Absolute Stereochemistry of the Second Step of Ribonuclease Action

No abstract is available for this paper.

• Publication year

  1970

• Venue

  Nature

• Publication date

  1970-11-14

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1038/228663A0PMID 5474937
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nucleoside phosphorothioates.

  1970cited by this paper
• The hydrolysis of uridine cyclic phosphonate catalyzed by ribonuclease-A: implications for the mechanism of action of the enzyme.

  1969cited by this paper
• The mechanism of action of ribonuclease.

  1969cited by this paper
• On the mechanism of ribonuclease action.

  1969cited by this paper
• Facilitated Proton Transfer in Enzyme Catalysis

  1968cited by this paper
• Relaxation spectrometry of biological systems.

  1968cited by this paper
• Uridine 2′,3′‐O,O‐cyclophosphorothioate as substrate for pancreatic ribonuclease (I)

  1968cited by this paper
• Facilitated proton transfer in enzyme catalysis. It may have a crucial role in determining the efficiency and specificity of enzymes.

  1968cited by this paper
• Pseudo-rotation in the hydrolysis of phosphate esters

  1968cited by this paper
• Ligand Reorganization in the Trigonal Bipyramid

  1968cited by this paper
• [On the mechanism of the ribonuclease reaction. 1. The function of the pyrimidine base in the reaction].

  1967cited by this paper
• Mechanism of Action of Bovine Pancreatic Ribonuclease

  1966cited by this paper
• KINETICS AND MECHANISMS OF REACTIONS CATALYZED BY PANCREATIC RIBONUCLEASE

  1966cited by this paper
• Mechanism of action of bovine pancreatic ribonuclease.

  1966cited by this paper
• Cleavage point during hydrolyses catalyzed by ribonuclease and phosphodiesterase.

  1961cited by this paper
• The Active Site and Mechanism of Action of Bovine Pancreatic Ribonuclease

  1961cited by this paper
• Isotopic analysis of oxygen in inorganic compounds.

  1959cited by this paper

• C-Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2’-OH

  2025cites this paper
• C‑Nucleosides Stabilize RNA by Reducing Nucleophilicity at 2′-OH

  2025cites this paper
• Structural basis of substrate specificity in porcine RNase 4

  2016cites this paper
• Conservation et modulation de secteurs dynamiques fonctionnels entre ribonucléases homologues.

  2014cites this paper
• Structural basis of porcine RNase 4 recognition

  2014cites this paper
• Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

  2014cites this paper
• The Discovery and Characterization of NAD-Linked RNA

  2012cites this paper
• Use of Chiral [16O,17O,18O]Phosphate Esters to Determine the Stereochemical Course of Enzymatic Phosphoryl Transfer Reactions

  2012cites this paper
• Hydrolysis of organophosphate compounds by mutant butyrylcholinesterase: A story of two histidines

  2011cites this paper
• A STUDY OF RNASE ENZYMES IN SALIVA SAMPLES FROM WOMEN WITH BREAST TUMORS

  2011cites this paper
• Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism.

  2011cites this paper
• Studies on polypeptides XXXIX. The role of the imidazole tele‐nitrogen atom of histidine‐12 in the catalytic action of RNase S′

  2010cites this paper
• Identification and Characterization of the Enzymes Involved in Biosynthesis of FAD and Tetrahydromethanopterin in Methanocaldococcus jannaschii

  2010cites this paper
• Hybridization of phosphate‐methylated DNA and natural oligonucleotides. Implications for protein‐induced DNA duplex destabilization

  2010cites this paper
• An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.

  2009cites this paper
• Sigmoid Kinetics of the Monomeric Ribonuclease I. Due to Ligand-Induced Shifts of Conformation Equilibria

  2009cites this paper
• LC/MS analysis of cellular RNA reveals NAD-linked RNA

  2009cites this paper
• A square pyramidal model for ribonuclease action.

  2009cites this paper
• Site-specific DNA transesterification catalyzed by a restriction enzyme

  2007cites this paper
• Understanding Assembly of AGO2 RISC: the RNAi enzyme: a Dissertation

  2007cites this paper
• Probing the Active Sites of Enzymes with Conformationally Restricted Substrate Analogs

  2007cites this paper
• Control of the Catalytic Activity of Enzymes by the Near and Remote Environment of a Polyatomic Framework

  2007cites this paper
• Stereochemistry of biological reactions at proprochiral centers

  2007cites this paper
• Phosphorothioatanaloga von Nucleotiden — Werkzeuge zur Untersuchung biochemischer Prozesse

  2006cites this paper
• Enzymatic mechanisms of phosphate and sulfate transfer.

  2006cites this paper
• Mechanistic Studies on Enzyme-Catalyzed Phosphoryl Transfer

  2005cites this paper
• Understanding the transition states of phosphodiester bond cleavage: insights from heavy atom isotope effects.

  2004cites this paper
• IDENTIFICACIÓ IMMUNOLÒGICA I CARACTERITZACIÓ DE LES PROPIETATS BIOLÒGIQUES DE LA PROTEÏNA CATIÒNICA D'EOSINÒFIL

  2004cites this paper
• Active Site of Ribonuclease A

  2004cites this paper
• Quantum chemical studies of intermediates and reaction pathways in selected enzymes and catalytic synthetic systems.

  2004cites this paper
• RISC is a 5' phosphomonoester-producing RNA endonuclease.

  2004cites this paper
• Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.

  2003cites this paper
• Theoretical examination of Mg(2+)-mediated hydrolysis of a phosphodiester linkage as proposed for the hammerhead ribozyme.

  2003cites this paper
• Overview of the Synthesis of Nucleoside Phosphates and Polyphosphates

  2003cites this paper
• Metal ions and the stereochemistry of ribozyme reactions.

  2002cites this paper
• Synthetic constructs functionally mimicking ribonuclease A

  2000cites this paper
• Mechanism of phosphatidylinositol-specific phospholipase C: a unified view of the mechanism of catalysis.

  1998cites this paper
• [Chemical ribonucleases].

  1998cites this paper
• Crystallographic Studies of Ribonuclease Complexes

  1997cites this paper
• X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution.

  1997cites this paper
• 9 – Pancreatic Ribonucleases

  1997cites this paper
• Hydrolytic dethiophosphorylation and desulfurization of the monothioate analogues of uridine monophosphates under acidic conditions

  1996cites this paper
• Probing the Cleavage Activity of the Hammerhead Ribozyme Using Analog Complexes

  1996cites this paper
• Hydrolysis and Desulfurization of the Diastereomeric Phosphoromonothioate Analogs of Uridine 2',3'-Cyclic Monophosphate.

  1996cites this paper
• Effect of nucleotide substrate binding on the pKa of catalytic residues in barnase

  1996cites this paper
• Ionic interactions in crystalline bovine pancreatic ribonuclease A.

  1996cites this paper
• COMPUTER SIMULATION OF RIBONUCLEASE ACTION ON URIDYLYL-(3′-5′)-ADENOSINE

  1995cites this paper
• Mechanism-Based Inactivation of Ribonuclease A.

  1995cites this paper
• Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11.

  1995cites this paper
• Interaction of substrate uridyl 3',5'-adenosine with ribonuclease A: a molecular dynamics study.

  1995cites this paper
• Subsite binding in an RNase: structure of a barnase-tetranucleotide complex at 1.76-A resolution.

  1994cites this paper
• Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines.

  1994cites this paper
• Crystal structure of ribonuclease A.d(ApTpApApG) complex. Direct evidence for extended substrate recognition.

  1994cites this paper
• Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A.

  1993cites this paper
• Comparative molecular modeling and crystallization of P‐30 protein: A novel antitumor protein of Rana pipiens oocytes and early embryos

  1992cites this paper
• Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites.

  1992cites this paper
• 2 Metal Ions at Enzyme Active Sites

  1992cites this paper
• 3 Phosphate Ester Hydrolysis

  1992cites this paper
• Synthesis and kinetic study of transition state analogs for ribonuclease T1.

  1991cites this paper
• Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis.

  1990cites this paper
• Energetics of RNA cleavage: implications for the mechanism of action of ribozymes.

  1990cites this paper
• Construction of a novel artificial-ribozyme-releasing plasmid.

  1990cites this paper
• Mechanism and Catalysis of Nucleophilic Substitution in Phosphate Esters

  1989cites this paper
• A computational approach to the mechanism of self-cleavage of hammerhead RNA.

  1989cites this paper
• Bioorganic Chemistry of the Phosphate Groups and Polynucleotides

  1989cites this paper
• Chiral phosphorothioates: stereochemical analysis of enzymatic substitution at phosphorus.

  1989cites this paper
• Silicon-phosphorus analogies. Nucleophilic catalysis in the alcoholysis of chlorophosphorus derivatives

  1989cites this paper
• Cyclic oxyphosphoranes as model intermediates during splicing and cleavage of RNA: ab initio molecular orbital calculations on the conformational analysis.

  1989cites this paper
• A molecular orbital study of a model of the Mg2+ coordination complex of the self splicing reaction of ribosomal RNA.

  1988cites this paper
• Amino acids and peptides. XIV. Synthesis and biological activity of three S-peptide analogues of bovine pancreatic ribonuclease A (RNase A).

  1987cites this paper
• The chemistry of self-splicing RNA and RNA enzymes.

  1987cites this paper
• Chapter 7 Pancreatic ribonuclease A: the most studied endoribonuclease

  1987cites this paper
• Stereoelectronic control in the hydrolysis of RNA by imidazole.

  1987cites this paper
• REMOTE CONTROL OF DIASTEREOSELECTIVITY OF DN-ASE II AND ENDONUCLEASE ECO RI TOWARDS PHOSPHOROTHIOATE ANALOGUES OF OLIGONUCLEOTIDES

  1986cites this paper
• Degradation and modification of nucleic acids

  1986cites this paper
• Galactose-1-phosphate uridylyltransferase. Purification of the enzyme and stereochemical course of each step of the double-displacement mechanism.

  1986cites this paper
• Studies on stereospecific formation of P-chiral internucleotide linkage

  1986cites this paper
• Nucleoside phosphorothioates.

  1985cites this paper
• Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis.

  1985cites this paper
• Crystallographic and biochemical investigation of the lead(II)-catalyzed hydrolysis of yeast phenylalanine tRNA.

  1985cites this paper
• Nuclear magnetic resonance and neutron diffraction studies of the complex of ribonuclease A with uridine vanadate, a transition-state analogue.

  1985cites this paper
• Proteins at work: "stop-action" pictures at subzero temperatures.

  1984cites this paper
• 2'-deoxyribonucleoside 3'-aryl phosphoranilidates: key intermediates in the stereospecific synthesis of 2'-deoxyribonucleoside cyclic 3',5'-phosphorothioates and dinucleoside(3'→5')-phosphorothioates

  1984cites this paper
• Amino acids and peptides. XII. Synthesis of C-terminal decapeptide of bovine pancreatic ribonuclease A (RNase A) and its analogs and determination of their ability to reactivate Des(121-124) RNase A.

  1984cites this paper
• Syntheses and configurational analyses of thymidine 4-nitrophenyl [17O,18O]phosphates and the stereochemical course of a reaction catalyzed by bovine pancreatic deoxyribonuclease I.

  1984cites this paper
• Molecular model for messenger RNA splicing.

  1984cites this paper
• Energetics of ribonuclease A catalysis. 1. pH, ionic strength, and solvent isotope dependence of the hydrolysis of cytidine cyclic 2',3'-phosphate.

  1983cites this paper
• Phosphorothioate Analogues of Nucleotides—Tools for the Investigation of Biochemical Processes

  1983cites this paper
• Enzyme specificity: base recognition and hydrolysis of RNA by ribonuclease A

  1983cites this paper
• Wadsworth-Emmons reaction revisited

  1983cites this paper
• Active site of RNase: neutron diffraction study of a complex with uridine vanadate, a transition-state analog.

  1983cites this paper
• Pb(II)-catalysed cleavage of the sugar–phosphate backbone of yeast tRNAPhe—implications for lead toxicity and self-splicing RNA

  1983cites this paper
• Oxygen chiral phosphate esters.

  1983cites this paper
• Stereochemistry of enzymic phosphoryl and nucleotidyl transfer.

  1982cites this paper
• Stereochemistry of enzymatic reactions of phosphates

  1982cites this paper
• Chiral [16O, 17O, 18O]phosphoric monoesters as stereochemical probes of phosphotransferases.

  1982cites this paper
• Phospho transfer enzymes: lessons from stereochemistry.

  1982cites this paper
• Effect of ribonucleoside-vanadyl complexes on enzyme-catalyzed reactions central to recombinant DNA technology

  1982cites this paper
• 12 Pancreatic Ribonuclease

  1982cites this paper
• 7 – Case Studies of Selected Enzyme Mechanisms

  1982cites this paper