Development and regulation of dendritic spine synapses.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Physiology

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/PHYSIOL.00042.2005PMID 16443821
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
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