Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Neurobiology of Aging

• Publication date

  2006-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NEUROBIOLAGING.2005.09.016PMID 16271278
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Running wheel accessibility affects the regional electroencephalogram during sleep in mice.

  2006cited by this paper
• The exercise-induced expression of BDNF within the hippocampus varies across life-span.

  2005cited by this paper
• Doublecortin expression levels in adult brain reflect neurogenesis

  2005cited by this paper
• Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice.

  2004cited by this paper
• Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus

  2004cited by this paper
• Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.

  2004cited by this paper
• Age‐dependent expression of glucocorticoid‐ and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus

  2004cited by this paper
• Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation.

  2004cited by this paper
• Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo.

  2004cited by this paper
• Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

  2004cited by this paper
• Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non‐running spontaneously hypertensive rats

  2004cited by this paper
• Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

  2004cited by this paper
• Neural stem and progenitor cells in nestin‐GFP transgenic mice

  2004cited by this paper
• Excitation-neurogenesis coupling in adult neural stem/progenitor cells.

  2004cited by this paper
• Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections

  2004cited by this paper
• Marked species and age‐dependent differences in cell proliferation and neurogenesis in the hippocampus of wild‐living rodents

  2004cited by this paper
• Adult hippocampal neurogenesis and voluntary running activity: Circadian and dose‐dependent effects

  2004cited by this paper
• Cardiovascular fitness, cortical plasticity, and aging.

  2004cited by this paper
• Milestones of neuronal development in the adult hippocampus.

  2004cited by this paper
• Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats.

  2003cited by this paper
• Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice

  2003cited by this paper
• VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

  2003cited by this paper
• Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes.

  2003cited by this paper
• Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus

  2003cited by this paper
• IGF-I has a direct proliferative effect in adult hippocampal progenitor cells.

  2003cited by this paper
• Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

  2003cited by this paper
• Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice.

  2003cited by this paper
• Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit.

  2003cited by this paper
• Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis.

  2002cited by this paper
• Exercise, experience and the aging brain.

  2002cited by this paper
• Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

  2002cited by this paper
• Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

  2002cited by this paper
• Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis

  2002cited by this paper
• Participation in cognitively stimulating activities and risk of incident Alzheimer disease.

  2002cited by this paper
• Complex Trait Analysis of the Hippocampus: Mapping and Biometric Analysis of Two Novel Gene Loci with Specific Effects on Hippocampal Structure in Mice

  2001cited by this paper
• Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

  2001cited by this paper
• Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

  2001cited by this paper
• Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

  2000cited by this paper
• Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

  2000cited by this paper
• The Ki‐67 protein: From the known and the unknown

  2000cited by this paper
• Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain.

  2000cited by this paper
• Adrenalectomy increases neurogenesis but not PSA‐NCAM expression in aged dentate gyrus

  1999cited by this paper
• Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

  1999cited by this paper
• Rapid extension of axons into the CA3 region by adult‐generated granule cells

  1999cited by this paper
• Neurogenesis in adulthood : a possible role in learning

  1999cited by this paper
• Adult‐generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles

  1999cited by this paper
• Restoring production of hippocampal neurons in old age

  1999cited by this paper
• Running enhances neurogenesis, learning, and long-term potentiation in mice.

  1999cited by this paper
• Neurogenesis in adulthood: a possible role in learning.

  1999cited by this paper
• Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

  1999cited by this paper
• Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

  1998cited by this paper
• Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise.

  1998cited by this paper
• Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway.

  1997cited by this paper
• Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

  1997cited by this paper
• Genetic influence on neurogenesis in the dentate gyrus of adult mice.

  1997cited by this paper
• Physical exercise induces FGF-2 and its mRNA in the hippocampus.

  1997cited by this paper
• More hippocampal neurons in adult mice living in an enriched environment

  1997cited by this paper
• The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression.

  1996cited by this paper
• Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

  1996cited by this paper
• Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus.

  1994cited by this paper
• Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material

  1988cited by this paper
• Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus

  1984cited by this paper
• Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

  1965cited by this paper

• The Emerging Role of L-Arginine and Creatine Supplementation Combined with Exercise on Hippocampal Neurogenesis, Spatial Learning, and Cognitive Flexibility in Aging and Neurodegenerative Diseases

  2026cites this paper
• Increasing degradation-independent linear polyubiquitin in the hippocampus enhances memory in young adult but not aged rats.

  2025cites this paper
• Can the inhibition of Glycogen Synthase Kinase 3 mimic the physiological effects of exercise on muscle and other organs?

  2025cites this paper
• The Effect of Suspension Training vs. Traditional Resistance Training in Older Adults: Randomized Controlled Trial

  2025cites this paper
• The Significance of Prolonged Physical Activity in Neurogenesis and Neural Regeneration: Comparing Clinical Studies With Proposed AI-Based Framework.

  2025cites this paper
• Sex in aging matters: exercise and chronic stress differentially impact females and males across the lifespan

  2025cites this paper
• Neuronal Primary Cilia Mediate Noggin Release to Enable Extracellular Signaling

  2025cites this paper
• Cognition on the Move: Examining the Role of Physical Exercise and Neurogenesis in Counteracting Cognitive Aging.

  2025cites this paper
• Therapeutic modulation of neurogenesis to improve hippocampal plasticity and cognition in aging and Alzheimer's disease

  2025cites this paper
• The Rise and Deceleration of Neuronal Excitability in Aging and Alzheimer's Disease: Mechanisms, Implications, and Therapeutic Targets.

  2025cites this paper
• Active Travel Mode and Incident Dementia and Brain Structure

  2025cites this paper
• Leisure Activity Interventions on Cognition in Mild Cognitive Impairment Patients: A Meta-Analysis

  2025cites this paper
• Effect of leisure activities on cognitive and memory function in older adults: A systematic review and meta-analysis of randomized controlled trials.

  2025cites this paper
• Tau, amyloid, iron, oligodendrocytes ferroptosis, and inflammaging in the hippocampal formation of aged rats submitted to an aerobic exercise program.

  2024cites this paper
• Senescence- and Immunity-Related Changes in the Central Nervous System: A Comprehensive Review

  2024cites this paper
• Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer’s disease

  2024cites this paper
• The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats

  2024cites this paper
• Associations between rest-activity/light-exposure rhythm characteristics and depression in United States adults: A population-based study.

  2024cites this paper
• Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis

  2024cites this paper
• Sequential physical and cognitive training disrupts cocaine-context associations via multi-level stimulation of adult hippocampal neurogenesis.

  2024cites this paper
• Addressing the Effect of Exercise on Glial Cells: Focus on Ependymal Cells.

  2024cites this paper
• Physical activity promotes brain development through serotonin during early childhood.

  2024cites this paper
• Adult hippocampal neurogenesis (AHN) controls central nervous system and promotes peripheral nervous system regeneration via physical exercise.

  2023cites this paper
• Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis

  2023cites this paper
• A systematic review and meta-analysis on the levels of brain-derived neurotrophic factor in insomnia patients with and without comorbid depression

  2023cites this paper
• Effect of physical activity intervention on cognitive function in China: A cluster randomized trial

  2023cites this paper
• Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated

  2023cites this paper
• Can Exercise Make Us Smarter, Happier, and Have More Neurons? A Hormetic Perspective

  2023cites this paper
• Environmental Enrichment Engages Vesicular Zinc Signaling to Enhance Hippocampal Neurogenesis

  2023cites this paper
• Effects of a 1 year aerobic and strength training on cognitive functioning after transient ischemic attack or minor stroke: A randomized controlled trial.

  2023cites this paper
• Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice.

  2023cites this paper
• Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

  2023cites this paper
• Repeated Anodal Transcranial Direct Current Stimulation (RA-tDCS) over the Left Frontal Lobe Increases Bilateral Hippocampal Cell Proliferation in Young Adult but Not Middle-Aged Female Mice

  2023cites this paper
• The Effects of Exercise for Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

  2023cites this paper
• Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias

  2022cites this paper
• Benefits of Tai Chi Quan on neurodegenerative diseases: A systematic review.

  2022cites this paper
• Exercise duration differentially effects age-related neuroinflammation and hippocampal neurogenesis.

  2022cites this paper
• It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

  2022cites this paper
• Targeting hippocampal neurogenesis to protect astronauts' cognition and mood from decline due to space radiation effects.

  2022cites this paper
• Alterations in hippocampal mitochondrial dynamics are associated with neurodegeneration and recognition memory decline in old male mice

  2022cites this paper
• Effectiveness and acceptability of non-pharmacological interventions in people with mild cognitive impairment: Overview of systematic reviews and network meta-analysis.

  2022cites this paper
• Treadmill training improves cognitive function by increasing IGF2 targeted downregulation of miRNA-483.

  2022cites this paper
• Adult Born Dentate Granule Cell Mediated Upregulation of Feedback Inhibition in a Mouse Model of Traumatic Brain Injury

  2022cites this paper
• The Effects of Combined Cognitive-Physical Interventions on Cognitive Functioning in Healthy Older Adults: A Systematic Review and Multilevel Meta-Analysis

  2022cites this paper
• What Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?

  2022cites this paper
• Sex differences in in ammation in the hippocampus and amygdala across the lifespan associations with cognitive bias

  2022cites this paper
• The Effect of Exercise on the Total Number of BrdU+ Cell Counts in Rats' Hippocampal Dentate Gyrus: A Meta-Analysis Study.

  2021cites this paper
• YAŞLI SIÇANLARDA AGMATİN TAKVİYESİ VE AEROBİK EGZERSİZİN UZAYSAL ÖĞRENME ÜZERİNE ETKİSİ

  2021cites this paper
• Physical exercise promotes brain remodeling by regulating epigenetics, neuroplasticity and neurotrophins

  2021cites this paper
• Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

  2021cites this paper
• Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval

  2021cites this paper
• CADASIL from Bench to Bedside: Disease Models and Novel Therapeutic Approaches

  2021cites this paper
• Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes

  2021influential citation
• Mentale Gesundheit und physische Aktivität

  2021cites this paper
• Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice

  2021cites this paper
• An exercise “sweet spot” reverses cognitive deficits of aging by growth-hormone-induced neurogenesis

  2021influential citation
• Hippocampal Adaptations to Continuous Aerobic Training: A Functional and Ultrastructural Evaluation in a Young Murine Model

  2021cites this paper
• Molecular and cellular pathways contributing to brain aging

  2021cites this paper
• Reuniting the Body "Neck Up and Neck Down" to Understand Cognitive Aging: The Nexus of Geroscience and Neuroscience.

  2021cites this paper
• Mini review: The relationship between energy status and adult hippocampal neurogenesis

  2021cites this paper
• Behavioral, neuroplasticity and metabolic effects of 7,8-dihydroxy-4-methylcoumarin associated with physical activity in mice

  2021cites this paper
• The Effects of Combined Physical and Cognitive Training on Inhibitory Control: A Systematic Review and Meta-Analysis

  2021cites this paper
• Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective

  2021cites this paper
• Feasibility and effectiveness of interactive stepping exercise on community-dwelling older adults: A pilot randomized controlled trial.

  2021cites this paper
• Stress-Related Dysfunction of Adult Hippocampal Neurogenesis—An Attempt for Understanding Resilience?

  2021cites this paper
• Adult Neurogenesis: A Story Ranging from Controversial New Neurogenic Areas and Human Adult Neurogenesis to Molecular Regulation

  2021cites this paper
• Treadmill Training Improves Cognitive Function via Increasing IGF2 Targeted Downregulation of miRNA-483

  2020cites this paper
• The effect of acute exercise on cognition

  2020cites this paper
• Molecular and Cellular Mechanisms Regulating Quiescence and Division of Hippocampal Stem Cells

  2020cites this paper
• Brain Changes in Response to Exercise

  2020cites this paper
• Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

  2020cites this paper
• Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging

  2020cites this paper
• Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

  2020cites this paper
• Memory Traces Diminished by Exercise Affect New Learning as Proactive Facilitation

  2020cites this paper
• An Endogenous Ligand of Aryl Hydrocarbon Receptor 6-Formylindolo[3,2-b]Carbazole (FICZ) Is a Signaling Molecule in Neurogenesis of Adult Hippocampal Neurons

  2020cites this paper
• The Unique Contribution of Physical Activity to Successful Cognitive Aging

  2020cites this paper
• Neuroplasticity

  2020cites this paper
• Cognitive impairment is associated with elevated serum homocysteine levels among older adults

  2019cites this paper
• MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis

  2019cites this paper
• Programming of the brain by early-life stress : The impact of early nutritional interventions and later life challenges

  2019cites this paper
• Prenatal Exposure to Oxcarbazepine Increases Hippocampal Apoptosis in Rat Offspring.

  2019cites this paper
• Cholesterol or Fat Rich Diets Accelerate Natural Age-Decline on Adult Hippocampal Neurogenesis and Have an Impact in Memory and Like-Anxiety Behavior

  2019cites this paper
• Honey as an antioxidant therapy to reduce cognitive ageing

  2019cites this paper
• Proteasome activation by insulin‐like growth factor‐1/nuclear factor erythroid 2‐related factor 2 signaling promotes exercise‐induced neurogenesis

  2019cites this paper
• Environmental enrichment, new neurons and the neurobiology of individuality

  2019cites this paper
• Adult Neurogenesis, Glia, and the Extracellular Matrix.

  2019cites this paper
• Are the neuroprotective effects of exercise training systemically mediated?

  2019cites this paper
• Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation

  2019cites this paper
• Regulation of developmentally-born and adult-born neurons in the dentate gyrus

  2019influential citation
• Recalibrating the Relevance of Adult Neurogenesis.

  2019cites this paper
• Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.

  2019cites this paper
• Rejuvenating the Brain With Chronic Exercise Through Adult Neurogenesis

  2019cites this paper
• Regulation of adult hippocampal neurogenesis exerted by sexual, cognitive and physical activity: An update.

  2019cites this paper
• Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis

  2019cites this paper
• Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging

  2019cites this paper
• Rejuvenation of the Epigenetic Landscape of the Aged Brain Through Manipulation of Circulating Factors

  2019cites this paper
• Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

  2019cites this paper
• New Advances in Neurorehabilitation

  2019cites this paper
• Effects of physical exercise and stress on hippocampal CA1 and dentate gyrus synaptic transmission and long-term potentiation in adolescent and adult Wistar rats.

  2019cites this paper
• Exercise for Brain Health: An Investigation into the Underlying Mechanisms Guided by Dose

  2019cites this paper