Molecular Targets of General Anesthetics in the Nervous System

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-60761-462-3_2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.

  2009cited by this paper
• Nicotinic receptor-evoked hippocampal norepinephrine release is highly sensitive to inhibition by isoflurane.

  2009cited by this paper
• The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAA Receptor β3N265M Knock-In Mouse

  2009cited by this paper
• Neurotoxicity of General Anesthetics: Cause for Concern?

  2009cited by this paper
• HCN1 Channel Subunits Are a Molecular Substrate for Hypnotic Actions of Ketamine

  2009cited by this paper
• Comparative Effects of Halogenated Inhaled Anesthetics on Voltage-gated Na+ Channel Function

  2009cited by this paper
• Isoflurane Inhibits the Tetrodotoxin-resistant Voltage-gated Sodium Channel Nav1.8

  2009cited by this paper
• Neurotoxicity of General Anesthetics Cause for Concern?

  2009cited by this paper
• Amnestic Concentrations of Etomidate Modulate GABAA,slow Synaptic Inhibition in Hippocampus

  2009cited by this paper
• Xenon Reduces N-Methyl-d-aspartate and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor–mediated Synaptic Transmission in the Amygdala

  2008cited by this paper
• Inhibitory ligand-gated ion channels as substrates for general anesthetic actions.

  2008influential reference
• Mutation of α1G T-type Calcium Channels in Mice Does Not Change Anesthetic Requirements for Loss of the Righting Reflex and Minimum Alveolar Concentration but Delays the Onset of Anesthetic Induction

  2007cited by this paper
• Competitive Inhibition at the Glycine Site of the N-Methyl-d-aspartate Receptor by the Anesthetics Xenon and Isoflurane: Evidence from Molecular Modeling and Electrophysiology

  2007cited by this paper
• Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK‐1

  2007cited by this paper
• General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo.

  2007cited by this paper
• The Common Chemical Motifs Within Anesthetic Binding Sites

  2007cited by this paper
• Isoflurane Inhibits NaChBac, a Prokaryotic Voltage-Gated Sodium Channel

  2007cited by this paper
• TASK-3 Knockout Mice Exhibit Exaggerated Nocturnal Activity, Impairments in Cognitive Functions, and Reduced Sensitivity to Inhalation Anesthetics

  2007cited by this paper
• Isoform-selective Effects of Isoflurane on Voltage-gated Na+ Channels

  2007cited by this paper
• Differential Modulation of Human N-Methyl-d-Aspartate Receptors by Structurally Diverse General Anesthetics

  2006cited by this paper
• α5GABAA Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

  2006cited by this paper
• The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the α2 Adrenergic Sedative Dexmedetomidine, and Cannabinoid Agonists

  2006cited by this paper
• Altered hippocampal gene expression 2 days after general anesthesia in rats.

  2006cited by this paper
• Different kinetic properties of two T‐type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane

  2005cited by this paper
• Emerging molecular mechanisms of general anesthetic action.

  2005cited by this paper
• The Effect of Three Inhaled Anesthetics in Mice Harboring Mutations in the GluR6 (Kainate) Receptor Gene

  2005cited by this paper
• HCN Subunit-Specific and cAMP-Modulated Effects of Anesthetics on Neuronal Pacemaker Currents

  2005cited by this paper
• Depression by Isoflurane of the Action Potential and Underlying Voltage-Gated Ion Currents in Isolated Rat Neurohypophysial Nerve Terminals

  2005cited by this paper
• Selective activation of G-protein coupled receptors by volatile anesthetics.

  2005cited by this paper
• Foundations of Anesthesia: Basic Sciences for Clinical Practice

  2005cited by this paper
• The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis

  2005cited by this paper
• Inhibition of spinal protein kinase C-epsilon or -gamma isozymes does not affect halothane minimum alveolar anesthetic concentration in rats.

  2004cited by this paper
• Tonically active GABA A receptors: modulating gain and maintaining the tone.

  2004cited by this paper
• Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

  2004cited by this paper
• Selective Enhancement of Tonic GABAergic Inhibition in Murine Hippocampal Neurons by Low Concentrations of the Volatile Anesthetic Isoflurane

  2004cited by this paper
• Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.

  2004cited by this paper
• Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitability.

  2004cited by this paper
• Molecular and neuronal substrates for general anaesthetics

  2004cited by this paper
• Effects of Alcohols and Anesthetics on Recombinant Voltage-Gated Na+ Channels

  2004cited by this paper
• The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis

  2004cited by this paper
• Alterations in Rat Brain Proteins after Desflurane Anesthesia

  2004cited by this paper
• Isoflurane Inhibits Transmitter Release and the Presynaptic Action Potential

  2004influential reference
• TREK‐1, a K+ channel involved in neuroprotection and general anesthesia

  2004cited by this paper
• Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

  2004cited by this paper
• Defining the propofol binding site location on the GABAA receptor.

  2004cited by this paper
• Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates.

  2004cited by this paper
• The TREK K2P channels and their role in general anaesthesia and neuroprotection.

  2004cited by this paper
• Identification of a General Anesthetic Binding Site in the Diacylglycerol-binding Domain of Protein Kinase Cδ*

  2004cited by this paper
• Mechanism of Action of Volatile Anesthetics: Role of Protein Kinase C

  2003cited by this paper
• Selective Depression by General Anesthetics of Glutamate Versus GABA Release from Isolated Cortical Nerve Terminals

  2003cited by this paper
• Presynaptic Actions of General Anesthetics

  2003cited by this paper
• Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms

  2003cited by this paper
• Inhaled Anesthetics and Immobility: Mechanisms, Mysteries, and Minimum Alveolar Anesthetic Concentration

  2003cited by this paper
• Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals.

  2003cited by this paper
• Actions of General Anesthetic on Voltage-Gated Ion Channels

  2003cited by this paper
• Hyperpolarization-activated cation currents: from molecules to physiological function.

  2003cited by this paper
• Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel.

  2003cited by this paper
• General anesthetic actions in vivo strongly attenuated by a point mutation in the GABAA receptor β3 subunit

  2003cited by this paper
• Neural Mechanisms of Anesthesia

  2003cited by this paper
• Anaesthetic actions on other targets: protein kinase C and guanine nucleotide-binding proteins.

  2002cited by this paper
• Convergent and reciprocal modulation of a leak K+ current and Ih by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones

  2002cited by this paper
• Nonhalogenated Alkane Anesthetics Fail to Potentiate Agonist Actions on Two Ligand-gated Ion Channels

  2001cited by this paper
• Relevant Concentrations of Inhaled Anesthetics for In Vitro Studies of Anesthetic Mechanisms

  2001cited by this paper
• Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.

  2001cited by this paper
• Evidence for a Common Binding Cavity for Three General Anesthetics within the GABAA Receptor

  2001influential reference
• Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics.

  2001cited by this paper
• Anesthetic-sensitive 2P Domain K+ Channels

  2001cited by this paper
• Interaction of Volatile Anesthetics with Human Kv Channels in Relation to Clinical Concentrations

  2001cited by this paper
• Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide.

  2001cited by this paper
• Anesthetics and ion channels: molecular models and sites of action.

  2001influential reference
• Structure and regulation of voltage-gated Ca2+ channels.

  2000cited by this paper
• Xenon Does Not Alter Cardiac Function or Major Cation Currents in Isolated Guinea Pig Hearts or Myocytes

  2000cited by this paper
• Differential Effects of Anesthetic and Nonanesthetic Cyclobutanes on Neuronal Voltage-gated Sodium Channels

  2000cited by this paper
• The Effects of Pentobarbital, Isoflurane, and Propofol on Immediate-Early Gene Expression in the Vital Organs of the Rat

  2000cited by this paper
• The TASK-1 Two-Pore Domain K+ Channel Is a Molecular Substrate for Neuronal Effects of Inhalation Anesthetics

  2000cited by this paper
• Effects of halothane and isoflurane on fast and slow inactivation of human heart hH1a sodium channels.

  1999cited by this paper
• Isoflurane inhibits neuronal Ca2+ channels through enhancement of current inactivation.

  1999cited by this paper
• The glutamate receptor ion channels.

  1999influential reference
• Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds.

  1999cited by this paper
• General anaesthetic actions on ligand-gated ion channels

  1999cited by this paper
• Inhalational anesthetics activate two-pore-domain background K+ channels

  1999cited by this paper
• Agonist gating and isoflurane potentiation in the human gamma-aminobutyric acid type A receptor determined by the volume of a second transmembrane domain residue.

  1999cited by this paper
• Potassium channels: basic aspects, functional roles, and medical significance.

  1999cited by this paper
• Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

  1998cited by this paper
• How does xenon produce anaesthesia?

  1998cited by this paper
• General anesthetic effects on protein kinase C.

  1998cited by this paper
• Inhibition of Presynaptic Sodium Channels by Halothane

  1998cited by this paper
• Halothane depresses action potential conduction in hippocampal axons.

  1998influential reference
• Effect of Nitrous Oxide on Excitatory and Inhibitory Synaptic Transmission in Hippocampal Cultures

  1998cited by this paper
• Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin

  1998influential reference
• Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

  1998influential reference
• Alpha4beta2 Neuronal Nicotinic Acetylcholine Receptors in the Central Nervous System Are Inhibited by Isoflurane and Propofol, but alpha7‐type Nicotinic Acetylcholine Receptors Are Unaffected

  1997cited by this paper
• Inhibitory effects of anesthetics and ethanol on muscarinic receptors expressed in Xenopus oocytes.

  1997cited by this paper
• The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid.

  1997cited by this paper
• Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

  1997influential reference
• Inhibition of 5-hydroxytryptamine type 2A receptor-induced currents by n-alcohols and anesthetics.

  1997cited by this paper
• Differential Sensitivities of Mammalian Neuronal and Muscle Nicotinic Acetylcholine Receptors to General Anesthetics

  1997cited by this paper
• Volatile Anesthetics Depress Glutamate Transmission Via Presynaptic Actions

  1996cited by this paper
• Actions of general anaesthetics on 5‐HT3 receptors in N1E‐115 neuroblastoma cells

  1996cited by this paper
• Nicotinic receptors in the development and modulation of CNS synapses.

  1996cited by this paper

• General anesthesia bullies the gut: a toxic relationship with dysbiosis and cognitive dysfunction

  2022cites this paper
• Effects of General Anesthetics on Synaptic Transmission and Plasticity

  2021cites this paper
• Explaining anaesthetic hysteresis with effect-site equilibration.

  2020cites this paper
• Mechanisms of Action of Inhaled Volatile General Anesthetics: Unconsciousness at the Molecular Level

  2019cites this paper
• Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.

  2019cites this paper
• Development and validation of brain target controlled infusion of propofol in mice

  2018cites this paper
• Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury

  2014cites this paper
• Mechanisms of action of general anesthetics.

  2014cites this paper
• Modulation of the Hippocampal θ-Rhythm as a Mechanism for Anesthetic-Induced Amnesia

  2009cites this paper
• Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects

  2009cites this paper