The diverse biological properties of the chemically inert noble gases.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Pharmacology and Therapeutics

• Publication date

  2016-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.pharmthera.2016.02.002PMID 26896563
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of helium on inflammatory and oxidative stress-induced endothelial cell damage.

  2015cited by this paper
• [Neuroprotection by noble gases: New developments and insights].

  2015cited by this paper
• Argon: a novel therapeutic option to treat neuronal ischemia and reperfusion injuries?

  2015cited by this paper
• Pharmacokinetic analysis of the chronic administration of the inert gases Xe and Ar using a physiological based model

  2015cited by this paper
• Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in the nucleus accumbens

  2015cited by this paper
• Neuroprotektion durch Edelgase

  2015cited by this paper
• Therapeutic gas delivery via microbubbles and liposomes.

  2015cited by this paper
• Xenon triggers pro-inflammatory effects and suppresses the anti-inflammatory response compared to sevoflurane in patients undergoing cardiac surgery

  2015cited by this paper
• Comparison of the effects of xenon and sevoflurane anaesthesia on leucocyte function in surgical patients: a randomized trial.

  2014cited by this paper
• Delayed post-ischaemic administration of xenon reduces brain damage in a rat model of global ischaemia

  2014cited by this paper
• Argon: Systematic Review on Neuro- and Organoprotective Properties of an “Inert” Gas

  2014cited by this paper
• Xenon Ventilation During Therapeutic Hypothermia in Neonatal Encephalopathy: A Feasibility Study

  2014cited by this paper
• The effects of xenon and nitrous oxide gases on alcohol relapse.

  2014cited by this paper
• Experimental evidence on interaction between xenon and bovine serum albumin.

  2014cited by this paper
• Anticonvulsant effect of xenon on neonatal asphyxial seizures

  2013cited by this paper
• Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions.

  2013cited by this paper
• Antiapoptotic activity of argon and xenon

  2013cited by this paper
• Xenon-related Analgesia: A New Target for Pain Treatment

  2013cited by this paper
• Xenon consumption during general surgery: a retrospective observational study

  2013cited by this paper
• Protecting both heart and brain: a noble goal for a noble gas.

  2013cited by this paper
• Biophysical changes induced by xenon on phospholipid bilayers.

  2013cited by this paper
• Xenon treatment attenuates early renal allograft injury associated with prolonged hypothermic storage in rats

  2013cited by this paper
• [Xenon and sevoflurane anti stress activity comparative assessment during elective anaesthesia in pediatric patients].

  2013cited by this paper
• Therapeutic Time Window and Dose Dependence of Xenon Delivered via Echogenic Liposomes for Neuroprotection in Stroke

  2013cited by this paper
• Nanoemulsion contrast agents with sub-picomolar sensitivity for xenon NMR.

  2013cited by this paper
• Xenon Treatment Protects Against Cold Ischemia Associated Delayed Graft Function and Prolongs Graft Survival in Rats

  2013cited by this paper
• Diffusive nature of xenon anesthetic changes properties of a lipid bilayer: molecular dynamics simulations.

  2012cited by this paper
• The Shaker Potassium Channel Is No Target for Xenon Anesthesia in Short-Sleeping Drosophila melanogaster Mutants

  2012cited by this paper
• Ex Vivo and In Vivo Neuroprotection Induced by Argon When Given after an Excitotoxic or Ischemic Insult

  2012cited by this paper
• Modulation by the noble gas argon of the catalytic and thrombolytic efficiency of tissue plasminogen activator

  2012cited by this paper
• Argon: the 'lazy' noble gas with organoprotective properties.

  2012cited by this paper
• Xenon Anesthesia Reduces TNFα and IL10 in Bariatric Patients

  2012cited by this paper
• Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents

  2012cited by this paper
• The noble gas argon modifies extracellular signal-regulated kinase 1/2 signaling in neurons and glial cells.

  2012cited by this paper
• The origin of the terrestrial noble-gas signature

  2012cited by this paper
• Noble Gas (Argon and Xenon)-Saturated Cold Storage Solutions Reduce Ischemia-Reperfusion Injury in a Rat Model of Renal Transplantation

  2012cited by this paper
• Xenon is not superior to isoflurane on cardiovascular function during experimental acute pulmonary hypertension

  2012cited by this paper
• Online monitoring of intelligent polymers for drug release with hyperpolarized xenon.

  2012cited by this paper
• Xenonnarkosen – Klinische Besonderheiten, Vor- und Nachteile sowie mögliche Einsatzgebiete

  2012cited by this paper
• Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia

  2012cited by this paper
• The protective profile of argon, helium, and xenon in a model of neonatal asphyxia in rats*

  2012cited by this paper
• Xenon Enhances LPS-Induced IL-1β Expression in Microglia via the Extracellular Signal-Regulated Kinase 1/2 Pathway

  2011cited by this paper
• Neuroprotective effects of argon in an in vivo model of transient middle cerebral artery occlusion in rats*

  2011cited by this paper
• MDpocket: open-source cavity detection and characterization on molecular dynamics trajectories

  2011cited by this paper
• [Xenon for postoperative analgesia: why not?].

  2011cited by this paper
• Intranasal Application of Xenon Reduces Opioid Requirement and Postoperative Pain in Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial

  2011cited by this paper
• Xenon Pretreatment May Prevent Early Memory Decline after Isoflurane Anesthesia and Surgery in Mice

  2011cited by this paper
• Xenon exposure in the neonatal rat brain: effects on genes that regulate apoptosis.

  2011cited by this paper
• Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs

  2010cited by this paper
• Adsorption of xenon on a protein arising from the translational motion of solvent molecules.

  2010cited by this paper
• Competitive Inhibition at the Glycine Site of the N-Methyl-d-Aspartate Receptor Mediates Xenon Neuroprotection against Hypoxia–Ischemia

  2010cited by this paper
• Xenon inhibits excitatory but not inhibitory transmission in rat spinal cord dorsal horn neurons

  2010cited by this paper
• [Current developments in xenon research. Importance for anesthesia and intensive care medicine].

  2010cited by this paper
• Xenon-induced changes in CNS sensitization to pain

  2010cited by this paper
• [Benefits and indications of xenon anaesthesia].

  2010cited by this paper
• In Vivo Therapeutic Gas Delivery for Neuroprotection With Echogenic Liposomes

  2010cited by this paper
• Xenon as an anesthetic agent.

  2010cited by this paper
• Recovery index, attentiveness and state of memory after xenon or isoflurane anaesthesia: a randomized controlled trial

  2010cited by this paper
• Xenon anaesthesia produces better early postoperative cognitive recovery than sevoflurane anaesthesia

  2010cited by this paper
• Intranasal application of xenon: describing the pharmacokinetics in experimental animals and the increased pain tolerance within a placebo-controlled experimental human study.

  2010cited by this paper
• Mechanistic insights into xenon inhibition of NMDA receptors from MD simulations.

  2010cited by this paper
• Cellular Effects of Helium in Different Organs

  2010cited by this paper
• Xenon prevents inflammation-induced delayed pain hypersensitivity in rats

  2010cited by this paper
• Noble Gas Xenon Is a Novel Adenosine Triphosphate-sensitive Potassium Channel Opener

  2010cited by this paper
• Xenon is an Inhibitor of Tissue-Plasminogen Activator: Adverse and Beneficial Effects in a Rat Model of Thromboembolic Stroke

  2010cited by this paper
• Xenon blocks AMPA and NMDA receptor channels by different mechanisms.

  2009cited by this paper
• The effect of xenon on isoflurane protection against experimental myocardial infarction.

  2009cited by this paper
• Xenon out of its shell.

  2009cited by this paper
• Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation.

  2009cited by this paper
• Xenon Attenuates Excitatory Synaptic Transmission in the Rodent Prefrontal Cortex and Spinal Cord Dorsal Horn

  2009cited by this paper
• The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala.

  2009cited by this paper
• Neuronal Preconditioning by Inhalational Anesthetics: Evidence for the Role of Plasmalemmal Adenosine Triphosphate–sensitive Potassium Channels

  2009cited by this paper
• Argon: Neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury

  2009cited by this paper
• Helium Breathing Provides Modest Antiinflammatory, but No Endothelial Protection Against Ischemia-Reperfusion Injury in Humans In Vivo

  2009cited by this paper
• A Closed-Circuit Neonatal Xenon Delivery System: A Technical and Practical Neuroprotection Feasibility Study in Newborn Pigs

  2009cited by this paper
• In vitro-evaluation of lipid emulsions as vehicles for the administration of xenon: interaction with NMDA receptors.

  2009cited by this paper
• Noble Gas Binding to Human Serum Albumin Using Docking Simulation: Nonimmobilizers and Anesthetics Bind to Different Sites

  2008cited by this paper
• Evidence that Xenon does not produce open channel blockade of the NMDA receptor.

  2008cited by this paper
• Xenon Reduces N-Methyl-d-aspartate and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor–mediated Synaptic Transmission in the Amygdala

  2008cited by this paper
• Intermitted Pharmacologic Pretreatment by Xenon, Isoflurane, Nitrous Oxide, and the Opioid Morphine Prevents Tumor Necrosis Factor α–induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cells

  2008cited by this paper
• Xenon induces transcription of ADNP in neonatal rat brain.

  2008cited by this paper
• Xenon and Sevoflurane Protect against Brain Injury in a Neonatal Asphyxia Model

  2008cited by this paper
• Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia.

  2008cited by this paper
• Xenon Does Not Affect γ-Aminobutyric Acid Type A Receptor Binding in Humans

  2008cited by this paper
• Xenon Up-regulates Several Genes That are not Up-regulated by Nitrous Oxide

  2008cited by this paper
• The neuroprotective effects of xenon and helium in an in vitro model of traumatic brain injury*

  2008cited by this paper
• The Effect of Xenon Anesthesia on the Size of Experimental Myocardial Infarction

  2007cited by this paper
• Three-dimensional distribution function theory for the prediction of protein-ligand binding sites and affinities: application to the binding of noble gases to hen egg-white lysozyme in aqueous solution.

  2007cited by this paper
• Competitive Inhibition at the Glycine Site of the N-Methyl-d-aspartate Receptor by the Anesthetics Xenon and Isoflurane: Evidence from Molecular Modeling and Electrophysiology

  2007cited by this paper
• Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action.

  2007cited by this paper
• Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin.

  2006cited by this paper
• The Differential Effects of Nitrous Oxide and Xenon on Extracellular Dopamine Levels in the Rat Nucleus Accumbens: A Microdialysis Study

  2006cited by this paper
• Xenon Preconditioning Reduces Brain Damage from Neonatal Asphyxia in Rats

  2006cited by this paper
• Xenon as an anaesthetic gas.

  2006cited by this paper
• Xenon preconditioning differently regulates p44/42 MAPK (ERK 1/2) and p46/54 MAPK (JNK 1/2 and 3) in vivo.

  2006cited by this paper
• Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization.

  2006cited by this paper
• Handbook on Hyperbaric Medicine

  2006cited by this paper
• The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC‐ɛ and p38 MAPK

  2005cited by this paper
• Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones.

  2005cited by this paper
• Xenon Acts by Inhibition of Non–N-methyl-d-aspartate Receptor–mediated Glutamatergic Neurotransmission in Caenorhabditis elegans

  2005cited by this paper

• Gas Goes Nano: Transformative nanotechnology redefines gas therapeutics for brain disorders

  2026cites this paper
• Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders

  2025cites this paper
• Argon Alleviates Bone Cancer Pain by Mitigating Neuronal Ferroptosis via the TLR2-COX-2 Pathway.

  2025cites this paper
• Confinement-intensified multi-heavy-atom effect in a tetrahedral iodine cage enables unprecedented capture of trace xenon and krypton

  2025cites this paper
• A detailed review of the recent development of needle-free drug delivery devices

  2025cites this paper
• Biomimetic Hydrophobic-Polar Metal-Organic Frameworks for Record-Breaking Separation and Capture of Xenon and Krypton.

  2025cites this paper
• Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy.

  2025cites this paper
• Ultrasensitive 129Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing

  2025cites this paper
• Noble Gases in Medicine: Current Status and Future Prospects

  2024cites this paper
• A Review on the Nobility and Medical Importance of Helium

  2024cites this paper
• Therapeutic Effects of Noble Gases

  2024cites this paper
• Effective approaches to boost Xe/Kr separation in Metal-Organic Frameworks: A review

  2024cites this paper
• Molecular Hydrogen: From Molecular Effects to Stem Cells Management and Tissue Regeneration

  2023cites this paper
• 3D ultra-micropore organic polymers with fixed group and thieno[3,2-b]thiophene to enhance adsorption and separation of Xe/Kr

  2023cites this paper
• Combination of High-Throughput Screening and Assembly to Discover Efficient Metal-Organic Frameworks on Kr/Xe Adsorption Separation.

  2023cites this paper
• A method for the identification of potentially bioactive argon binding sites in protein families

  2023cites this paper
• Separation of Xenon from Noble Gas Mixtures of Argon, Krypton, and Xenon Using Gas Hydrate Technology

  2023cites this paper
• Chemiluminescent Analysis of Oxidative Metabolism in Rat Blood under the Influence of Argon and Helium

  2023cites this paper
• The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature

  2023cites this paper
• Local Xenon-Protein Interaction Produces Global Conformational Change and Allosteric Inhibition in Lysozyme.

  2023cites this paper
• Brain Targeted Xenon Protects Cerebral Vasculature After Traumatic Brain Injury

  2023cites this paper
• Accurate measurement of sequential Ar desorption energies from the dispersion-dominated Ar1-3 complexes of aromatic molecules.

  2023cites this paper
• Some Beneficial Effects of Inert Gases on Blood Oxidative Metabolism: In Vivo Study

  2022cites this paper
• Identifying medically relevant xenon protein targets by in silico screening of the structural proteome

  2022cites this paper
• Method for the Identification of Potentially Bioactive Argon Binding Sites in Protein Families

  2022cites this paper
• Discovery of the Xenon-Protein Interactome Using Large-Scale Measurements of Protein Folding and Stability.

  2022cites this paper
• How to Survive 33 min after the Umbilical of a Saturation Diver Severed at a Depth of 90 msw?

  2022cites this paper
• Medical Gas Therapy for Tissue, Organ, and CNS Protection: A Systematic Review of Effects, Mechanisms, and Challenges

  2022cites this paper
• Efficient Xe/Kr Separation Based on a Lanthanide-Organic Framework with One-Dimensional Local Positively Charged Rhomboid Channels.

  2022cites this paper
• Efficient and selective capture of Xenon over Krypton by a window-cage metal-organic framework with parallel aromatic rings

  2022cites this paper
• Argon pharmacokinetics: a solubility measurement technique

  2022cites this paper
• Study of heat loss mechanism in argon-circulated hydrogen engine combustion chamber wall surface conditions

  2022cites this paper
• Noble gas and neuroprotection: From bench to bedside

  2022cites this paper
• Creating Optimal Pockets in a Clathrochelate-Based Metal-Organic Framework for Gas Adsorption and Separation: Experimental and Computational Studies.

  2022cites this paper
• Application of Gas Hydrates in the Separation and Purification of Xenon from a Mixture of Xenon and Argon

  2021cites this paper
• Inhalational Gases for Neuroprotection in Traumatic Brain Injury

  2021cites this paper
• Effects of High Pressure on the Activity of Ordinary Animals, Including Humans, and on the Function of Their Excitable Cells and Ion Channels

  2021cites this paper
• Timely and Appropriate Administration of Inhaled Argon Provides Better Outcomes for tMCAO Mice: A Controlled, Randomized, and Double-Blind Animal Study

  2021cites this paper
• Divers: Air-Breathing Animals, Including Humans, at High Pressure

  2021cites this paper
• A combined spectroscopic and computational investigation on dispersion-controlled docking of Ar atoms on 2-(2'-pyridyl)benzimidazole.

  2021cites this paper
• The role of flexibility in MOFs

  2020cites this paper
• Double-blind, randomized, placebo-controlled study of Xenon in cancer pain therapy

  2020cites this paper
• Revisiting the Effects of Xenon on Urate Oxidase and Tissue Plasminogen Activator: No Evidence for Inhibition by Noble Gases

  2020cites this paper
• Computational fluid dynamics applied to the ventilation of small-animal laboratory cages

  2020cites this paper
• Neuroprotection of dopamine neurons by xenon against low-level excitotoxic insults is not reproduced by other noble gases

  2019cites this paper
• Inhaled xenon neuro- and cardioprotection following out-of-hospital cardiac arrest. A randomized, controlled trial

  2019cites this paper
• Numerical analysis of mechanical ventilation using high concentration medical gas mixtures in newborns

  2019cites this paper
• A Massive In Silico Study of Noble Gas Binding to the Structural Proteome.

  2019cites this paper
• Decoding the Rich Biological Properties of Noble Gases: How Well Can We Predict Noble Gas Binding to Diverse Proteins?

  2018cites this paper
• References

  2018cites this paper
• Pulmonary static inflation with 50% xenon attenuates decline in tissue factor in patients undergoing Stanford type A acute aortic dissection repair.

  2018cites this paper
• Xenon-Protein Interactions: Characterization by X-Ray Crystallography and Hyper-CEST NMR.

  2018cites this paper
• Xenon Gas Separation and Storage Using Metal-Organic Frameworks

  2018cites this paper
• Pulmonary Delivery of Therapeutic and Diagnostic Gases

  2018cites this paper
• Inert Gas Deactivates Protein Activity by Aggregation

  2017cites this paper
• Effects of pulmonary static inflation with 50% xenon on oxygen impairment during cardiopulmonary bypass for stanford type A acute aortic dissection

  2017cites this paper
• Pretreatment With Argon Protects Human Cardiac Myocyte-Like Progenitor Cells from Oxygen Glucose Deprivation-Induced Cell Death by Activation of AKT and Differential Regulation of Mapkinases

  2017cites this paper
• Anesthetic activity and the electrostatic potential (revisited)

  2017cites this paper
• Protection of xenon against postoperative oxygen impairment in adults undergoing Stanford Type-A acute aortic dissection surgery

  2017cites this paper
• Xenon Recovery at Room Temperature using Metal-Organic Frameworks.

  2017cites this paper
• Gas transport during in vitro and in vivo preclinical testing of inert gas therapies

  2016cites this paper
• Neuroprotective and neurorestorative potential of xenon

  2016cites this paper