The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.
Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
Quanguo He,Jun Liu,Jing Liang,Xiaopeng Liu,W. Li,Zhi Liu,Ziyu Ding,Du Tuo
Published 2018 in Cells
ABSTRACT
PUBLICATION RECORD
- Publication year
2018
- Venue
Cells
- Publication date
2018-03-23
- Fields of study
Medicine, Materials Science
- Identifiers
- External record
- Source metadata
Semantic Scholar, PubMed
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