Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Molecular and Cellular Biology

• Publication date

  1998-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.18.10.5699PMID 9742087PMCID PMC109156
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

  1998influential reference
• Phosphoinositide kinases.

  1998influential reference
• 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.

  1998cited by this paper
• Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

  1998cited by this paper
• Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav.

  1998influential reference
• Phosphorylation and activation of p70s6k by PDK1.

  1998influential reference
• Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

  1997influential reference
• Cyclin-dependent kinases: engines, clocks, and microprocessors.

  1997influential reference
• Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

  1997cited by this paper
• PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond.

  1997influential reference
• Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

  1997influential reference
• Signalling through the lipid products of phosphoinositide-3-OH kinase

  1997cited by this paper
• Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.

  1997cited by this paper
• PI3K: downstream AKTion blocks apoptosis.

  1997influential reference
• Role of Translocation in the Activation and Function of Protein Kinase B*

  1997influential reference
• Differential effects of constitutively active phosphatidylinositol 3-kinase on glucose transport, glycogen synthase activity, and DNA synthesis in 3T3-L1 adipocytes

  1997influential reference
• Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k

  1997cited by this paper
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  1997influential reference
• Regulation of mammalian cyclin-dependent kinase 2.

  1997cited by this paper
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  1997influential reference
• Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion.

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• Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B.

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• High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity*

  1997influential reference
• Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

  1996influential reference
• Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase.

  1996influential reference
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  1996influential reference
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• Cancer Cell Cycles

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• Activation of cyclin‐dependent kinases by Myc mediates induction of cyclin A, but not apoptosis.

  1996influential reference
• Rapamycin blocks the phosphorylation of 4E‐BP1 and inhibits cap‐dependent initiation of translation.

  1996influential reference
• Overexpression of a Constitutively Active Form of Phosphatidylinositol 3-Kinase Is Sufficient to Promote Glut 4 Translocation in Adipocytes*

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• Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase.

  1995influential reference
• The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

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• Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells

  1995influential reference
• Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

  1995influential reference
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995influential reference
• Evidence for phosphatidylinositol 3-kinase as a regulator of endocytosis via activation of Rab5.

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  1994influential reference
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  1994influential reference
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  1994influential reference
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  1994influential reference
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  1994influential reference
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  1993influential reference
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  1993influential reference
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• Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

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• Association of human cyclin E with a periodic G1-S phase protein kinase.

  1992influential reference
• Induction of apoptosis in fibroblasts by c-myc protein.

  1992influential reference
• A chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside.

  1991influential reference
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  1991influential reference
• A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

  1991influential reference
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  1985cited by this paper
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  1970influential reference

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