Effects of non-steroidal anti-inflammatory drugs on fatty acid cyclooxygenase and prostaglandin hydroperoxidase activities.

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Prostaglandins

• Publication date

  1982-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 6812164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acetylation of prostaglandin endoperoxide synthetase with acetylsalicylic acid.

  1980cited by this paper
• Protection of cyclooxygenase activity during heme-induced destabilization.

  1980cited by this paper
• Evidence for a peroxide-initiated free radical mechanism of prostaglandin biosynthesis.

  1980cited by this paper
• On the haemoprotein character of prostaglandin endoperoxide synthetase.

  1979cited by this paper
• Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

  1979cited by this paper
• Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase.

  1979cited by this paper
• Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins.

  1978cited by this paper
• Acetylation of the NH2-terminal serine of prostaglandin synthetase by aspirin.

  1978cited by this paper
• Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands.

  1977cited by this paper
• Lack of covalent modification of prostaglandin synthetase (cyclo-oxygenase) by indomethacin.

  1977cited by this paper
• Aspirin as a quantitative acetylating reagent for the fatty acid oxygenase that forms prostaglandins.

  1976cited by this paper
• Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme.

  1976cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

  1976cited by this paper
• Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

  1975cited by this paper
• Lowry determination of protein in the presence of Triton X-100.

  1975cited by this paper
• Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.

  1974cited by this paper
• Effects of anti-inflammatory drugs on prostaglandin biosynthesis.

  1972cited by this paper
• Relationship between inhibition of prostaglandin synthesis and drug efficacy: support for the current theory on mode of action of aspirin-like drugs.

  1972cited by this paper
• Stimulation and blockade of prostaglandin biosynthesis.

  1971cited by this paper
• Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

  1971cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid.

  2016cites this paper
• Relative efficacy and tolerability of etoricoxib, celecoxib, and naproxen in the treatment of osteoarthritis

  2016cites this paper
• Multimodal Analgesia in Inguinal Hernia Repair Using a Cyclooxygenase-2-Specific Inhibitor: A Randomised Controlled Trial

  2015cites this paper
• Protective Effect of Wheat Peptides Against Small Intestinal Damage Induced by Non-Steroidal Anti-Inflammatory Drugs in Rats

  2014cites this paper
• Heme enzyme structure and function.

  2014cites this paper
• Acetylsalicylic Acid and NS-398 Prevention of NNK-induced Lung Tumorigenesis in A/J Mice by

  2013cites this paper
• Purification and characterization of the recombinant human prostaglandin H synthase-2 expressed in Pichia pastoris.

  2012cites this paper
• Cyclooxygenase Pathway of the Arachidonate Cascade

  2012cites this paper
• Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.

  2011cites this paper
• HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death.

  2011cites this paper
• Biochemische Charakterisierung von PpoA aus Aspergillus nidulans

  2010cites this paper
• Selective COX-1 inhibition: A therapeutic target to be reconsidered.

  2010cites this paper
• Hyperpotassemia and bradycardia in a bedridden elderly woman with selective hypoaldosteronism associated with low renin activity.

  2010cites this paper
• Rôle de la cyclo-oxygénase-2 constitutive dans la synthèse des prostaglandines et caractérisation de ses relations avec les prostaglandines synthases terminales

  2008cites this paper
• Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation.

  2007cites this paper
• Prostaglandin Synthesis in the Coral Plexaura homomalla : Control of Prostaglandin Stereochemistry at Carbon 15 by Cyclooxygenases

  2007cites this paper
• Overexpression of COX-2 in human osteosarcoma cells decreases proliferation and increases apoptosis.

  2006cites this paper
• Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity.

  2005cites this paper
• A Michaelis-Menten-style model for the autocatalytic enzyme prostaglandin H synthase

  2005cites this paper
• Aromatic hydroxamic acids and hydrazides as inhibitors of the peroxidase activity of prostaglandin H2 synthase-2.

  2004cites this paper
• Permeability and vasomotor response of cerebral vessels during exposure to arachidonic acid

  2004cites this paper
• Effect of Aspirin and Indomethacin on Prostaglandin E2 Synthesis in C6 Glioma Cells

  2004cites this paper
• Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition

  2004cites this paper
• Ketorolaco trometamina y parecoxib sódico como coadyuvantes de la anestesia general balanceda: sus efectos sobre los requerimientos transoperatorios de citrato de fentanilo

  2004cites this paper
• Histidine 386 and Its Role in Cyclooxygenase and Peroxidase Catalysis by Prostaglandin-endoperoxide H Synthases*

  2003cites this paper
• Structural insights into the mechanism and inhibition of prostaglandin H2 synthase-1

  2003cites this paper
• Expression of cyclooxygenase-2 in rat testis.

  2003cites this paper
• Cyclooxygenase-2 Inhibitors

  2003cites this paper
• Comparison of the properties of prostaglandin H synthase-1 and -2.

  2003cites this paper
• Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide.

  2003cites this paper
• Responses to endothelium‐derived factors and their interaction in mesenteric arteries from Wistar‐Kyoto and stroke‐prone spontaneously hypertensive rats

  2002cites this paper
• The enzymology of prostaglandin endoperoxide H synthases-1 and -2.

  2002cites this paper
• Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats.

  2002cites this paper
• Colonic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in subjects at high risk or at normal risk for colorectal cancer.

  2001cites this paper
• A study of the dose-response of YM177 for treatment of postsurgical dental pain

  2001cites this paper
• Peripheral Levels of Inflammatory Mediators in Migraineurs During Headache‐free Periods

  2001cites this paper
• Peroxidase Self-inactivation in Prostaglandin H Synthase-1 Pretreated with Cyclooxygenase Inhibitors or Substituted with Mangano Protoporphyrin IX*

  2001cites this paper
• Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats.

  2001cites this paper
• Prostaglandin Endoperoxide H Synthase-1

  2001cites this paper
• Functional status and health-related quality of life of elderly osteoarthritic patients treated with celecoxib.

  2001cites this paper
• Lipopolysaccharide Receptor, Toll -Like Receptor 4, Mediated Signaling Pathways Leading to Cyclooxygenase-2 Expression in Murine Macrophages.

  2001cites this paper
• Evaluation of health-related quality of life of rheumatoid arthritis patients treated with celecoxib.

  2000cites this paper
• Peroxidase activity in prostaglandin endoperoxide H synthase-1 occurs with a neutral histidine proximal heme ligand.

  2000cites this paper
• Fatty-acid substrate interactions with cyclo-oxygenases.

  2000cites this paper
• Effect of chronic treatment with perindopril on endothelium-dependent relaxation of aorta and carotid artery in SHRSP.

  2000cites this paper
• Cyclooxygenases: structural, cellular, and molecular biology.

  2000cites this paper
• The Effects of Dietary Fatty Acids and Non -Steroidal Anti -Inflammatory Drugs on Cyclooxygenase-2 Expression.

  2000cites this paper
• Different Catalytically Competent Arrangements of Arachidonic Acid within the Cyclooxygenase Active Site of Prostaglandin Endoperoxide H Synthase-1 Lead to the Formation of Different Oxygenated Products*

  2000cites this paper
• Effects of Celecoxib, a Novel Cyclooxygenase‐2 Inhibitor, on Platelet Function in Healthy Adults: A Randomized, Controlled Trial

  2000cites this paper
• Endothelium‐derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats

  1999cites this paper
• Evaluation of the Functional Status Aspects of Health‐Related Quality of Life of Patients with Osteoarthritis Treated with Celecoxib

  1999cites this paper
• Kinetic basis for selective inhibition of cyclo-oxygenases.

  1999cites this paper
• Studies on Cyclooxygenase-2 Expression in Lipopolysaccharide-Stimulated Macrophages.

  1999cites this paper
• [Molecular biological study on enzymes involved in cyclooxygenase pathway: structure of their genes and proteins].

  1999cites this paper
• Neue nichtsteroidale Antirheumatika: Selektive Hemmstoffe der induzierbaren Cyclooxygenase

  1998cites this paper
• Cyclooxygenase-2 inhibitors in tumorigenesis (part I).

  1998cites this paper
• Cyclooxygenase-2 inhibitors in tumorigenesis (Part II).

  1998cites this paper
• [New non-steroidal anti-rheumatic drugs: selective inhibitors of inducible cyclooxygenase].

  1998cites this paper
• Involvement of endothelium-derived factors in controlling the active tone of smooth muscle in aorta from hypertensive rats.

  1998cites this paper
• Transcriptional regulation of fatty acid cyclooxygenases-1 and -2.

  1998cites this paper
• Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.

  1998cites this paper
• Cyclooxygenases as the principal targets for the actions of NSAIDs.

  1998cites this paper
• Prevention of NNK-induced lung tumorigenesis in A/J mice by acetylsalicylic acid and NS-398.

  1998cites this paper
• Effect of vitamin E and indomethacin treatment on adenylate cyclase activity, PGE2 and cAMP levels in murine melanoma cells.

  1997cites this paper
• Osmotic Regulation of Na+ Transport Across A6 Epithelium: Interactions with Prostaglandin E2 and Cyclic AMP

  1997cites this paper
• Modulation of cardiac gap junctions: the mode of action of arachidonic acid.

  1997cites this paper
• Expression of recombinant human cyclooxygenase isoenzymes in transfected COS-7 cells in vitro and inhibition by tenoxicam, indomethacin and aspirin.

  1997cites this paper
• Inhibition Site of Methylallyl Trisulfide: A Volatile Oil Component of Garlic, in the Platelet Arachidonic Acid Cascade

  1997cites this paper
• Prostaglandin endoperoxide synthase isozymes

  1997cites this paper
• Induction of cyclo-oxygenase and nitric oxide synthase in inflammation.

  1996cites this paper
• Prostaglandin endoperoxide H synthases-1 and -2.

  1996cites this paper
• Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2*

  1996cites this paper
• The Physiological and Therapeutic Significance of Separate Pathways for Prostaglandin Synthesis

  1996cites this paper
• Prostaglandins and Related Compounds Lipid Messengers with Many Actions

  1996cites this paper
• Role of Val509 in Time-dependent Inhibition of Human Prostaglandin H Synthase-2 Cyclooxygenase Activity by Isoform-selective Agents*

  1996cites this paper
• Prostaglandin synthase 2.

  1996cites this paper
• Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-Iiodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site (*)

  1996cites this paper
• Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1 (*)

  1996cites this paper
• Differences in fatty acid composition of immature and mature articular cartilage in humans and sheep

  1995cites this paper
• Enzymatic Oxidation of Dopamine: The Role of Prostaglandin H Synthase

  1995cites this paper
• Novel intracellular signaling function of prostaglandin H synthase-1 in NF-kappa B activation.

  1995cites this paper
• Tepoxalin, a Novel Dual Inhibitor of the Prostaglandin-H Synthase Cyclooxygenase and Peroxidase Activities (*)

  1995cites this paper
• Modulation of Glutamate and Aspartate Release from Slices of Hippocampal Area CA1 by Inhibitors of Arachidonic Acid Metabolism

  1995cites this paper
• Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid (*)

  1995cites this paper
• Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs.

  1995cites this paper
• Inflammation, reproduction, cancer and all that…. The regulation and role of the inducible prostaglandin synthase

  1995cites this paper
• Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms.

  1995cites this paper
• Prostaglandin endoperoxide synthases-1 and -2.

  1995cites this paper
• Regulation of prostaglandin endoperoxide H synthase by glucocorticoids and activators of protein kinase C in the human amnion.

  1994cites this paper
• Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

  1994cites this paper
• Reaction and free radical kinetics of prostaglandin H synthase with manganese protoporphyrin IX as the prosthetic group.

  1994cites this paper
• Section Review: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Differential interactions of prostaglandin endoperoxide synthases with nonsteroidal anti-inflammatory drugs

  1994cites this paper
• Section Review: Recent progress in the development of leukotriene B4 antagonists

  1994cites this paper
• Prostaglandin-endoperoxide synthase

  1994cites this paper
• The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.

  1994cites this paper
• Oxidation kinetics of caffeic acid by prostaglandin H synthase: potential role in regulation of prostaglandin biosynthesis.

  1994cites this paper
• N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum.

  1993cites this paper
• Selenium deficiency alters the lipoxygenase pathway and mitogenic response in bovine lymphocytes.

  1992cites this paper
• Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

  1992cites this paper
• [Anti-inflammatory activity of sabal fruit extracts prepared with supercritical carbon dioxide. In vitro antagonists of cyclooxygenase and 5-lipoxygenase metabolism].

  1992cites this paper