Xenon Reduces N-Methyl-d-aspartate and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor–mediated Synaptic Transmission in the Amygdala

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Anesthesiology

• Publication date

  2008-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/ALN.0b013e31818d6aeePMID 19034096
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nitrous oxide (N2O) pre- and postsynaptically attenuates NMDA receptor-mediated neurotransmission in the amygdala.

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• Xenon Acts by Inhibition of Non–N-methyl-d-aspartate Receptor–mediated Glutamatergic Neurotransmission in Caenorhabditis elegans

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• Does the Amygdala Mediate Anesthetic-induced Amnesia?: Basolateral Amygdala Lesions Block Sevoflurane-induced Amnesia

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• Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor‐mediated inhibition

  2005cited by this paper
• Xenon, a modern anaesthesia gas.

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• Molecular and neuronal substrates for general anaesthetics

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• Determinants of the Sensitivity of AMPA Receptors to Xenon

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• Synaptic Plasticity in the Amygdala in a Model of Arthritic Pain: Differential Roles of Metabotropic Glutamate Receptors 1 and 5

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• Mechanisms of actions of inhaled anesthetics.

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• Mechanisms of Anesthesia: Towards Integrating Network, Cellular, and Molecular Level Modeling

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• Multicenter Randomized Comparison of the Efficacy and Safety of Xenon and Isoflurane in Patients Undergoing Elective Surgery

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• Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.

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• Which GABA ,-receptor subtypes really occur in the brain ?

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• Effects of Gaseous Anesthetics Nitrous Oxide and Xenon on Ligand-gated Ion Channels: Comparison with Isoflurane and Ethanol

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• Nitrous oxide and xenon increase the efficacy of GABA at recombinant mammalian GABA(A) receptors.

  2000cited by this paper
• A Single Glycine Residue at the Entrance to the First Membrane-Spanning Domain of the γ-Aminobutyric Acid Type A Receptor β2 Subunit Affects Allosteric Sensitivity to GABA and Anesthetics

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• Nitrous Oxide and Xenon Increase the Efficacy of GABA at Recombinant Mammalian GABAA Receptors

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• Contrasting Synaptic Actions of the Inhalational General Anesthetics Isoflurane and Xenon

  2000influential reference
• Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.

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• theta, a novel gamma-aminobutyric acid type A receptor subunit.

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• Molecular modulation of recombinant rat α1β2γ2 GABAA receptor channels by diazepam

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• Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury.

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• Desensitized states prolong GABAA channel responses to brief agonist pulses.

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• Selective actions of volatile general anaesthetics at molecular and cellular levels.

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• Electrophysiological and morphological properties of rat basolateral amygdaloid neurons in vitro

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• Bridging the deft at GABA synapses in the brain

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• Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders

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  2025influential citation
• Synaptic effects of xenon on NMDA receptor-mediated response in rat spinal neuron.

  2024cites this paper
• Therapeutic Effects of Noble Gases

  2024cites this paper
• Xenon’s Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice

  2023cites this paper
• The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature

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• Protein Kinase A Is Responsible for the Presynaptic Inhibition of Glycinergic and Glutamatergic Transmissions by Xenon in Rat Spinal Cord and Hippocampal CA3 Neurons

  2023cites this paper
• The Anaesthetics Isoflurane and Xenon Reverse the Synaptotoxic Effects of Aβ1–42 on Megf10-Dependent Astrocytic Synapse Elimination and Spine Density in Ex Vivo Hippocampal Brain Slices

  2023cites this paper
• Depression of Synaptic N-methyl-D-Aspartate Responses by Xenon and Nitrous Oxide

  2022cites this paper
• Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

  2022cites this paper
• Xenon modulates the GABA and glutamate responses at genuine synaptic levels in rat spinal neurons.

  2020cites this paper
• Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders.

  2019cites this paper
• The anaesthetic xenon partially restores an amyloid beta‐induced impairment in murine hippocampal synaptic plasticity

  2019cites this paper
• Inhibition of NR2B-containing NMDA receptors during nitrogen narcosis.

  2019cites this paper
• Mechanism and Development of Modern General Anesthetics.

  2019cites this paper
• The Challenge of Accidental Awareness During General Anesthesia

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• Xenon modulates synaptic transmission to rat hippocampal CA3 neurons at both pre‐ and postsynaptic sites

  2019influential citation
• Combining Xenon Inhalation With Trauma Memory Reactivation to Reduce Symptoms of Posttraumatic Stress Disorder: Case Report, Justification of Approach, and Review of the Literature.

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• Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties

  2017cites this paper
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• Molecular Targets of General Anesthetics in the Nervous System

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• Anesthesia and postoperative cognitive dysfunction (POCD).

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