanate (MITC): Using its toxicological reaction

  2018cites this paper
• Effects of heavy metal stress on Chlamydomonas reinhardtii: A comprehensive study.

  2018cites this paper
• Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: A combined kinetic and docking study.

  2018cites this paper
• Prediction and characterization of the stability enhancing effect of the Cherry-Tag™ in highly concentrated protein solutions by complex rheological measurements and MD simulations.

  2017cites this paper
• Crystal structure of a class‐mu glutathione S‐transferase from whiteleg shrimp Litopenaeus vannamei: structural changes in the xenobiotic binding H‐site may alter the spectra of molecules bound

  2017cites this paper
• Evaluation of the Xenobiotic Effects of Various Stressors in the Hypothalamus and Test is of Laboratory Mouse with Special Reference to GST Gene

  2017cites this paper
• Human cytosolic glutathione-S-transferases: quantitative analysis of expression, comparative analysis of structures and inhibition strategies of isozymes involved in drug resistance

  2017cites this paper
• The Review of Certain In Vivo Antioxidant Effects on Essential Oils of Origanum Minutiflorum O Schwarz-Ph Davis, Juniperus Excelsa Bieb.subsp. Excelsa and Histopathologic Changes

  2017cites this paper
• Differential effects of metal ions on TCDD-induced cytotoxicity and cytochrome P4501A1 gene expression in a zebrafish liver (ZFL) cell-line.

  2016cites this paper
• Assembly of ligands interaction models for glutathione-S-transferases from Plasmodium falciparum, human and mouse using enzyme kinetics and molecular docking

  2016cites this paper
• Investigating State Restriction in Fluorescent Protein FRET Using Time-Resolved Fluorescence and Anisotropy

  2016cites this paper
• Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of Intranasally Administered Drugs.

  2016cites this paper
• Structure-cytotoxicity relationship of methacrylate-based resin monomers as evaluated by an anti-oxidant responsive element-luciferase reporter assay.

  2016cites this paper
• Application of synthetic insecticide and change in detoxifying enzyme levels in Culex quinquefasciatus Say

  2016cites this paper
• Radiosensitization of HT-29 Colorectal Cells and Xenografts by the Nitric Oxide Donor JSK

  2016cites this paper
• Development of Resistance Mechanism in Mosquitoes: Cytochrome P450, the Ultimate Detoxifier

  2016cites this paper
• Different Mechanisms of Drug Resistance in Myelodysplastic Syndromes and Acute Myeloid Leukemia

  2016cites this paper
• Oxidative Stress Responses and NRF2 in Human Leukaemia

  2015cites this paper
• GSTP1-1 and thiazolide-induced apoptosis in colon carcinoma cells

  2015cites this paper
• Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

  2015cites this paper
• Investigating the dual function of the chloride intracellular ion channel proteins

  2015cites this paper
• A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins.

  2015cites this paper
• Thermal‐ and urea‐induced unfolding processes of glutathione S‐transferase by molecular dynamics simulation

  2015cites this paper
• Purification and characterisation of recombinant human eukaryotic elongation factor 1 gamma.

  2014influential citation
• Efficacy of a Combined Treatment of Neem Oil Formulation and Endosulfan against Helicoverpa armigera (Hub.) (Lepidoptera: Noctuidae)

  2014cites this paper
• An Alternate Pathway of Arsenate Resistance in E. coli Mediated by the Glutathione S-Transferase GstB

  2014cites this paper
• In-vitro inhibition of camel hepatic glutathione transferase by Quercetin

  2014influential citation
• Inducible Expression of Mu-Class Glutathione S-Transferases Is Associated with Fenpropathrin Resistance in Tetranychus cinnabarinus

  2014cites this paper
• Structure of glutathione S-transferase 1 from the major human hookworm parasite Necator americanus (Na-GST-1) in complex with glutathione.

  2014cites this paper
• Characterization of Glutathione Transferase in Some Organs of Nile Tilapia (Oreochromis niloticus)

  2014cites this paper
• Busca por compostos de Trichilia pallida Swartz, Trichilia pallens C. DC. e Toona ciliata M. Roemer com bioatividade sobre Spodoptera frugiperda (J. E. Smith, 1797)

  2014cites this paper
• Recovery from hypoxia and hypercapnic hypoxia: impacts on the transcription of key antioxidants in the shrimp Litopenaeus vannamei.

  2014cites this paper
• Regulation of glutathione transferase P1-1 by S-nitrosation

  2014cites this paper
• Copper-zinc superoxide dismutase and glucose metabolism as redox targets for bortezomib resistance in multiple myeloma

  2014cites this paper
• Computational evidence for the detoxifying mechanism of epsilon class glutathione transferase toward the insecticide DDT.

  2014cites this paper
• Long-term biomonitoring of breast cancer patients under adjuvant chemotherapy: the comet assay as a possible predictive factor.

  2013cites this paper
• Genes involved in adult plant resistance to stripe rust in wheat cultivar Xingzi 9104

  2013cites this paper
• Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot.

  2013cites this paper
• Glutathione transferases, regulators of cellular metabolism and physiology.

  2013cites this paper
• The role of GSTs in the tolerance of Rhizobium leguminosarum to cadmium

  2013cites this paper
• Glutathion-S-Transferase P1 polymorphisms association with broncopulmonary dysplasia in preterm infants.

  2013cites this paper
• A Study of Glutathione S-transferase Inhibitors obtained from Allium cepa var. cepa Extract

  2013cites this paper
• The N-subdomain of the thioredoxin fold of glutathione transferase is stabilised by topologically conserved leucine residue

  2013influential citation
• Glutathione-S-transferases: tools and targets for characterization of chemically reactive drug metabolites

  2013cites this paper
• A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

  2013cites this paper
• Catalytic function of an Epsilon‐class glutathione S‐transferase of the silkworm

  2013influential citation