A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Nature

• Publication date

  1996-08-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/382536A0PMID 8700226
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

  2002cited by this paper
• Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.

  1996cited by this paper
• Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.

  1995cited by this paper
• Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

  1995cited by this paper
• The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

  1995cited by this paper
• The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

  1995cited by this paper
• Genes that regulate both development and longevity in Caenorhabditis elegans.

  1995cited by this paper
• When is a lipid kinase not a lipid kinase? When it is a protein kinase.

  1995cited by this paper
• The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase.

  1995cited by this paper
• Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

  1995cited by this paper
• Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells.

  1994cited by this paper
• Neurosecretory cells expressing the gene for common precursor for diapause hormone and pheromone biosynthesis-activating neuropeptide in the suboesophageal ganglion of the silkworm, Bombyx mori.

  1994cited by this paper
• Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.

  1994cited by this paper
• Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

  1994cited by this paper
• daf-2, daf-16 and daf-23: genetically interacting genes controlling Dauer formation in Caenorhabditis elegans.

  1994cited by this paper
• Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

  1994cited by this paper
• PI 3‐kinase: structural and functional analysis of intersubunit interactions.

  1994cited by this paper
• Phosphatidylinositol 3‐kinase

  1994cited by this paper
• Oxidative stress and ageing in Caenorhabditis elegans.

  1993cited by this paper
• A C. elegans mutant that lives twice as long as wild type

  1993cited by this paper
• Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans.

  1993cited by this paper
• Aging and resistance to oxidative damage in Caenorhabditis elegans.

  1993cited by this paper
• Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

  1993cited by this paper
• A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

  1993cited by this paper
• Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.

  1992cited by this paper
• The C. elegans genome sequencing project: a beginning

  1992cited by this paper
• Longevity, senescence, and the genome

  1990cited by this paper
• A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results.

  1983cited by this paper
• Interacting genes in nematode dauer larva formation

  1981cited by this paper

• FGF-dependent, polarized SOS activity orchestrates directed migration of C. elegans muscle progenitors independently of canonical effectors in vivo

  2026cites this paper
• Fava bean and pea protein hydrolysates modulate stress responses in C. elegans through different mechanisms.

  2026cites this paper
• Three Muscle-Specific DAF-16/FOXO Transcriptional Targets Activated by Reduced Insulin/IGF-1 Signaling

  2026influential citation
• Studies of Foxo1 over the Past 25 Years: Mechanisms of Insulin Resistance and Glucose Dysregulation

  2026cites this paper
• DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance

  2025cites this paper
• Metabolic state modulates risky foraging behavior via multiple branches of the insulin/IGF-1-like pathway in C. elegans

  2025cites this paper
• Systems genetics of lifespan and senescence in Drosophila melanogaster

  2025cites this paper
• Insulin receptor substrate family member IST-1 regulates the development of Caenorhabditis elegans age-1 and aap-1 mutants

  2025cites this paper
• Nictation behavior in nematodes

  2025cites this paper
• Optimized synthesis of 5N-D and the exploration of its role as a promising anti-aging agent via AKR1B1 inhibition and PI3K/Akt/Nrf2 regulation.

  2025cites this paper
• INS-17, an insulin-receptor ligand, confers specificity in adult IIS-regulated phenotypes in C. elegans

  2025cites this paper
• An mTOR inhibitor discovery system using drug-sensitized yeast

  2025cites this paper
• The Role of Hypoxia in Longevity

  2025cites this paper
• Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans

  2025cites this paper
• The many roads to C. elegans dauer arrest: A review and perspective

  2025cites this paper
• Chromatin and epigenetics in aging biology.

  2025cites this paper
• Effect of Drying Methods on the Structural Characteristics and Antioxidant Stress Potential of Pumpkin Polysaccharides

  2024cites this paper
• The evolution of developmental biology through conceptual and technological revolutions.

  2024cites this paper
• Silencing Ditylenchus destructor cathepsin L-like cysteine protease has negative pleiotropic effect on nematode ontogenesis

  2024cites this paper
• An insulin-like signalling pathway model for Fasciola gigantica

  2024cites this paper
• Illuminating Genetic Diversity and Selection Signatures in Matou Goats through Whole-Genome Sequencing Analysis

  2024cites this paper
• Memory defects in post-dauer Caenorhabditis elegans are a result of altered insulin signalling

  2024cites this paper
• [Regulation of Aging Processes: A Perspective of Dietary Restriction Models].

  2024cites this paper
• HORMESIS DETERMINES LIFESPAN.

  2024cites this paper
• Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms.

  2024cites this paper
• Caenorhabditis elegans as a Model to Study Aging and Photoaging

  2024cites this paper
• Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function

  2024cites this paper
• Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology

  2024cites this paper
• Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements

  2023cites this paper
• The role of nutrition and oxidative stress as aging factors in Caenorhabditis elegans

  2023cites this paper
• Mechanisms underlying retardation of aging by dietary energy restriction

  2023cites this paper
• Restructuring of an asymmetric neural circuit during associative learning

  2023cites this paper
• Banking on a new understanding: translational opportunities from veterinary biobanks

  2023cites this paper
• Biological resilience and aging: Activation of stress response pathways contributes to lifespan extension.

  2023cites this paper
• Decelerating aging process with physical activity - a review

  2023cites this paper
• Anatomical restructuring of a lateralized neural circuit during associative learning by asymmetric insulin signaling.

  2023cites this paper
• DNA damage signals from somatic uterine tissue arrest oogenesis through activated FOXO/DAF-16.

  2023cites this paper
• TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

  2023cites this paper
• Metabolic plasticity sustains the robustness of Caenorhabditis elegans embryogenesis

  2023cites this paper
• Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode Caenorhabditis elegans.

  2023cites this paper
• Starvation-induced changes in somatic insulin/IGF-1R signaling drive metabolic programming across generations

  2023cites this paper
• C. elegans as an Animal Model to Study the Intersection of DNA Repair, Aging and Neurodegeneration

  2022cites this paper
• Lung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis

  2022cites this paper
• Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections

  2022cites this paper
• HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network

  2022cites this paper
• Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans

  2022cites this paper
• FOXO3, a Resilience Gene: Impact on Lifespan, Healthspan, and Deathspan.

  2022cites this paper
• Bioactive phlorotannin as autophagy modulator in cervical cancer cells and advanced glycation end products inhibitor in glucotoxic C. elegans

  2022cites this paper
• Nutrient-Response Pathways in Healthspan and Lifespan Regulation

  2022cites this paper
• Resilience integrates concepts in aging research

  2022cites this paper
• Genetic analysis of daf-18/PTEN missense mutants for starvation resistance and developmental regulation during Caenorhabditis elegans L1 arrest

  2022cites this paper
• Evaluation of Paecilomyces tenuis producing Huperzine A for the management of root-knot nematode Meloidogyne incognita (Nematoda: Meloidogynidae)

  2022cites this paper
• Conserved neuropeptidergic regulation of intestinal integrity in invertebrate models of aging

  2022cites this paper
• A cell non-autonomous FOXO/DAF-16-mediated germline quality assurance program that responds to somatic DNA damage

  2022cites this paper
• Ageing induces tissue‐specific transcriptomic changes in Caenorhabditis elegans

  2022cites this paper
• Oxidation and Antioxidation of Natural Products in the Model Organism Caenorhabditis elegans

  2022cites this paper
• Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost

  2022cites this paper
• DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome

  2022cites this paper
• Hormonal Regulation of Diapause and Development in Nematodes, Insects, and Fishes

  2021cites this paper
• PI3K inhibitors are finally coming of age

  2021cites this paper
• Molecular and cellular pathways contributing to brain aging

  2021cites this paper
• Degrading intestinal DAF-2 nearly doubles Caenorhabditis elegans lifespan without affecting development or reproduction

  2021cites this paper
• On the role of dauer in the adaptation of nematodes to a parasitic lifestyle

  2021cites this paper
• Investigating the molecular mechanisms of learning and memory using Caenorhabditis elegans

  2021influential citation
• A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

  2021cites this paper
• Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF‐1 pathway

  2021cites this paper
• Immunity-longevity tradeoff neurally controlled by GABAergic transcription factor PITX1/UNC-30

  2021cites this paper
• Career Retrospective: Tom Johnson - Genetics, Genomics, Stress, Stochastic Variation and Aging.

  2021cites this paper
• Mutation of daf‐2 extends lifespan via tissue‐specific effectors that suppress distinct life‐limiting pathologies

  2021influential citation
• Targeting SHIP1 and SHIP2 in Cancer

  2021cites this paper
• Hydrogen sulfide in longevity and pathologies: inconsistency is malodorous.

  2021cites this paper
• Signaling pathways and effectors of aging.

  2021cites this paper
• The hypothalamus for whole-body physiology: from metabolism to aging

  2021cites this paper
• p110δ PI3K as a therapeutic target of solid tumours.

  2020cites this paper
• Role of insulin/insulin-like growth factor-1 signaling pathway genes on the lifespan of Caenorhabditis elegans

  2020cites this paper
• [Genetics and evolution of developmental plasticity in the nematode C. elegans: Environmental induction of the dauer stage].

  2020cites this paper
• Forward genetic approach for behavioral neuroscience using animal models

  2020cites this paper
• You Have Come A Long Way Baby: Five Decades of Research on the Biology of Aging from the Perspective of a Researcher Studying Aging.

  2020cites this paper
• Bring Back the Rat!

  2020influential citation
• DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling

  2020cites this paper
• Gluconeogenesis and PEPCK are critical components of healthy aging and dietary restriction life extension

  2020cites this paper
• Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum

  2020cites this paper
• An Old Question Revisited: Current Understanding of Aging Theories

  2020cites this paper
• Growth hormone and aging

  2020cites this paper
• The Promise of a Golden Era for Exploring the Frontiers of Aging, Metabolism and Redox Biology

  2020cites this paper
• Caenorhabditis elegans as a Useful Model for Studying Aging Mutations

  2020cites this paper
• Die eukaryotische Zelle und Modellorganismen

  2020cites this paper
• Thermotolerance of tax-2 Is Uncoupled From Life Span Extension and Influenced by Temperature During Development in C. elegans

  2020cites this paper
• A serine/threonine‐specific protein kinase of Haemonchus contortus with a role in the development

  2019cites this paper
• Metabolic Biomarkers in Nematode C. elegans During Aging.

  2019cites this paper
• Insulin is produced in choroid plexus and its release is regulated by serotonergic signaling.

  2019cites this paper
• On the epigenetic ageing clock in humans

  2019cites this paper
• Plausible Links Between Metabolic Networks, Stem Cells, and Longevity.

  2019cites this paper
• The role of decreasing protein synthesis in delaying ageing : emphasis on translation accuracy

  2019cites this paper
• Inhibition of advanced glycation end products formation and inflammation in C. elegans: Studies of potential of Lyngbya sp. against expression of stress related genes and Live cell imaging

  2019cites this paper
• Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response.

  2019cites this paper
• PI 3 ‐ kinase isoforms at the crossroads of signalling and vesicular traffic

  2019cites this paper
• Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

  2019cites this paper
• Genes that Delay Aging

  2019cites this paper
• Invertebrate and vertebrate models in aging research. A review.

  2019cites this paper