High-Affinity Zn2+ Uptake System ZnuABC Is Required for Bacterial Zinc Homeostasis in Intracellular Environments and Contributes to the Virulence of Salmonella enterica

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Infection and Immunity

• Publication date

  2007-10-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00559-07PMID 17923515PMCID PMC2168356
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ligand-Controlled Proteolysis of the Escherichia coli Transcriptional Regulator ZntR

  2007cited by this paper
• Structural Analysis of ABC-family Periplasmic Zinc Binding Protein Provides New Insights Into Mechanism of Ligand Uptake and Release

  2007cited by this paper
• A Galvanizing Story—Protein Stability and Zinc Homeostasis

  2007cited by this paper
• Use of a zinc fluorophore to measure labile pools of zinc in body fluids and cell-conditioned media.

  2006cited by this paper
• Mammalian Zinc Transport, Trafficking, and Signals*

  2006cited by this paper
• Counting the zinc-proteins encoded in the human genome.

  2006cited by this paper
• Deletion of znuA Virulence Factor Attenuates Brucella abortus and Confers Protection against Wild-Type Challenge

  2006cited by this paper
• The NRAMP family of metal-ion transporters.

  2006cited by this paper
• Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.

  2005cited by this paper
• Transcriptional Response of Escherichia coli to External Zinc

  2005cited by this paper
• A nutritive view on the host-pathogen interplay.

  2005cited by this paper
• Bacterial zinc uptake and regulators.

  2005cited by this paper
• Genome Watch: Enemies within

  2005cited by this paper
• Zinc and the risk for infectious disease.

  2004cited by this paper
• Zinc uptake system (znuA locus) of Brucella abortus is essential for intracellular survival and virulence in mice.

  2004cited by this paper
• Labile Zinc and Zinc Transporter ZnT4 in Mast Cell Granules: Role in Regulation of Caspase Activation and NF-κB Translocation1

  2004influential reference
• Periplasmic competition for zinc uptake between the metallochaperone ZnuA and Cu,Zn superoxide dismutase

  2004cited by this paper
• Mn2+ and bacterial pathogenesis.

  2004cited by this paper
• Salmonella‐induced macrophage death: multiple mechanisms, different outcomes

  2004cited by this paper
• The high-affinity zinc-uptake system znuACB is under control of the iron-uptake regulator (fur) gene in the animal pathogen Pasteurella multocida.

  2003cited by this paper
• Zinc-altered immune function.

  2003cited by this paper
• Genomic Profiling of Iron-Responsive Genes in Salmonella enterica Serovar Typhimurium by High-Throughput Screening of a Random Promoter Library

  2003cited by this paper
• Iron, manganese, and cobalt transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane.

  2003cited by this paper
• Isolation and Characterization of Mini-Tn5Km2 Insertion Mutants of Brucella abortus Deficient in Internalization and Intracellular Growth in HeLa Cells

  2003cited by this paper
• Zn(II) metabolism in prokaryotes.

  2003cited by this paper
• Differential accumulation of Salmonella[Cu, Zn] superoxide dismutases SodCI and SodCII in intracellular bacteria: correlation with their relative contribution to pathogenicity

  2002influential reference
• Role of the High-Affinity Zinc Uptake znuABC System in Salmonella enterica Serovar Typhimurium Virulence

  2002influential reference
• Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis

  2001influential reference
• Haemophilus ducreyi Associates with Phagocytes, Collagen, and Fibrin and Remains Extracellular throughout Infection of Human Volunteers

  2001cited by this paper
• Identification and characterization of a high-affinity zinc uptake system in Neisseria gonorrhoeae.

  2001cited by this paper
• Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions.

  2001cited by this paper
• Characterization of the metal receptor sites in Escherichia coli Zur, an ultrasensitive zinc(II) metalloregulatory protein.

  2001cited by this paper
• Epitope tagging of chromosomal genes in Salmonella

  2001influential reference
• The Zinc-responsive Regulator Zur and Its Control of theznu Gene Cluster Encoding the ZnuABC Zinc Uptake System in Escherichia coli *

  2000cited by this paper
• Iron metabolism in pathogenic bacteria.

  2000cited by this paper
• One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

  2000cited by this paper
• Identification of the znuA-Encoded Periplasmic Zinc Transport Protein of Haemophilus ducreyi

  1999cited by this paper
• Acute-phase proteins and other systemic responses to inflammation.

  1999cited by this paper
• Zinc and immune function: the biological basis of altered resistance to infection.

  1998cited by this paper
• Effect of infections on plasma zinc concentration and implications for zinc status assessment in low-income countries.

  1998cited by this paper
• The ZnuABC high‐affinity zinc uptake system and its regulator Zur in Escherichia coli

  1998cited by this paper
• Zinc enzymes.

  1998cited by this paper
• Identification of the Key Protein for Zinc Uptake in Hemophilus influenzae *

  1997cited by this paper
• Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

  1996cited by this paper
• Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

  1995cited by this paper
• Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.

  1994cited by this paper
• Measurement of invasion by gentamicin resistance.

  1994cited by this paper
• Interaction of six global transcription regulators in expression of manganese superoxide dismutase in Escherichia coli K-12

  1993cited by this paper
• Iron acquisition in microbial pathogenesis.

  1993cited by this paper
• Systemic Transport of Zinc

  1989cited by this paper
• Zinc in Human Biology

  1989cited by this paper
• Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent.

  1986cited by this paper
• Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism.

  1984cited by this paper
• pEMBL: a new family of single stranded plasmids.

  1983cited by this paper
• Zinc in enzymes

  1976cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Mechanisms and Therapeutic Potential of Nutritional Immunity.

  2026cites this paper
• SLC11A2 affects nutritional immunity in the gut epithelium

  2025cites this paper
• Kupyaphores─Self-Assembling Diisocyanolipopeptide ZnII Ionophores in Mycobacterium tuberculosis ZnII/CuI/II Homeostasis and Antibacterial Effects.

  2025cites this paper
• Resilience mechanisms of rhizosphere microorganisms in lead-zinc tailings: Metagenomic insights into heavy metal resistance.

  2025cites this paper
• The exploitation of nutrient metals by bacteria for survival and infection in the gut

  2025cites this paper
• ZntR is a critical regulator for zinc homeostasis and involved in pathogenicity in Riemerella anatipestifer

  2025cites this paper
• Bioremediation of heavy metals by mangrove rhizosphere microbes: Extracellular adsorption mechanisms and enhanced performance of immobilized Aestuariibaculum sp. JKB11.

  2025cites this paper
• Two zinc ABC transporters contribute to Rhizobium leguminosarum symbiosis with Pisum sativum and Lens culinaris

  2025cites this paper
• Computational and experimental mapping of the allosteric network of two manganese ABC transporters

  2025cites this paper
• Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host–Pathogen Interaction

  2025cites this paper
• Salmonella exploits host- and bacterial-derived β-alanine for replication inside host macrophages

  2025influential citation
• The intricacies of Acinetobacter baumannii: a multifaceted comprehensive review of a multidrug-resistant pathogen and its clinical significance and implications

  2025cites this paper
• Development of a Providencia stuartii multilocus sequence typing scheme

  2024cites this paper
• The Leptospira interrogans proteome’s response to zinc highlights the potential involvement of this metal in translational—machinery and virulence

  2024cites this paper
• Determinants of bacterial survival and proliferation in blood

  2024cites this paper
• Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile.

  2024cites this paper
• Evaluation of attenuated Salmonella Typhimurium (STMΔznuABC) anticancer activity on canine mammary cancer-associated fibroblasts.

  2024cites this paper
• Complete genome of single locus sequence typing D1 strain Cutibacterium acnes CN6 isolated from healthy facial skin

  2024cites this paper
• UMetals in the Gut: Microbial Strategies to Overcome Nutritional Immunity in the Intestinal Tract.

  2024cites this paper
• Emerging roles for ABC transporters as virulence factors in uropathogenic Escherichia coli

  2024cites this paper
• Investigation of Zur-regulated metal transport systems reveals an unexpected role of pyochelin in zinc homeostasis

  2024cites this paper
• Removal of BPA by Pseudomonas asiatica P1: Synergistic response mechanism of toxicity resistance and biodegradation.

  2024cites this paper
• Zinc acquisition and its contribution to Klebsiella pneumoniae virulence

  2024cites this paper
• Live and inactivated Piscirickettsia salmonis activated nutritional immunity in Atlantic salmon (Salmo salar)

  2023cites this paper
• New insights into bacterial Zn homeostasis and molecular architecture of the metal resistome in soil polluted with nano zinc oxide.

  2023cites this paper
• Transcriptional Response of Burkholderia cenocepacia H111 to Severe Zinc Starvation

  2023cites this paper
• Investigation of the Role of a Zinc Uptake Regulator (Zur) in the Virulence of Pectobacterium odoriferum

  2023cites this paper
• MntP and YiiP Contribute to Manganese Efflux in Salmonella enterica Serovar Typhimurium under Conditions of Manganese Overload and Nitrosative Stress

  2022cites this paper
• Role of rhizosphere microbiome during phytoremediation of heavy metals

  2022cites this paper
• Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation

  2022cites this paper
• The role of bacterial ATP-binding cassette (ABC) transporters in pathogenesis and virulence: Therapeutic and vaccine potential.

  2022cites this paper
• Acclimation to Nutritional Immunity and Metal Intoxication Requires Zinc, Manganese, and Copper Homeostasis in the Pathogenic Neisseriae

  2022cites this paper
• Impairment of the Zn/Cd detoxification systems affects the ability of Salmonella to colonize Arabidopsis thaliana

  2022cites this paper
• Structural and biochemical characterization of Acinetobacter baumannii ZnuA.

  2022cites this paper
• Conformational flexibility in the zinc solute-binding protein ZnuA

  2022cites this paper
• Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues

  2021cites this paper
• A molecular docking and dynamic approach to screen inhibitors against ZnuA1 of Candidatus Liberibacter asiaticus

  2021cites this paper
• Vibrio cholerae’s mysterious Seventh Pandemic island (VSP-II) encodes novel Zur-regulated zinc starvation genes involved in chemotaxis and autoaggregation

  2021cites this paper
• Salmonella Typhimurium and Pseudomonas aeruginosa Respond Differently to the Fe Chelator Deferiprone and to Some Novel Deferiprone Derivatives

  2021cites this paper
• Zinc is an important inter-kingdom signal between the host and microbe

  2021influential citation
• The Zinc Nutritional Immunity of Epinephelus coioides Contributes to the Importance of znuC During Pseudomonas plecoglossicida Infection

  2021cites this paper
• Challenges in Drug Discovery for Intracellular Bacteria

  2021cites this paper
• Zur: Zinc-Sensing Transcriptional Regulator in a Diverse Set of Bacterial Species

  2021cites this paper
• Microsoft Word-uqab001.docx

  2021cites this paper
• Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to intracellular S. Typhimurium

  2021cites this paper
• Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake in Streptococcus pneumoniae

  2021cites this paper
• Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.

  2021cites this paper
• Integration of RNA-seq and RNAi reveals the contribution of znuA gene to the pathogenicity of Pseudomonas plecoglossicida and to the immune response of Epinephelus coioides.

  2021cites this paper
• Characterization of Global Gene Expression, Regulation of Metal Ions, and Infection Outcomes in Immune-Competent 129S6 Mouse Macrophages

  2021cites this paper
• Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A

  2021cites this paper
• Infection of immune competent macrophages expressing functional Slc11a1 alters global gene expression, regulation of metal ions, and infection outcomes

  2021cites this paper
• Identification and Characterization of Mycobacterium smegmatis and Mycobacterium avium subsp. paratuberculosis Zinc Transporters

  2021cites this paper
• An overview of Salmonella enterica metal homeostasis pathways during infection

  2021cites this paper
• Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

  2021cites this paper
• Tolerogenic Immunoregulation towards Salmonella Enteritidis Contributes to Colonization Persistence in Young Chicks

  2021cites this paper
• A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA

  2021cites this paper
• The transcriptional regulator Zur regulates the expression of ZnuABC and T6SS4 in response to stresses in Yersinia pseudotuberculosis.

  2021cites this paper
• Adaptation of Cupriavidus metallidurans CH34 to Toxic Zinc Concentrations Involves an Uncharacterized ABC-Type Transporter

  2021cites this paper
• The Zinc Transporter ZnuABC Is Critical for the Virulence of Chromobacterium violaceum and Contributes to Diverse Zinc-Dependent Physiological Processes

  2021cites this paper
• Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica

  2021cites this paper
• Vibrio cholerae’s mysterious Seventh Pandemic island (VSP-II) encodes novel Zur-regulated zinc starvation genes involved in chemotaxis and cell congregation

  2021cites this paper
• Niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica

  2021cites this paper
• Bioinformatic Mapping of Opine-Like Zincophore Biosynthesis in Bacteria

  2020cites this paper
• Periplasmic targets for the development of effective antimicrobials against gram-negative bacteria.

  2020cites this paper
• Zinc uptake system ZnuACB is essential for maintaining pathogenic phenotype of F4ac+ enterotoxigenic E. coli (ETEC) under a zinc restricted environment

  2020cites this paper
• Metal-Limited Growth of Neisseria gonorrhoeae for Characterization of Metal-Responsive Genes and Metal Acquisition from Host Ligands.

  2020cites this paper
• Critical Role of Zur and SmtB in Zinc Homeostasis of Mycobacterium smegmatis

  2020cites this paper
• Metal Complexes of Two Specific Regions of ZnuA, a Periplasmic Zinc(II) Transporter from Escherichia coli

  2020cites this paper
• Pathogenic Escherichia coli (E. coli) detection through tuned nanoparticles enhancement study

  2020cites this paper
• Frontline Science: LPS‐inducible SLC30A1 drives human macrophage‐mediated zinc toxicity against intracellular Escherichia coli

  2020cites this paper
• Specificity of Interactions between Components of Two Zinc ABC Transporters in Paracoccus denitrificans

  2020cites this paper
• Cobalt can fully recover the phenotypes related to zinc deficiency in Salmonella Typhimurium.

  2020cites this paper
• Cyclic-di-GMP Regulates Autoaggregation Through the Putative Peptidoglycan Hydrolase, EagA, and Regulates Transcription of the znuABC Zinc Uptake Gene Cluster in Erwinia amylovora

  2020cites this paper
• Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

  2020cites this paper
• Egg-White Proteins Have a Minor Impact on the Bactericidal Action of Egg White Toward Salmonella Enteritidis at 45°C

  2020cites this paper
• Novel insights into the metal binding ability of ZinT periplasmic protein from Escherichia coli and Salmonella enterica.

  2020cites this paper
• Comprehensive Single Cell Analyses of the Nutritional Environment of Intracellular Salmonella enterica

  2020cites this paper
• The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host zinc restriction

  2019cites this paper
• The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation

  2019cites this paper
• Nutrient Zinc at the Host-Pathogen Interface.

  2019cites this paper
• Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity

  2019cites this paper
• Salmonella

  2019cites this paper
• Effects of zinc orthophosphate on the antibiotic resistant bacterial community of a source water used for drinking water treatment

  2019cites this paper
• Disclosing the zinc acquisition and homeostatic machinery of Leishmania parasites

  2019cites this paper
• An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

  2019cites this paper
• Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation

  2019cites this paper
• Transition metals and host-microbe interactions in the inflamed intestine

  2019cites this paper
• Identification, Functional Characterization, and Regulon Prediction of the Zinc Uptake Regulator (zur) of Bacillus anthracis – An Insight Into the Zinc Homeostasis of the Pathogen

  2019cites this paper
• The Systemic Zinc Homeostasis Was Modulated in Broilers Challenged by Salmonella

  2019cites this paper
• Supplementary Materials for

  2019cites this paper
• Functional Gene Array-Based Ultrasensitive and Quantitative Detection of Microbial Populations in Complex Communities

  2019cites this paper
• Two ABC Transporters and a Periplasmic Metallochaperone Participate in Zinc Acquisition in Paracoccus denitrificans

  2018cites this paper
• Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens

  2018cites this paper
• Zinc-dependent substrate-level phosphorylation powers Salmonella growth under nitrosative stress of the innate host response

  2018cites this paper
• 16 Salmonella : Invasion , Evasion & Persistence

  2018cites this paper
• Nitric Oxide Disrupts Zinc Homeostasis in Salmonella enterica Serovar Typhimurium

  2018cites this paper
• Automated Analysis Pipeline for Inferring Phenotypic Changes in Cell Granules

  2018cites this paper
• Investigation of the Role of Genes Encoding Zinc Exporters zntA, zitB, and fieF during Salmonella Typhimurium Infection

  2018cites this paper
• Zinc homeostasis mechanism and its role in bacterial virulence capacity

  2018cites this paper
• For when bacterial infections persist: Toll‐like receptor‐inducible direct antimicrobial pathways in macrophages

  2018cites this paper