Effect of Gonadal Hormones on Neurotransmitters Implicated in the Pathophysiology of Obsessive-Compulsive Disorder: A Critical Review

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Neuroendocrinology

• Publication date

  2016-11-28

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1159/000453664PMID 27894107
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Obsessive-compulsive disorder (OCD).

  2019cited by this paper
• The need for inclusion of sex and age of onset variables in genetic association studies of obsessive-compulsive disorder: Overview.

  2016cited by this paper
• Association of Hormonal Contraception With Depression.

  2016cited by this paper
• Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial.

  2015cited by this paper
• High-Dose Testosterone Treatment Increases Serotonin Transporter Binding in Transgender People

  2015cited by this paper
• Pregnancy-Onset Obsessive-Compulsive Disorder: Clinical Features, Comorbidity, and Associated Factors

  2015cited by this paper
• Plasma Oxytocin Levels in Untreated Adult Obsessive-Compulsive Disorder Patients

  2015cited by this paper
• 1H-MRS of the anterior cingulate cortex in childhood and adolescent obsessive-compulsive disorder: a case-control study.

  2015cited by this paper
• Effect of sex steroid hormones on the number of serotonergic neurons in rat dorsal raphe nucleus.

  2015cited by this paper
• Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women - a PET study

  2015cited by this paper
• Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study.

  2015cited by this paper
• The role of serotonin 5-HT2A receptors in memory and cognition

  2015cited by this paper
• Glutamate modulators in the treatment of obsessive-compulsive disorder.

  2015cited by this paper
• Relation of progesterone and DHEAS serum levels to 5-HT1A receptor binding potential in pre- and postmenopausal women.

  2014cited by this paper
• 12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

  2014cited by this paper
• OBSESSIVE–COMPULSIVE DISORDER AND FEMALE REPRODUCTIVE CYCLE EVENTS: RESULTS FROM THE OCD AND REPRODUCTION COLLABORATIVE STUDY

  2014cited by this paper
• The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD

  2014cited by this paper
• Greater monoamine oxidase a binding in perimenopausal age as measured with carbon 11-labeled harmine positron emission tomography.

  2014cited by this paper
• Estrogen receptors’ neuroprotective effect against glutamate-induced neurotoxicity

  2014cited by this paper
• Effects of hormone replacement therapy on cerebral serotonin-1A receptor binding in postmenopausal women examined with [carbonyl-¹¹C]WAY-100635.

  2014cited by this paper
• Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress.

  2013cited by this paper
• Plasma oxytocin changes and anti-obsessive response during serotonin reuptake inhibitor treatment: a placebo controlled study

  2013cited by this paper
• Progesterone increases the activity of glutamate transporter type 3 expressed in Xenopus oocytes.

  2013cited by this paper
• Pharmacotherapy of obsessive-compulsive disorder: Evidence-based treatment and beyond

  2013cited by this paper
• Risk of obsessive-compulsive disorder in pregnant and postpartum women: a meta-analysis.

  2013cited by this paper
• Sex steroids and personality traits in the middle luteal phase of healthy normally menstruating young professional women

  2012cited by this paper
• β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.

  2012cited by this paper
• Estradiol induces partial desensitization of serotonin 1A receptor signaling in the paraventricular nucleus of the hypothalamus and alters expression and interaction of RGSZ1 and Gαz.

  2012cited by this paper
• Effect of ovarian steroids on gene expression related to synapse assembly in serotonin neurons of macaques

  2012cited by this paper
• Effect of a chronic treatment with 17β-estradiol on striatal dopamine neurotransmission and the Akt/GSK3 signaling pathway in the brain of ovariectomized monkeys.

  2012cited by this paper
• Ovarian steroids increase glutamatergic related gene expression in serotonin neurons of macaques.

  2012cited by this paper
• Effects of estrogen on the serotonergic system and calcitonin gene-related peptide in trigeminal ganglia of rats

  2012cited by this paper
• The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder.

  2012cited by this paper
• Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy.

  2011cited by this paper
• Kalirin‐7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons

  2011cited by this paper
• Clinical correlates of worsening in obsessive-compulsive symptoms during pregnancy.

  2011cited by this paper
• Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment.

  2011cited by this paper
• Anxiety-like behaviors and expression of SERT and TPH in the dorsal raphé of estrogen- and fluoxetine-treated ovariectomized rats.

  2011cited by this paper
• Depression in women: windows of vulnerability and new insights into the link between estrogen and serotonin.

  2011cited by this paper
• The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: an autoradiography study.

  2010cited by this paper
• Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period.

  2010cited by this paper
• Role of dopamine in the pathophysiology and treatment of obsessive–compulsive disorder

  2010cited by this paper
• Elevated brain monoamine oxidase A binding in the early postpartum period.

  2010cited by this paper
• Dopamine D(1) receptor binding in the anterior cingulate cortex of patients with obsessive-compulsive disorder.

  2010cited by this paper
• Conceptualizing the role of estrogens and serotonin in the development and maintenance of bulimia nervosa.

  2010cited by this paper
• Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes.

  2009cited by this paper
• Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field.

  2009cited by this paper
• Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus.

  2009cited by this paper
• Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

  2009cited by this paper
• The serotonin-1A receptor in anxiety disorders.

  2009cited by this paper
• Anti-Brain Autoantibodies and Altered Excitatory Neurotransmitters in Obsessive–Compulsive Disorder

  2009cited by this paper
• Ovarian hormones modulate 'compulsive' lever-pressing in female rats.

  2009cited by this paper
• Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder.

  2009cited by this paper
• Children with obsessive-compulsive disorder: are they just "little adults"?

  2009cited by this paper
• Riluzole in the Treatment of Mood and Anxiety Disorders

  2008cited by this paper
• In vivo PET study of 5HT2A serotonin and D2 dopamine dysfunction in drug-naive obsessive-compulsive disorder

  2008cited by this paper
• Estradiol induces hypothalamic dendritic spines by enhancing glutamate release: a mechanism for organizational sex differences.

  2008cited by this paper
• Changes in Thalamus–Hypothalamus Serotonin Transporter Availability during Clomipramine Administration in Patients with Obsessive–Compulsive Disorder

  2008cited by this paper
• Long-term estrogen therapy and 5-HT(2A) receptor binding in postmenopausal women; a single photon emission tomography (SPET) study.

  2008cited by this paper
• Postpartum-onset obsessive-compulsive disorder: incidence, clinical features, and related factors.

  2007cited by this paper
• Fluvoxamine Treatment and D2 Receptors: a Pet Study on OCD Drug-Naïve Patients

  2007cited by this paper
• [123I]-β-CIT SPECT Imaging Shows Reduced Thalamus–Hypothalamus Serotonin Transporter Availability in 24 Drug-Free Obsessive-Compulsive Checkers

  2007cited by this paper
• Estradiol Targets Synaptic Proteins to Induce Glutamatergic Synapse Formation in Cultured Hippocampal Neurons: Critical Role of Estrogen Receptor-α

  2007cited by this paper
• Influence of Oestrogenic Compounds on Monoamine Transporters in Rat Striatum

  2006cited by this paper
• The Effects of Estradiol on Estrogen Receptor and Glutamate Transporter Expression in Organotypic Hippocampal Cultures Exposed to Oxygen--Glucose Deprivation

  2006cited by this paper
• Ovarian steroids counteract serotonergic drugs actions in an animal model of obsessive-compulsive disorder.

  2006cited by this paper
• Female hormones affect symptom severity in obsessive–compulsive disorder

  2006cited by this paper
• Glutamatergic Dysfunction in OCD

  2005cited by this paper
• Female reproductive cycle and obsessive-compulsive disorder.

  2005cited by this paper
• SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD).

  2005cited by this paper
• Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder.

  2005cited by this paper
• A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques.

  2005cited by this paper
• Bupropion for patients with obsessive-compulsive disorder: an open-label, fixed-dose study.

  2005cited by this paper
• Reduced anterior cingulate glutamatergic concentrations in childhood OCD and major depression versus healthy controls.

  2004cited by this paper
• Enhanced dopamine transporter density in psychotropic-naive patients with obsessive-compulsive disorder shown by [123I]{beta}-CIT SPECT.

  2004cited by this paper
• Reduced serotonin transporter–availability in obsessive–compulsive disorder (OCD)

  2004cited by this paper
• Effects of Ovarian Steroids and Raloxifene on Proteins that Synthesize, Transport, and Degrade Serotonin in the Raphe Region of Macaques

  2004cited by this paper
• Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women.

  2004cited by this paper
• The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence.

  2004cited by this paper
• Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder.

  2004cited by this paper
• Progesterone inhibition of dopamine-induced increase in frequency of spontaneous excitatory postsynaptic currents in rat prelimbic cortical neurons.

  2004cited by this paper
• Effects of estrogen and progesterone treatment on rat hippocampal NMDA receptors: Relationship to Morris water maze performance

  2004cited by this paper
• Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder

  2003cited by this paper
• Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652.

  2003cited by this paper
• Estrogens inhibit l‐glutamate uptake activity of astrocytes via membrane estrogen receptor α

  2003cited by this paper
• Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder.

  2003cited by this paper
• Increase in prefrontal cortex serotonin 2A receptors following estrogen treatment in postmenopausal women.

  2003cited by this paper
• Ovarian hormone influences on the density of immunoreactivity for tyrosine hydroxylase and serotonin in the primate corpus striatum.

  2003cited by this paper
• Amisulpiride augmentation in treatment resistant obsessive–compulsive disorder: an open trial

  2003cited by this paper
• Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients

  2002cited by this paper
• Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats.

  2002cited by this paper
• Estrogenic Properties of Raloxifene, but Not Tamoxifen, on D2 and D3 Dopamine Receptors in the Rat Forebrain

  2002cited by this paper
• Obsessive-compulsive disorder

  2002cited by this paper
• Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function.

  2002cited by this paper
• Diverse actions of ovarian steroids in the serotonin neural system.

  2002cited by this paper
• Ovarian steroid regulation of monoamine oxidase-A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei

  2002cited by this paper
• Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats.

  2002cited by this paper
• Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study.

  2000cited by this paper
• Ovarian steroid action in the serotonin neural system of macaques.

  2000cited by this paper
• Neurobiology of the obsessive-compulsive spectrum disorders.

  2000cited by this paper

• Altered resting-state sensorimotor network in patients with obsessive-compulsive disorder: An EEG study.

  2026cites this paper
• Obsessive-compulsive disorder and menopause: a scoping review.

  2025cites this paper
• Breaking New Ground With Endoxifen: Augmentation Strategies in OCD Management—A Case Series

  2025cites this paper
• Dynamic flexibility of the murine gut microbiota to morphine disturbance enables escape from the stable dysbiosis associated with addiction-like behavior

  2025cites this paper
• Cuscutae Semen in depression-induced ovarian dysfunction: metabolomics with UPLC-QToF-MS in female mice

  2025cites this paper
• Association between duration of birth control pill use and risk of depression among US women

  2025cites this paper
• Atopic Dermatitis and Obsessive-Compulsive Disorder: A Systematic Review.

  2025cites this paper
• Comparison of autogenous and reactive type obsessive-compulsive disorders in terms of clinical characteristics: A meta-analysis study.

  2024cites this paper
• Potential Differences in Psychedelic Actions Based on Biological Sex

  2024cites this paper
• The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder.

  2024cites this paper
• Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls

  2023cites this paper
• Predictors of clinical worsening during a discontinuation trial of serotonin reuptake inhibitors for obsessive compulsive disorder.

  2023cites this paper
• Reproductive Hormones and Female Mental Wellbeing

  2023cites this paper
• Increased error rate and delayed response to negative emotional stimuli in antisaccade task in obsessive-compulsive disorder

  2023cites this paper
• Specific Aspects of Eye Movement Reactions as Markers of Cognitive Control Disorders in Patients with Obsessive-Compulsive Disorder (Review)

  2022cites this paper
• Impact of menstrual cycle events on bipolar disorder course: a narrative review of current evidence

  2022cites this paper
• Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues.

  2022cites this paper
• Potential effects of noni (Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models

  2022cites this paper
• Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

  2022cites this paper
• Obsessive-Compulsive Disorder and Metabolic Disorders

  2022cites this paper
• Obsessive-Compulsive Tendencies & Self-Concept Clarity Among Females With and Without Hormonal Imbalance

  2021cites this paper
• Nosographic considerations on obsessive-compulsive disorder occurring exclusively during the menstrual phase

  2021cites this paper
• Endocrine , Reproductive , Neurophysiologic and Extraneous Activities of Estrogen in Vertebrates

  2021cites this paper
• Effect OF ISOFLAVONE ON MEMORY IN RAT MODEL OF SURGICALLY INDUCED MENOPAUSE; POSSIBLE ROLE OF GLUTAMATE AND GAMMA AMINO BUTYRIC ACID.

  2021cites this paper
• Gender-specific approach in psychiatric diseases: because sex matters.

  2021cites this paper
• Prenatal sex hormones and finger length: Digit ratio (2D:4D) as a biological marker of early developmental processes in patients with obsessive-compulsive disorder (OCD)

  2020cites this paper
• The therapeutic potential of exercise for neuropsychiatric diseases: A review.

  2020cites this paper
• Potential Role of Plants Hordeum vulgare L. and Panax ginseng L. in Resolving the Fertility Disorders and Stress-Induced Oxidative Stress Arises from Hypothyroidism in Adult Female Rats

  2020cites this paper
• 5-HT3 Receptor Antagonism: A Potential Therapeutic Approach for the Treatment of Depression and other Disorders

  2020cites this paper
• Autoreceptor control of serotonin dynamics

  2020cites this paper
• The Economic Impact on Australian Patients with Neuroendocrine Tumours

  2020cites this paper
• Hormonal contributions to perinatal obsessive–compulsive disorder

  2020cites this paper
• Obsessive compulsive-disorder and reproductive life events.

  2020cites this paper
• Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation

  2019cites this paper
• Oral Contraceptives Reduced Pica Behavior in a Female with Autism Spectrum Disorder

  2019cites this paper
• The effect of Hordeum vulgare on the monoaminergic system modulating neural-thyroid dysfunction in hypothyroid female rats.

  2019cites this paper
• A CASE OF PERIPARTUM OBSESSIVE-COMPULSIVE DISORDER: The Potential Role of Corticosteroids, Gonadal Steroids, and the Neuropeptide Oxytocin in its Pathogenesis.

  2019cites this paper
• Jaclyn Corbin: Thesis!

  year unknowncites this paper