PI(3,4,5)P3 Interactome.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Proteome Research

• Publication date

  2009-06-08

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/pr900320aPMID 19463016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inositol trisphosphate and calcium signalling mechanisms.

  2009cited by this paper
• Ral GTPases and cancer: linchpin support of the tumorigenic platform

  2008cited by this paper
• Understanding PTEN regulation: PIP2, polarity and protein stability

  2008cited by this paper
• The PTEN–PI3K pathway: of feedbacks and cross-talks

  2008cited by this paper
• Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association.

  2008cited by this paper
• Multiple ways to switch platelet integrins on and off

  2008cited by this paper
• The PI(3,5)P2 and PI(4,5)P2 interactomes.

  2008cited by this paper
• Membrane recognition by phospholipid-binding domains

  2008cited by this paper
• PI3K pathway alterations in cancer: variations on a theme

  2008cited by this paper
• Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.

  2007cited by this paper
• The small G proteins of the Arf family and their regulators.

  2007cited by this paper
• The SPFH domain-containing proteins: more than lipid raft markers.

  2007cited by this paper
• Controlling cell growth and survival through regulated nutrient transporter expression.

  2007cited by this paper
• Regulation of ion transport proteins by membrane phosphoinositides

  2007cited by this paper
• Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis

  2007cited by this paper
• A Chemical Proteomics Approach to Phosphatidylinositol 3-Kinase Signaling in Macrophages*S

  2007cited by this paper
• Membrane targeting and remodeling through phosphoinositide‐binding domains

  2006cited by this paper
• Membrane and juxtamembrane targeting by PH and PTB domains.

  2006cited by this paper
• Determining selectivity of phosphoinositide-binding domains.

  2006cited by this paper
• Cancer-specific mutations in PIK3CA are oncogenic in vivo

  2006cited by this paper
• Signalling through Class I PI3Ks in mammalian cells.

  2006cited by this paper
• Intestinal sugar transport.

  2006cited by this paper
• Phosphoinositides in cell regulation and membrane dynamics

  2006cited by this paper
• PI(3,4,5)P3 and PI(4,5)P2 Lipids Target Proteins with Polybasic Clusters to the Plasma Membrane

  2006cited by this paper
• Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners

  2005cited by this paper
• Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

  2005cited by this paper
• The Ras superfamily at a glance

  2005cited by this paper
• Recruitment of Phosphoinositide 3-Kinase Defines a Positive Contribution of Tyrosine Kinase Signaling to E-cadherin Function*

  2005cited by this paper
• SNARE complexes prepare for membrane fusion.

  2005cited by this paper
• Colorectal cancer: Mutations in a signalling pathway

  2005cited by this paper
• Galectins as modulators of tumour progression

  2005cited by this paper
• Coincidence detection in phosphoinositide signaling.

  2005cited by this paper
• Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.

  2005cited by this paper
• Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions

  2005cited by this paper
• Regulation of the Akt kinase by interacting proteins

  2005cited by this paper
• Phosphoinositide 3-kinase: diverse roles in immune cell activation.

  2004cited by this paper
• The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

  2004cited by this paper
• Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis

  2004cited by this paper
• PDK1, the master regulator of AGC kinase signal transduction.

  2004cited by this paper
• Pleckstrin homology domains: not just for phosphoinositides.

  2004cited by this paper
• Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells.

  2004cited by this paper
• The phosphoinositide (PI) 3-kinase family

  2003cited by this paper
• Affinity purification-mass spectrometry. Powerful tools for the characterization of protein complexes.

  2003cited by this paper
• The structure and function of PKN, a protein kinase having a catalytic domain homologous to that of PKC.

  2003cited by this paper
• Phosphoinositide Recognition Domains

  2003cited by this paper
• Phosphoinositide signaling disorders in human diseases

  2003cited by this paper
• Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.

  2002cited by this paper
• The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

  2002cited by this paper
• Biological aspects of signal transduction by cell adhesion receptors.

  2002cited by this paper
• The phosphoinositide 3-kinase pathway.

  2002cited by this paper
• Synthesis and function of 3-phosphorylated inositol lipids.

  2001cited by this paper
• The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex.

  2001cited by this paper
• Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides.

  2001cited by this paper
• Structural mechanism of endosome docking by the FYVE domain.

  2001cited by this paper
• Signal-dependent membrane targeting by pleckstrin homology (PH) domains.

  2000cited by this paper
• Proteomic analysis of the human colon carcinoma cell line (LIM 1215): Development of a membrane protein database

  2000cited by this paper
• A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1*

  2000cited by this paper
• Inhibition of Akt and Its Anti-apoptotic Activities by Tumor Necrosis Factor-induced Protein Kinase C-related Kinase 2 (PRK2) Cleavage*

  2000cited by this paper
• Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains.

  2000cited by this paper
• Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling.

  2000cited by this paper
• PIK3CA is implicated as an oncogene in ovarian cancer

  1999cited by this paper
• PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

  1999cited by this paper
• H-Ras Activation Promotes Cytoplasmic Accumulation and Phosphoinositide 3-Oh Kinase Association of β-Catenin in Epidermal Keratinocytes

  1999cited by this paper
• New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.

  1999cited by this paper
• Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

  1998cited by this paper
• Phospholipid-binding protein domains.

  1998cited by this paper
• Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling.

  1998cited by this paper
• Pleckstrin homology domains: a common fold with diverse functions.

  1998cited by this paper
• Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking.

  1998cited by this paper
• Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.

  1998cited by this paper
• Phosphoinositide kinases.

  1998cited by this paper
• Akt Signaling--Linking Membrane Events to Life and Death Decisions

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997cited by this paper
• S‐Pyridylethylation of intact polyacrylamide gels and in situ digestion of electrophoretically separated proteins: A rapid mass spectrometric method for identifying cysteine‐containing peptides

  1996cited by this paper
• Mechanism of activation of protein kinase B by insulin and IGF‐1.

  1996cited by this paper
• A colon cancer cell line (LIM1215) derived from a patient with inherited nonpolyposis colorectal cancer.

  1985cited by this paper

• Functional requirements of the liver isoform of phosphofructokinase-1 in breast cancer cell migration

  2025cites this paper
• Thermal Stability of bivalent cation/phosphoinositide domains in model membranes.

  2024cites this paper
• PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P3 Effector Signaling in Colorectal Cancer

  2023cites this paper
• SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages.

  2023cites this paper
• Structure–Activity Studies on Bis-Sulfonamide SHIP1 Activators

  2023cites this paper
• Cetylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection: Super-resolution microscopy reveals CPC interference with multiple protein interactions with phosphatidylinositol 4,5-bisphosphate in immune function

  2021cites this paper
• Synthetic studies on the indane SHIP1 agonist AQX-1125.

  2021cites this paper
• The phosphoinositide code is read by a plethora of protein domains

  2021cites this paper
• Targeting SHIP1 and SHIP2 in Cancer

  2021cites this paper
• Regulation of the Phosphoinositide Code by Phosphorylation of Membrane Readers

  2021cites this paper
• Phosphoinositide Recognition Sites Are Blocked by Metabolite Attachment

  2021influential citation
• Lipid Signaling in Human Diseases

  2020cites this paper
• Nuclear Phosphatidylinositol 3,4,5-Trisphosphate Interactome Uncovers an Enrichment in Nucleolar Proteins

  2020cites this paper
• Recent developments in the synthesis of biologically relevant inositol derivatives

  2020cites this paper
• SHIP1 inhibits cell growth, migration, and invasion in non‑small cell lung cancer through the PI3K/AKT pathway.

  2019cites this paper
• Functions of Nuclear Polyphosphoinositides.

  2019cites this paper
• Polyphosphoinositides in the nucleus: Roadmap of their effectors and mechanisms of interaction.

  2019cites this paper
• The lipid products of phosphoinositide 3-kinase isoforms in cancer and thrombosis

  2018cites this paper
• In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

  2017cites this paper
• α-Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

  2017cites this paper
• α -Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

  2017cites this paper
• α -Catenin homodimers are recruited to phosphoinositide-activated membranes to promote adhesion

  2017cites this paper
• Liposomes in proteome microarrays for the study of lipid-protein interactions

  2016cites this paper
• Synthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.

  2016cites this paper
• Dropping in on the lipid droplet- tumor protein D52 (TPD52) as a new regulator and resident protein

  2016cites this paper
• Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms

  2016cites this paper
• Use of a Phosphatidylinositol Phosphate Affinity Chromatography (PIP Chromatography) for the Isolation of Proteins Involved in Protein Quality Control and Proteostasis Mechanisms in Plants.

  2016cites this paper
• Understanding PI3K signalling in colorectal cancer: from function to therapy

  2016influential citation
• Lipidomics in Health and Diseases - Beyond the Analysis of Lipids

  2015cites this paper
• Synthesis of Highly Water-Soluble Adamantyl Phosphoinositide Derivatives

  2015cites this paper
• Physical chemistry and biophysics of polyphosphoinositide mediated lipid signaling.

  2014cites this paper
• Discovery and Development of Small Molecule SHIP Phosphatase Modulators

  2014cites this paper
• Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.

  2014cites this paper
• Specificity and commonality of the phosphoinositide-binding proteome analyzed by quantitative mass spectrometry.

  2014cites this paper
• Global approaches for the elucidation of phosphoinositide-binding proteins.

  2014cites this paper
• Nuclear phosphoinositides and their impact on nuclear functions

  2013cites this paper
• The PI(3)P interactome from a colon cancer cell.

  2013cites this paper
• Label-free and spike-in standard-free mass spectrometry in the proteomic analysis of plasma membrane proteins and membrane-associated protein networks

  2013cites this paper
• Incorporation of a fluorous diazirine group into phosphatidylinositol 4,5-bisphosphate to illustrate its interaction with ADP-ribosylation factor 1.

  2012cites this paper
• 19 Functional Proteomics : Mapping Lipid-Protein Interactomes

  2012cites this paper
• Profiling Lipid–protein Interactions Using Nonquenched Fluorescent Liposomal Nanovesicles and Proteome Microarrays*

  2012cites this paper
• Microarray analysis of Akt PH domain binding employing synthetic biotinylated analogs of all seven phosphoinositide headgroup isomers.

  2012cites this paper
• Conditional peripheral membrane proteins: facing up to limited specificity.

  2012cites this paper
• Functional Proteomics: Mapping Lipid-Protein Interactomes

  2012cites this paper
• Emerging methodologies to investigate lipid-protein interactions.

  2012cites this paper
• Phosphoinositides in neuroexocytosis and neuronal diseases.

  2012cites this paper
• Studying protein–protein affinity and immobilized ligand–protein affinity interactions using MS-based methods

  2011cites this paper
• A Screen for Novel Phosphoinositide 3-kinase Effector Proteins*

  2011cites this paper
• Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners.

  2011cites this paper
• Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: structure, synthesis, and development of probes for studying biological activity.

  2010cites this paper
• A screen for phosphatidylinositol 3,4-bisphosphate and other 3-phosphoinositide effector proteins

  2010influential citation
• Analysis of cellular phosphatidylinositol (3,4,5)-trisphosphate levels and distribution using confocal fluorescent microscopy.

  2010cites this paper
• Identification of Dynamin-2-Mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates

  2010cites this paper
• An unnatural PIP simulates growth factor signaling.

  2009cites this paper
• Synthesis and biological evaluation of a novel cardiolipin affinity matrix.

  2009cites this paper